********** MODEL NAME
model_1cpt_linear_tc2

********** MODEL NOTES

PK model for simulation of drug concentration in central compartment
with following characteristics:
Compartments:  1
Elimination :  linear
Absorption  :  2 transit compartments

Unit convention
Dose: mg
Concentration: ug/mL
Time: hours

The annotation of the parameter units is consistent with the given unit convention.
Units of the inputs (dose) and outputs (concentration) in the dataset for parameter estimation need to match the unit convention.

********** MODEL STATES
d/dt(Ad) 	= -kabs*Ad + Fabs1*INPUT1
d/dt(TC1) 	= +kabs*Ad - ktr*TC1
d/dt(TC2) 	=          + ktr*TC1 - ktr*TC2
d/dt(Ac) 	=          + ktr*TC2 - CL/Vc*Ac

Ad(0) 	 	= 0
TC1(0) 	 	= 0
TC2(0) 	 	= 0
Ac(0)    	= 0

********** MODEL PARAMETERS
Fabs1    	= 1   # Relative bioavailability (-)
kabs 	        = 2   # Absorption rate parameter (1/hour)
CL 		= 3   # Apparent clearance (L/hour)
Vc 		= 32  # Apparent central volume (L)
ktr             = 0.5 # Transit compartment rate constant (1/hours)

********** MODEL VARIABLES

% Calculation of concentration in central compartment
Cc 			  = Ac/Vc

% Defining an output (only needed when interfacing with NLME
% parameter estimation tools such as NONMEM and MONOLIX)
OUTPUT1  	  = Cc  # Compound concentration (ug/mL)

********** MODEL REACTIONS


********** MODEL FUNCTIONS


********** MODEL EVENTS