********** MODEL NAME model_1cpt_linear_abs0 ********** MODEL NOTES PK model for simulation of drug concentration in central compartment with following characteristics: Compartments: 1 Elimination : linear Absorption : zero order (with lag time) Unit convention Dose: mg Concentration: ug/mL Time: hours The annotation of the parameter units is consistent with the given unit convention. Units of the inputs (dose) and outputs (concentration) in the dataset for parameter estimation need to match the unit convention. ********** MODEL STATES d/dt(Ac) = - CL/Vc*Ac + Fabs0*INPUT1 Ac(0) = 0 ********** MODEL PARAMETERS Fabs0 = 1 # Relative bioavailability (-) CL = 3 # Apparent clearance (L/hour) Vc = 32 # Apparent central volume (L) Tk0 = 1 # Absorption time (hours) Tlag1 = 0 # Absorption lag time (hours) ********** MODEL VARIABLES % Calculation of concentration in central compartment Cc = Ac/Vc % Defining an output (only needed when interfacing with NLME % parameter estimation tools such as NONMEM and MONOLIX) OUTPUT1 = Cc # Compound concentration (ug/mL) ********** MODEL REACTIONS ********** MODEL FUNCTIONS ********** MODEL EVENTS