8 Analysis dataset preparation

IQR Tools implements functionality to facilitate the creation of analysis or modeling datasets based on a general dataset format. The general dataset format aims to at least contain a minimum if inforamtion required and - at the same time - to be flexible to store all information that is relevant for the analysis.

The functions provided by IQRtools enable a traceable programming of the analysis data set. Metadata (e.g., covariate value units, or covariate category labels) is retained and available for documentation and producing meaningful graphs and tables. When manipulating the data for a particular task, e.g., removal of outliers, imputing covariates, log files are written.

In a first section (Example workflow) of this chapter a basic example for establishing a analysis dataset in the following steps is given:

  • Dataset specification of origin
    • Import to the IQRdataGENERAL format
    • Graphical data exploration
    • Cleaning the data to establish analysis dataset
    • Export to .csv and .xpt

The second section, (Further options) discusses more features for the following steps with which the basic workflow can be customized.

  • Settings for dataset import
  • Statistical exploration
  • Graphical exploration

8.1 Example workflow

8.1.1 Original dataset in general row-based format

In our example, the source data contains data from a single ascending dose study in healthy male subjects that should be prepared for a population PK analysis. The dataset is provided as a comma separated file:

# Define dataset location
dataFile <- "material/01-01-DataProgAnal/dataSource01.csv"
sourceData <- read.csv(dataFile)
Table 8.1: Source example dataset 1
USUBJID TRTNAME TIME NT TIMEUNIT NAME VALUE VALUETXT UNIT LLOQ ROUTE CENTER VISIT STUDY
IQ00701-0100-0001 Placebo -167.88 -168.00 Hours Age 34 . Years . . 100 1 FIH
IQ00701-0100-0001 Placebo -167.88 -168.00 Hours Gender 1 male . . . 100 1 FIH
IQ00701-0100-0001 Placebo -1.00 -1.00 Hours Bodyweight 89 . kg . . 100 2 FIH
IQ00701-0100-0001 Placebo -1.00 -1.00 Hours Height 185 . cm . . 100 2 FIH
IQ00701-0100-0001 Placebo 23.00 23.00 Hours Height 200 . cm . . 100 2 FIH
IQ00701-0100-0001 Placebo 39.00 39.00 Hours Height 250 . cm . . 100 2 FIH
IQ00701-0100-0001 Placebo -0.08 -0.08 Hours Plasma concentration IQ0815 0 . ug/mL 0.001 . 100 2 FIH
IQ00701-0100-0001 Placebo 0.00 0.00 Hours Dose IQ0815 0 . mg . oral 100 2 FIH
IQ00701-0100-0001 Placebo 0.08 0.08 Hours Plasma concentration IQ0815 0 . ug/mL 0.001 . 100 2 FIH
IQ00701-0100-0001 Placebo 0.25 0.25 Hours Plasma concentration IQ0815 0 . ug/mL 0.001 . 100 2 FIH
IQ00701-0100-0002 1mg oral single dose -167.35 -168.00 Hours Age 29 . Years . . 100 1 FIH
IQ00701-0100-0002 1mg oral single dose -167.35 -168.00 Hours Gender 1 male . . . 100 1 FIH

The source dataset contains all information (doses, observations, covariates) in a row-based format and has preserved column names used for the data import in IQR Tools (see table below for a description of the columns of the example dataset). Of the columns in the data only seven (written in bold) are required, but there exist more preserved column names such as "STUDY", "PART", or "COMPOUND" to cover the typical information used in pharmacometric or systems pharamacology analyses. The general dataset format is described in detail in the chapter General Dataset Format

An important column is the NAME column identifying which type of event is recorded, e.g., whether the row reports an dosing event, measured plasma concentration value or the age of the subject. Typical entries for these example could be "Aspririn dose", "Aspirin concentration", or "Age at screening visit". The VALUE column exclusively contains numerical values. For categorical covariates the VALUETXT column is used instead or in addition to note the category value, e.g., "yes"/"no" or "red"/"blue"/"green".

Column Description
USUBJID Unique subject identifier
TRTNAME Name of actual treatment given to subject
TIME (NUMERIC) Actual time of event relative to first dose administration
NT (NUMERIC) Nominal event time
TIMEUNIT Unit of all numeric time definitions in the dataset (HOURS, MINUTES, DAYS, SECONDS, WEEKS, MONTHS, YEARS)
NAME Unique short name of event
VALUE (NUMERIC) Value of event defined by NAME
VALUETXT Text version of value (If VALUETXT is defined, VALUE can be undefined and is used to code categorical information
UNIT Unit of the value reported in the VALUE column
LLOQ (NUMERIC) Lower limit of quantification for event defined by NAME (value only interpreted for observation events)
ROUTE Route of administration (e.g., IV,SUBCUT,ORAL,TOPICAL) (value only interpreted for dosing events)
CENTER Center number
VISIT Visit number

8.1.2 Import as IQRdataGENERAL format

To create an analysis dataset, we need to reformat the dataset and add columns needed for the model-based analysis:

  • Numerical columns need to be created
    • to discriminate dosing from observation records,
    • to identify different observation and dosing types, and
    • to flag whether records are valid, missing or out of the measureable range
  • Covariates need to be provided in (numerical) columns

Based on the NAME column, we can specify which records are dosing information, observations, and covariate information. For the dosing and observation records, they only need to be listed in a vector. For the covariate records, we need to have a named vector. The names are used as the column names of the covariate columns that will be created.

# Define the names (NAME column) of the records you want to consider as dose records
doseNAMES <- "Dose IQ0815"
# Define the names (NAME column) of the records you want to consider as observation records
obsNAMES <- "Plasma concentration IQ0815"
# Define the CONTINUOUS covariate columns (time INDEPENDENT)
cov0 <- c(
  WT0  = "Bodyweight",          # COLNAME = "NAME of the event"
  AGE0 = "Age",
  HT0  = "Height"
)
# Define the CATEGORICAL covariate columns (time INDEPENDENT) that you want to generate
# from event records in the general dataset
cat0 <- c(
  SEX  = "Gender"
)
# Convert general dataset as an IQRdataGENERAL object
data1 <- IQRdataGENERAL(input=dataFile,
                        doseNAMES=doseNAMES, obsNAMES=obsNAMES,
                        cov0=cov0,cat0=cat0)
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of WT0 for
## IQ00701-0100-0008 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of AGE0 for
## IQ00701-0100-0008 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of HT0 for
## IQ00701-0100-0008 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of HT0 for
## IQ00701-0100-0013 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for
## IQ00701-0100-0008 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for
## IQ00701-0100-0011 defined.

The resulting data object data1 contains additional columns that are needed for model-based anylsis. Some important columns that have been created are

  • the column EVID indicating dosing events (EVID = 1) and observarion records (EVID = 0),
  • the column YTYPE discriminating different observation types,
  • the column ADM discriminating different dosing types,
  • the column AMT to annotate dosing amount,
  • the column MDV flagging missing data values (MDV = 1),
  • the column CENS flagging data values outside the measurable range (e.g., CENS = 1 for BLQ values)
  • the column IXGDF with a unique record number for each row of the dataset.

The covariate columns WT0, HT0, AGE0, and SEX have been added as well containing numerical values.

Table 8.2: Example dataset 1 imported as IQRdataGENERAL (selected columns and first 12 rows)
IXGDF USUBJID TRTNAME TIME TIMEUNIT VALUE AMT EVID YTYPE ADM MDV CENS WT0 HT0 AGE0 SEX
5 7 IQ00701-0100-0001 Placebo -0.08 HOURS 0 0 0 1 0 1 0 89 185 34 1
6 8 IQ00701-0100-0001 Placebo 0.00 HOURS 0 0 1 0 1 1 0 89 185 34 1
7 9 IQ00701-0100-0001 Placebo 0.08 HOURS 0 0 0 1 0 1 0 89 185 34 1
8 10 IQ00701-0100-0001 Placebo 0.25 HOURS 0 0 0 1 0 1 0 89 185 34 1
15 15 IQ00701-0100-0002 1mg oral single dose 0.00 HOURS 1 1 1 0 1 1 0 65 186 29 1
20 20 IQ00701-0100-0003 1mg oral single dose -0.08 HOURS 0 0 0 1 0 1 0 80 180 28 1
21 21 IQ00701-0100-0003 1mg oral single dose 0.00 HOURS 1 1 1 0 1 1 0 80 180 28 1
22 22 IQ00701-0100-0003 1mg oral single dose 0.08 HOURS 0 0 0 1 0 1 0 80 180 28 1
23 23 IQ00701-0100-0003 1mg oral single dose 0.25 HOURS 0 0 0 1 0 0 0 80 180 28 1
24 24 IQ00701-0100-0003 1mg oral single dose 0.50 HOURS 0 0 0 1 0 0 0 80 180 28 1
25 25 IQ00701-0100-0003 1mg oral single dose 1.00 HOURS 0 0 0 1 0 0 0 80 180 28 1
26 26 IQ00701-0100-0003 1mg oral single dose 2.00 HOURS 0 0 0 1 0 0 0 80 180 28 1

The variable data1 adopted the class IQRdataGENERAL that stores metadata in its attributes. Amongst others, the attributes store the information on units, category and covariate names and can be called using the convenience functions covInfo() and catInfo(). Importantly, if present in the source data, the columns STUDY and TRTNAME containing character values covariate columns were used to create covariate columns STUDYN and TRT containing numerical values.

# Display information on continuous covariates
covInfo(data1)
COLNAME NAME UNIT TIME.VARYING
WT0 Bodyweight kg FALSE
AGE0 Age Years FALSE
HT0 Height cm FALSE
# Display information on categorical covariates
catInfo(data1)
COLNAME NAME UNIT VALUETXT VALUES TIME.VARYING
SEX Gender NA male 1 FALSE
STUDYN Study
FIH,FIH extension 1,2 FALSE
TRT TRTNAME
Placebo,1mg oral single dose,2mg oral single dose,5mg oral single dose,10mg oral single dose,20mg oral single dose,50mg oral single dose,100mg oral single dose,200mg oral single dose 9,3,6,8,2,5,7,1,4 FALSE

Using the summary function useful information on the data is displayed. In addition, data integrity checks are performed.

summary(data1)
##    INFO                                          | NAME                        | VALUE                                              
##    ---------------------------------------------------------------------------------------------------------------------------------
##    Dose events                                   | Dose IQ0815                 | Ntotal: 48,  Nindiv (min/median/max): 1/1/1)       
##    Observation events (all)                      | Plasma concentration IQ0815 | Ntotal: 543,  Nindiv (min/median/max): 3/12/12)    
##    Observation events (MDV=0)                    | Plasma concentration IQ0815 | Ntotal: 410,  Nindiv (min/median/max): 5/10/11)    
##    Doses AMT=0 present                           | ALL dose events             | TRUE (N=1)                                         
##    Placebo subjects present (AMT=0 or no doses)  | ALL dose events             | TRUE (N=1)                                         
##    IGNORED (MDV=1) observation records present   | ALL observation events      | TRUE (N=133)                                       
##    Subjects without observations (MDV=0) present | ALL observation events      | TRUE (N=3)                                         
##    Total BLLOQ information                       | Plasma concentration IQ0815 | N=133 / 24.5%                                      
##    Max % BLLOQ values in a subject               | Plasma concentration IQ0815 | 8.33%                                              
##    BLLOQ handling method                         | All observation events      | M1                                                 
##    NLME columns containing NA                    | All events                  | WT0, AGE0, HT0, SEX                                
##    Issues present in the data                    | Minor                       | YES (see text below the table for more information)
##    Issues present in the data                    | Warnings                    | NONE                                               
##    Issues present in the data                    | Errors                      | NONE                                               
## 
## 
## IQRoutputTable object
## 
## MINOR issues in the dataset that might be addressed
## ===================================================
## SUBJECT LEVEL (IQ00701-0100-0005): Subject has records of NAME "Plasma concentration IQ0815" at same TIME points

The summary and checks help to detect issues in the dataset that should be fixed before an analysis starts. In this example, there is only one placebo subject, but there are 3 individuals without any observation records. Thus, we may want to remove these individuals as well as a duplicated plasma record for subject "IQ00701_0100_0005". Also, the covariate columns contain NA values and we probably need to impute values for some individuals.

8.1.3 Source data exploration

An recommended step before any data analysis or modeling activity is to explore the data visually. IQR Tools provides a range of standard plotting function. Here, we make use of two of them, the function plotSpaghetti_IQRdataGENERAL() producing line plots per treatment group that is very useful to get an overview on the observation time courses and the function plotIndiv_IQRdataGENERAL() producing much more detailed plots for evry individual in a pdf file.

# Line plots stratified by treatment group
plotSpaghetti_IQRdataGENERAL(data1)
## $unstratified
## $unstratified$`Plasma concentration IQ0815`

