; ============================================= DESCRIPTION: model_2cpt_linear_abs1 PK model for simulation of drug concentration in central compartment with following characteristics: Compartments: 2 Elimination : linear Absorption : first order (with lag t) Unit convention Dose: mg Concentration: ug/mL Time: hours The annotation of the parameter units is consistent with the given unit convention. Units of the inputs (dose) and outputs (concentration) in the dataset for parameter estimation need to match the unit convention. ; ============================================= [LONGITUDINAL] input = {ka,CL,Vc,Q1,Vp1} ; ============================================= PK: ; ============================================= ; Model parameters ; ---------------- Tlag1 = 0 ; Absorption lag t (hours) ; Model compartments ; ------------------ compartment(cmt=1, amount=Ac) compartment(cmt=2, amount=Ap1) ; Model dosing ; ------------ absorption(cmt=1, type=1, ka=ka, p=1, Tlag=Tlag1) ; Transfer and elimination definitions ; ------------------------------------ elimination(cmt=1, k=-(-(CL/Vc + Q1/Vc))-(Q1/Vc)) transfer(from=2, to=1, kt=Q1/Vp1) transfer(from=1, to=2, kt=Q1/Vc) ; Output variables ; ---------------- Cc = Ac/Vc ; ============================================= OUTPUT: ; ============================================= output = {Cc}