********** MODEL NAME model_2cpt_linear_abs01par ********** MODEL NOTES PK model for simulation of drug concentration in central compartment with following characteristics: Compartments: 2 Elimination : linear Absorption : parallel zero and first order (with lag time) Unit convention Dose: mg Concentration: ug/mL Time: hours The annotation of the parameter units is consistent with the given unit convention. Units of the inputs (dose) and outputs (concentration) in the dataset for parameter estimation need to match the unit convention. ********** MODEL STATES d/dt(Ad) = + Fabs0*(1-Frel0) *INPUT1 - kabs*Ad d/dt(Ac) = + Fabs0*Frel0*INPUT2 - Q1/Vc*Ac + Q1/Vp1*Ap1 - CL/Vc*Ac + kabs*Ad d/dt(Ap1) = + Q1/Vc*Ac - Q1/Vp1*Ap1 Ad(0) = 0 Ac(0) = 0 Ap1(0) = 0 ********** MODEL PARAMETERS Fabs0 = 1 # Relative bioavailability (fraction) CL = 3 # Apparent clearance (L/hour) Vc = 32 # Apparent central volume (L) Q1 = 1 # Apparent intercompartmental clearance (L/hour) Vp1 = 10 # Apparent peripheral volume (L) Tk0 = 1 # Absorption time (hours) Tlag1 = 0 # Absorption lag time in 1th order process(hours) Tlag2 = 0 # Absorption lag time in 0th order process(hours) kabs = 0.8 # First-order absorption rate constant (1/hours) Frel0 = 0.5 # Relative fraction absorbed in 0th order process (fraction) ********** MODEL VARIABLES % Calculation of concentration in central compartment Cc = Ac/Vc % Defining an output (only needed when interfacing with NLME % parameter estimation tools such as NONMEM and MONOLIX) OUTPUT1 = Cc # Compound concentration (ug/mL) ********** MODEL REACTIONS ********** MODEL FUNCTIONS ********** MODEL EVENTS