## 
## attr(,"split_type")
## [1] "data.frame"
## attr(,"split_labels")
##                          NAME
## 1 Plasma concentration IQ0815
## 
## $stratified
## list()
## attr(,"strat_info")
## data frame with 0 columns and 0 rows
## 
## attr(,"data")
## attr(,"data")$unstratified
## attr(,"data")$unstratified$`Plasma concentration IQ0815`
##     IXGDF IGNORE           USUBJID CENTER         STUDY STUDYN
## 1      23   <NA> IQ00701-0100-0003    100           FIH      1
## 2      24   <NA> IQ00701-0100-0003    100           FIH      1
## 3      25   <NA> IQ00701-0100-0003    100           FIH      1
## 4      26   <NA> IQ00701-0100-0003    100           FIH      1
## 5      27   <NA> IQ00701-0100-0003    100           FIH      1
## 6      39   <NA> IQ00701-0100-0004    100           FIH      1
## 7      40   <NA> IQ00701-0100-0004    100           FIH      1
## 8      41   <NA> IQ00701-0100-0004    100           FIH      1
## 9      42   <NA> IQ00701-0100-0004    100           FIH      1
## 10     43   <NA> IQ00701-0100-0004    100           FIH      1
## 11     44   <NA> IQ00701-0100-0004    100           FIH      1
## 12     57   <NA> IQ00701-0100-0005    100           FIH      1
## 13     58   <NA> IQ00701-0100-0005    100           FIH      1
## 14     59   <NA> IQ00701-0100-0005    100           FIH      1
## 15     60   <NA> IQ00701-0100-0005    100           FIH      1
## 16     61   <NA> IQ00701-0100-0005    100           FIH      1
## 17     62   <NA> IQ00701-0100-0005    100           FIH      1
## 18     74   <NA> IQ00701-0100-0006    100           FIH      1
## 19     75   <NA> IQ00701-0100-0006    100           FIH      1
## 20     76   <NA> IQ00701-0100-0006    100           FIH      1
## 21     77   <NA> IQ00701-0100-0006    100           FIH      1
## 22     78   <NA> IQ00701-0100-0006    100           FIH      1
## 23     90   <NA> IQ00701-0100-0007    100           FIH      1
## 24     91   <NA> IQ00701-0100-0007    100           FIH      1
## 25     92   <NA> IQ00701-0100-0007    100           FIH      1
## 26     93   <NA> IQ00701-0100-0007    100           FIH      1
## 27     94   <NA> IQ00701-0100-0007    100           FIH      1
## 28     95   <NA> IQ00701-0100-0007    100           FIH      1
## 29     98   <NA> IQ00701-0100-0007    100           FIH      1
## 30    108   <NA> IQ00701-0100-0009    100           FIH      1
## 31    109   <NA> IQ00701-0100-0009    100           FIH      1
## 32    110   <NA> IQ00701-0100-0009    100           FIH      1
## 33    111   <NA> IQ00701-0100-0009    100           FIH      1
## 34    112   <NA> IQ00701-0100-0009    100           FIH      1
## 35    113   <NA> IQ00701-0100-0009    100           FIH      1
## 36    114   <NA> IQ00701-0100-0009    100           FIH      1
## 37    125   <NA> IQ00701-0100-0010    100           FIH      1
## 38    126   <NA> IQ00701-0100-0010    100           FIH      1
## 39    127   <NA> IQ00701-0100-0010    100           FIH      1
## 40    128   <NA> IQ00701-0100-0010    100           FIH      1
## 41    129   <NA> IQ00701-0100-0010    100           FIH      1
## 42    130   <NA> IQ00701-0100-0010    100           FIH      1
## 43    141   <NA> IQ00701-0100-0011    100           FIH      1
## 44    142   <NA> IQ00701-0100-0011    100           FIH      1
## 45    143   <NA> IQ00701-0100-0011    100           FIH      1
## 46    144   <NA> IQ00701-0100-0011    100           FIH      1
## 47    145   <NA> IQ00701-0100-0011    100           FIH      1
## 48    146   <NA> IQ00701-0100-0011    100           FIH      1
## 49    159   <NA> IQ00701-0100-0012    100           FIH      1
## 50    160   <NA> IQ00701-0100-0012    100           FIH      1
## 51    161   <NA> IQ00701-0100-0012    100           FIH      1
## 52    162   <NA> IQ00701-0100-0012    100           FIH      1
## 53    163   <NA> IQ00701-0100-0012    100           FIH      1
## 54    174   <NA> IQ00701-0100-0013    100           FIH      1
## 55    175   <NA> IQ00701-0100-0013    100           FIH      1
## 56    176   <NA> IQ00701-0100-0013    100           FIH      1
## 57    177   <NA> IQ00701-0100-0013    100           FIH      1
## 58    178   <NA> IQ00701-0100-0013    100           FIH      1
## 59    179   <NA> IQ00701-0100-0013    100           FIH      1
## 60    180   <NA> IQ00701-0100-0013    100           FIH      1
## 61    191   <NA> IQ00701-0100-0014    100           FIH      1
## 62    192   <NA> IQ00701-0100-0014    100           FIH      1
## 63    193   <NA> IQ00701-0100-0014    100           FIH      1
## 64    194   <NA> IQ00701-0100-0014    100           FIH      1
## 65    195   <NA> IQ00701-0100-0014    100           FIH      1
## 66    197   <NA> IQ00701-0100-0014    100           FIH      1
## 67    208   <NA> IQ00701-0100-0015    100           FIH      1
## 68    209   <NA> IQ00701-0100-0015    100           FIH      1
## 69    210   <NA> IQ00701-0100-0015    100           FIH      1
## 70    211   <NA> IQ00701-0100-0015    100           FIH      1
## 71    212   <NA> IQ00701-0100-0015    100           FIH      1
## 72    213   <NA> IQ00701-0100-0015    100           FIH      1
## 73    214   <NA> IQ00701-0100-0015    100           FIH      1
## 74    225   <NA> IQ00701-0100-0016    100           FIH      1
## 75    226   <NA> IQ00701-0100-0016    100           FIH      1
## 76    227   <NA> IQ00701-0100-0016    100           FIH      1
## 77    228   <NA> IQ00701-0100-0016    100           FIH      1
## 78    229   <NA> IQ00701-0100-0016    100           FIH      1
## 79    230   <NA> IQ00701-0100-0016    100           FIH      1
## 80    231   <NA> IQ00701-0100-0016    100           FIH      1
## 81    235   <NA> IQ00701-0100-0016    100           FIH      1
## 82    242   <NA> IQ00701-0100-0017    100           FIH      1
## 83    243   <NA> IQ00701-0100-0017    100           FIH      1
## 84    244   <NA> IQ00701-0100-0017    100           FIH      1
## 85    245   <NA> IQ00701-0100-0017    100           FIH      1
## 86    246   <NA> IQ00701-0100-0017    100           FIH      1
## 87    247   <NA> IQ00701-0100-0017    100           FIH      1
## 88    248   <NA> IQ00701-0100-0017    100           FIH      1
## 89    259   <NA> IQ00701-0100-0018    100           FIH      1
## 90    260   <NA> IQ00701-0100-0018    100           FIH      1
## 91    261   <NA> IQ00701-0100-0018    100           FIH      1
## 92    262   <NA> IQ00701-0100-0018    100           FIH      1
## 93    263   <NA> IQ00701-0100-0018    100           FIH      1
## 94    264   <NA> IQ00701-0100-0018    100           FIH      1
## 95    265   <NA> IQ00701-0100-0018    100           FIH      1
## 96    266   <NA> IQ00701-0100-0018    100           FIH      1
## 97    267   <NA> IQ00701-0100-0018    100           FIH      1
## 98    268   <NA> IQ00701-0100-0018    100           FIH      1
## 99    269   <NA> IQ00701-0100-0018    100           FIH      1
## 100   276   <NA> IQ00701-0100-0019    100           FIH      1
## 101   277   <NA> IQ00701-0100-0019    100           FIH      1
## 102   278   <NA> IQ00701-0100-0019    100           FIH      1
## 103   279   <NA> IQ00701-0100-0019    100           FIH      1
## 104   280   <NA> IQ00701-0100-0019    100           FIH      1
## 105   281   <NA> IQ00701-0100-0019    100           FIH      1
## 106   282   <NA> IQ00701-0100-0019    100           FIH      1
## 107   283   <NA> IQ00701-0100-0019    100           FIH      1
## 108   293   <NA> IQ00701-0100-0020    100           FIH      1
## 109   294   <NA> IQ00701-0100-0020    100           FIH      1
## 110   295   <NA> IQ00701-0100-0020    100           FIH      1
## 111   296   <NA> IQ00701-0100-0020    100           FIH      1
## 112   297   <NA> IQ00701-0100-0020    100           FIH      1
## 113   298   <NA> IQ00701-0100-0020    100           FIH      1
## 114   299   <NA> IQ00701-0100-0020    100           FIH      1
## 115   300   <NA> IQ00701-0100-0020    100           FIH      1
## 116   301   <NA> IQ00701-0100-0020    100           FIH      1
## 117   303   <NA> IQ00701-0100-0020    100           FIH      1
## 118   310   <NA> IQ00701-0100-0021    100           FIH      1
## 119   311   <NA> IQ00701-0100-0021    100           FIH      1
## 120   312   <NA> IQ00701-0100-0021    100           FIH      1
## 121   313   <NA> IQ00701-0100-0021    100           FIH      1
## 122   314   <NA> IQ00701-0100-0021    100           FIH      1
## 123   315   <NA> IQ00701-0100-0021    100           FIH      1
## 124   316   <NA> IQ00701-0100-0021    100           FIH      1
## 125   317   <NA> IQ00701-0100-0021    100           FIH      1
## 126   319   <NA> IQ00701-0100-0021    100           FIH      1
## 127   327   <NA> IQ00701-0100-0022    100           FIH      1
## 128   328   <NA> IQ00701-0100-0022    100           FIH      1
## 129   329   <NA> IQ00701-0100-0022    100           FIH      1
## 130   330   <NA> IQ00701-0100-0022    100           FIH      1
## 131   331   <NA> IQ00701-0100-0022    100           FIH      1
## 132   332   <NA> IQ00701-0100-0022    100           FIH      1
## 133   333   <NA> IQ00701-0100-0022    100           FIH      1
## 134   334   <NA> IQ00701-0100-0022    100           FIH      1
## 135   344   <NA> IQ00701-0100-0023    100           FIH      1
## 136   345   <NA> IQ00701-0100-0023    100           FIH      1
## 137   346   <NA> IQ00701-0100-0023    100           FIH      1
## 138   347   <NA> IQ00701-0100-0023    100           FIH      1
## 139   348   <NA> IQ00701-0100-0023    100           FIH      1
## 140   349   <NA> IQ00701-0100-0023    100           FIH      1
## 141   350   <NA> IQ00701-0100-0023    100           FIH      1
## 142   351   <NA> IQ00701-0100-0023    100           FIH      1
## 143   361   <NA> IQ00701-0100-0024    100           FIH      1
## 144   362   <NA> IQ00701-0100-0024    100           FIH      1
## 145   363   <NA> IQ00701-0100-0024    100           FIH      1
## 146   364   <NA> IQ00701-0100-0024    100           FIH      1
## 147   365   <NA> IQ00701-0100-0024    100           FIH      1
## 148   366   <NA> IQ00701-0100-0024    100           FIH      1
## 149   367   <NA> IQ00701-0100-0024    100           FIH      1
## 150   368   <NA> IQ00701-0100-0024    100           FIH      1
## 151   369   <NA> IQ00701-0100-0024    100           FIH      1
## 152   370   <NA> IQ00701-0100-0024    100           FIH      1
## 153   371   <NA> IQ00701-0100-0024    100           FIH      1
## 154   378   <NA> IQ00701-0100-0025    100           FIH      1
## 155   379   <NA> IQ00701-0100-0025    100           FIH      1
## 156   380   <NA> IQ00701-0100-0025    100           FIH      1
## 157   381   <NA> IQ00701-0100-0025    100           FIH      1
## 158   382   <NA> IQ00701-0100-0025    100           FIH      1
## 159   383   <NA> IQ00701-0100-0025    100           FIH      1
## 160   384   <NA> IQ00701-0100-0025    100           FIH      1
## 161   385   <NA> IQ00701-0100-0025    100           FIH      1
## 162   386   <NA> IQ00701-0100-0025    100           FIH      1
## 163   388   <NA> IQ00701-0100-0025    100           FIH      1
## 164   395   <NA> IQ00701-0100-0026    100           FIH      1
## 165   396   <NA> IQ00701-0100-0026    100           FIH      1
## 166   397   <NA> IQ00701-0100-0026    100           FIH      1
## 167   398   <NA> IQ00701-0100-0026    100           FIH      1
## 168   399   <NA> IQ00701-0100-0026    100           FIH      1
## 169   400   <NA> IQ00701-0100-0026    100           FIH      1
## 170   401   <NA> IQ00701-0100-0026    100           FIH      1
## 171   402   <NA> IQ00701-0100-0026    100           FIH      1
## 172   412   <NA> IQ00701-0100-0027    100           FIH      1
## 173   413   <NA> IQ00701-0100-0027    100           FIH      1
## 174   414   <NA> IQ00701-0100-0027    100           FIH      1
## 175   415   <NA> IQ00701-0100-0027    100           FIH      1
## 176   416   <NA> IQ00701-0100-0027    100           FIH      1
## 177   417   <NA> IQ00701-0100-0027    100           FIH      1
## 178   418   <NA> IQ00701-0100-0027    100           FIH      1
## 179   419   <NA> IQ00701-0100-0027    100           FIH      1
## 180   420   <NA> IQ00701-0100-0027    100           FIH      1
## 181   421   <NA> IQ00701-0100-0027    100           FIH      1
## 182   422   <NA> IQ00701-0100-0027    100           FIH      1
## 183   429   <NA> IQ00701-0100-0028    100           FIH      1
## 184   430   <NA> IQ00701-0100-0028    100           FIH      1
## 185   431   <NA> IQ00701-0100-0028    100           FIH      1
## 186   432   <NA> IQ00701-0100-0028    100           FIH      1
## 187   433   <NA> IQ00701-0100-0028    100           FIH      1
## 188   434   <NA> IQ00701-0100-0028    100           FIH      1
## 189   435   <NA> IQ00701-0100-0028    100           FIH      1
## 190   436   <NA> IQ00701-0100-0028    100           FIH      1
## 191   437   <NA> IQ00701-0100-0028    100           FIH      1
## 192   438   <NA> IQ00701-0100-0028    100           FIH      1
## 193   439   <NA> IQ00701-0100-0028    100           FIH      1
## 194   446   <NA> IQ00701-0100-0029    100           FIH      1
## 195   447   <NA> IQ00701-0100-0029    100           FIH      1
## 196   448   <NA> IQ00701-0100-0029    100           FIH      1
## 197   449   <NA> IQ00701-0100-0029    100           FIH      1
## 198   450   <NA> IQ00701-0100-0029    100           FIH      1
## 199   451   <NA> IQ00701-0100-0029    100           FIH      1
## 200   452   <NA> IQ00701-0100-0029    100           FIH      1
## 201   453   <NA> IQ00701-0100-0029    100           FIH      1
## 202   454   <NA> IQ00701-0100-0029    100           FIH      1
## 203   455   <NA> IQ00701-0100-0029    100           FIH      1
## 204   463   <NA> IQ00701-0100-0030    100           FIH      1
## 205   464   <NA> IQ00701-0100-0030    100           FIH      1
## 206   465   <NA> IQ00701-0100-0030    100           FIH      1
## 207   466   <NA> IQ00701-0100-0030    100           FIH      1
## 208   467   <NA> IQ00701-0100-0030    100           FIH      1
## 209   468   <NA> IQ00701-0100-0030    100           FIH      1
## 210   469   <NA> IQ00701-0100-0030    100           FIH      1
## 211   470   <NA> IQ00701-0100-0030    100           FIH      1
## 212   471   <NA> IQ00701-0100-0030    100           FIH      1
## 213   472   <NA> IQ00701-0100-0030    100           FIH      1
## 214   473   <NA> IQ00701-0100-0030    100           FIH      1
## 215   480   <NA> IQ00701-0100-0031    100           FIH      1
## 216   481   <NA> IQ00701-0100-0031    100           FIH      1
## 217   482   <NA> IQ00701-0100-0031    100           FIH      1
## 218   483   <NA> IQ00701-0100-0031    100           FIH      1
## 219   484   <NA> IQ00701-0100-0031    100           FIH      1
## 220   485   <NA> IQ00701-0100-0031    100           FIH      1
## 221   486   <NA> IQ00701-0100-0031    100           FIH      1
## 222   487   <NA> IQ00701-0100-0031    100           FIH      1
## 223   488   <NA> IQ00701-0100-0031    100           FIH      1
## 224   489   <NA> IQ00701-0100-0031    100           FIH      1
## 225   497   <NA> IQ00701-0100-0032    100           FIH      1
## 226   498   <NA> IQ00701-0100-0032    100           FIH      1
## 227   499   <NA> IQ00701-0100-0032    100           FIH      1
## 228   500   <NA> IQ00701-0100-0032    100           FIH      1
## 229   501   <NA> IQ00701-0100-0032    100           FIH      1
## 230   502   <NA> IQ00701-0100-0032    100           FIH      1
## 231   503   <NA> IQ00701-0100-0032    100           FIH      1
## 232   504   <NA> IQ00701-0100-0032    100           FIH      1
## 233   505   <NA> IQ00701-0100-0032    100           FIH      1
## 234   506   <NA> IQ00701-0100-0032    100           FIH      1
## 235   507   <NA> IQ00701-0100-0032    100           FIH      1
## 236   514   <NA> IQ00701-0100-0033    100           FIH      1
## 237   515   <NA> IQ00701-0100-0033    100           FIH      1
## 238   516   <NA> IQ00701-0100-0033    100           FIH      1
## 239   517   <NA> IQ00701-0100-0033    100           FIH      1
## 240   518   <NA> IQ00701-0100-0033    100           FIH      1
## 241   519   <NA> IQ00701-0100-0033    100           FIH      1
## 242   520   <NA> IQ00701-0100-0033    100           FIH      1
## 243   521   <NA> IQ00701-0100-0033    100           FIH      1
## 244   522   <NA> IQ00701-0100-0033    100           FIH      1
## 245   523   <NA> IQ00701-0100-0033    100           FIH      1
## 246   524   <NA> IQ00701-0100-0033    100           FIH      1
## 247   531   <NA> IQ00701-0100-0034    100           FIH      1
## 248   532   <NA> IQ00701-0100-0034    100           FIH      1
## 249   533   <NA> IQ00701-0100-0034    100           FIH      1
## 250   534   <NA> IQ00701-0100-0034    100           FIH      1
## 251   535   <NA> IQ00701-0100-0034    100           FIH      1
## 252   536   <NA> IQ00701-0100-0034    100           FIH      1
## 253   537   <NA> IQ00701-0100-0034    100           FIH      1
## 254   538   <NA> IQ00701-0100-0034    100           FIH      1
## 255   539   <NA> IQ00701-0100-0034    100           FIH      1
## 256   540   <NA> IQ00701-0100-0034    100           FIH      1
## 257   548   <NA> IQ00701-0100-0035    100           FIH      1
## 258   549   <NA> IQ00701-0100-0035    100           FIH      1
## 259   550   <NA> IQ00701-0100-0035    100           FIH      1
## 260   551   <NA> IQ00701-0100-0035    100           FIH      1
## 261   552   <NA> IQ00701-0100-0035    100           FIH      1
## 262   553   <NA> IQ00701-0100-0035    100           FIH      1
## 263   554   <NA> IQ00701-0100-0035    100           FIH      1
## 264   555   <NA> IQ00701-0100-0035    100           FIH      1
## 265   556   <NA> IQ00701-0100-0035    100           FIH      1
## 266   557   <NA> IQ00701-0100-0035    100           FIH      1
## 267   558   <NA> IQ00701-0100-0035    100           FIH      1
## 268   565   <NA> IQ00701-0100-0036    100           FIH      1
## 269   566   <NA> IQ00701-0100-0036    100           FIH      1
## 270   567   <NA> IQ00701-0100-0036    100           FIH      1
## 271   568   <NA> IQ00701-0100-0036    100           FIH      1
## 272   569   <NA> IQ00701-0100-0036    100           FIH      1
## 273   570   <NA> IQ00701-0100-0036    100           FIH      1
## 274   571   <NA> IQ00701-0100-0036    100           FIH      1
## 275   572   <NA> IQ00701-0100-0036    100           FIH      1
## 276   573   <NA> IQ00701-0100-0036    100           FIH      1
## 277   574   <NA> IQ00701-0100-0036    100           FIH      1
## 278   575   <NA> IQ00701-0100-0036    100           FIH      1
## 279   582   <NA> IQ00701-0100-0037    100 FIH extension      2
## 280   583   <NA> IQ00701-0100-0037    100 FIH extension      2
## 281   584   <NA> IQ00701-0100-0037    100 FIH extension      2
## 282   585   <NA> IQ00701-0100-0037    100 FIH extension      2
## 283   586   <NA> IQ00701-0100-0037    100 FIH extension      2
## 284   587   <NA> IQ00701-0100-0037    100 FIH extension      2
## 285   588   <NA> IQ00701-0100-0037    100 FIH extension      2
## 286   589   <NA> IQ00701-0100-0037    100 FIH extension      2
## 287   590   <NA> IQ00701-0100-0037    100 FIH extension      2
## 288   591   <NA> IQ00701-0100-0037    100 FIH extension      2
## 289   592   <NA> IQ00701-0100-0037    100 FIH extension      2
## 290   599   <NA> IQ00701-0100-0038    100 FIH extension      2
## 291   600   <NA> IQ00701-0100-0038    100 FIH extension      2
## 292   601   <NA> IQ00701-0100-0038    100 FIH extension      2
## 293   602   <NA> IQ00701-0100-0038    100 FIH extension      2
## 294   603   <NA> IQ00701-0100-0038    100 FIH extension      2
## 295   604   <NA> IQ00701-0100-0038    100 FIH extension      2
## 296   605   <NA> IQ00701-0100-0038    100 FIH extension      2
## 297   606   <NA> IQ00701-0100-0038    100 FIH extension      2
## 298   607   <NA> IQ00701-0100-0038    100 FIH extension      2
## 299   608   <NA> IQ00701-0100-0038    100 FIH extension      2
## 300   609   <NA> IQ00701-0100-0038    100 FIH extension      2
## 301   616   <NA> IQ00701-0100-0039    100 FIH extension      2
## 302   617   <NA> IQ00701-0100-0039    100 FIH extension      2
## 303   618   <NA> IQ00701-0100-0039    100 FIH extension      2
## 304   619   <NA> IQ00701-0100-0039    100 FIH extension      2
## 305   620   <NA> IQ00701-0100-0039    100 FIH extension      2
## 306   621   <NA> IQ00701-0100-0039    100 FIH extension      2
## 307   622   <NA> IQ00701-0100-0039    100 FIH extension      2
## 308   623   <NA> IQ00701-0100-0039    100 FIH extension      2
## 309   624   <NA> IQ00701-0100-0039    100 FIH extension      2
## 310   625   <NA> IQ00701-0100-0039    100 FIH extension      2
## 311   626   <NA> IQ00701-0100-0039    100 FIH extension      2
## 312   633   <NA> IQ00701-0100-0040    100 FIH extension      2
## 313   634   <NA> IQ00701-0100-0040    100 FIH extension      2
## 314   635   <NA> IQ00701-0100-0040    100 FIH extension      2
## 315   636   <NA> IQ00701-0100-0040    100 FIH extension      2
## 316   637   <NA> IQ00701-0100-0040    100 FIH extension      2
## 317   638   <NA> IQ00701-0100-0040    100 FIH extension      2
## 318   639   <NA> IQ00701-0100-0040    100 FIH extension      2
## 319   640   <NA> IQ00701-0100-0040    100 FIH extension      2
## 320   641   <NA> IQ00701-0100-0040    100 FIH extension      2
## 321   642   <NA> IQ00701-0100-0040    100 FIH extension      2
## 322   643   <NA> IQ00701-0100-0040    100 FIH extension      2
## 323   650   <NA> IQ00701-0100-0041    100 FIH extension      2
## 324   651   <NA> IQ00701-0100-0041    100 FIH extension      2
## 325   652   <NA> IQ00701-0100-0041    100 FIH extension      2
## 326   653   <NA> IQ00701-0100-0041    100 FIH extension      2
## 327   654   <NA> IQ00701-0100-0041    100 FIH extension      2
## 328   655   <NA> IQ00701-0100-0041    100 FIH extension      2
## 329   656   <NA> IQ00701-0100-0041    100 FIH extension      2
## 330   657   <NA> IQ00701-0100-0041    100 FIH extension      2
## 331   658   <NA> IQ00701-0100-0041    100 FIH extension      2
## 332   659   <NA> IQ00701-0100-0041    100 FIH extension      2
## 333   660   <NA> IQ00701-0100-0041    100 FIH extension      2
## 334   667   <NA> IQ00701-0100-0042    100 FIH extension      2
## 335   668   <NA> IQ00701-0100-0042    100 FIH extension      2
## 336   669   <NA> IQ00701-0100-0042    100 FIH extension      2
## 337   670   <NA> IQ00701-0100-0042    100 FIH extension      2
## 338   671   <NA> IQ00701-0100-0042    100 FIH extension      2
## 339   672   <NA> IQ00701-0100-0042    100 FIH extension      2
## 340   673   <NA> IQ00701-0100-0042    100 FIH extension      2
## 341   674   <NA> IQ00701-0100-0042    100 FIH extension      2
## 342   675   <NA> IQ00701-0100-0042    100 FIH extension      2
## 343   676   <NA> IQ00701-0100-0042    100 FIH extension      2
## 344   677   <NA> IQ00701-0100-0042    100 FIH extension      2
## 345   684   <NA> IQ00701-0100-0043    100 FIH extension      2
## 346   685   <NA> IQ00701-0100-0043    100 FIH extension      2
## 347   686   <NA> IQ00701-0100-0043    100 FIH extension      2
## 348   687   <NA> IQ00701-0100-0043    100 FIH extension      2
## 349   688   <NA> IQ00701-0100-0043    100 FIH extension      2
## 350   689   <NA> IQ00701-0100-0043    100 FIH extension      2
## 351   690   <NA> IQ00701-0100-0043    100 FIH extension      2
## 352   691   <NA> IQ00701-0100-0043    100 FIH extension      2
## 353   692   <NA> IQ00701-0100-0043    100 FIH extension      2
## 354   693   <NA> IQ00701-0100-0043    100 FIH extension      2
## 355   694   <NA> IQ00701-0100-0043    100 FIH extension      2
## 356   701   <NA> IQ00701-0100-0044    100 FIH extension      2
## 357   702   <NA> IQ00701-0100-0044    100 FIH extension      2
## 358   703   <NA> IQ00701-0100-0044    100 FIH extension      2
## 359   704   <NA> IQ00701-0100-0044    100 FIH extension      2
## 360   705   <NA> IQ00701-0100-0044    100 FIH extension      2
## 361   706   <NA> IQ00701-0100-0044    100 FIH extension      2
## 362   707   <NA> IQ00701-0100-0044    100 FIH extension      2
## 363   708   <NA> IQ00701-0100-0044    100 FIH extension      2
## 364   709   <NA> IQ00701-0100-0044    100 FIH extension      2
## 365   710   <NA> IQ00701-0100-0044    100 FIH extension      2
## 366   711   <NA> IQ00701-0100-0044    100 FIH extension      2
## 367   718   <NA> IQ00701-0100-0045    100 FIH extension      2
## 368   719   <NA> IQ00701-0100-0045    100 FIH extension      2
## 369   720   <NA> IQ00701-0100-0045    100 FIH extension      2
## 370   721   <NA> IQ00701-0100-0045    100 FIH extension      2
## 371   722   <NA> IQ00701-0100-0045    100 FIH extension      2
## 372   723   <NA> IQ00701-0100-0045    100 FIH extension      2
## 373   724   <NA> IQ00701-0100-0045    100 FIH extension      2
## 374   725   <NA> IQ00701-0100-0045    100 FIH extension      2
## 375   726   <NA> IQ00701-0100-0045    100 FIH extension      2
## 376   727   <NA> IQ00701-0100-0045    100 FIH extension      2
## 377   728   <NA> IQ00701-0100-0045    100 FIH extension      2
## 378   735   <NA> IQ00701-0100-0046    100 FIH extension      2
## 379   736   <NA> IQ00701-0100-0046    100 FIH extension      2
## 380   737   <NA> IQ00701-0100-0046    100 FIH extension      2
## 381   738   <NA> IQ00701-0100-0046    100 FIH extension      2
## 382   739   <NA> IQ00701-0100-0046    100 FIH extension      2
## 383   740   <NA> IQ00701-0100-0046    100 FIH extension      2
## 384   741   <NA> IQ00701-0100-0046    100 FIH extension      2
## 385   742   <NA> IQ00701-0100-0046    100 FIH extension      2
## 386   743   <NA> IQ00701-0100-0046    100 FIH extension      2
## 387   744   <NA> IQ00701-0100-0046    100 FIH extension      2
## 388   745   <NA> IQ00701-0100-0046    100 FIH extension      2
## 389   752   <NA> IQ00701-0100-0047    100 FIH extension      2
## 390   753   <NA> IQ00701-0100-0047    100 FIH extension      2
## 391   754   <NA> IQ00701-0100-0047    100 FIH extension      2
## 392   755   <NA> IQ00701-0100-0047    100 FIH extension      2
## 393   756   <NA> IQ00701-0100-0047    100 FIH extension      2
## 394   757   <NA> IQ00701-0100-0047    100 FIH extension      2
## 395   758   <NA> IQ00701-0100-0047    100 FIH extension      2
## 396   759   <NA> IQ00701-0100-0047    100 FIH extension      2
## 397   760   <NA> IQ00701-0100-0047    100 FIH extension      2
## 398   761   <NA> IQ00701-0100-0047    100 FIH extension      2
## 399   762   <NA> IQ00701-0100-0047    100 FIH extension      2
## 400   769   <NA> IQ00701-0100-0048    100 FIH extension      2
## 401   770   <NA> IQ00701-0100-0048    100 FIH extension      2
## 402   771   <NA> IQ00701-0100-0048    100 FIH extension      2
## 403   772   <NA> IQ00701-0100-0048    100 FIH extension      2
## 404   773   <NA> IQ00701-0100-0048    100 FIH extension      2
## 405   774   <NA> IQ00701-0100-0048    100 FIH extension      2
## 406   775   <NA> IQ00701-0100-0048    100 FIH extension      2
## 407   776   <NA> IQ00701-0100-0048    100 FIH extension      2
## 408   777   <NA> IQ00701-0100-0048    100 