********** MODEL NAME
model_3cpt_linear_abs01seq
********** MODEL NOTES
PK model for simulation of drug concentration in central compartment
with following characteristics:
Compartments: 3
Elimination : linear
Absorption : sequential zero and first order (with lag time)
Unit convention
Dose: mg
Concentration: ug/mL
Time: hours
The annotation of the parameter units is consistent with the given unit convention.
Units of the inputs (dose) and outputs (concentration) in the dataset for parameter estimation need to match the unit convention.
********** MODEL STATES
d/dt(Ad) = Fabs0*INPUT1 - kabs*Ad
d/dt(Ac) = - Q1/Vc*Ac + Q1/Vp1*Ap1 - Q2/Vc*Ac + Q2/Vp2*Ap2 - CL/Vc*Ac + kabs*Ad
d/dt(Ap1) = + Q1/Vc*Ac - Q1/Vp1*Ap1
d/dt(Ap2) = + Q2/Vc*Ac - Q2/Vp2*Ap2
Ad(0) = 0
Ac(0) = 0
Ap1(0) = 0
Ap2(0) = 0
********** MODEL PARAMETERS
Fabs0 = 1 # Relative bioavailability (-)
CL = 3 # Apparent clearance (L/hour)
Vc = 32 # Apparent central volume (L)
Q1 = 1 # Apparent intercompartmental clearance to first peripheral compartment (L/hour)
Vp1 = 10 # Apparent first peripheral volume (L)
Q2 = 1 # Apparent intercompartmental clearance to second peripheral compartment (L/hour)
Vp2 = 10 # Apparent second peripheral volume (L)
Tk0 = 1 # Absorption time (hours)
Tlag1 = 0 # Absorption lag time (hours)
kabs = 0.8 # First-order absorption rate constant (1/hours)
********** MODEL VARIABLES
% Calculation of concentration in central compartment
Cc = Ac/Vc
% Defining an output (only needed when interfacing with NLME
% parameter estimation tools such as NONMEM and MONOLIX)
OUTPUT1 = Cc # Compound concentration (ug/mL)
********** MODEL REACTIONS
********** MODEL FUNCTIONS
********** MODEL EVENTS