********** MODEL NAME
model_3cpt_linear_iv
********** MODEL NOTES
PK model for simulation of drug concentration in central compartment
with following characteristics:
Compartments: 3
Elimination : linear
Absorption : none (infusion/iv)
Unit convention
Dose: mg
Concentration: ug/mL
Time: hours
The annotation of the parameter units is consistent with the given unit convention.
Units of the inputs (dose) and outputs (concentration) in the dataset for parameter estimation need to match the unit convention.
********** MODEL STATES
d/dt(Ac) = - Q1/Vc*Ac + Q1/Vp1*Ap1 - Q2/Vc*Ac + Q2/Vp2*Ap2 - CL/Vc*Ac + INPUT1
d/dt(Ap1) = + Q1/Vc*Ac - Q1/Vp1*Ap1
d/dt(Ap2) = + Q2/Vc*Ac - Q2/Vp2*Ap2
Ac(0) = 0
Ap1(0) = 0
Ap2(0) = 0
********** MODEL PARAMETERS
CL = 3 # Clearance (L/hour)
Vc = 32 # Central volume (L)
Q1 = 1 # Intercompartmental clearance to first peripheral compartment (L/hour)
Vp1 = 10 # First peripheral volume (L)
Q2 = 1 # Intercompartmental clearance to second peripheral compartment (L/hour)
Vp2 = 10 # Second peripheral volume (L)
********** MODEL VARIABLES
% Calculation of concentration in central compartment
Cc = Ac/Vc
% Defining an output (only needed when interfacing with NLME
% parameter estimation tools such as NONMEM and MONOLIX)
OUTPUT1 = Cc # Compound concentration (ug/mL)
********** MODEL REACTIONS
********** MODEL FUNCTIONS
********** MODEL EVENTS