FIH extension      2
## 409   778   <NA> IQ00701-0100-0048    100 FIH extension      2
## 410   779   <NA> IQ00701-0100-0048    100 FIH extension      2
##                    TRTNAME TRT VISIT BASE SCREEN TIMEUNIT           NT    TIME
## 1     1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.250
## 2     1mg oral single dose   3     2    0      0    HOURS   0.50000000   0.500
## 3     1mg oral single dose   3     2    0      0    HOURS   1.00000000   1.000
## 4     1mg oral single dose   3     2    0      0    HOURS   2.00000000   2.000
## 5     1mg oral single dose   3     2    0      0    HOURS   4.00000000   4.000
## 6     1mg oral single dose   3     2    0      0    HOURS   0.08333333   0.083
## 7     1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.250
## 8     1mg oral single dose   3     2    0      0    HOURS   0.50000000   0.500
## 9     1mg oral single dose   3     2    0      0    HOURS   1.00000000   1.000
## 10    1mg oral single dose   3     2    0      0    HOURS   2.00000000   2.000
## 11    1mg oral single dose   3     2    0      0    HOURS   4.00000000   4.000
## 12    1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.250
## 13    1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.250
## 14    1mg oral single dose   3     2    0      0    HOURS   0.50000000   0.500
## 15    1mg oral single dose   3     2    0      0    HOURS   1.00000000   1.000
## 16    1mg oral single dose   3     2    0      0    HOURS   2.00000000   2.000
## 17    1mg oral single dose   3     2    0      0    HOURS   4.00000000   4.000
## 18    1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.250
## 19    1mg oral single dose   3     2    0      0    HOURS   0.50000000   0.500
## 20    1mg oral single dose   3     2    0      0    HOURS   1.00000000   1.000
## 21    1mg oral single dose   3     2    0      0    HOURS   2.00000000   2.000
## 22    1mg oral single dose   3     2    0      0    HOURS   4.00000000   4.000
## 23    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.083
## 24    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.250
## 25    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.500
## 26    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.000
## 27    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.000
## 28    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.000
## 29    2mg oral single dose   6     4    0      0    HOURS  48.00000000  48.000
## 30    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.083
## 31    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.250
## 32    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.500
## 33    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.000
## 34    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.000
## 35    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.000
## 36    2mg oral single dose   6     2    0      0    HOURS  12.00000000  12.000
## 37    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.083
## 38    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.250
## 39    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.500
## 40    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.000
## 41    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.000
## 42    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.000
## 43    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.083
## 44    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.250
## 45    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.500
## 46    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.000
## 47    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.000
## 48    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.000
## 49    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.250
## 50    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.500
## 51    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.000
## 52    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.000
## 53    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.000
## 54    5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.083
## 55    5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.250
## 56    5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.500
## 57    5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.000
## 58    5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.000
## 59    5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.000
## 60    5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.000
## 61    5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.083
## 62    5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.250
## 63    5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.500
## 64    5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.000
## 65    5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.000
## 66    5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.000
## 67    5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.083
## 68    5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.250
## 69    5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.500
## 70    5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.000
## 71    5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.000
## 72    5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.000
## 73    5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.000
## 74    5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.083
## 75    5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.250
## 76    5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.500
## 77    5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.000
## 78    5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.000
## 79    5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.000
## 80    5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.000
## 81    5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.000
## 82    5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.083
## 83    5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.250
## 84    5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.500
## 85    5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.000
## 86    5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.000
## 87    5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.000
## 88    5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.000
## 89    5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.083
## 90    5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.250
## 91    5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.500
## 92    5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.000
## 93    5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.000
## 94    5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.000
## 95    5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.000
## 96    5mg oral single dose   8     3    0      0    HOURS  24.00000000  24.000
## 97    5mg oral single dose   8     4    0      0    HOURS  48.00000000  48.000
## 98    5mg oral single dose   8     5    0      0    HOURS  96.00000000  96.000
## 99    5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.000
## 100  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.083
## 101  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.250
## 102  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.500
## 103  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.000
## 104  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.000
## 105  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.000
## 106  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.000
## 107  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.000
## 108  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.083
## 109  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.250
## 110  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.500
## 111  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.000
## 112  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.000
## 113  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.000
## 114  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.000
## 115  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.000
## 116  10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.000
## 117  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.000
## 118  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.083
## 119  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.250
## 120  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.500
## 121  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.000
## 122  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.000
## 123  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.000
## 124  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.000
## 125  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.000
## 126  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.000
## 127  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.083
## 128  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.250
## 129  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.500
## 130  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.000
## 131  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.000
## 132  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.000
## 133  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.000
## 134  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.000
## 135  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.083
## 136  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.250
## 137  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.500
## 138  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.000
## 139  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.000
## 140  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.000
## 141  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.000
## 142  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.000
## 143  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.083
## 144  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.250
## 145  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.500
## 146  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.000
## 147  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.000
## 148  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.000
## 149  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.000
## 150  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.000
## 151  10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.000
## 152  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.000
## 153  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.000
## 154  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.083
## 155  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.250
## 156  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.500
## 157  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.000
## 158  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.000
## 159  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.000
## 160  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.000
## 161  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.000
## 162  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.000
## 163  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.000
## 164  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.083
## 165  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.250
## 166  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.500
## 167  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.000
## 168  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.000
## 169  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.000
## 170  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.000
## 171  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.000
## 172  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.083
## 173  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.250
## 174  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.500
## 175  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.000
## 176  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.000
## 177  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.000
## 178  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.000
## 179  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.000
## 180  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.000
## 181  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.000
## 182  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.000
## 183  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.083
## 184  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.250
## 185  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.500
## 186  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.000
## 187  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.000
## 188  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.000
## 189  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.000
## 190  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.000
## 191  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.000
## 192  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.000
## 193  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.000
## 194  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.083
## 195  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.250
## 196  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.500
## 197  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.000
## 198  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.000
## 199  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.000
## 200  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.000
## 201  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.000
## 202  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.000
## 203  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.000
## 204  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.083
## 205  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.250
## 206  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.500
## 207  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.000
## 208  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.000
## 209  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.000
## 210  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.000
## 211  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.000
## 212  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.000
## 213  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.000
## 214  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.000
## 215  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.083
## 216  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.250
## 217  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.500
## 218  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.000
## 219  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.000
## 220  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.000
## 221  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.000
## 222  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.000
## 223  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.000
## 224  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.000
## 225  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.083
## 226  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.250
## 227  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.500
## 228  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.000
## 229  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.000
## 230  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.000
## 231  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.000
## 232  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.000
## 233  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.000
## 234  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.000
## 235  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.000
## 236  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.083
## 237  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.250
## 238  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.500
## 239  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.000
## 240  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.000
## 241  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.000
## 242  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.000
## 243  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.000
## 244  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.000
## 245  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.000
## 246  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.000
## 247  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.083
## 248  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.250
## 249  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.500
## 250  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.000
## 251  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.000
## 252  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.000
## 253  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.000
## 254  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.000
## 255  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.000
## 256  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.000
## 257  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.083
## 258  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.250
## 259  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.500
## 260  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.000
## 261  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.000
## 262  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.000
## 263  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.000
## 264  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.000
## 265  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.000
## 266  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.000
## 267  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.000
## 268  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.083
## 269  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.250
## 270  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.500
## 271  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.000
## 272  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.000
## 273  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.000
## 274  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.000
## 275  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.000
## 276  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.000
## 277  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.000
## 278  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.000
## 279 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.083
## 280 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.250
## 281 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.500
## 282 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.000
## 283 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.000
## 284 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.000
## 285 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.000
## 286 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.000
## 287 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.000
## 288 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.000
## 289 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.000
## 290 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.083
## 291 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.250
## 292 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.500
## 293 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.000
## 294 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.000
## 295 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.000
## 296 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.000
## 297 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.000
## 298 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.000
## 299 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.000
## 300 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.000
## 301 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.083
## 302 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.250
## 303 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.500
## 304 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.000
## 305 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.000
## 306 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.000
## 307 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.000
## 308 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.000
## 309 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.000
## 310 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.000
## 311 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.000
## 312 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.083
## 313 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.250
## 314 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.500
## 315 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.000
## 316 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.000
## 317 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.000
## 318 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.000
## 319 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.000
## 320 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.000
## 321 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.000
## 322 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.000
## 323 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.083
## 324 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.250
## 325 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.500
## 326 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.000
## 327 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.000
## 328 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.000
## 329 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.000
## 330 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.000
## 331 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.000
## 332 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.000
## 333 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.000
## 334 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.083
## 335 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.250
## 336 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.500
## 337 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.000
## 338 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.000
## 339 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.000
## 340 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.000
## 341 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.000
## 342 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.000
## 343 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.000
## 344 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.000
## 345 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.083
## 346 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.250
## 347 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.500
## 348 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.000
## 349 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.000
## 350 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.000
## 351 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.000
## 352 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.000
## 353 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.000
## 354 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.000
## 355 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.000
## 356 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.083
## 357 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.250
## 358 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.500
## 359 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.000
## 360 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.000
## 361 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.000
## 362 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.000
## 363 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.000
## 364 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.000
## 365 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.000
## 366 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.000
## 367 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.083
## 368 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.250
## 369 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.500
## 370 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.000
## 371 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.000
## 372 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.000
## 373 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.000
## 374 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.000
## 375 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.000
## 376 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.000
## 377 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.000
## 378 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.083
## 379 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.250
## 380 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.500
## 381 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.000
## 382 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.000
## 383 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.000
## 384 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.000
## 385 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.000
## 386 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.000
## 387 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.000
## 388 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.000
## 389 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.083
## 390 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.250
## 391 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.500
## 392 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.000
## 393 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.000
## 394 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.000
## 395 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.000
## 396 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.000
## 397 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.000
## 398 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.000
## 399 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.000
## 400 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.083
## 401 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.250
## 402 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.500
## 403 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.000
## 404 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.000
## 405 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.000
