********** MODEL NAME model_2cpt_linear_abs11 ********** MODEL NOTES PK model for simulation of drug concentration in central compartment with following characteristics: Compartments: 2 Elimination : linear Absorption : parallel dual first order absorption (with lags times) Unit convention Dose: mg Concentration: ug/mL Time: hours The annotation of the parameter units is consistent with the given unit convention. Units of the inputs (dose) and outputs (concentration) in the dataset for parameter estimation need to match the unit convention. ********** MODEL STATES d/dt(Ad1) = -ka1*Ad1 + Fabs*(1-Frel0)*1000*INPUT1 d/dt(Ad2) = -ka2*Ad2 + Fabs*Frel0*1000*INPUT2 d/dt(Ac) = +ka1*Ad1 + ka2*Ad2 - Q1/Vc*Ac + Q1/Vp1*Ap1 - CL/Vc*Ac d/dt(Ap1) = + Q1/Vc*Ac - Q1/Vp1*Ap1 Ad1(0) = 0 Ad2(0) = 0 Ac(0) = 0 Ap1(0) = 0 ********** MODEL PARAMETERS Fabs = 1 # Relative oral bioavailability (fraction) Frel0 = 0.5 # Relative fraction absorbed in 0th order process (fraction) ka1 = 0.8 # Absorption rate parameter fast (1/hour) ka2 = 0.2 # Absorption rate parameter slow (1/hour) Tlag1 = 0 # Lag time fast absorption process (hour) Tlag2 = 0 # Lag time slow absorption process (hour) CL = 3 # Apparent clearance (L/hour) Vc = 32 # Apparent central volume (L) Q1 = 1 # Apparent intercompartmental clearance (L/hour) Vp1 = 10 # Apparent peripheral volume (L) ********** MODEL VARIABLES % Calculation of concentration in central compartment Cc = Ac/Vc % Defining an output (only needed when interfacing with NLME % parameter estimation tools such as NONMEM and MONOLIX) OUTPUT1 = Cc # Compound concentration (ug/mL) ********** MODEL REACTIONS ********** MODEL FUNCTIONS ********** MODEL EVENTS