********** MODEL NAME
model_1cpt_linear_abs1emax

********** MODEL NOTES

PK model for simulation of drug concentration in central compartment
with following characteristics:
Compartments:  1
Elimination :  linear
Absorption  :  first order time dependent absorption Emax model (with lag time)

Unit convention
Dose: mg
Concentration: ug/mL
Time: hours

The annotation of the parameter units is consistent with the given unit convention.
Units of the inputs (dose) and outputs (concentration) in the dataset for parameter estimation need to match the unit convention.

********** MODEL STATES
d/dt(Ad) 	= - ka*Ad + Fabs1*INPUT1
d/dt(Ac) 	=   ka*Ad - CL/Vc*Ac
Ad(0) 	 	= 0
Ac(0)    	= 0

********** MODEL PARAMETERS
Fabs1         = 1   # Relative bioavailability (fraction)
kafin 	      = 2   # Asymptotic value of ka (1/hour)
CL 	      = 3   # Apparent clearance (L/hour)
Vc 	      = 32  # Apparent central volume (L)
Tlag1         = 0   # Absorption lag time (hours)
Hill          = 1   # Hill coefficient (-)
T50           = 2   # Time at which kabs is half of kafin

********** MODEL VARIABLES
ka   = kafin*(time^Hill/(T50^Hill+time^Hill))
Cc		  = Ac/Vc
OUTPUT1  	  = Cc 

********** MODEL REACTIONS


********** MODEL FUNCTIONS


********** MODEL EVENTS