## 406 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.000
## 407 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.000
## 408 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.000
## 409 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.000
## 410 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.000
##     DURATION                        NAME   VALUE VALUETXT  UNIT  LLOQ ROUTE II
## 1          0 Plasma concentration IQ0815 0.00153     <NA> ug/mL 0.001  <NA>  0
## 2          0 Plasma concentration IQ0815 0.00350     <NA> ug/mL 0.001  <NA>  0
## 3          0 Plasma concentration IQ0815 0.00380     <NA> ug/mL 0.001  <NA>  0
## 4          0 Plasma concentration IQ0815 0.00333     <NA> ug/mL 0.001  <NA>  0
## 5          0 Plasma concentration IQ0815 0.00291     <NA> ug/mL 0.001  <NA>  0
## 6          0 Plasma concentration IQ0815 0.00138     <NA> ug/mL 0.001  <NA>  0
## 7          0 Plasma concentration IQ0815 0.00212     <NA> ug/mL 0.001  <NA>  0
## 8          0 Plasma concentration IQ0815 0.00359     <NA> ug/mL 0.001  <NA>  0
## 9          0 Plasma concentration IQ0815 0.00542     <NA> ug/mL 0.001  <NA>  0
## 10         0 Plasma concentration IQ0815 0.00526     <NA> ug/mL 0.001  <NA>  0
## 11         0 Plasma concentration IQ0815 0.00391     <NA> ug/mL 0.001  <NA>  0
## 12         0 Plasma concentration IQ0815 0.00168     <NA> ug/mL 0.001  <NA>  0
## 13         0 Plasma concentration IQ0815 0.00168     <NA> ug/mL 0.001  <NA>  0
## 14         0 Plasma concentration IQ0815 0.02000     <NA> ug/mL 0.001  <NA>  0
## 15         0 Plasma concentration IQ0815 0.00221     <NA> ug/mL 0.001  <NA>  0
## 16         0 Plasma concentration IQ0815 0.00307     <NA> ug/mL 0.001  <NA>  0
## 17         0 Plasma concentration IQ0815 0.00133     <NA> ug/mL 0.001  <NA>  0
## 18         0 Plasma concentration IQ0815 0.00128     <NA> ug/mL 0.001  <NA>  0
## 19         0 Plasma concentration IQ0815 0.00220     <NA> ug/mL 0.001  <NA>  0
## 20         0 Plasma concentration IQ0815 0.00278     <NA> ug/mL 0.001  <NA>  0
## 21         0 Plasma concentration IQ0815 0.00221     <NA> ug/mL 0.001  <NA>  0
## 22         0 Plasma concentration IQ0815 0.00153     <NA> ug/mL 0.001  <NA>  0
## 23         0 Plasma concentration IQ0815 0.00174     <NA> ug/mL 0.001  <NA>  0
## 24         0 Plasma concentration IQ0815 0.00299     <NA> ug/mL 0.001  <NA>  0
## 25         0 Plasma concentration IQ0815 0.00555     <NA> ug/mL 0.001  <NA>  0
## 26         0 Plasma concentration IQ0815 0.00780     <NA> ug/mL 0.001  <NA>  0
## 27         0 Plasma concentration IQ0815 0.00706     <NA> ug/mL 0.001  <NA>  0
## 28         0 Plasma concentration IQ0815 0.00526     <NA> ug/mL 0.001  <NA>  0
## 29         0 Plasma concentration IQ0815 0.50000     <NA> ug/mL 0.001  <NA>  0
## 30         0 Plasma concentration IQ0815 0.00123     <NA> ug/mL 0.001  <NA>  0
## 31         0 Plasma concentration IQ0815 0.00238     <NA> ug/mL 0.001  <NA>  0
## 32         0 Plasma concentration IQ0815 0.00480     <NA> ug/mL 0.001  <NA>  0
## 33         0 Plasma concentration IQ0815 0.00672     <NA> ug/mL 0.001  <NA>  0
## 34         0 Plasma concentration IQ0815 0.00509     <NA> ug/mL 0.001  <NA>  0
## 35         0 Plasma concentration IQ0815 0.00396     <NA> ug/mL 0.001  <NA>  0
## 36         0 Plasma concentration IQ0815 0.00160     <NA> ug/mL 0.001  <NA>  0
## 37         0 Plasma concentration IQ0815 0.00157     <NA> ug/mL 0.001  <NA>  0
## 38         0 Plasma concentration IQ0815 0.00205     <NA> ug/mL 0.001  <NA>  0
## 39         0 Plasma concentration IQ0815 0.00446     <NA> ug/mL 0.001  <NA>  0
## 40         0 Plasma concentration IQ0815 0.00462     <NA> ug/mL 0.001  <NA>  0
## 41         0 Plasma concentration IQ0815 0.00555     <NA> ug/mL 0.001  <NA>  0
## 42         0 Plasma concentration IQ0815 0.00329     <NA> ug/mL 0.001  <NA>  0
## 43         0 Plasma concentration IQ0815 0.00127     <NA> ug/mL 0.001  <NA>  0
## 44         0 Plasma concentration IQ0815 0.00345     <NA> ug/mL 0.001  <NA>  0
## 45         0 Plasma concentration IQ0815 0.00491     <NA> ug/mL 0.001  <NA>  0
## 46         0 Plasma concentration IQ0815 0.00692     <NA> ug/mL 0.001  <NA>  0
## 47         0 Plasma concentration IQ0815 0.00736     <NA> ug/mL 0.001  <NA>  0
## 48         0 Plasma concentration IQ0815 0.00420     <NA> ug/mL 0.001  <NA>  0
## 49         0 Plasma concentration IQ0815 0.00380     <NA> ug/mL 0.001  <NA>  0
## 50         0 Plasma concentration IQ0815 0.00510     <NA> ug/mL 0.001  <NA>  0
## 51         0 Plasma concentration IQ0815 0.00396     <NA> ug/mL 0.001  <NA>  0
## 52         0 Plasma concentration IQ0815 0.00596     <NA> ug/mL 0.001  <NA>  0
## 53         0 Plasma concentration IQ0815 0.00445     <NA> ug/mL 0.001  <NA>  0
## 54         0 Plasma concentration IQ0815 0.00593     <NA> ug/mL 0.001  <NA>  0
## 55         0 Plasma concentration IQ0815 0.01100     <NA> ug/mL 0.001  <NA>  0
## 56         0 Plasma concentration IQ0815 0.02130     <NA> ug/mL 0.001  <NA>  0
## 57         0 Plasma concentration IQ0815 0.02640     <NA> ug/mL 0.001  <NA>  0
## 58         0 Plasma concentration IQ0815 0.02360     <NA> ug/mL 0.001  <NA>  0
## 59         0 Plasma concentration IQ0815 0.00808     <NA> ug/mL 0.001  <NA>  0
## 60         0 Plasma concentration IQ0815 0.00128     <NA> ug/mL 0.001  <NA>  0
## 61         0 Plasma concentration IQ0815 0.00428     <NA> ug/mL 0.001  <NA>  0
## 62         0 Plasma concentration IQ0815 0.01080     <NA> ug/mL 0.001  <NA>  0
## 63         0 Plasma concentration IQ0815 0.01920     <NA> ug/mL 0.001  <NA>  0
## 64         0 Plasma concentration IQ0815 0.01960     <NA> ug/mL 0.001  <NA>  0
## 65         0 Plasma concentration IQ0815 0.01400     <NA> ug/mL 0.001  <NA>  0
## 66         0 Plasma concentration IQ0815 0.00112     <NA> ug/mL 0.001  <NA>  0
## 67         0 Plasma concentration IQ0815 0.00174     <NA> ug/mL 0.001  <NA>  0
## 68         0 Plasma concentration IQ0815 0.00432     <NA> ug/mL 0.001  <NA>  0
## 69         0 Plasma concentration IQ0815 0.00766     <NA> ug/mL 0.001  <NA>  0
## 70         0 Plasma concentration IQ0815 0.01030     <NA> ug/mL 0.001  <NA>  0
## 71         0 Plasma concentration IQ0815 0.00802     <NA> ug/mL 0.001  <NA>  0
## 72         0 Plasma concentration IQ0815 0.00742     <NA> ug/mL 0.001  <NA>  0
## 73         0 Plasma concentration IQ0815 0.00300     <NA> ug/mL 0.001  <NA>  0
## 74         0 Plasma concentration IQ0815 0.00370     <NA> ug/mL 0.001  <NA>  0
## 75         0 Plasma concentration IQ0815 0.00826     <NA> ug/mL 0.001  <NA>  0
## 76         0 Plasma concentration IQ0815 0.01440     <NA> ug/mL 0.001  <NA>  0
## 77         0 Plasma concentration IQ0815 0.01460     <NA> ug/mL 0.001  <NA>  0
## 78         0 Plasma concentration IQ0815 0.01770     <NA> ug/mL 0.001  <NA>  0
## 79         0 Plasma concentration IQ0815 0.00857     <NA> ug/mL 0.001  <NA>  0
## 80         0 Plasma concentration IQ0815 0.00199     <NA> ug/mL 0.001  <NA>  0
## 81         0 Plasma concentration IQ0815 0.00101     <NA> ug/mL 0.001  <NA>  0
## 82         0 Plasma concentration IQ0815 0.00386     <NA> ug/mL 0.001  <NA>  0
## 83         0 Plasma concentration IQ0815 0.00888     <NA> ug/mL 0.001  <NA>  0
## 84         0 Plasma concentration IQ0815 0.01700     <NA> ug/mL 0.001  <NA>  0
## 85         0 Plasma concentration IQ0815 0.01830     <NA> ug/mL 0.001  <NA>  0
## 86         0 Plasma concentration IQ0815 0.01980     <NA> ug/mL 0.001  <NA>  0
## 87         0 Plasma concentration IQ0815 0.00950     <NA> ug/mL 0.001  <NA>  0
## 88         0 Plasma concentration IQ0815 0.00334     <NA> ug/mL 0.001  <NA>  0
## 89         0 Plasma concentration IQ0815 0.02000     <NA> ug/mL 0.001  <NA>  0
## 90         0 Plasma concentration IQ0815 0.04000     <NA> ug/mL 0.001  <NA>  0
## 91         0 Plasma concentration IQ0815 0.06000     <NA> ug/mL 0.001  <NA>  0
## 92         0 Plasma concentration IQ0815 0.08000     <NA> ug/mL 0.001  <NA>  0
## 93         0 Plasma concentration IQ0815 0.10000     <NA> ug/mL 0.001  <NA>  0
## 94         0 Plasma concentration IQ0815 0.12000     <NA> ug/mL 0.001  <NA>  0
## 95         0 Plasma concentration IQ0815 0.14000     <NA> ug/mL 0.001  <NA>  0
## 96         0 Plasma concentration IQ0815 0.16000     <NA> ug/mL 0.001  <NA>  0
## 97         0 Plasma concentration IQ0815 0.18000     <NA> ug/mL 0.001  <NA>  0
## 98         0 Plasma concentration IQ0815 0.20000     <NA> ug/mL 0.001  <NA>  0
## 99         0 Plasma concentration IQ0815 0.22000     <NA> ug/mL 0.001  <NA>  0
## 100        0 Plasma concentration IQ0815 0.00689     <NA> ug/mL 0.001  <NA>  0
## 101        0 Plasma concentration IQ0815 0.01530     <NA> ug/mL 0.001  <NA>  0
## 102        0 Plasma concentration IQ0815 0.02390     <NA> ug/mL 0.001  <NA>  0
## 103        0 Plasma concentration IQ0815 0.04110     <NA> ug/mL 0.001  <NA>  0
## 104        0 Plasma concentration IQ0815 0.03820     <NA> ug/mL 0.001  <NA>  0
## 105        0 Plasma concentration IQ0815 0.02730     <NA> ug/mL 0.001  <NA>  0
## 106        0 Plasma concentration IQ0815 0.00528     <NA> ug/mL 0.001  <NA>  0
## 107        0 Plasma concentration IQ0815 0.00198     <NA> ug/mL 0.001  <NA>  0
## 108        0 Plasma concentration IQ0815 0.00515     <NA> ug/mL 0.001  <NA>  0
## 109        0 Plasma concentration IQ0815 0.01130     <NA> ug/mL 0.001  <NA>  0
## 110        0 Plasma concentration IQ0815 0.01910     <NA> ug/mL 0.001  <NA>  0
## 111        0 Plasma concentration IQ0815 0.03580     <NA> ug/mL 0.001  <NA>  0
## 112        0 Plasma concentration IQ0815 0.02670     <NA> ug/mL 0.001  <NA>  0
## 113        0 Plasma concentration IQ0815 0.01850     <NA> ug/mL 0.001  <NA>  0
## 114        0 Plasma concentration IQ0815 0.00755     <NA> ug/mL 0.001  <NA>  0
## 115        0 Plasma concentration IQ0815 0.00219     <NA> ug/mL 0.001  <NA>  0
## 116        0 Plasma concentration IQ0815 0.13000     <NA> ug/mL 0.001  <NA>  0
## 117        0 Plasma concentration IQ0815 0.00101     <NA> ug/mL 0.001  <NA>  0
## 118        0 Plasma concentration IQ0815 0.00374     <NA> ug/mL 0.001  <NA>  0
## 119        0 Plasma concentration IQ0815 0.00866     <NA> ug/mL 0.001  <NA>  0
## 120        0 Plasma concentration IQ0815 0.01570     <NA> ug/mL 0.001  <NA>  0
## 121        0 Plasma concentration IQ0815 0.01960     <NA> ug/mL 0.001  <NA>  0
## 122        0 Plasma concentration IQ0815 0.02190     <NA> ug/mL 0.001  <NA>  0
## 123        0 Plasma concentration IQ0815 0.02200     <NA> ug/mL 0.001  <NA>  0
## 124        0 Plasma concentration IQ0815 0.00786     <NA> ug/mL 0.001  <NA>  0
## 125        0 Plasma concentration IQ0815 0.00382     <NA> ug/mL 0.001  <NA>  0
## 126        0 Plasma concentration IQ0815 0.00108     <NA> ug/mL 0.001  <NA>  0
## 127        0 Plasma concentration IQ0815 0.00241     <NA> ug/mL 0.001  <NA>  0
## 128        0 Plasma concentration IQ0815 0.01060     <NA> ug/mL 0.001  <NA>  0
## 129        0 Plasma concentration IQ0815 0.01630     <NA> ug/mL 0.001  <NA>  0
## 130        0 Plasma concentration IQ0815 0.02530     <NA> ug/mL 0.001  <NA>  0
## 131        0 Plasma concentration IQ0815 0.20500     <NA> ug/mL 0.001  <NA>  0
## 132        0 Plasma concentration IQ0815 0.01860     <NA> ug/mL 0.001  <NA>  0
## 133        0 Plasma concentration IQ0815 0.00534     <NA> ug/mL 0.001  <NA>  0
## 134        0 Plasma concentration IQ0815 0.00213     <NA> ug/mL 0.001  <NA>  0
## 135        0 Plasma concentration IQ0815 0.00905     <NA> ug/mL 0.001  <NA>  0
## 136        0 Plasma concentration IQ0815 0.02640     <NA> ug/mL 0.001  <NA>  0
## 137        0 Plasma concentration IQ0815 0.03400     <NA> ug/mL 0.001  <NA>  0
## 138        0 Plasma concentration IQ0815 0.04700     <NA> ug/mL 0.001  <NA>  0
## 139        0 Plasma concentration IQ0815 0.03710     <NA> ug/mL 0.001  <NA>  0
## 140        0 Plasma concentration IQ0815 0.02450     <NA> ug/mL 0.001  <NA>  0
## 141        0 Plasma concentration IQ0815 0.00779     <NA> ug/mL 0.001  <NA>  0
## 142        0 Plasma concentration IQ0815 0.00116     <NA> ug/mL 0.001  <NA>  0
## 143        0 Plasma concentration IQ0815 0.00433     <NA> ug/mL 0.001  <NA>  0
## 144        0 Plasma concentration IQ0815 0.01200     <NA> ug/mL 0.001  <NA>  0
## 145        0 Plasma concentration IQ0815 0.01940     <NA> ug/mL 0.001  <NA>  0
## 146        0 Plasma concentration IQ0815 0.03030     <NA> ug/mL 0.001  <NA>  0
## 147        0 Plasma concentration IQ0815 0.03300     <NA> ug/mL 0.001  <NA>  0
## 148        0 Plasma concentration IQ0815 0.02270     <NA> ug/mL 0.001  <NA>  0
## 149        0 Plasma concentration IQ0815 0.00835     <NA> ug/mL 0.001  <NA>  0
## 150        0 Plasma concentration IQ0815 0.00266     <NA> ug/mL 0.001  <NA>  0
## 151        0 Plasma concentration IQ0815 0.00241     <NA> ug/mL 0.001  <NA>  0
## 152        0 Plasma concentration IQ0815 0.00127     <NA> ug/mL 0.001  <NA>  0
## 153        0 Plasma concentration IQ0815 0.00124     <NA> ug/mL 0.001  <NA>  0
## 154        0 Plasma concentration IQ0815 0.01190     <NA> ug/mL 0.001  <NA>  0
## 155        0 Plasma concentration IQ0815 0.03410     <NA> ug/mL 0.001  <NA>  0
## 156        0 Plasma concentration IQ0815 0.05540     <NA> ug/mL 0.001  <NA>  0
## 157        0 Plasma concentration IQ0815 0.05080     <NA> ug/mL 0.001  <NA>  0
## 158        0 Plasma concentration IQ0815 0.05230     <NA> ug/mL 0.001  <NA>  0
## 159        0 Plasma concentration IQ0815 0.03200     <NA> ug/mL 0.001  <NA>  0
## 160        0 Plasma concentration IQ0815 0.01060     <NA> ug/mL 0.001  <NA>  0
## 161        0 Plasma concentration IQ0815 0.00196     <NA> ug/mL 0.001  <NA>  0
## 162        0 Plasma concentration IQ0815 0.00168     <NA> ug/mL 0.001  <NA>  0
## 163        0 Plasma concentration IQ0815 0.00117     <NA> ug/mL 0.001  <NA>  0
## 164        0 Plasma concentration IQ0815 0.00936     <NA> ug/mL 0.001  <NA>  0
## 165        0 Plasma concentration IQ0815 0.02200     <NA> ug/mL 0.001  <NA>  0
## 166        0 Plasma concentration IQ0815 0.03310     <NA> ug/mL 0.001  <NA>  0
## 167        0 Plasma concentration IQ0815 0.05420     <NA> ug/mL 0.001  <NA>  0
## 168        0 Plasma concentration IQ0815 0.05030     <NA> ug/mL 0.001  <NA>  0
## 169        0 Plasma concentration IQ0815 0.04100     <NA> ug/mL 0.001  <NA>  0
## 170        0 Plasma concentration IQ0815 0.01170     <NA> ug/mL 0.001  <NA>  0
## 171        0 Plasma concentration IQ0815 0.00311     <NA> ug/mL 0.001  <NA>  0
## 172        0 Plasma concentration IQ0815 0.01390     <NA> ug/mL 0.001  <NA>  0
## 173        0 Plasma concentration IQ0815 0.03260     <NA> ug/mL 0.001  <NA>  0
## 174        0 Plasma concentration IQ0815 0.05050     <NA> ug/mL 0.001  <NA>  0
## 175        0 Plasma concentration IQ0815 0.06240     <NA> ug/mL 0.001  <NA>  0
## 176        0 Plasma concentration IQ0815 0.05440     <NA> ug/mL 0.001  <NA>  0
## 177        0 Plasma concentration IQ0815 0.03180     <NA> ug/mL 0.001  <NA>  0
## 178        0 Plasma concentration IQ0815 0.00749     <NA> ug/mL 0.001  <NA>  0
## 179        0 Plasma concentration IQ0815 0.00232     <NA> ug/mL 0.001  <NA>  0
## 180        0 Plasma concentration IQ0815 0.00309     <NA> ug/mL 0.001  <NA>  0
## 181        0 Plasma concentration IQ0815 0.00261     <NA> ug/mL 0.001  <NA>  0
## 182        0 Plasma concentration IQ0815 0.00165     <NA> ug/mL 0.001  <NA>  0
## 183        0 Plasma concentration IQ0815 0.00609     <NA> ug/mL 0.001  <NA>  0
## 184        0 Plasma concentration IQ0815 0.01570     <NA> ug/mL 0.001  <NA>  0
## 185        0 Plasma concentration IQ0815 0.02970     <NA> ug/mL 0.001  <NA>  0
## 186        0 Plasma concentration IQ0815 0.05030     <NA> ug/mL 0.001  <NA>  0
## 187        0 Plasma concentration IQ0815 0.04650     <NA> ug/mL 0.001  <NA>  0
## 188        0 Plasma concentration IQ0815 0.04090     <NA> ug/mL 0.001  <NA>  0
## 189        0 Plasma concentration IQ0815 0.00898     <NA> ug/mL 0.001  <NA>  0
## 190        0 Plasma concentration IQ0815 0.00265     <NA> ug/mL 0.001  <NA>  0
## 191        0 Plasma concentration IQ0815 0.00169     <NA> ug/mL 0.001  <NA>  0
## 192        0 Plasma concentration IQ0815 0.00170     <NA> ug/mL 0.001  <NA>  0
## 193        0 Plasma concentration IQ0815 0.00145     <NA> ug/mL 0.001  <NA>  0
## 194        0 Plasma concentration IQ0815 0.00971     <NA> ug/mL 0.001  <NA>  0
## 195        0 Plasma concentration IQ0815 0.02690     <NA> ug/mL 0.001  <NA>  0
## 196        0 Plasma concentration IQ0815 0.04840     <NA> ug/mL 0.001  <NA>  0
## 197        0 Plasma concentration IQ0815 0.06530     <NA> ug/mL 0.001  <NA>  0
## 198        0 Plasma concentration IQ0815 0.05790     <NA> ug/mL 0.001  <NA>  0
## 199        0 Plasma concentration IQ0815 0.03360     <NA> ug/mL 0.001  <NA>  0
## 200        0 Plasma concentration IQ0815 0.00991     <NA> ug/mL 0.001  <NA>  0
## 201        0 Plasma concentration IQ0815 0.00188     <NA> ug/mL 0.001  <NA>  0
## 202        0 Plasma concentration IQ0815 0.00296     <NA> ug/mL 0.001  <NA>  0
## 203        0 Plasma concentration IQ0815 0.00149     <NA> ug/mL 0.001  <NA>  0
## 204        0 Plasma concentration IQ0815 0.01290     <NA> ug/mL 0.001  <NA>  0
## 205        0 Plasma concentration IQ0815 0.03290     <NA> ug/mL 0.001  <NA>  0
## 206        0 Plasma concentration IQ0815 0.04310     <NA> ug/mL 0.001  <NA>  0
## 207        0 Plasma concentration IQ0815 0.05360     <NA> ug/mL 0.001  <NA>  0
## 208        0 Plasma concentration IQ0815 0.05700     <NA> ug/mL 0.001  <NA>  0
## 209        0 Plasma concentration IQ0815 0.04370     <NA> ug/mL 0.001  <NA>  0
## 210        0 Plasma concentration IQ0815 0.01170     <NA> ug/mL 0.001  <NA>  0
## 211        0 Plasma concentration IQ0815 0.00297     <NA> ug/mL 0.001  <NA>  0
## 212        0 Plasma concentration IQ0815 0.00114     <NA> ug/mL 0.001  <NA>  0
## 213        0 Plasma concentration IQ0815 0.00131     <NA> ug/mL 0.001  <NA>  0
## 214        0 Plasma concentration IQ0815 0.00121     <NA> ug/mL 0.001  <NA>  0
## 215        0 Plasma concentration IQ0815 0.01480     <NA> ug/mL 0.001  <NA>  0
## 216        0 Plasma concentration IQ0815 0.03720     <NA> ug/mL 0.001  <NA>  0
## 217        0 Plasma concentration IQ0815 0.06000     <NA> ug/mL 0.001  <NA>  0
## 218        0 Plasma concentration IQ0815 0.08750     <NA> ug/mL 0.001  <NA>  0
## 219        0 Plasma concentration IQ0815 0.07030     <NA> ug/mL 0.001  <NA>  0
## 220        0 Plasma concentration IQ0815 0.07920     <NA> ug/mL 0.001  <NA>  0
## 221        0 Plasma concentration IQ0815 0.02850     <NA> ug/mL 0.001  <NA>  0
## 222        0 Plasma concentration IQ0815 0.00963     <NA> ug/mL 0.001  <NA>  0
## 223        0 Plasma concentration IQ0815 0.00283     <NA> ug/mL 0.001  <NA>  0
## 224        0 Plasma concentration IQ0815 0.00248     <NA> ug/mL 0.001  <NA>  0
## 225        0 Plasma concentration IQ0815 0.04720     <NA> ug/mL 0.001  <NA>  0
## 226        0 Plasma concentration IQ0815 0.11400     <NA> ug/mL 0.001  <NA>  0
## 227        0 Plasma concentration IQ0815 0.15200     <NA> ug/mL 0.001  <NA>  0
## 228        0 Plasma concentration IQ0815 0.17300     <NA> ug/mL 0.001  <NA>  0
## 229        0 Plasma concentration IQ0815 0.14500     <NA> ug/mL 0.001  <NA>  0
## 230        0 Plasma concentration IQ0815 0.10100     <NA> ug/mL 0.001  <NA>  0
## 231        0 Plasma concentration IQ0815 0.01950     <NA> ug/mL 0.001  <NA>  0
## 232        0 Plasma concentration IQ0815 0.00940     <NA> ug/mL 0.001  <NA>  0
## 233        0 Plasma concentration IQ0815 0.00528     <NA> ug/mL 0.001  <NA>  0
## 234        0 Plasma concentration IQ0815 0.00482     <NA> ug/mL 0.001  <NA>  0
## 235        0 Plasma concentration IQ0815 0.00229     <NA> ug/mL 0.001  <NA>  0
## 236        0 Plasma concentration IQ0815 0.02670     <NA> ug/mL 0.001  <NA>  0
## 237        0 Plasma concentration IQ0815 0.06480     <NA> ug/mL 0.001  <NA>  0
## 238        0 Plasma concentration IQ0815 0.11000     <NA> ug/mL 0.001  <NA>  0
## 239        0 Plasma concentration IQ0815 0.12500     <NA> ug/mL 0.001  <NA>  0
## 240        0 Plasma concentration IQ0815 0.14300     <NA> ug/mL 0.001  <NA>  0
## 241        0 Plasma concentration IQ0815 0.06950     <NA> ug/mL 0.001  <NA>  0
## 242        0 Plasma concentration IQ0815 0.01640     <NA> ug/mL 0.001  <NA>  0
## 243        0 Plasma concentration IQ0815 0.00447     <NA> ug/mL 0.001  <NA>  0
## 244        0 Plasma concentration IQ0815 0.00313     <NA> ug/mL 0.001  <NA>  0
## 245        0 Plasma concentration IQ0815 0.00299     <NA> ug/mL 0.001  <NA>  0
## 246        0 Plasma concentration IQ0815 0.00201     <NA> ug/mL 0.001  <NA>  0
## 247        0 Plasma concentration IQ0815 0.01730     <NA> ug/mL 0.001  <NA>  0
## 248        0 Plasma concentration IQ0815 0.04370     <NA> ug/mL 0.001  <NA>  0
## 249        0 Plasma concentration IQ0815 0.07930     <NA> ug/mL 0.001  <NA>  0
## 250        0 Plasma concentration IQ0815 0.08940     <NA> ug/mL 0.001  <NA>  0
## 251        0 Plasma concentration IQ0815 0.09610     <NA> ug/mL 0.001  <NA>  0
## 252        0 Plasma concentration IQ0815 0.07590     <NA> ug/mL 0.001  <NA>  0
## 253        0 Plasma concentration IQ0815 0.01350     <NA> ug/mL 0.001  <NA>  0
## 254        0 Plasma concentration IQ0815 0.00340     <NA> ug/mL 0.001  <NA>  0
## 255        0 Plasma concentration IQ0815 0.00208     <NA> ug/mL 0.001  <NA>  0
## 256        0 Plasma concentration IQ0815 0.00112     <NA> ug/mL 0.001  <NA>  0
## 257        0 Plasma concentration IQ0815 0.04720     <NA> ug/mL 0.001  <NA>  0
## 258        0 Plasma concentration IQ0815 0.10600     <NA> ug/mL 0.001  <NA>  0
## 259        0 Plasma concentration IQ0815 0.13700     <NA> ug/mL 0.001  <NA>  0
## 260        0 Plasma concentration IQ0815 0.18200     <NA> ug/mL 0.001  <NA>  0
## 261        0 Plasma concentration IQ0815 0.16700     <NA> ug/mL 0.001  <NA>  0
## 262        0 Plasma concentration IQ0815 0.09100     <NA> ug/mL 0.001  <NA>  0
## 263        0 Plasma concentration IQ0815 0.01220     <NA> ug/mL 0.001  <NA>  0
## 264        0 Plasma concentration IQ0815 0.00554     <NA> ug/mL 0.001  <NA>  0
## 265        0 Plasma concentration IQ0815 0.00404     <NA> ug/mL 0.001  <NA>  0
## 266        0 Plasma concentration IQ0815 0.00415     <NA> ug/mL 0.001  <NA>  0
## 267        0 Plasma concentration IQ0815 0.00204     <NA> ug/mL 0.001  <NA>  0
## 268        0 Plasma concentration IQ0815 0.03750     <NA> ug/mL 0.001  <NA>  0
## 269        0 Plasma concentration IQ0815 0.08430     <NA> ug/mL 0.001  <NA>  0
## 270        0 Plasma concentration IQ0815 0.13000     <NA> ug/mL 0.001  <NA>  0
## 271        0 Plasma concentration IQ0815 0.22300     <NA> ug/mL 0.001  <NA>  0
## 272        0 Plasma concentration IQ0815 0.19500     <NA> ug/mL 0.001  <NA>  0
## 273        0 Plasma concentration IQ0815 0.14900     <NA> ug/mL 0.001  <NA>  0
## 274        0 Plasma concentration IQ0815 0.02950     <NA> ug/mL 0.001  <NA>  0
## 275        0 Plasma concentration IQ0815 0.00783     <NA> ug/mL 0.001  <NA>  0
## 276        0 Plasma concentration IQ0815 0.00447     <NA> ug/mL 0.001  <NA>  0
## 277        0 Plasma concentration IQ0815 0.00439     <NA> ug/mL 0.001  <NA>  0
## 278        0 Plasma concentration IQ0815 0.00191     <NA> ug/mL 0.001  <NA>  0
## 279        0 Plasma concentration IQ0815 0.03800     <NA> ug/mL 0.001  <NA>  0
## 280        0 Plasma concentration IQ0815 0.11800     <NA> ug/mL 0.001  <NA>  0
## 281        0 Plasma concentration IQ0815 0.15600     <NA> ug/mL 0.001  <NA>  0
## 282        0 Plasma concentration IQ0815 0.26800     <NA> ug/mL 0.001  <NA>  0
## 283        0 Plasma concentration IQ0815 0.22600     <NA> ug/mL 0.001  <NA>  0
## 284        0 Plasma concentration IQ0815 0.18700     <NA> ug/mL 0.001  <NA>  0
## 285        0 Plasma concentration IQ0815 0.07220     <NA> ug/mL 0.001  <NA>  0
## 286        0 Plasma concentration IQ0815 0.01980     <NA> ug/mL 0.001  <NA>  0
## 287        0 Plasma concentration IQ0815 0.00557     <NA> ug/mL 0.001  <NA>  0
## 288        0 Plasma concentration IQ0815 0.00625     <NA> ug/mL 0.001  <NA>  0
## 289        0 Plasma concentration IQ0815 0.00489     <NA> ug/mL 0.001  <NA>  0
## 290        0 Plasma concentration IQ0815 0.05450     <NA> ug/mL 0.001  <NA>  0
## 291        0 Plasma concentration IQ0815 0.17100     <NA> ug/mL 0.001  <NA>  0
## 292        0 Plasma concentration IQ0815 0.25400     <NA> ug/mL 0.001  <NA>  0
## 293        0 Plasma concentration IQ0815 0.25600     <NA> ug/mL 0.001  <NA>  0
## 294        0 Plasma concentration IQ0815 0.25300     <NA> ug/mL 0.001  <NA>  0
## 295        0 Plasma concentration IQ0815 0.20200     <NA> ug/mL 0.001  <NA>  0
## 296        0 Plasma concentration IQ0815 0.09480     <NA> ug/mL 0.001  <NA>  0
## 297        0 Plasma concentration IQ0815 0.02510     <NA> ug/mL 0.001  <NA>  0
## 298        0 Plasma concentration IQ0815 0.00726     <NA> ug/mL 0.001  <NA>  0
## 299        0 Plasma concentration IQ0815 0.00550     <NA> ug/mL 0.001  <NA>  0
## 300        0 Plasma concentration IQ0815 0.00584     <NA> ug/mL 0.001  <NA>  0
## 301        0 Plasma concentration IQ0815 0.07300     <NA> ug/mL 0.001  <NA>  0
## 302        0 Plasma concentration IQ0815 0.19400     <NA> ug/mL 0.001  <NA>  0
## 303        0 Plasma concentration IQ0815 0.25700     <NA> ug/mL 0.001  <NA>  0
## 304        0 Plasma concentration IQ0815 0.41900     <NA> ug/mL 0.001  <NA>  0
## 305        0 Plasma concentration IQ0815 0.43900     <NA> ug/mL 0.001  <NA>  0
## 306        0 Plasma concentration IQ0815 0.32000     <NA> ug/mL 0.001  <NA>  0
## 307        0 Plasma concentration IQ0815 0.05640     <NA> ug/mL 0.001  <NA>  0
## 308        0 Plasma concentration IQ0815 0.01690     <NA> ug/mL 0.001  <NA>  0
## 309        0 Plasma concentration IQ0815 0.01180     <NA> ug/mL 0.001  <NA>  0
## 310        0 Plasma concentration IQ0815 0.00834     <NA> ug/mL 0.001  <NA>  0
## 311        0 Plasma concentration IQ0815 0.00685     <NA> ug/mL 0.001  <NA>  0
## 312        0 Plasma concentration IQ0815 0.08670     <NA> ug/mL 0.001  <NA>  0
## 313        0 Plasma concentration IQ0815 0.20300     <NA> ug/mL 0.001  <NA>  0
## 314        0 Plasma concentration IQ0815 0.29300     <NA> ug/mL 0.001  <NA>  0
## 315        0 Plasma concentration IQ0815 0.33400     <NA> ug/mL 0.001  <NA>  0
## 316        0 Plasma concentration IQ0815 0.29100     <NA> ug/mL 0.001  <NA>  0
## 317        0 Plasma concentration IQ0815 0.24300     <NA> ug/mL 0.001  <NA>  0
## 318        0 Plasma concentration IQ0815 0.05680     <NA> ug/mL 0.001  <NA>  0
## 319        0 Plasma concentration IQ0815 0.01150     <NA> ug/mL 0.001  <NA>  0
## 320        0 Plasma concentration IQ0815 0.00503     <NA> ug/mL 0.001  <NA>  0
## 321        0 Plasma concentration IQ0815 0.00278     <NA> ug/mL 0.001  <NA>  0
## 322        0 Plasma concentration IQ0815 0.00216     <NA> ug/mL 0.001  <NA>  0
## 323        0 Plasma concentration IQ0815 0.06290     <NA> ug/mL 0.001  <NA>  0
## 324        0 Plasma concentration IQ0815 0.14200     <NA> ug/mL 0.001  <NA>  0
## 325        0 Plasma concentration IQ0815 0.21500     <NA> ug/mL 0.001  <NA>  0
## 326        0 Plasma concentration IQ0815 0.31800     <NA> ug/mL 0.001  <NA>  0
## 327        0 Plasma concentration IQ0815 0.25400     <NA> ug/mL 0.001  <NA>  0
## 328        0 Plasma concentration IQ0815 0.16900     <NA> ug/mL 0.001  <NA>  0
## 329        