********** MODEL NAME model_1cpt_linear_abs1_urine ********** MODEL NOTES PK model for simulation of drug concentration in central compartment with following characteristics: Compartments: 1 Elimination : linear + urine data Absorption : first order (with lag time) Unit convention Dose: mg Concentration: ug/mL Time: hours The annotation of the parameter units is consistent with the given unit convention. Units of the inputs (dose) and outputs (concentration) in the dataset for parameter estimation need to match the unit convention. ********** MODEL STATES d/dt(Ad) = -kabs*Ad + Fabs1*INPUT1 d/dt(Ac) = kabs*Ad - CLNR/Vc*Ac - CLR/Vc*Ac d/dt(UR) = + CLR/Vc*Ac Ad(0) = 0 Ac(0) = 0 UR(0) = 0 ********** MODEL PARAMETERS Fabs1 = 1 # Relative bioavailability (-) kabs = 2 # Absorption rate parameter (1/hour) CLNR = 3 # Non-renal clearance (L/hour) CLR = 3 # Renal clearance (L/hour) Vc = 32 # Apparent central volume (L) Tlag1 = 0 # Absorption lag time (hours) ********** MODEL VARIABLES % Calculation of concentration in central compartment Cc = Ac/Vc % Calculation of Urine Urine = UR % Defining an output (only needed when interfacing with NLME % parameter estimation tools such as NONMEM and MONOLIX) OUTPUT1 = Cc # Compound concentration (ug/mL) OUTPUT2 = Urine # Amount (ug) ********** MODEL REACTIONS ********** MODEL FUNCTIONS ********** MODEL EVENTS