0 Plasma concentration IQ0815 0.02870     <NA> ug/mL 0.001  <NA>  0
## 330        0 Plasma concentration IQ0815 0.00977     <NA> ug/mL 0.001  <NA>  0
## 331        0 Plasma concentration IQ0815 0.00555     <NA> ug/mL 0.001  <NA>  0
## 332        0 Plasma concentration IQ0815 0.00413     <NA> ug/mL 0.001  <NA>  0
## 333        0 Plasma concentration IQ0815 0.00196     <NA> ug/mL 0.001  <NA>  0
## 334        0 Plasma concentration IQ0815 0.08270     <NA> ug/mL 0.001  <NA>  0
## 335        0 Plasma concentration IQ0815 0.20200     <NA> ug/mL 0.001  <NA>  0
## 336        0 Plasma concentration IQ0815 0.28400     <NA> ug/mL 0.001  <NA>  0
## 337        0 Plasma concentration IQ0815 0.31000     <NA> ug/mL 0.001  <NA>  0
## 338        0 Plasma concentration IQ0815 0.25600     <NA> ug/mL 0.001  <NA>  0
## 339        0 Plasma concentration IQ0815 0.18200     <NA> ug/mL 0.001  <NA>  0
## 340        0 Plasma concentration IQ0815 0.02720     <NA> ug/mL 0.001  <NA>  0
## 341        0 Plasma concentration IQ0815 0.01400     <NA> ug/mL 0.001  <NA>  0
## 342        0 Plasma concentration IQ0815 0.01130     <NA> ug/mL 0.001  <NA>  0
## 343        0 Plasma concentration IQ0815 0.00537     <NA> ug/mL 0.001  <NA>  0
## 344        0 Plasma concentration IQ0815 0.00258     <NA> ug/mL 0.001  <NA>  0
## 345        0 Plasma concentration IQ0815 0.16600     <NA> ug/mL 0.001  <NA>  0
## 346        0 Plasma concentration IQ0815 0.37400     <NA> ug/mL 0.001  <NA>  0
## 347        0 Plasma concentration IQ0815 0.50400     <NA> ug/mL 0.001  <NA>  0
## 348        0 Plasma concentration IQ0815 0.86200     <NA> ug/mL 0.001  <NA>  0
## 349        0 Plasma concentration IQ0815 0.78800     <NA> ug/mL 0.001  <NA>  0
## 350        0 Plasma concentration IQ0815 0.49000     <NA> ug/mL 0.001  <NA>  0
## 351        0 Plasma concentration IQ0815 0.14300     <NA> ug/mL 0.001  <NA>  0
## 352        0 Plasma concentration IQ0815 0.02110     <NA> ug/mL 0.001  <NA>  0
## 353        0 Plasma concentration IQ0815 0.00575     <NA> ug/mL 0.001  <NA>  0
## 354        0 Plasma concentration IQ0815 0.00667     <NA> ug/mL 0.001  <NA>  0
## 355        0 Plasma concentration IQ0815 0.00593     <NA> ug/mL 0.001  <NA>  0
## 356        0 Plasma concentration IQ0815 0.08550     <NA> ug/mL 0.001  <NA>  0
## 357        0 Plasma concentration IQ0815 0.18200     <NA> ug/mL 0.001  <NA>  0
## 358        0 Plasma concentration IQ0815 0.32300     <NA> ug/mL 0.001  <NA>  0
## 359        0 Plasma concentration IQ0815 0.43400     <NA> ug/mL 0.001  <NA>  0
## 360        0 Plasma concentration IQ0815 0.41700     <NA> ug/mL 0.001  <NA>  0
## 361        0 Plasma concentration IQ0815 0.23200     <NA> ug/mL 0.001  <NA>  0
## 362        0 Plasma concentration IQ0815 0.03960     <NA> ug/mL 0.001  <NA>  0
## 363        0 Plasma concentration IQ0815 0.00877     <NA> ug/mL 0.001  <NA>  0
## 364        0 Plasma concentration IQ0815 0.00778     <NA> ug/mL 0.001  <NA>  0
## 365        0 Plasma concentration IQ0815 0.00419     <NA> ug/mL 0.001  <NA>  0
## 366        0 Plasma concentration IQ0815 0.00410     <NA> ug/mL 0.001  <NA>  0
## 367        0 Plasma concentration IQ0815 0.17500     <NA> ug/mL 0.001  <NA>  0
## 368        0 Plasma concentration IQ0815 0.37600     <NA> ug/mL 0.001  <NA>  0
## 369        0 Plasma concentration IQ0815 0.59300     <NA> ug/mL 0.001  <NA>  0
## 370        0 Plasma concentration IQ0815 0.63500     <NA> ug/mL 0.001  <NA>  0
## 371        0 Plasma concentration IQ0815 0.51700     <NA> ug/mL 0.001  <NA>  0
## 372        0 Plasma concentration IQ0815 0.42900     <NA> ug/mL 0.001  <NA>  0
## 373        0 Plasma concentration IQ0815 0.09240     <NA> ug/mL 0.001  <NA>  0
## 374        0 Plasma concentration IQ0815 0.01930     <NA> ug/mL 0.001  <NA>  0
## 375        0 Plasma concentration IQ0815 0.01220     <NA> ug/mL 0.001  <NA>  0
## 376        0 Plasma concentration IQ0815 0.00661     <NA> ug/mL 0.001  <NA>  0
## 377        0 Plasma concentration IQ0815 0.00625     <NA> ug/mL 0.001  <NA>  0
## 378        0 Plasma concentration IQ0815 0.08050     <NA> ug/mL 0.001  <NA>  0
## 379        0 Plasma concentration IQ0815 0.19300     <NA> ug/mL 0.001  <NA>  0
## 380        0 Plasma concentration IQ0815 0.32400     <NA> ug/mL 0.001  <NA>  0
## 381        0 Plasma concentration IQ0815 0.54500     <NA> ug/mL 0.001  <NA>  0
## 382        0 Plasma concentration IQ0815 0.48700     <NA> ug/mL 0.001  <NA>  0
## 383        0 Plasma concentration IQ0815 0.32100     <NA> ug/mL 0.001  <NA>  0
## 384        0 Plasma concentration IQ0815 0.05940     <NA> ug/mL 0.001  <NA>  0
## 385        0 Plasma concentration IQ0815 0.01070     <NA> ug/mL 0.001  <NA>  0
## 386        0 Plasma concentration IQ0815 0.00319     <NA> ug/mL 0.001  <NA>  0
## 387        0 Plasma concentration IQ0815 0.00324     <NA> ug/mL 0.001  <NA>  0
## 388        0 Plasma concentration IQ0815 0.00277     <NA> ug/mL 0.001  <NA>  0
## 389        0 Plasma concentration IQ0815 0.11000     <NA> ug/mL 0.001  <NA>  0
## 390        0 Plasma concentration IQ0815 0.26500     <NA> ug/mL 0.001  <NA>  0
## 391        0 Plasma concentration IQ0815 0.42700     <NA> ug/mL 0.001  <NA>  0
## 392        0 Plasma concentration IQ0815 0.55200     <NA> ug/mL 0.001  <NA>  0
## 393        0 Plasma concentration IQ0815 0.43200     <NA> ug/mL 0.001  <NA>  0
## 394        0 Plasma concentration IQ0815 0.35400     <NA> ug/mL 0.001  <NA>  0
## 395        0 Plasma concentration IQ0815 0.09750     <NA> ug/mL 0.001  <NA>  0
## 396        0 Plasma concentration IQ0815 0.02520     <NA> ug/mL 0.001  <NA>  0
## 397        0 Plasma concentration IQ0815 0.01240     <NA> ug/mL 0.001  <NA>  0
## 398        0 Plasma concentration IQ0815 0.01140     <NA> ug/mL 0.001  <NA>  0
## 399        0 Plasma concentration IQ0815 0.00855     <NA> ug/mL 0.001  <NA>  0
## 400        0 Plasma concentration IQ0815 0.18300     <NA> ug/mL 0.001  <NA>  0
## 401        0 Plasma concentration IQ0815 0.50000     <NA> ug/mL 0.001  <NA>  0
## 402        0 Plasma concentration IQ0815 0.70600     <NA> ug/mL 0.001  <NA>  0
## 403        0 Plasma concentration IQ0815 0.98400     <NA> ug/mL 0.001  <NA>  0
## 404        0 Plasma concentration IQ0815 0.83000     <NA> ug/mL 0.001  <NA>  0
## 405        0 Plasma concentration IQ0815 0.59300     <NA> ug/mL 0.001  <NA>  0
## 406        0 Plasma concentration IQ0815 0.19600     <NA> ug/mL 0.001  <NA>  0
## 407        0 Plasma concentration IQ0815 0.05670     <NA> ug/mL 0.001  <NA>  0
## 408        0 Plasma concentration IQ0815 0.01880     <NA> ug/mL 0.001  <NA>  0
## 409        0 Plasma concentration IQ0815 0.01930     <NA> ug/mL 0.001  <NA>  0
## 410        0 Plasma concentration IQ0815 0.01510     <NA> ug/mL 0.001  <NA>  0
##     ADDL ID  TIMEPOS EVID MDV CENS AMT      DV TINF RATE ADM YTYPE     TAD DOSE
## 1      0  3 167.9163    0   0    0   0 0.00153    0    0   0     1   0.250    1
## 2      0  3 168.1663    0   0    0   0 0.00350    0    0   0     1   0.500    1
## 3      0  3 168.6663    0   0    0   0 0.00380    0    0   0     1   1.000    1
## 4      0  3 169.6663    0   0    0   0 0.00333    0    0   0     1   2.000    1
## 5      0  3 171.6663    0   0    0   0 0.00291    0    0   0     1   4.000    1
## 6      0  4 168.1660    0   0    0   0 0.00138    0    0   0     1   0.083    1
## 7      0  4 168.3330    0   0    0   0 0.00212    0    0   0     1   0.250    1
## 8      0  4 168.5830    0   0    0   0 0.00359    0    0   0     1   0.500    1
## 9      0  4 169.0830    0   0    0   0 0.00542    0    0   0     1   1.000    1
## 10     0  4 170.0830    0   0    0   0 0.00526    0    0   0     1   2.000    1
## 11     0  4 172.0830    0   0    0   0 0.00391    0    0   0     1   4.000    1
## 12     0  5 168.3830    0   0    0   0 0.00168    0    0   0     1   0.250    1
## 13     0  5 168.3830    0   0    0   0 0.00168    0    0   0     1   0.250    1
## 14     0  5 168.6330    0   0    0   0 0.02000    0    0   0     1   0.500    1
## 15     0  5 169.1330    0   0    0   0 0.00221    0    0   0     1   1.000    1
## 16     0  5 170.1330    0   0    0   0 0.00307    0    0   0     1   2.000    1
## 17     0  5 172.1330    0   0    0   0 0.00133    0    0   0     1   4.000    1
## 18     0  6 168.2997    0   0    0   0 0.00128    0    0   0     1   0.250    1
## 19     0  6 168.5497    0   0    0   0 0.00220    0    0   0     1   0.500    1
## 20     0  6 169.0497    0   0    0   0 0.00278    0    0   0     1   1.000    1
## 21     0  6 170.0497    0   0    0   0 0.00221    0    0   0     1   2.000    1
## 22     0  6 172.0497    0   0    0   0 0.00153    0    0   0     1   4.000    1
## 23     0  7 168.0993    0   0    0   0 0.00174    0    0   0     1   0.083    2
## 24     0  7 168.2663    0   0    0   0 0.00299    0    0   0     1   0.250    2
## 25     0  7 168.5163    0   0    0   0 0.00555    0    0   0     1   0.500    2
## 26     0  7 169.0163    0   0    0   0 0.00780    0    0   0     1   1.000    2
## 27     0  7 170.0163    0   0    0   0 0.00706    0    0   0     1   2.000    2
## 28     0  7 172.0163    0   0    0   0 0.00526    0    0   0     1   4.000    2
## 29     0  7 216.0163    0   0    0   0 0.50000    0    0   0     1  48.000    2
## 30     0  9 168.1493    0   0    0   0 0.00123    0    0   0     1   0.083    2
## 31     0  9 168.3163    0   0    0   0 0.00238    0    0   0     1   0.250    2
## 32     0  9 168.5663    0   0    0   0 0.00480    0    0   0     1   0.500    2
## 33     0  9 169.0663    0   0    0   0 0.00672    0    0   0     1   1.000    2
## 34     0  9 170.0663    0   0    0   0 0.00509    0    0   0     1   2.000    2
## 35     0  9 172.0663    0   0    0   0 0.00396    0    0   0     1   4.000    2
## 36     0  9 180.0663    0   0    0   0 0.00160    0    0   0     1  12.000    2
## 37     0 10 168.0993    0   0    0   0 0.00157    0    0   0     1   0.083    2
## 38     0 10 168.2663    0   0    0   0 0.00205    0    0   0     1   0.250    2
## 39     0 10 168.5163    0   0    0   0 0.00446    0    0   0     1   0.500    2
## 40     0 10 169.0163    0   0    0   0 0.00462    0    0   0     1   1.000    2
## 41     0 10 170.0163    0   0    0   0 0.00555    0    0   0     1   2.000    2
## 42     0 10 172.0163    0   0    0   0 0.00329    0    0   0     1   4.000    2
## 43     0 11 167.7993    0   0    0   0 0.00127    0    0   0     1   0.083    2
## 44     0 11 167.9663    0   0    0   0 0.00345    0    0   0     1   0.250    2
## 45     0 11 168.2163    0   0    0   0 0.00491    0    0   0     1   0.500    2
## 46     0 11 168.7163    0   0    0   0 0.00692    0    0   0     1   1.000    2
## 47     0 11 169.7163    0   0    0   0 0.00736    0    0   0     1   2.000    2
## 48     0 11 171.7163    0   0    0   0 0.00420    0    0   0     1   4.000    2
## 49     0 12 169.0330    0   0    0   0 0.00380    0    0   0     1   0.250    2
## 50     0 12 169.2830    0   0    0   0 0.00510    0    0   0     1   0.500    2
## 51     0 12 169.7830    0   0    0   0 0.00396    0    0   0     1   1.000    2
## 52     0 12 170.7830    0   0    0   0 0.00596    0    0   0     1   2.000    2
## 53     0 12 172.7830    0   0    0   0 0.00445    0    0   0     1   4.000    2
## 54     0 13 168.6660    0   0    0   0 0.00593    0    0   0     1   0.083    5
## 55     0 13 168.8330    0   0    0   0 0.01100    0    0   0     1   0.250    5
## 56     0 13 169.0830    0   0    0   0 0.02130    0    0   0     1   0.500    5
## 57     0 13 169.5830    0   0    0   0 0.02640    0    0   0     1   1.000    5
## 58     0 13 170.5830    0   0    0   0 0.02360    0    0   0     1   2.000    5
## 59     0 13 172.5830    0   0    0   0 0.00808    0    0   0     1   4.000    5
## 60     0 13 180.5830    0   0    0   0 0.00128    0    0   0     1  12.000    5
## 61     0 14 168.7327    0   0    0   0 0.00428    0    0   0     1   0.083    5
## 62     0 14 168.8997    0   0    0   0 0.01080    0    0   0     1   0.250    5
## 63     0 14 169.1497    0   0    0   0 0.01920    0    0   0     1   0.500    5
## 64     0 14 169.6497    0   0    0   0 0.01960    0    0   0     1   1.000    5
## 65     0 14 170.6497    0   0    0   0 0.01400    0    0   0     1   2.000    5
## 66     0 14 180.6497    0   0    0   0 0.00112    0    0   0     1  12.000    5
## 67     0 15 168.4827    0   0    0   0 0.00174    0    0   0     1   0.083    5
## 68     0 15 168.6497    0   0    0   0 0.00432    0    0   0     1   0.250    5
## 69     0 15 168.8997    0   0    0   0 0.00766    0    0   0     1   0.500    5
## 70     0 15 169.3997    0   0    0   0 0.01030    0    0   0     1   1.000    5
## 71     0 15 170.3997    0   0    0   0 0.00802    0    0   0     1   2.000    5
## 72     0 15 172.3997    0   0    0   0 0.00742    0    0   0     1   4.000    5
## 73     0 15 180.3997    0   0    0   0 0.00300    0    0   0     1  12.000    5
## 74     0 16 167.4493    0   0    0   0 0.00370    0    0   0     1   0.083    5
## 75     0 16 167.6163    0   0    0   0 0.00826    0    0   0     1   0.250    5
## 76     0 16 167.8663    0   0    0   0 0.01440    0    0   0     1   0.500    5
## 77     0 16 168.3663    0   0    0   0 0.01460    0    0   0     1   1.000    5
## 78     0 16 169.3663    0   0    0   0 0.01770    0    0   0     1   2.000    5
## 79     0 16 171.3663    0   0    0   0 0.00857    0    0   0     1   4.000    5
## 80     0 16 179.3663    0   0    0   0 0.00199    0    0   0     1  12.000    5
## 81     0 16 335.3663    0   0    0   0 0.00101    0    0   0     1 168.000    5
## 82     0 17 168.8327    0   0    0   0 0.00386    0    0   0     1   0.083    5
## 83     0 17 168.9997    0   0    0   0 0.00888    0    0   0     1   0.250    5
## 84     0 17 169.2497    0   0    0   0 0.01700    0    0   0     1   0.500    5
## 85     0 17 169.7497    0   0    0   0 0.01830    0    0   0     1   1.000    5
## 86     0 17 170.7497    0   0    0   0 0.01980    0    0   0     1   2.000    5
## 87     0 17 172.7497    0   0    0   0 0.00950    0    0   0     1   4.000    5
## 88     0 17 180.7497    0   0    0   0 0.00334    0    0   0     1  12.000    5
## 89     0 18 167.3660    0   0    0   0 0.02000    0    0   0     1   0.083    5
## 90     0 18 167.5330    0   0    0   0 0.04000    0    0   0     1   0.250    5
## 91     0 18 167.7830    0   0    0   0 0.06000    0    0   0     1   0.500    5
## 92     0 18 168.2830    0   0    0   0 0.08000    0    0   0     1   1.000    5
## 93     0 18 169.2830    0   0    0   0 0.10000    0    0   0     1   2.000    5
## 94     0 18 171.2830    0   0    0   0 0.12000    0    0   0     1   4.000    5
## 95     0 18 179.2830    0   0    0   0 0.14000    0    0   0     1  12.000    5
## 96     0 18 191.2830    0   0    0   0 0.16000    0    0   0     1  24.000    5
## 97     0 18 215.2830    0   0    0   0 0.18000    0    0   0     1  48.000    5
## 98     0 18 263.2830    0   0    0   0 0.20000    0    0   0     1  96.000    5
## 99     0 18 335.2830    0   0    0   0 0.22000    0    0   0     1 168.000    5
## 100    0 19 169.2493    0   0    0   0 0.00689    0    0   0     1   0.083   10
## 101    0 19 169.4163    0   0    0   0 0.01530    0    0   0     1   0.250   10
## 102    0 19 169.6663    0   0    0   0 0.02390    0    0   0     1   0.500   10
## 103    0 19 170.1663    0   0    0   0 0.04110    0    0   0     1   1.000   10
## 104    0 19 171.1663    0   0    0   0 0.03820    0    0   0     1   2.000   10
## 105    0 19 173.1663    0   0    0   0 0.02730    0    0   0     1   4.000   10
## 106    0 19 181.1663    0   0    0   0 0.00528    0    0   0     1  12.000   10
## 107    0 19 193.1663    0   0    0   0 0.00198    0    0   0     1  24.000   10
## 108    0 20 168.5327    0   0    0   0 0.00515    0    0   0     1   0.083   10
## 109    0 20 168.6997    0   0    0   0 0.01130    0    0   0     1   0.250   10
## 110    0 20 168.9497    0   0    0   0 0.01910    0    0   0     1   0.500   10
## 111    0 20 169.4497    0   0    0   0 0.03580    0    0   0     1   1.000   10
## 112    0 20 170.4497    0   0    0   0 0.02670    0    0   0     1   2.000   10
## 113    0 20 172.4497    0   0    0   0 0.01850    0    0   0     1   4.000   10
## 114    0 20 180.4497    0   0    0   0 0.00755    0    0   0     1  12.000   10
## 115    0 20 192.4497    0   0    0   0 0.00219    0    0   0     1  24.000   10
## 116    0 20 216.4497    0   0    0   0 0.13000    0    0   0     1  48.000   10
## 117    0 20 336.4497    0   0    0   0 0.00101    0    0   0     1 168.000   10
## 118    0 21 167.7660    0   0    0   0 0.00374    0    0   0     1   0.083   10
## 119    0 21 167.9330    0   0    0   0 0.00866    0    0   0     1   0.250   10
## 120    0 21 168.1830    0   0    0   0 0.01570    0    0   0     1   0.500   10
## 121    0 21 168.6830    0   0    0   0 0.01960    0    0   0     1   1.000   10
## 122    0 21 169.6830    0   0    0   0 0.02190    0    0   0     1   2.000   10
## 123    0 21 171.6830    0   0    0   0 0.02200    0    0   0     1   4.000   10
## 124    0 21 179.6830    0   0    0   0 0.00786    0    0   0     1  12.000   10
## 125    0 21 191.6830    0   0    0   0 0.00382    0    0   0     1  24.000   10
## 126    0 21 263.6830    0   0    0   0 0.00108    0    0   0     1  96.000   10
## 127    0 22 167.6160    0   0    0   0 0.00241    0    0   0     1   0.083   10
## 128    0 22 167.7830    0   0    0   0 0.01060    0    0   0     1   0.250   10
## 129    0 22 168.0330    0   0    0   0 0.01630    0    0   0     1   0.500   10
## 130    0 22 168.5330    0   0    0   0 0.02530    0    0   0     1   1.000   10
## 131    0 22 169.5330    0   0    0   0 0.20500    0    0   0     1   2.000   10
## 132    0 22 171.5330    0   0    0   0 0.01860    0    0   0     1   4.000   10
## 133    0 22 179.5330    0   0    0   0 0.00534    0    0   0     1  12.000   10
## 134    0 22 191.5330    0   0    0   0 0.00213    0    0   0     1  24.000   10
## 135    0 23 167.9327    0   0    0   0 0.00905    0    0   0     1   0.083   10
## 136    0 23 168.0997    0   0    0   0 0.02640    0    0   0     1   0.250   10
## 137    0 23 168.3497    0   0    0   0 0.03400    0    0   0     1   0.500   10
## 138    0 23 168.8497    0   0    0   0 0.04700    0    0   0     1   1.000   10
## 139    0 23 169.8497    0   0    0   0 0.03710    0    0   0     1   2.000   10
## 140    0 23 171.8497    0   0    0   0 0.02450    0    0   0     1   4.000   10
## 141    0 23 179.8497    0   0    0   0 0.00779    0    0   0     1  12.000   10
## 142    0 23 191.8497    0   0    0   0 0.00116    0    0   0     1  24.000   10
## 143    0 24 168.2993    0   0    0   0 0.00433    0    0   0     1   0.083   10
## 144    0 24 168.4663    0   0    0   0 0.01200    0    0   0     1   0.250   10
## 145    0 24 168.7163    0   0    0   0 0.01940    0    0   0     1   0.500   10
## 146    0 24 169.2163    0   0    0   0 0.03030    0    0   0     1   1.000   10
## 147    0 24 170.2163    0   0    0   0 0.03300    0    0   0     1   2.000   10
## 148    0 24 172.2163    0   0    0   0 0.02270    0    0   0     1   4.000   10
## 149    0 24 180.2163    0   0    0   0 0.00835    0    0   0     1  12.000   10
## 150    0 24 192.2163    0   0    0   0 0.00266    0    0   0     1  24.000   10
## 151    0 24 216.2163    0   0    0   0 0.00241    0    0   0     1  48.000   10
## 152    0 24 264.2163    0   0    0   0 0.00127    0    0   0     1  96.000   10
## 153    0 24 336.2163    0   0    0   0 0.00124    0    0   0     1 168.000   10
## 154    0 25 167.6660    0   0    0   0 0.01190    0    0   0     1   0.083   20
## 155    0 25 167.8330    0   0    0   0 0.03410    0    0   0     1   0.250   20
## 156    0 25 168.0830    0   0    0   0 0.05540    0    0   0     1   0.500   20
## 157    0 25 168.5830    0   0    0   0 0.05080    0    0   0     1   1.000   20
## 158    0 25 169.5830    0   0    0   0 0.05230    0    0   0     1   2.000   20
## 159    0 25 171.5830    0   0    0   0 0.03200    0    0   0     1   4.000   20
## 160    0 25 179.5830    0   0    0   0 0.01060    0    0   0     1  12.000   20
## 161    0 25 191.5830    0   0    0   0 0.00196    0    0   0     1  24.000   20
## 162    0 25 215.5830    0   0    0   0 0.00168    0    0   0     1  48.000   20
## 163    0 25 335.5830    0   0    0   0 0.00117    0    0   0     1 168.000   20
## 164    0 26 167.6493    0   0    0   0 0.00936    0    0   0     1   0.083   20
## 165    0 26 167.8163    0   0    0   0 0.02200    0    0   0     1   0.250   20
## 166    0 26 168.0663    0   0    0   0 0.03310    0    0   0     1   0.500   20
## 167    0 26 168.5663    0   0    0   0 0.05420    0    0   0     1   1.000   20
## 168    0 26 169.5663    0   0    0   0 0.05030    0    0   0     1   2.000   20
## 169    0 26 171.5663    0   0    0   0 0.04100    0    0   0     1   4.000   20
## 170    0 26 179.5663    0   0    0   0 0.01170    0    0   0     1  12.000   20
## 171    0 26 191.5663    0   0    0   0 0.00311    0    0   0     1  24.000   20
## 172    0 27 168.9660    0   0    0   0 0.01390    0    0   0     1   0.083   20
## 173    0 27 169.1330    0   0    0   0 0.03260    0    0   0     1   0.250   20
## 174    0 27 169.3830    0   0    0   0 0.05050    0    0   0     1   0.500   20
## 175    0 27 169.8830    0   0    0   0 0.06240    0    0   0     1   1.000   20
## 176    0 27 170.8830    0   0    0   0 0.05440    0    0   0     1   2.000   20
## 177    0 27 172.8830    0   0    0   0 0.03180    0    0   0     1   4.000   20
## 178    0 27 180.8830    0   0    0   0 0.00749    0    0   0     1  12.000   20
## 179    0 27 192.8830    0   0    0   0 0.00232    0    0   0     1  24.000   20
## 180    0 27 216.8830    0   0    0   0 0.00309    0    0   0     1  48.000   20
## 181    0 27 264.8830    0   0    0   0 0.00261    0    0   0     1  96.000   20
## 182    0 27 336.8830    0   0    0   0 0.00165    0    0   0     1 168.000   20
## 183    0 28 168.0327    0   0    0   0 0.00609    0    0   0     1   0.083   20
## 184    0 28 168.1997    0   0    0   0 0.01570    0    0   0     1   0.250   20
## 185    0 28 168.4497    0   0    0   0 0.02970    0    0   0     1   0.500   20
## 186    0 28 168.9497    0   0    0   0 0.05030    0    0   0     1   1.000   20
## 187    0 28 169.9497    0   0    0   0 0.04650    0    0   0     1   2.000   20
## 188    0 28 171.9497    0   0    0   0 0.04090    0    0   0     1   4.000   20
## 189    0 28 179.9497    0   0    0   0 0.00898    0    0   0     1  12.000   20
## 190    0 28 191.9497    0   0    0   0 0.00265    0    0   0     1  24.000   20
## 191    0 28 215.9497    0   0    0   0 0.00169    0    0   0     1  48.000   20
## 192    0 28 263.9497    0   0    0   0 0.00170    0    0   0     1  96.000   20
## 193    0 28 335.9497    0   0    0   0 0.00145    0    0   0     1 168.000   20
## 194    0 29 167.9660    0   0    0   0 0.00971    0    0   0     1   0.083   20
## 195    0 29 168.1330    0   0    0   0 0.02690    0    0   0     1   0.250   20
## 196    0 29 168.3830    0   0    0   0 0.04840    0    0   0     1   0.500   20
## 197    0 29 168.8830    0   0    0   0 0.06530    0    0   0     1   1.000   20
## 198    0 29 169.8830    0   0    0   0 0.05790    0    0   0     1   2.000   20
## 199    0 29 171.8830    0   0    0   0 0.03360    0    0   0     1   4.000   20
## 200    0 29 179.8830    0   0    0   0 0.00991    0    0   0     1  12.000   20
## 201    0 29 191.8830    0   0    0   0 0.00188    0    0   0     1  24.000   20
## 202    0 29 215.8830    0   0    0   0 0.00296    0    0   0     1  48.000   20
## 203    0 29 263.8830    0   0    0   0 0.00149    0    0   0     1  96.000   20
## 204    0 30 167.7993    0   0    0   0 0.01290    0    0   0     1   0.083   20
## 205    0 30 167.9663    0   0    0   0 0.03290    0    0   0     1   0.250   20
## 206    0 30 168.2163    0   0    0   0 0.04310    0    0   0     1   0.500   20
## 207    0 30 168.7163    0   0    0   0 0.05360    0    0   0     1   1.000   20
## 208    0 30 169.7163    0   0    0   0 0.05700    0    0   0     1   2.000   20
## 209    0 30 171.7163    0   0    0   0 0.04370    0    0   0     1   4.000   20
## 210    0 30 179.7163    0   0    0   0 0.01170    0    0   0     1  12.000   20
## 211    0 30 191.7163    0   0    0   0 0.00297    0    0   0     1  24.000   20
## 212    0 30 215.7163    0   0    0   0 0.00114    0    0   0     1  48.000   20
## 213    0 30 263.7163    0   0    0   0 0.00131    0    0   0     1  96.000   20
## 214    0 30 335.7163    0   0    0   0 0.00121    0    0   0     1 168.000   20
## 215    0 31 168.2493    0   0    0   0 0.01480    0    0   0     1   0.083   50
## 216    0 31 168.4163    0   0    0   0 0.03720    0    0   0     1   0.250   50
## 217    0 31 168.6663    0   0    0   0 0.06000    0    0   0     1   0.500   50
## 218    0 31 169.1663    0   0    0   0 0.08750    0    0   0     1   1.000   50
## 219    0 31 170.1663    0   0    0   0 0.07030    0    0   0     1   2.000   50
## 220    0 31 172.1663    0   0    0   0 0.07920    0    0   0     1   4.000   50
## 221    0 31 180.1663    0   0    0   0 0.02850    0    0   0     1  12.000   50
## 222    0 31 192.1663    0   0    0   0 0.00963    0    0   0     1  24.000   50
## 223    0 31 216.1663    0   0    0   0 0.00283    0    0   0     1  48.000   50
## 224    0 31 264.1663    0   0    0   0 0.00248    0    0   0     1  96.000   50
## 225    0 32 168.2993    0   0    0   0 0.04720    0    0   0     1   0.083   50
## 226    0 32 168.4663    0   0    0   0 0.11400    0    0   0     1   0.250   50
## 227    0 32 168.7163    0   0    0   0 0.15200    0    0   0     1   0.500   50
## 228    0 32 169.2163    0   0    0   0 0.17300    0    0   0     1   1.000   50
## 229    0 32 170.2163    0   0    0   0 0.14500    0    0   0     1   2.000   50
## 230    0 32 172.2163    0   0    0   0 0.10100    0    0   0     1   4.000   50
## 231    0 32 180.2163    0   0    0   0 0.01950    0    0   0     1  12.000   50
## 232    0 32 192.2163    0   0    0   0 0.00940    0    0   0     1  24.000   50
## 233    0 32 216.2163    0   0    0   0 0.00528    0    0   0     1  48.000   50
## 234    0 32 264.2163    0   0    0   0 0.00482    0    0   0     1  96.000   50
## 235    0 32 336.2163    0   0    0   0 0.00229    0    0   0     1 168.000   50
## 236    0 33 168.6827    0   0    0   0 0.02670    0    0   0     1   0.083   50
## 237    0 33 168.8497    0   0    0   0 0.06480    0    0   0     1   0.250   50
## 238    0 33 169.0997    0   0    0   0 0.11000    0    0   0     1   0.500   50
## 239    0 33 169.5997    0   0    0   0 0.12500    0    0   0     1   1.000   50
## 240    0 33 170.5997    0   0    0   0 0.14300    0    0   0     1   2.000   50
## 241    0 33 172.5997    0   0    0   0 0.06950    0    0   0     1   4.000   50
## 242    0 33 180.5997    0   0    0   0 0.01640    0    0   0     1  12.000   50
## 243    0 33 192.5997    0   0    0   0 0.00447    0    0   0     1  24.000   50
## 244    0 33 216.5997    0   0    0   0 0.00313    0    0   0     1  48.000   50
## 245    0 33 264.5997    0   0    0   0 0.00299    0    0   0     1  96.000   50
## 246    0 33 336.5997    0   0    0   0 0.00201    0    0   0     1 168.000   50
## 247    0 34 168.0327    0   0    0   0 0.01730    0    0   0     1   0.083   50
## 248    0 34 168.1997    0   0    0   0 0.04370    0    0   0     1   0.250   50
## 249    0 34 168.4497    0   0    0   0 0.07930    0    0   0     1   0.500   50
## 250    0 34 168.9497    0   0    0   0 0.08940    0    0   0     1   1.000   50
## 251    0 34 169.9497    0   0    0   0 0.09610    0    0   0     1   2.000   50
## 252    0 34 171.9497    0   0    0   0 0.07590    0    0   0     1   4.000   50
## 253    0 34 179.9497    0   0    0   0 0.01350    0    0   0     1  12.000   50
## 254    0 34 191.9497    0   0    0   0 0.00340    0    0   0     1  24.000   50
## 255    0 34 215.9497    0   0    0   0 0.00208    0    0   0     1  48.000   50
## 256    0 34 263.9497    0   0    0   0 0.00112    0    0   0     1  96.000   50
## 257    0 35 168.4493    0   0    0   0 0.04720    0    0   0     1   0.083   50
## 258    0 35 168.6163    0   0    0   0 0.10600    0    0   0     1   0.250   50
## 259    0 35 168.8663    0   0    0   0 0.13700    0    0   0     1   0.500   50
## 260    0 35 169.3663    0   0    0   0 0.18200    0    0   0     1   1.000   50
## 261    0 35 170.3663    0   0    0   0 0.16700    0    0   0     1   2.000   50
## 262    0 35 172.3663    0   0    0   0 0.09100    0    0   0     1   4.000   50
## 263    0 35 180.3663    0   0    0   0 0.01220    0    0   0     1  12.000   50
## 264    0 35 192.3663    0   0    0   0 0.00554    0    0   0     1  24.000   50
## 265    0 35 216.3663    0   0    0   0 0.00404    0    0   0     1  48.000   50
## 266    0 35 264.3663    0   0    0   0 0.00415    0    0   0     1  96.000   50
## 267    0 35 336.3663    0   0    0   0 0.00204    0    0   0     1 168.000   50
## 268    0 36 168.7493    0   0    0   0 0.03750    0    0   0     1   0.083   50
## 269    0 36 168.9163    0   0    0   0 0.08430    0    0   0     1   0.250   50
## 270    0 36 169.1663    0   0    0   0 0.13000    0    0   0     1   0.500   50
## 271    0 36 169.6663    0   0    0   0 0.22300    0    0   0     1   1.000   50
## 272    0 36 170.6663    0   0    0   0 0.19500    0    0   0     1   2.000   50
## 273    0 36 172.6663    0   0    0   0 0.14900    0    0   0     1   4.000   50
## 274    0 36 180.6663    0   0    0   0 0.02950    0    0   0     1  12.000   50
## 275    0 36 192.6663    0   0    0   0 0.00783    0    0   0     1  24.000   50
## 276    0 36 216.6663    0   0    0   0 0.00447    0    0   0     1  48.000   50
## 277    0 36 264.6663    0   0    0   0 0.00439    0    0   0     1  96.000   50
## 278    0 36 336.6663    0   0    0   0 0.00191    0    0   0     1 168.000   50
## 279    0 37 168.0660    0   0    0   0 0.03800    0    0   0     1   0.083  100
## 280    0 37 168.2330    0   0    0   0 0.11800    0    0   0     1   0.250  100
## 281    0 37 168.4830    0   0    0   0 0.15600    0    0   0     1   0.500  100
## 282    0 37 168.9830    0   0    0   0 0.26800    0    0   0     1   1.000  100
## 283    0 37 169.9830    0   0    0   0 0.22600    0    0   0     1   2.000  100
## 284    0 37 171.9830    0   0    0   0 0.18700    0    0   0     1   4.000  100
## 285    0 37 179.9830    0   0    0   0 0.07220    0    0   0     1  12.000  100
## 286    0 37 191.9830    0   0    0   0 0.01980    0    0   0     1  24.000  100
## 287    0 37 215.9830    0   0    0   0 0.00557    0    0   0     1  48.000  100
## 288    0 37 263.9830    0   0    0   0 0.00625    0    0   0     1  96.000  100
## 289    0 37 335.9830    0   0    0   0 0.00489    0    0   0     1 168.000  100
## 290    0 38 167.3493    0   0    0   0 0.05450    0    0   0     1   0.083  100
## 291    0 38 167.5163    0   0    0   0 0.17100    0    0   0     1   0.250  100
## 292    0 38 167.7663    0   0    0   0 0.25400    0    0   0     1   0.500  100
## 293    0 38 168.2663    0   0    0   0 0.25600    0    0   0     1   1.000  100
## 294    0 38 169.2663    0   0    0   0 0.25300    0    0   0     1   2.000  100
## 295    0 38 171.2663    0   0    0   0 0.20200    0    0   0     1   4.000  100
## 296    0 38 179.2663    0   0    0   0 0.09480    0    0   0     1  12.000  100
## 297    0 38 191.2663    0   0    0   0 0.02510    0    0   0     1  24.000  100
## 298    0 38 215.2663    0   0    0   0 0.00726    0    0   0     1  48.000  100
## 299    0 38 263.2663    0   0    0   0 0.00550    0    0   0     1  96.000  100
## 300    0 38 335.2663    0   0    0   0 0.00584    0    0   0     1 168.000  100
## 301    0 39 168.0660    0   0    0   0 0.07300    0    0   0     1   0.083  100
## 302    0 39 168.2330    0   0    0   0 0.19400    0    0   0     1   0.250  100
## 303    0 39 168.4830    0   0    0   0 0.25700    0    0   0     1   0.500  100
## 304    0 39 168.9830    0   0    0   0 0.41900    0    0   0     1   1.000  100
## 305    0 39 169.9830    0   0    0   0 0.43900    0    0   0     1   2.000  100
## 306    0 39 171.9830    0   0    0   0 0.32000    0    0   0     1   4.000  100
## 307    0 39 179.9830    0   0    0   0 0.05640    0    0   0     1  12.000  100
## 308    0 39 191.9830    0   0    0   0 0.01690    0    0   0     1  24.000  100
## 309    0 39 215.9830    0   0    0   0 0.01180    0    0   0     1  48.000  100
## 310    0 39 263.9830    0   0    0   0 0.00834    0    0   0     1  96.000  100
## 311    0 39 335.9830    0   0    0   0 0.00685    0    0   0     1 168.000  100
## 312    0 40 168.3660    0   0    0   0 0.08670    0    0   0     1   0.083  100
## 313    0 40 168.5330    0   0    0   0 0.20300    0    0   0     1   0.250  100
## 314    0 40 168.7830    0   0    0   0 0.29300    0    0   0     1   0.500  100
## 315    0 40 169.2830    0   0    0   0 0.33400    0    0   0     1   1.000  100
## 316    0 40 170.2830    0   0    0   0 0.29100    0    0   0     1   2.000  100
## 317    0 40 172.2830    0   0    0   0 0.24300    0    0   0     1   4.000  100
## 318    0 40 180.2830    0   0    0   0 0.05680    0    0   0     1  12.000  100
## 319    0 40 192.2830    0   0    0   0 0.01150    0    0   0     1  24.000  100
## 320    0 40 216.2830    0   0    0   0 0.00503    0    0   0     1  48.000  100
## 321    0 40 264.2830    0   0    0   0 0.00278    0    0   0     1  96.000  100
## 322    0 40 336.2830    0   0    0   0 0.00216    0    0   0     1 168.000  100
## 323    0 41 168.3993    0   0    0   0 0.06290    0    0   0     1   0.083  100
## 324    0 41 168.5663    0   0    0   0 0.14200    0    0   0     1   0.250  100
## 325    0 41 168.8163    0   0    0   0 0.21500    0    0   0     1   0.500  100
## 326    0 41 169.3163    0   0    0   0 0.31800    0    0   0     1   1.000  100
## 327    0 41 170.3163    0   0    0   0 0.25400    0    0   0     1   2.000  100
## 328    0 41 172.3163    0   0    0   0 0.16900    0    0   0     1   4.000  100
## 329    0 41 180.3163    0   0    0   0 0.02870    0    0   0     1  12.000  100
## 330    0 41 192.3163    0   0    0   0 0.00977    0    0   0     1  24.000  100
## 331    0 41 216.3163    0   0    0   0 0.00555    0    0   0     1  48.000  100
## 332    0 41 264.3163    0   0    0   0 0.00413    0    0   0     1  96.000  100
## 333    0 41 336.3163    0   0    0   0 0.00196    0    0   0     1 168.000  100
## 334    0 42 169.0660    0   0    0   0 0.08270    0    0   0     1   0.083  100
## 335    0 42 169.2330    0   0    0   0 0.20200    0    0   0     1   0.250  100
## 336    0 42 169.4830    0   0    0   0 0.28400    0    0   0     1   0.500  100
## 337    0 42 169.9830    0   0    0   0 0.31000    0    0   0     1   1.000  100
## 338    0 42 170.9830    0   0    0   0 0.25600    0    0   0     1   2.000  100
## 339    0 42 172.9830    0   0    0   0 0.18200    0    0   0     1   4.000  100
## 340    0 42 180.9830    0   0    0   0 0.02720    0    0   0     1  12.000  100
## 341    0 42 192.9830    0   0    0   0 0.01400    0    0   0     1  24.000  100
## 342    0 42 216.9830    0   0    0   0 0.01130    0    0   0     1  48.000  100
## 343    0 42 264.9830    0   0    0   0 0.00537    0    0   0     1  96.000  100
## 344    0 42 336.9830    0   0    0   0 0.00258    0    0   0     1 168.000  100
## 345    0 43 168.8493    0   0    0   0 0.16600    0    0   0     1   0.083  200
## 346    0 43 169.0163    0   0    0   0 0.37400    0    0   0     1   0.250  200
## 347    0 43 169.2663    0   0    0   0 0.50400    0    0   0     1   0.500  200
## 348    0 43 169.7663    0   0    0   0 0.86200    0    0   0     1   1.000  200
## 349    0 43 170.7663    0   0    0   0 0.78800    0    0   0     1   2.000  200
## 350    0 43 172.7663    0   0    0   0 0.49000    0    0   0     1   4.000  200
## 351    0 43 180.7663    0   0    0   0 0.14300    0    0   0     1  12.000  200
## 352    0 43 192.7663    0   0    0   0 0.02110    0    0   0     1  24.000  200
## 353    0 43 216.7663    0   0    0   0 0.00575    0    0   0     1  48.000  200
## 354    0 43 264.7663    0   0    0   0 0.00667    0    0   0     1  96.000  200
## 355    0 43 336.7663    0   0    0   0 0.00593    0    0   0     1 168.000  200
## 356    0 44 168.4493    0   0    0   0 0.08550    0    0   0     1   0.083  200
## 357    0 44 168.6163    0   0    0   0 0.18200    0    0   0     1   0.250  200
## 358    0 44 168.8663    0   0    0   0 0.32300    0    0   0     1   0.500  200
## 359    0 44 169.3663    0   0    0   0 0.43400    0    0   0     1   1.000  200
## 360    0 44 170.3663    0   0    0   0 0.41700    0    0   0     1   2.000  200
## 361    0 44 172.3663    0   0    0   0 0.23200    0    0   0     1   4.000  200
## 362    0 44 180.3663    0   0    0   0 0.03960    0    0   0     1  12.000  200
## 363    0 44 192.3663    0   0    0   0 0.00877    0    0   0     1  24.000  200
## 364    0 44 216.3663    0   0    0   0 0.00778    0    0   0     1  48.000  200
## 365    0 44 264.3663    0   0    0   0 0.00419    0    0   0     1  96.000  200
## 366    0 44 336.3663    0   0    0   0 0.00410    0    0   0     1 168.000  200
## 367    0 45 168.6327    0   0    0   0 0.17500    0    0   0     1   0.083  200
## 368    0 45 168.7997    0   0    0   0 0.37600    0    0   0     1   0.250  200
## 369    0 45 169.0497    0   0    0   0 0.59300    0    0   0     1   0.500  200
## 370    0 45 169.5497    0   0    0   0 0.63500    0    0   0     1   1.000  200
## 371    0 45 170.5497    0   0    0   0 0.51700    0    0   0     1   2.000  200
## 372    0 45 172.5497    0   0    0   0 0.42900    0    0   0     1   4.000  200
## 373    0 45 180.5497    0   0    0   0 0.09240    0    0   0     1  12.000  200
## 374    0 45 192.5497    0   0    0   0 0.01930    0    0   0     1  24.000  200
## 375    0 45 216.5497    0   0    0   0 0.01220    0    0   0     1  48.000  200
## 376    0 45 264.5497    0   0    0   0 0.00661    0    0   0     1  96.000  200
## 377    0 45 336.5497    0   0    0   0 0.00625    0    0   0     1 168.000  200
## 378    0 46 168.0660    0   0    0   0 0.08050    0    0   0     1   0.083  200
## 379    0 46 168.2330    0   0    0   0 0.19300    0    0   0     1   0.250  200
## 380    0 46 168.4830    0   0    0   0 0.32400    0    0   0     1   0.500  200
## 381    0 46 168.9830    0   0    0   0 0.54500    0    0   0     1   1.000  200
## 382    0 46 169.9830    0   0    0   0 0.48700    0    0   0     1   2.000  200
## 383    0 46 171.9830    0   0    0   0 0.32100    0    0   0     1   4.000  200
## 384    0 46 179.9830    0   0    0   0 0.05940    0    0   0     1  12.000  200
## 385    0 46 191.9830    0   0    0   0 0.01070    0    0   0     1  24.000  200
## 386    0 46 215.9830    0   0    0   0 0.00319    0    0   0     1  48.000  200
## 387    0 46 263.9830    0   0    0   0 0.00324    0    0   0     1  96.000  200
## 388    0 46 335.9830    0   0    0   0 0.00277    0    0   0     1 168.000  200
## 389    0 47 168.2993    0   0    0   0 0.11000    0    0   0     1   0.083  200
## 390    0 47 168.4663    0   0    0   0 0.26500    0    0   0     1   0.250  200
## 391    0 47 168.7163    0   0    0   0 0.42700    0    0   0     1   0.500  200
## 392    0 47 169.2163    0   0    0   0 0.55200    0    0   0     1   1.000  200
## 393    0 47 170.2163    0   0    0   0 0.43200    0    0   0     1   2.000  200
## 394    0 47 172.2163    0   0    0   0 0.35400    0    0   0     1   4.000  200
## 395    0 47 180.2163    0   0    0   0 0.09750    0    0   0     1  12.000  200
## 396    0 47 192.2163    0   0    0   0 0.02520    0    0   0     1  24.000  200
## 397    0 47 216.2163    0   0    0   0 0.01240    0    0   0     1  48.000  200
## 398    0 47 264.2163    0   0    0   0 0.01140    0    0   0     1  96.000  200
## 399    0 47 336.2163    0   0    0   0 0.00855    0    0   0     1 168.000  200
## 400    0 48 167.7660    0   0    0   0 0.18300    0    0   0     1   0.083  200
## 401    0 48 167.9330    0   0    0   0 0.50000    0    0   0     1   0.250  200
## 402    0 48 168.1830    0   0    0   0 0.70600    0    0   0     1   0.500  200
## 403    0 48 168.6830    0   0    0   0 0.98400    0    0   0     1   1.000  200
## 404    0 48 169.6830    0   0    0   0 0.83000    0    0   0     1   2.000  200
## 405    0 48 171.6830    0   0    0   0 0.59300    0    0   0     1   4.000  200
## 406    0 48 179.6830    0   0    0   0 0.19600    0    0   0     1  12.000  200
## 407    0 48 191.6830    0   0    0   0 0.05670    0    0   0     1  24.000  200
## 408    0 48 215.6830    0   0    0   0 0.01880    0    0   0     1  48.000  200
## 409    0 48 263.6830    0   0    0   0 0.01930    0    0   0     1  96.000  200
## 410    0 48 335.6830    0   0    0   0 0.01510    0    0   0     1 168.000  200
##     WT0 AGE0 HT0 SEX BLOQ           TRTNAMElabel
## 1    80   28 180   1   no   1mg oral single dose
## 2    80   28 180   1   no   1mg oral single dose
## 3    80   28 180   1   no   1mg oral single dose
## 4    80   28 180   1   no   1mg oral single dose
## 5    80   28 180   1   no   1mg oral single dose
## 6    68   25 166   1   no   1mg oral single dose
## 7    68   25 166   1   no   1mg oral single dose
## 8    68   25 166   1   no   1mg oral single dose
## 9    68   25 166   1   no   1mg oral single dose
## 10   68   25 166   1   no   1mg oral single dose
## 11   68   25 166   1   no   1mg oral single dose
## 12   86   29 183   1   no   1mg oral single dose
## 13   86   29 183   1   no   1mg oral single dose
## 14   86   29 183   1   no   1mg oral single dose
## 15   86   29 183   1   no   1mg oral single dose
## 16   86   29 183   1   no   1mg oral single dose
## 17   86   29 183   1   no   1mg oral single dose
## 18   70   35 181   1   no   1mg oral single dose
## 19   70   35 181   1   no   1mg oral single dose
## 20   70   35 181   1   no   1mg oral single dose
## 21   70   35 181   1   no   1mg oral single dose
## 22   70   35 181   1   no   1mg oral single dose
## 23   88   28 181   1   no   2mg oral single dose
## 24   88   28 181   1   no   2mg oral single dose
## 25   88   28 181   1   no   2mg oral single dose
## 26   88   28 181   1   no   2mg oral single dose
## 27   88   28 181   1   no   2mg oral single dose
## 28   88   28 181   1   no   2mg oral single dose
## 29   88   28 181   1   no   2mg oral single dose
## 30   79   29 175   1   no   2mg oral single dose
## 31   79   29 175   1   no   2mg oral single dose
## 32   79   29 175   1   no   2mg oral single dose
## 33   79   29 175   1   no   2mg oral single dose
## 34   79   29 175   1   no   2mg oral single dose
## 35   79   29 175   1   no   2mg oral single dose
## 36   79   29 175   1   no   2mg oral single dose
## 37   87   32 174   1   no   2mg oral single dose
## 38   87   32 174   1   no   2mg oral single dose
## 39   87   32 174   1   no   2mg oral single dose
## 40   87   32 174   1   no   2mg oral single dose
## 41   87   32 174   1   no   2mg oral single dose
## 42   87   32 174   1   no   2mg oral single dose
## 43   79   30 177  NA   no   2mg oral single dose
## 44   79   30 177  NA   no   2mg oral single dose
## 45   79   30 177  NA   no   2mg oral single dose
## 46   79   30 177  NA   no   2mg oral single dose
## 47   79   30 177  NA   no   2mg oral single dose
## 48   79   30 177  NA   no   2mg oral single dose
## 49   68   28 178   1   no   2mg oral single dose
## 50   68   28 178   1   no   2mg oral single dose
## 51   68   28 178   1   no   2mg oral single dose
## 52   68   28 178   1   no   2mg oral single dose
## 53   68   28 178   1   no   2mg oral single dose
## 54   66   36  NA   1   no   5mg oral single dose
## 55   66   36  NA   1   no   5mg oral single dose
## 56   66   36  NA   1   no   5mg oral single dose
## 57   66   36  NA   1   no   5mg oral single dose
## 58   66   36  NA   1   no   5mg oral single dose
## 59   66   36  NA   1   no   5mg oral single dose
## 60   66   36  NA   1   no   5mg oral single dose
## 61   71   34 176   1   no   5mg oral single dose
## 62   71   34 176   1   no   5mg oral single dose
## 63   71   34 176   1   no   5mg oral single dose
## 64   71   34 176   1   no   5mg oral single dose
## 65   71   34 176   1   no   5mg oral single dose
## 66   71   34 176   1   no   5mg oral single dose
## 67   65   29 171   1   no   5mg oral single dose
## 68   65   29 171   1   no   5mg oral single dose
## 69   65   29 171   1   no   5mg oral single dose
## 70   65   29 171   1   no   5mg oral single dose
## 71   65   29 171   1   no   5mg oral single dose
## 72   65   29 171   1   no   5mg oral single dose
## 73   65   29 171   1   no   5mg oral single dose
## 74   74   24 174   1   no   5mg oral single dose
## 75   74   24 174   1   no   5mg oral single dose
## 76   74   24 174   1   no   5mg oral single dose
## 77   74   24 174   1   no   5mg oral single dose
## 78   74   24 174   1   no   5mg oral single dose
## 79   74   24 174   1   no   5mg oral single dose
## 80   74   24 174   1   no   5mg oral single dose
## 81   74   24 174   1   no   5mg oral single dose
## 82   90   25 176   1   no   5mg oral single dose
## 83   90   25 176   1   no   5mg oral single dose
## 84   90   25 176   1   no   5mg oral single dose
## 85   90   25 176   1   no   5mg oral single dose
## 86   90   25 176   1   no   5mg oral single dose
## 87   90   25 176   1   no   5mg oral single dose
## 88   90   25 176   1   no   5mg oral single dose
## 89   81   23 186   1   no   5mg oral single dose
## 90   81   23 186   1   no   5mg oral single dose
## 91   81   23 186   1   no   5mg oral single dose
## 92   81   23 186   1   no   5mg oral single dose
## 93   81   23 186   1   no   5mg oral single dose
## 94   81   23 186   1   no   5mg oral single dose
## 95   81   23 186   1   no   5mg oral single dose
## 96   81   23 186   1   no   5mg oral single dose
## 97   81   23 186   1   no   5mg oral single dose
## 98   81   23 186   1   no   5mg oral single dose
## 99   81   23 186   1   no   5mg oral single dose
## 100  83   27 178   1   no  10mg oral single dose
## 101  83   27 178   1   no  10mg oral single dose
## 102  83   27 178   1   no  10mg oral single dose
## 103  83   27 178   1   no  10mg oral single dose
## 104  83   27 178   1   no  10mg oral single dose
## 105  83   27 178   1   no  10mg oral single dose
## 106  83   27 178   1   no  10mg oral single dose
## 107  83   27 178   1   no  10mg oral single dose
## 108  77   29 175   1   no  10mg oral single dose
## 109  77   29 175   1   no  10mg oral single dose
## 110  77   29 175   1   no  10mg oral single dose
## 111  77   29 175   1   no  10mg oral single dose
## 112  77   29 175   1   no  10mg oral single dose
## 113  77   29 175   1   no  10mg oral single dose
## 114  77   29 175   1   no  10mg oral single dose
## 115  77   29 175   1   no  10mg oral single dose
## 116  77   29 175   1   no  10mg oral single dose
## 117  77   29 175   1   no  10mg oral single dose
## 118  78   34 181   1   no  10mg oral single dose
## 119  78   34 181   1   no  10mg oral single dose
## 120  78   34 181   1   no  10mg oral single dose
## 121  78   34 181   1   no  10mg oral single dose
## 122  78   34 181   1   no  10mg oral single dose
## 123  78   34 181   1   no  10mg oral single dose
## 124  78   34 181   1   no  10mg oral single dose
## 125  78   34 181   1   no  10mg oral single dose
## 126  78   34 181   1   no  10mg oral single dose
## 127  88   26 183   1   no  10mg oral single dose
## 128  88   26 183   1   no  10mg oral single dose
## 129  88   26 183   1   no  10mg oral single dose
## 130  88   26 183   1   no  10mg oral single dose
## 131  88   26 183   1   no  10mg oral single dose
## 132  88   26 183   1   no  10mg oral single dose
## 133  88   26 183   1   no  10mg oral single dose
## 134  88   26 183   1   no  10mg oral single dose
## 135  85   24 176   1   no  10mg oral single dose
## 136  85   24 176   1   no  10mg oral single dose
## 137  85   24 176   1   no  10mg oral single dose
## 138  85   24 176   1   no  10mg oral single dose
## 139  85   24 176   1   no  10mg oral single dose
## 140  85   24 176   1   no  10mg oral single dose
## 141  85   24 176   1   no  10mg oral single dose
## 142  85   24 176   1   no  10mg oral single dose
## 143  75   18 183   1   no  10mg oral single dose
## 144  75   18 183   1   no  10mg oral single dose
## 145  75   18 183   1   no  10mg oral single dose
## 146  75   18 183   1   no  10mg oral single dose
## 147  75   18 183   1   no  10mg oral single dose
## 148  75   18 183   1   no  10mg oral single dose
## 149  75   18 183   1   no  10mg oral single dose
## 150  75   18 183   1   no  10mg oral single dose
## 151  75   18 183   1   no  10mg oral single dose
## 152  75   18 183   1   no  10mg oral single dose
## 153  75   18 183   1   no  10mg oral single dose
## 154  78   32 186   1   no  20mg oral single dose
## 155  78   32 186   1   no  20mg oral single dose
## 156  78   32 186   1   no  20mg oral single dose
## 157  78   32 186   1   no  20mg oral single dose
## 158  78   32 186   1   no  20mg oral single dose
## 159  78   32 186   1   no  20mg oral single dose
## 160  78   32 186   1   no  20mg oral single dose
## 161  78   32 186   1   no  20mg oral single dose
## 162  78   32 186   1   no  20mg oral single dose
## 163  78   32 186   1   no  20mg oral single dose
## 164  87   23 179   1   no  20mg oral single dose
## 165  87   23 179   1   no  20mg oral single dose
## 166  87   23 179   1   no  20mg oral single dose
## 167  87   23 179   1   no  20mg oral single dose
## 168  87   23 179   1   no  20mg oral single dose
## 169  87   23 179   1   no  20mg oral single dose
## 170  87   23 179   1   no  20mg oral single dose
## 171  87   23 179   1   no  20mg oral single dose
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## 215  74   23 176   1   no  50mg oral single dose
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## 247  84   27 181   1   no  50mg oral single dose
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## 277  75   34 182   1   no  50mg oral single dose
## 278  75   34 182   1   no  50mg oral single dose
## 279  78   22 178   1   no 100mg oral single dose
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## 290  80   21 184   1   no 100mg oral single dose
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## 292  80   21 184   1   no 100mg oral single dose
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## 295  80   21 184   1   no 100mg oral single dose
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## 297  80   21 184   1   no 100mg oral single dose
## 298  80   21 184   1   no 100mg oral single dose
## 299  80   21 184   1   no 100mg oral single dose
## 300  80   21 184   1   no 100mg oral single dose
## 301  85   32 179   1   no 100mg oral single dose
## 302  85   32 179   1   no 100mg oral single dose
## 303  85   32 179   1   no 100mg oral single dose
## 304  85   32 179   1   no 100mg oral single dose
## 305  85   32 179   1   no 100mg oral single dose
## 306  85   32 179   1   no 100mg oral single dose
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## 308  85   32 179   1   no 100mg oral single dose
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## 311  85   32 179   1   no 100mg oral single dose
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## 315  92   33 179   1   no 100mg oral single dose
## 316  92   33 179   1   no 100mg oral single dose
## 317  92   33 179   1   no 100mg oral single dose
## 318  92   33 179   1   no 100mg oral single dose
## 319  92   33 179   1   no 100mg oral single dose
## 320  92   33 179   1   no 100mg oral single dose
## 321  92   33 179   1   no 100mg oral single dose
## 322  92   33 179   1   no 100mg oral single dose
## 323  88   34 178   1   no 100mg oral single dose
## 324  88   34 178   1   no 100mg oral single dose
## 325  88   34 178   1   no 100mg oral single dose
## 326  88   34 178   1   no 100mg oral single dose
## 327  88   34 178   1   no 100mg oral single dose
## 328  88   34 178   1   no 100mg oral single dose
## 329  88   34 178   1   no 100mg oral single dose
## 330  88   34 178   1   no 100mg oral single dose
## 331  88   34 178   1   no 100mg oral single dose
## 332  88   34 178   1   no 100mg oral single dose
## 333  88   34 178   1   no 100mg oral single dose
## 334  90   31 188   1   no 100mg oral single dose
## 335  90   31 188   1   no 100mg oral single dose
## 336  90   31 188   1   no 100mg oral single dose
## 337  90   31 188   1   no 100mg oral single dose
## 338  90   31 188   1   no 100mg oral single dose
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## 340  90   31 188   1   no 100mg oral single dose
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## 344  90   31 188   1   no 100mg oral single dose
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## 368  67   31 172   1   no 200mg oral single dose
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## 377  67   31 172   1   no 200mg oral single dose
## 378  77   32 178   1   no 200mg oral single dose
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## 380  77   32 178   1   no 200mg oral single dose
## 381  77   32 178   1   no 200mg oral single dose
## 382  77   32 178   1   no 200mg oral single dose
## 383  77   32 178   1   no 200mg oral single dose
## 384  77   32 178   1   no 200mg oral single dose
## 385  77   32 178   1   no 200mg oral single dose
## 386  77   32 178   1   no 200mg oral single dose
## 387  77   32 178   1   no 200mg oral single dose
## 388  77   32 178   1   no 200mg oral single dose
## 389  91   38 174   1   no 200mg oral single dose
## 390  91   38 174   1   no 200mg oral single dose
## 391  91   38 174   1   no 200mg oral single dose
## 392  91   38 174   1   no 200mg oral single dose
## 393  91   38 174   1   no 200mg oral single dose
## 394  91   38 174   1   no 200mg oral single dose
## 395  91   38 174   1   no 200mg oral single dose
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## 402  77   22 176   1   no 200mg oral single dose
## 403  77   22 176   1   no 200mg oral single dose
## 404  77   22 176   1   no 200mg oral single dose
## 405  77   22 176   1   no 200mg oral single dose
## 406  77   22 176   1   no 200mg oral single dose
## 407  77   22 176   1   no 200mg oral single dose
## 408  77   22 176   1   no 200mg oral single dose
## 409  77   22 176   1   no 200mg oral single dose
## 410  77   22 176   1   no 200mg oral single dose
# Generation of a pdf file containing detailed plots for each individual
plotIndiv_IQRdataGENERAL(data1, filename = "material/01-01-DataProgAnal/IndivPlots01.pdf")

From the overview plot we can see that one subject who received 5mg of IQ0815 has a implausible PK profile. Also, we can spot some outlying records. The detailed individual plots in the pdf file help to exactly identify the subject with implausible observations and the outlying records: The plots display the unique subject identifiers, all observations and dosing records as well as the treatment group name. The observation records are labelled with the unique record identifier IXGDF.

8.1.4 Cleaning to create an analysis dataset

Based on the data exploration, we want to clean the dataset before finally producing the modeling dataset.

Specification of records to be removed

Named lists are created containing either unique subject identifiers (USUBJID) for removing all data from specific subjects or unique record identifiers (IXGDF) for removing particular records. The list names can is to annotate the reason for removal.

removeSubjects <- list("No PK data" = c("IQ00701-0100-0002","IQ00701-0100-0008"),
                       "Nonsense profile" = c("IQ00701-0100-0018"))
removeRecords  <- list("Implausible value" = c(59, 98, 301))

Specification of covariate imputation

To impute covariates, we use names vectors for continuous and categorical covaraites respectively. The values given will be imputed for all missing covariates. For the continuous covariates, it is also possible to provide suitable function names like "mean" or "median" to calculat the imputation value based on the available values.

imputeContinuous = c("HT0" = "median", "WT0" = 70)
imputeCategory   = c("SEX"=1)

Perform documented dataset cleaning

For generating a cleaned analysis dataset, the function clean_IQRdataGENERAL() is used. It not only accepts the information on data removal or covariate imputation, but has more functionality and options. In this example, the method to handle BLLOQ data is chosen (methodBLLOQ = "M3"), ignored records are decided to be kept in the dataset (FLAGrmIGNOREDrecords = FALSE), but the placebo subjects are removed (FLAGrmPlacebo = TRUE). Very importantly, information on the cleaning process is written to the folder specified as pathname input argument.

data1CleanM3 <- clean_IQRdataGENERAL(data1,
                                  pathname = "material/01-01-DataProgAnal/DataCleaning01",
                                  methodBLLOQ = "M3",
                                  subjects = removeSubjects,
                                  records = removeRecords,
                                  FLAGrmIGNOREDrecords = FALSE,
                                  FLAGrmPlacebo = TRUE,
                                  continuousCovs = imputeContinuous, categoricalCovs = imputeCategory)

8.1.5 Export

To make the dataset available for parameter estimation with NONMEM or MONOLIX, it is exported with the function exportNLME_IQRdataGENERAL(). In this step, some adjustments to the data are done, e.g., removing spaces in character strings, such that the data set is accepted by the softwares.

# Export the NLME data set with BLQ method M3
exportNLME_IQRdataGENERAL(data1CleanM3,
                          filename = "material/01-01-DataProgAnal/dataNLME01/data.csv",
                          FLAGxpt = TRUE,
                          FLAGdefine = TRUE)

This function also has some options what export is performed. In any case, there will be a csv-file generated. However, we can use the option FLAGxpt = TRUE to additionally write an xpt-file and the option FLAGdefine = TRUE to produce a define file with data set specifications for the analysis dataset. Click here to download the example define file.

8.2 Workflow customization

8.2.1 Dataset handling

For showing more examples to import a dataset as IQRdataGENERAL object, we load another dataset from file.

dataSource2 <- IQRloadCSVdata("material/01-01-DataProgAnal/dataSource02.csv")

Multiple dose or observation types

This data contains dosings of two different drugs and two observations types. Note that the IQRdataGENERAL() function accepts the path to the source data (see example workflow above) but also the loaded data frame as input.

# Dose records
doseNAMES <- c("Dose Z","Dose X")
# Observation records
obsNAMES <- c("Plasma concentration Z","Efficacy marker")
# Import as IQRdataGENERAL
data2 <- IQRdataGENERAL(dataSource2, doseNAMES = doseNAMES, obsNAMES = obsNAMES)
## Adding default IXGDF column
## Adding default IND column
## Adding default STUDYN column
## Adding default TRT column
## Adding default TRTR column
## Adding default ID column
## Adding default TIMEPOS column
## Adding default EVID column
## Adding default MDV column
## Adding default CENS column
## Adding default AMT column
## Adding default DV column
## Adding default TINF column
## Adding default RATE column
## Adding default ADM column
## Adding default TAD column
## Adding default DOSE column
## Adding default YTYPE column
## Sorting by STUDY, USUBJID, TIME, TYPENAME, NAME
Table 8.3: Example dataset 2 (selected columns and first 12 rows)
USUBJID TRTNAME NAME TIME VALUE AMT EVID YTYPE ADM
1 ZY1000101066 SD IV 15 mg/kg Efficacy marker -7.1118056 21.152 0 0 2 0
3 ZY1000101066 SD IV 15 mg/kg Dose X 0.0000000 918.000 918 1 0 2
4 ZY1000101066 SD IV 15 mg/kg Plasma concentration Z 0.0826389 998.001 0 0 1 0
6 ZY1000101066 SD IV 15 mg/kg Plasma concentration Z 16.2076389 159.399 0 0 1 0
7 ZY1000101066 SD IV 15 mg/kg Plasma concentration Z 29.2006944 119.400 0 0 1 0
8 ZY1000101066 SD IV 15 mg/kg Plasma concentration Z 42.1701389 42.201 0 0 1 0
9 ZY1000101066 SD IV 15 mg/kg Efficacy marker 112.2256944 22.223 0 0 2 0
10 ZY1000101067 SD IV 15 mg/kg Efficacy marker -13.8138889 23.043 0 0 2 0
12 ZY1000101067 SD IV 15 mg/kg Dose X 0.0000000 1311.000 1311 1 0 2
13 ZY1000101067 SD IV 15 mg/kg Plasma concentration Z 0.0972222 1362.000 0 0 1 0
15 ZY1000101067 SD IV 15 mg/kg Plasma concentration Z 15.0736111 176.199 0 0 1 0
16 ZY1000101067 SD IV 15 mg/kg Plasma concentration Z 29.2506944 100.599 0 0 1 0

Time-varying covariates

Time-varying covariates are defined analogue to time-independent covariates. The PD observations are here used once as baseline covariate as well as time-dependent covariate. In the first case, all records are used in the covariate column according to the time of the observation records they are mapped onto. In case it is used as time independent covariate, the baseline value per individual (defined by columns BASE, SCREEN, or pre-first dose records, for details see ?IQRdataGENERAL) will be mapped to the observations.

# Define the CONTINUOUS covariate columns (time INDEPENDENT)
cov0 <- list(
  PDbase  = "Efficacy marker"
)
# Define the CONTINUOUS covariate columns (time DEPENDENT)
covT <- list(
  PDcont  = "Efficacy marker"
)
# Define the CATEGORICAL covariate columns (time INDEPENDENT)
cat0 <- list(
  SEX  = "Gender"
)
# Define the CATEGORICAL covariate columns (time DEPENDENT)
catT <- list(
  HSTAT   = "Health status"
)
# Import to IQRdataGENERAL object
data2 <- IQRdataGENERAL(dataSource2, doseNAMES = doseNAMES, obsNAMES = "Plasma concentration Z",
                        cov0 = cov0, cat0 = cat0,
                        covT = covT, catT = catT)
## Adding default IXGDF column
## Adding default IND column
## Adding default STUDYN column
## Adding default TRT column
## Adding default TRTR column
## Adding default ID column
## Adding default TIMEPOS column
## Adding default EVID column
## Adding default MDV column
## Adding default CENS column
## Adding default AMT column
## Adding default DV column
## Adding default TINF column
## Adding default RATE column
## Adding default ADM column
## Adding default TAD column
## Adding default DOSE column
## Adding default YTYPE column
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of PDbase for
## ZY100404123 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of PDbase for
## ZY100404124 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of PDbase for
## ZY100404125 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of PDbase for
## ZY100404126 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of PDbase for
## ZY100404127 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of PDbase for
## ZY100404128 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of PDbase for
## ZY100404129 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of PDbase for
## ZY100404130 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for
## ZY1000101066 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for
## ZY1000101067 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for
## ZY1000101068 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for
## ZY1000101069 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for
## ZY1000101075 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for
## ZY1000101076 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for
## ZY1000101077 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for
## ZY1000101078 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for
## ZY1000202079 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for
## ZY1000303070 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for
## ZY1000303071 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for
## ZY1000303072 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for
## ZY1000303073 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for
## ZY1000303074 defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for ZY100101113
## defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for ZY100101114
## defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for ZY100101120
## defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for ZY100101121
## defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for ZY100101122
## defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for ZY100404123
## defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for ZY100404124
## defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for ZY100404125
## defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for ZY100404126
## defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for ZY100404127
## defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for ZY100404128
## defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for ZY100404129
## defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for ZY100404130
## defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for ZY300505001
## defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for ZY300505002
## defined.
## Warning: No baseline value (BASE=1, SCREEN=1, or TIME<=0) of SEX for ZY800505071
## defined.
## Sorting by STUDY, USUBJID, TIME, TYPENAME, NAME
Table 8.4: Example dataset 2 with various covariate columns (selected columns and first 12 rows)
USUBJID TRTNAME NAME TIME VALUE AMT EVID YTYPE ADM PDbase PDcont SEX HSTAT
3 ZY1000101066 SD IV 15 mg/kg Dose X 0.0000000 918.000 918 1 0 2 21.152 21.152 NA 3
4 ZY1000101066 SD IV 15 mg/kg Plasma concentration Z 0.0826389 998.001 0 0 1 0 21.152 21.152 NA 3
6 ZY1000101066 SD IV 15 mg/kg Plasma concentration Z 16.2076389 159.399 0 0 1 0 21.152 21.152 NA 3
7 ZY1000101066 SD IV 15 mg/kg Plasma concentration Z 29.2006944 119.400 0 0 1 0 21.152 21.152 NA 3
8 ZY1000101066 SD IV 15 mg/kg Plasma concentration Z 42.1701389 42.201 0 0 1 0 21.152 21.152 NA 3
12 ZY1000101067 SD IV 15 mg/kg Dose X 0.0000000 1311.000 1311 1 0 2 23.043 23.043 NA 2
13 ZY1000101067 SD IV 15 mg/kg Plasma concentration Z 0.0972222 1362.000 0 0 1 0 23.043 23.043 NA 2
15 ZY1000101067 SD IV 15 mg/kg Plasma concentration Z 15.0736111 176.199 0 0 1 0 23.043 23.043 NA 3
16 ZY1000101067 SD IV 15 mg/kg Plasma concentration Z 29.2506944 100.599 0 0 1 0 23.043 23.043 NA 3
17 ZY1000101067 SD IV 15 mg/kg Plasma concentration Z 42.1562500 57.201 0 0 1 0 23.043 23.043 NA 3
21 ZY1000101068 SD IV 15 mg/kg Dose X 0.0000000 0.000 0 1 0 2 23.364 23.364 NA 4
26 ZY1000101069 SD IV 15 mg/kg Plasma concentration Z -0.0013889 0.933 0 0 1 0 16.993 16.993 NA 1

Existing covariate columns

Datasets may also contain (numerical) covariate columns instead of row-records for covariates. In this case the user needs to provide the metadata (verbose name, units, mapping of category names and values, ...) such that it is added to the covariate information in the attributes.

# Additional CONTINUOUS covariates
covInfoAdd <- list(
  COLNAME      = c("AST0",         "BMI0"),
  NAME         = c("Aspartate transaminase","Body mass index"),
  UNIT         = c("UI/mL",      "kg/m2"),
  TIME.VARYING = c(FALSE,              FALSE)
)
# Additional CATEGORICAL covariates
catInfoAdd <- list(
  COLNAME      = c("FOOD"),
  NAME         = c("Food taken"),
  UNIT         = c("y/n"),
  VALUETXT     = c("No,Yes"),
  VALUES       = c("0,1"),
  TIME.VARYING = c(FALSE)
)
# Import to IQRdataGENERAL object
data2 <- IQRdataGENERAL(dataSource2, doseNAMES = doseNAMES, obsNAMES = obsNAMES,
                        covInfoAdd = covInfoAdd, catInfoAdd = catInfoAdd)
## Adding default IXGDF column
## Adding default IND column
## Adding default STUDYN column
## Adding default TRT column
## Adding default TRTR column
## Adding default ID column
## Adding default TIMEPOS column
## Adding default EVID column
## Adding default MDV column
## Adding default CENS column
## Adding default AMT column
## Adding default DV column
## Adding default TINF column
## Adding default RATE column
## Adding default ADM column
## Adding default TAD column
## Adding default DOSE column
## Adding default YTYPE column
## Sorting by STUDY, USUBJID, TIME, TYPENAME, NAME
# Extended continuous covariate information
covInfo(data2)
COLNAME NAME UNIT TIME.VARYING
AST0 Aspartate transaminase UI/mL FALSE
BMI0 Body mass index kg/m2 FALSE
# Extended categorical covariate information
catInfo(data2)
COLNAME NAME UNIT VALUETXT VALUES TIME.VARYING
FOOD Food taken y/n No,Yes 0,1 FALSE
STUDYN Study
Y10,Y1,Y3,Y8 2,1,3,4 FALSE
TRT TRTNAME
SD IV 15 mg/kg,SD IV Placebo,SD IV 1.5 mg/kg,MD IV Placebo,MD IV 5mg/kg,SD or MD IV Placebo,MD IV 15mg/kg 5,6,4,3,2,7,1 FALSE

Existing NLME columns

The input argument FLAGforceOverwriteNLMEcols defines if "NLME" columns that already might be in the dataset are overwritten (TRUE=default) or not (FALSE). These NLME columns are the following numeric - NLME tool specific columns: ID, TIMEPOS, TAD, DV, MDV, EVID, CENS, AMT, ADM, TINF, RATE, YTYPE, and DOSE. Overwritting is good in a sense that these columns will be well-defined and aligned with the dataspec of IQRtools. Not over-writing them can be useful if the user manually wants to ensure certain things. But in this case the user should now what to do.

If this flag is set to TRUE than all already existing NLME columns will be overwritten. Non-present ones will be (in both cases) generated based on the default spec.

# Overwriting the NLME columns
data2 <- IQRdataGENERAL(dataSource2, doseNAMES, obsNAMES,FLAGforceOverwriteNLMEcols=TRUE)
Table 8.5: Example dataset 2 with overwritten existing NLME columns (selected columns and first 12 rows)
USUBJID TIME EVID YTYPE VALUE ADM AMT
1 ZY1000101066 -7.11 0 2 21.15 0 0
3 ZY1000101066 0.00 1 0 918.00 2 918
4 ZY1000101066 0.08 0 1 998.00 0 0
6 ZY1000101066 16.21 0 1 159.40 0 0
7 ZY1000101066 29.20 0 1 119.40 0 0
8 ZY1000101066 42.17 0 1 42.20 0 0
# Keeping existing NLME columns
data2 <- IQRdataGENERAL(dataSource2, doseNAMES, obsNAMES,FLAGforceOverwriteNLMEcols=FALSE)
Table 8.6: Example dataset 2 with kept existing NLME columns (selected columns and first 12 rows)
USUBJID TIME EVID YTYPE VALUE ADM AMT
1 ZY1000101066 -7.11 0 2 21.15 0 0
3 ZY1000101066 0.00 1 0 918.00 2 918
4 ZY1000101066 0.08 0 1 998.00 0 0
6 ZY1000101066 16.21 0 1 159.40 0 0
7 ZY1000101066 29.20 0 1 119.40 0 0
8 ZY1000101066 42.17 0 1 42.20 0 0

8.2.2 Import/export options

Export IQRdataGENERAL objects

An IQRdataGENERAL object can be exported with three different functions, export_IQRdataGENERAL(), exportNLME_IQRdataGENERAL(), or exportSYS_IQRdataGENERAL. The first will export the dataset without further modifications, the other apply estimation tool specific modifications (e.g., removal of whitespaces in strings) to be applicable as modeling dataset later on. All export function generate a .csv file and a .atr file storing the metadata and can additionally generate define files and .xpt files.

With all export functions a zipped file instead of the single files (.csv, .atr, ...) can be generated by setting FLAGzip = TRUE.

export_IQRdataGENERAL(data=data2, filename="material/01-01-DataProgAnal/dataGeneral02", FLAGzip = TRUE)

The exportNLME_IQRdataGENERAL() and exportSYS_IQRdataGENERAL() provide the possibility to subset the data to specific dosing records and observation records (inputs doseNAMES and obsNAMES) and define columns as regressor variables while exporting the data. Regressor columns are ordered in the exported dataset as given in the input regressorNames which is crucial for matching regressor variables between data and model for some estimation tools.

exportNLME_IQRdataGENERAL(data=data2, filename="material/01-01-DataProgAnal/dataNLME02", regressorNames = c("AST0", "FOOD"))

Load IQRdataGENERAL object

The load_IQRdataGENERAL() function is used to reload a dataset that was generated by the export_IQRdataGENERAL(), exportNLME_IQRdataGENERAL(), or exportSYS_IQRdataGENERAL function. In order for the loading to work the dataex.atr file needs to be present in the same folder as the .csv file. xpt files are not loaded. Also zip files can be reloaded.

data1reload <- load_IQRdataGENERAL("material/01-01-DataProgAnal/dataNLME01/data.csv")
data2reload <- load_IQRdataGENERAL("material/01-01-DataProgAnal/dataGeneral02.dat.zip")

8.2.3 Cleaning options

The cleaning functions clean_IQRdataGENERAL() is actually a wrapper function for various functions performing different steps during cleaning. They could be called individually. Please refer to the help for each function for detailed information.

Function Description Control in clean_IQRdataGENERAL Logfile written
blloq _IQRdataGENERAL Set the BLLOQ handling method set by methodBLLOQ No
setIGNORErecords _IQRdataGENERAL Set user defined records to IGNORE optional by setting records Yes
rmMissingTIMEobsRecords _IQRdataGENERAL Remove missing observation records with missing TIME always applied Yes
setMissingDVobsRecordsIGNORE _IQRdataGENERAL Set missing observation records with missing DV to IGNORE always applied Yes
rmSubjects _IQRdataGENERAL Remove user defined subjects optional by setting subjects Yes
rmNonTask _IQRdataGENERAL Remove non-dose and non-observation records always applied Yes
rmPLACEBO _IQRdataGENERAL Remove placebo subjects optional by setting FLAGrmPlacebo Yes
rmNOobsSUB _IQRdataGENERAL Removal of subjects without observations always applied Yes
rmAMT0 _IQRdataGENERAL Removal of dose records with AMT=0 always applied Yes
rmIGNOREd _IQRdataGENERAL Removal of ignored record (MDV=1) optional by setting FLAGrmIGNOREDrecords Yes
covImpute _IQRdataGENERAL Imputation of missing covariates optional by setting continuousCovs and categoricalCovs Yes
rmDosePostLastObs _IQRdataGENERAL Removal of doses post last observation optional by setting FLAGrmDosePostLastObs Yes

8.2.4 Data exploration

In the Example workflow discussed above some of the IQRtools functions to explore a dataset have been used to visualize and detect issues in the data and get an overview on the contained PK observations. In the following all available data exploration functions are introduced using the the cleaned dataset from the workflow as an example.

Summary tables

Summary tables can be generated for observations (summaryObservations_IQRdataGENERAL()) and for categorical or continuous covariates (summaryCat_IQRdataGENERAL() and summaryCov_IQRdataGENERAL). The tables can be stratified by a suitable dataset column (stratifyColumn with "STUDY" as default). Beside the actual content a table title and table footer are defined which can be modified by the user (tableTitle and footerAddText). They can be further customized by setting the number of digits values are rounded to (SIGNIF) and whether individuals should be termed as "subjects" or "patients" (FLAGpatients). If a filename is provided, the table is written to that file, otherwise a IQRoutputTable object is returned.

With this flexibility the summary tables are intended to be readily suitable to use in modeling reports in the data exploration section. The exported tables are prepared to be automatically imported to a report using IQReport (see Reporting in Microsoft Word).

Observations

For the observation summary table, numbers of subjects and numbers of observations are listed and subsetted for different criteria (e.g., number of observations below the limit of quantification). The input obsNames is available if only a subset of the contained observations should be summarized. In this example, there is only one observation, i.e., the "Plasma concentration IQ0815". The first two rows give the numbers per study while the last row contains total counts in the entire dataset.

summaryObservations_IQRdataGENERAL(data1CleanM3)
##    Summary of available observations                                                                                                                                                                               
##    ================================================================================================================================================================================================================
## 
##    Data          | N subjects | N samples | N BLOQ samples* | N BLOQ samples post first dose* | N missing observations | N missing time information | N total ignored observations | N samples included in analysis
##    ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
##    FIH           | 32         | 384       | 117 (30.5%)     | 85 (22.1%)                      | 0 (0%)                 | 0 (0%)                     | 3 (0.781%)                   | 381 (99.2%)                   
##    FIH extension | 12         | 144       | 12 (8.33%)      | 0 (0%)                          | 0 (0%)                 | 0 (0%)                     | 0 (0%)                       | 144 (100%)                    
##    TOTAL         | 44         | 528       | 129 (24.4%)     | 85 (16.1%)                      | 0 (0%)                 | 0 (0%)                     | 3 (0.568%)                   | 525 (99.4%)                   
##    ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
## N: Number of
## * These records are not excluded from the analysis but censored (M3 method).
##                                                                                                                        
## 
## IQRoutputTable object

This summary table contains information about samples before and after first dosing regarding BLQ and zero/non-zero values which is mainly of interest for summarizing PK samples. These can be neglected setting FLAGpk = FALSE:

summaryObservations_IQRdataGENERAL(data1CleanM3, FLAGpk = FALSE)
##    Summary of available observations                                                                                                                                             
##    ==============================================================================================================================================================================
## 
##    Data          | N subjects | N samples | N BLOQ samples* | N missing observations | N missing time information | N total ignored observations | N samples included in analysis
##    ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
##    FIH           | 32         | 384       | 117 (30.5%)     | 0 (0%)                 | 0 (0%)                     | 3 (0.781%)                   | 381 (99.2%)                   
##    FIH extension | 12         | 144       | 12 (8.33%)      | 0 (0%)                 | 0 (0%)                     | 0 (0%)                       | 144 (100%)                    
##    TOTAL         | 44         | 528       | 129 (24.4%)     | 0 (0%)                 | 0 (0%)                     | 3 (0.568%)                   | 525 (99.4%)                   
##    ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
## N: Number of
## * These records are not excluded from the analysis but censored (M3 method).
##                                                                                      
## 
## IQRoutputTable object
Covariates

Continuous covariates are summarized by the mean, standard deviation and range from minimum to maximum value while the number of individuals in therespective and the percent of total is given for categorical covariates. Summaries are given stratified defined in the stratification (e.g., stratifyColumns = "TRTNAME"; default: "STUDY") and a total column can be required (FLAGtotal = TRUE).

summaryCov_IQRdataGENERAL(data1CleanM3, stratifyColumns = "TRTNAME")
##    Summary of demographic and baseline characteristics for continuous information                                                                                                                                                                                
##    ==============================================================================================================================================================================================================================================================
## 
##    Characteristic  | 1mg oral single dose [N=4] | 2mg oral single dose [N=5] | 5mg oral single dose [N=5] | 10mg oral single dose [N=6] | 20mg oral single dose [N=6] | 50mg oral single dose [N=6] | 100mg oral single dose [N=6] | 200mg oral single dose [N=6]
##    --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
##    Bodyweight (kg) | 76 (8.49) [68-86]          | 80.2 (8.04) [68-88]        | 73.2 (10.1) [65-90]        | 81 (5.1) [75-88]            | 77 (6.2) [68-87]            | 81.3 (7.79) [74-94]         | 85.5 (5.58) [78-92]          | 77.2 (7.91) [67-91]         
##    Age (Years)     | 29.2 (4.19) [25-35]        | 29.4 (1.67) [28-32]        | 29.6 (5.32) [24-36]        | 26.3 (5.32) [18-34]         | 28.8 (3.54) [23-32]         | 30.3 (4.8) [23-35]          | 28.8 (5.78) [21-34]          | 30.3 (5.24) [22-38]         
##    Height (cm)     | 178 (7.77) [166-183]       | 177 (2.74) [174-181]       | 175 (2.65) [171-178]       | 179 (3.5) [175-183]         | 180 (6.31) [168-186]        | 179 (3.22) [174-182]        | 181 (4.1) [178-188]          | 176 (3.78) [172-183]        
##    --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
## N: Number of subjects
## Entries represent: Mean (Standard deviation) [Minimum-Maximum]                                                                                                                                                                            
## 
## IQRoutputTable object
summaryCat_IQRdataGENERAL(data1CleanM3, FLAGtotal = TRUE, catNames = c("STUDYN", "TRT"))
##    Summary of demographic and baseline characteristics for categorical information           
##    ==========================================================================================
## 
##    Characteristic | Category               | FIH [N=32] | FIH extension [N=12] | TOTAL [N=44]
##    ------------------------------------------------------------------------------------------
##    Study          | FIH                    | 32 (100%)  | 0 (0%)               | 32 (72.7%)  
##                   | FIH extension          | 0 (0%)     | 12 (100%)            | 12 (27.3%)  
##    TRTNAME        | Placebo                | 0 (0%)     | 0 (0%)               | 0 (0%)      
##                   | 1mg oral single dose   | 4 (12.5%)  | 0 (0%)               | 4 (9.09%)   
##                   | 2mg oral single dose   | 5 (15.6%)  | 0 (0%)               | 5 (11.4%)   
##                   | 5mg oral single dose   | 5 (15.6%)  | 0 (0%)               | 5 (11.4%)   
##                   | 10mg oral single dose  | 6 (18.8%)  | 0 (0%)               | 6 (13.6%)   
##                   | 20mg oral single dose  | 6 (18.8%)  | 0 (0%)               | 6 (13.6%)   
##                   | 50mg oral single dose  | 6 (18.8%)  | 0 (0%)               | 6 (13.6%)   
##                   | 100mg oral single dose | 0 (0%)     | 6 (50%)              | 6 (13.6%)   
##                   | 200mg oral single dose | 0 (0%)     | 6 (50%)              | 6 (13.6%)   
##    ------------------------------------------------------------------------------------------
## N: Number of subjects
## Number of subjects in each category and percentage within this category
## 
## IQRoutputTable object

Standard graphs

Details on individuals

One example for an indidual detail plot was already shown in the data preparation workflow above. This function creates a pdf with one page per individual and/or a list of graphs (one list element per individual.) It displays the observations along with the dose administrations and gives information on subject ID and treatment groups. Each data point is labeled with the IXGDF number. The data can be inspected in detail to check correctness of the data and problematic data points spotted and identified easily.

Please refer to the help of this function to look up possible customization (e.g., log-scale, selection of observations to include).

plotIndiv_IQRdataGENERAL(data1CleanM3, filename = "material/01-01-DataProgAnal/IndivPlotsClean01.pdf")
Dosing

The dosing schedule per individual can be inspected using the plotDoseSchedule_IQRdataGENERAL() function. The individual panels are distributed over multiple pages/graphs accoding to the number of individuals to be plot on one page (NperPage, defaults to 25).

plotDoseSchedule_IQRdataGENERAL(data1CleanM3, filename = "material/01-01-DataProgAnal/Dosing01.pdf")
Observations

The sampling schedule per individual can be inspected using the plotSampleSchedule_IQRdataGENERAL() function. The individual panels are distributed over multiple pages/graphs accoding to the number of individuals to be plot on one page (here set by NperPage = 6).

plotSampleSchedule_IQRdataGENERAL(data1CleanM3, filename = "material/01-01-DataProgAnal/Sampling01.pdf", NperPage = 6)

The actual observations can be visualized with plotRange_IQRdataGENERAL() and plotSpaghetti_IQRdataGENERAL(). In both cases, the data will be stratified to panels per treatment group. The first function provides the median and 90% range from the 5th to the 95th percentile of the data per nomnal time point. The second function will plot the data points at the actual times connected by lines per subjects. Besides changing the scale (scale = "log" or "lin", not shown here), the plots can be subsetted by a stratification column and the non-stratified as well as stratified graphs are provided.

# Median and 90% interval per nominal time point
plotRange_IQRdataGENERAL(data1CleanM3)
## $unstratified
## $unstratified$`Plasma concentration IQ0815`

## 
## attr(,"split_type")
## [1] "data.frame"
## attr(,"split_labels")
##                          NAME
## 1 Plasma concentration IQ0815
## 
## $stratified
## list()
## attr(,"strat_info")
## data frame with 0 columns and 0 rows
## 
## attr(,"data")
## attr(,"data")$unstratified
## attr(,"data")$unstratified$`Plasma concentration IQ0815`
##     IXGDF IGNORE           USUBJID CENTER         STUDY STUDYN
## 1      20   <NA> IQ00701-0100-0003    100           FIH      1
## 2      22   <NA> IQ00701-0100-0003    100           FIH      1
## 3      23   <NA> IQ00701-0100-0003    100           FIH      1
## 4      24   <NA> IQ00701-0100-0003    100           FIH      1
## 5      25   <NA> IQ00701-0100-0003    100           FIH      1
## 6      26   <NA> IQ00701-0100-0003    100           FIH      1
## 7      27   <NA> IQ00701-0100-0003    100           FIH      1
## 8      28   <NA> IQ00701-0100-0003    100           FIH      1
## 9      29   <NA> IQ00701-0100-0003    100           FIH      1
## 10     30   <NA> IQ00701-0100-0003    100           FIH      1
## 11     31   <NA> IQ00701-0100-0003    100           FIH      1
## 12     32   <NA> IQ00701-0100-0003    100           FIH      1
## 13     37   <NA> IQ00701-0100-0004    100           FIH      1
## 14     39   <NA> IQ00701-0100-0004    100           FIH      1
## 15     40   <NA> IQ00701-0100-0004    100           FIH      1
## 16     41   <NA> IQ00701-0100-0004    100           FIH      1
## 17     42   <NA> IQ00701-0100-0004    100           FIH      1
## 18     43   <NA> IQ00701-0100-0004    100           FIH      1
## 19     44   <NA> IQ00701-0100-0004    100           FIH      1
## 20     45   <NA> IQ00701-0100-0004    100           FIH      1
## 21     46   <NA> IQ00701-0100-0004    100           FIH      1
## 22     47   <NA> IQ00701-0100-0004    100           FIH      1
## 23     48   <NA> IQ00701-0100-0004    100           FIH      1
## 24     49   <NA> IQ00701-0100-0004    100           FIH      1
## 25     54   <NA> IQ00701-0100-0005    100           FIH      1
## 26     56   <NA> IQ00701-0100-0005    100           FIH      1
## 27     57   <NA> IQ00701-0100-0005    100           FIH      1
## 28     58   <NA> IQ00701-0100-0005    100           FIH      1
## 29     60   <NA> IQ00701-0100-0005    100           FIH      1
## 30     61   <NA> IQ00701-0100-0005    100           FIH      1
## 31     62   <NA> IQ00701-0100-0005    100           FIH      1
## 32     63   <NA> IQ00701-0100-0005    100           FIH      1
## 33     64   <NA> IQ00701-0100-0005    100           FIH      1
## 34     65   <NA> IQ00701-0100-0005    100           FIH      1
## 35     66   <NA> IQ00701-0100-0005    100           FIH      1
## 36     71   <NA> IQ00701-0100-0006    100           FIH      1
## 37     73   <NA> IQ00701-0100-0006    100           FIH      1
## 38     74   <NA> IQ00701-0100-0006    100           FIH      1
## 39     75   <NA> IQ00701-0100-0006    100           FIH      1
## 40     76   <NA> IQ00701-0100-0006    100           FIH      1
## 41     77   <NA> IQ00701-0100-0006    100           FIH      1
## 42     78   <NA> IQ00701-0100-0006    100           FIH      1
## 43     79   <NA> IQ00701-0100-0006    100           FIH      1
## 44     80   <NA> IQ00701-0100-0006    100           FIH      1
## 45     81   <NA> IQ00701-0100-0006    100           FIH      1
## 46     82   <NA> IQ00701-0100-0006    100           FIH      1
## 47     83   <NA> IQ00701-0100-0006    100           FIH      1
## 48     88   <NA> IQ00701-0100-0007    100           FIH      1
## 49     90   <NA> IQ00701-0100-0007    100           FIH      1
## 50     91   <NA> IQ00701-0100-0007    100           FIH      1
## 51     92   <NA> IQ00701-0100-0007    100           FIH      1
## 52     93   <NA> IQ00701-0100-0007    100           FIH      1
## 53     94   <NA> IQ00701-0100-0007    100           FIH      1
## 54     95   <NA> IQ00701-0100-0007    100           FIH      1
## 55     96   <NA> IQ00701-0100-0007    100           FIH      1
## 56     97   <NA> IQ00701-0100-0007    100           FIH      1
## 57     99   <NA> IQ00701-0100-0007    100           FIH      1
## 58    100   <NA> IQ00701-0100-0007    100           FIH      1
## 59    106   <NA> IQ00701-0100-0009    100           FIH      1
## 60    108   <NA> IQ00701-0100-0009    100           FIH      1
## 61    109   <NA> IQ00701-0100-0009    100           FIH      1
## 62    110   <NA> IQ00701-0100-0009    100           FIH      1
## 63    111   <NA> IQ00701-0100-0009    100           FIH      1
## 64    112   <NA> IQ00701-0100-0009    100           FIH      1
## 65    113   <NA> IQ00701-0100-0009    100           FIH      1
## 66    114   <NA> IQ00701-0100-0009    100           FIH      1
## 67    115   <NA> IQ00701-0100-0009    100           FIH      1
## 68    116   <NA> IQ00701-0100-0009    100           FIH      1
## 69    117   <NA> IQ00701-0100-0009    100           FIH      1
## 70    118   <NA> IQ00701-0100-0009    100           FIH      1
## 71    123   <NA> IQ00701-0100-0010    100           FIH      1
## 72    125   <NA> IQ00701-0100-0010    100           FIH      1
## 73    126   <NA> IQ00701-0100-0010    100           FIH      1
## 74    127   <NA> IQ00701-0100-0010    100           FIH      1
## 75    128   <NA> IQ00701-0100-0010    100           FIH      1
## 76    129   <NA> IQ00701-0100-0010    100           FIH      1
## 77    130   <NA> IQ00701-0100-0010    100           FIH      1
## 78    131   <NA> IQ00701-0100-0010    100           FIH      1
## 79    132   <NA> IQ00701-0100-0010    100           FIH      1
## 80    133   <NA> IQ00701-0100-0010    100           FIH      1
## 81    134   <NA> IQ00701-0100-0010    100           FIH      1
## 82    135   <NA> IQ00701-0100-0010    100           FIH      1
## 83    139   <NA> IQ00701-0100-0011    100           FIH      1
## 84    141   <NA> IQ00701-0100-0011    100           FIH      1
## 85    142   <NA> IQ00701-0100-0011    100           FIH      1
## 86    143   <NA> IQ00701-0100-0011    100           FIH      1
## 87    144   <NA> IQ00701-0100-0011    100           FIH      1
## 88    145   <NA> IQ00701-0100-0011    100           FIH      1
## 89    146   <NA> IQ00701-0100-0011    100           FIH      1
## 90    147   <NA> IQ00701-0100-0011    100           FIH      1
## 91    148   <NA> IQ00701-0100-0011    100           FIH      1
## 92    149   <NA> IQ00701-0100-0011    100           FIH      1
## 93    150   <NA> IQ00701-0100-0011    100           FIH      1
## 94    151   <NA> IQ00701-0100-0011    100           FIH      1
## 95    156   <NA> IQ00701-0100-0012    100           FIH      1
## 96    158   <NA> IQ00701-0100-0012    100           FIH      1
## 97    159   <NA> IQ00701-0100-0012    100           FIH      1
## 98    160   <NA> IQ00701-0100-0012    100           FIH      1
## 99    161   <NA> IQ00701-0100-0012    100           FIH      1
## 100   162   <NA> IQ00701-0100-0012    100           FIH      1
## 101   163   <NA> IQ00701-0100-0012    100           FIH      1
## 102   164   <NA> IQ00701-0100-0012    100           FIH      1
## 103   165   <NA> IQ00701-0100-0012    100           FIH      1
## 104   166   <NA> IQ00701-0100-0012    100           FIH      1
## 105   167   <NA> IQ00701-0100-0012    100           FIH      1
## 106   168   <NA> IQ00701-0100-0012    100           FIH      1
## 107   172   <NA> IQ00701-0100-0013    100           FIH      1
## 108   174   <NA> IQ00701-0100-0013    100           FIH      1
## 109   175   <NA> IQ00701-0100-0013    100           FIH      1
## 110   176   <NA> IQ00701-0100-0013    100           FIH      1
## 111   177   <NA> IQ00701-0100-0013    100           FIH      1
## 112   178   <NA> IQ00701-0100-0013    100           FIH      1
## 113   179   <NA> IQ00701-0100-0013    100           FIH      1
## 114   180   <NA> IQ00701-0100-0013    100           FIH      1
## 115   181   <NA> IQ00701-0100-0013    100           FIH      1
## 116   182   <NA> IQ00701-0100-0013    100           FIH      1
## 117   183   <NA> IQ00701-0100-0013    100           FIH      1
## 118   184   <NA> IQ00701-0100-0013    100           FIH      1
## 119   189   <NA> IQ00701-0100-0014    100           FIH      1
## 120   191   <NA> IQ00701-0100-0014    100           FIH      1
## 121   192   <NA> IQ00701-0100-0014    100           FIH      1
## 122   193   <NA> IQ00701-0100-0014    100           FIH      1
## 123   194   <NA> IQ00701-0100-0014    100           FIH      1
## 124   195   <NA> IQ00701-0100-0014    100           FIH      1
## 125   196   <NA> IQ00701-0100-0014    100           FIH      1
## 126   197   <NA> IQ00701-0100-0014    100           FIH      1
## 127   198   <NA> IQ00701-0100-0014    100           FIH      1
## 128   199   <NA> IQ00701-0100-0014    100           FIH      1
## 129   200   <NA> IQ00701-0100-0014    100           FIH      1
## 130   201   <NA> IQ00701-0100-0014    100           FIH      1
## 131   206   <NA> IQ00701-0100-0015    100           FIH      1
## 132   208   <NA> IQ00701-0100-0015    100           FIH      1
## 133   209   <NA> IQ00701-0100-0015    100           FIH      1
## 134   210   <NA> IQ00701-0100-0015    100           FIH      1
## 135   211   <NA> IQ00701-0100-0015    100           FIH      1
## 136   212   <NA> IQ00701-0100-0015    100           FIH      1
## 137   213   <NA> IQ00701-0100-0015    100           FIH      1
## 138   214   <NA> IQ00701-0100-0015    100           FIH      1
## 139   215   <NA> IQ00701-0100-0015    100           FIH      1
## 140   216   <NA> IQ00701-0100-0015    100           FIH      1
## 141   217   <NA> IQ00701-0100-0015    100           FIH      1
## 142   218   <NA> IQ00701-0100-0015    100           FIH      1
## 143   223   <NA> IQ00701-0100-0016    100           FIH      1
## 144   225   <NA> IQ00701-0100-0016    100           FIH      1
## 145   226   <NA> IQ00701-0100-0016    100           FIH      1
## 146   227   <NA> IQ00701-0100-0016    100           FIH      1
## 147   228   <NA> IQ00701-0100-0016    100           FIH      1
## 148   229   <NA> IQ00701-0100-0016    100           FIH      1
## 149   230   <NA> IQ00701-0100-0016    100           FIH      1
## 150   231   <NA> IQ00701-0100-0016    100           FIH      1
## 151   232   <NA> IQ00701-0100-0016    100           FIH      1
## 152   233   <NA> IQ00701-0100-0016    100           FIH      1
## 153   234   <NA> IQ00701-0100-0016    100           FIH      1
## 154   235   <NA> IQ00701-0100-0016    100           FIH      1
## 155   240   <NA> IQ00701-0100-0017    100           FIH      1
## 156   242   <NA> IQ00701-0100-0017    100           FIH      1
## 157   243   <NA> IQ00701-0100-0017    100           FIH      1
## 158   244   <NA> IQ00701-0100-0017    100           FIH      1
## 159   245   <NA> IQ00701-0100-0017    100           FIH      1
## 160   246   <NA> IQ00701-0100-0017    100           FIH      1
## 161   247   <NA> IQ00701-0100-0017    100           FIH      1
## 162   248   <NA> IQ00701-0100-0017    100           FIH      1
## 163   249   <NA> IQ00701-0100-0017    100           FIH      1
## 164   250   <NA> IQ00701-0100-0017    100           FIH      1
## 165   251   <NA> IQ00701-0100-0017    100           FIH      1
## 166   252   <NA> IQ00701-0100-0017    100           FIH      1
## 167   274   <NA> IQ00701-0100-0019    100           FIH      1
## 168   276   <NA> IQ00701-0100-0019    100           FIH      1
## 169   277   <NA> IQ00701-0100-0019    100           FIH      1
## 170   278   <NA> IQ00701-0100-0019    100           FIH      1
## 171   279   <NA> IQ00701-0100-0019    100           FIH      1
## 172   280   <NA> IQ00701-0100-0019    100           FIH      1
## 173   281   <NA> IQ00701-0100-0019    100           FIH      1
## 174   282   <NA> IQ00701-0100-0019    100           FIH      1
## 175   283   <NA> IQ00701-0100-0019    100           FIH      1
## 176   284   <NA> IQ00701-0100-0019    100           FIH      1
## 177   285   <NA> IQ00701-0100-0019    100           FIH      1
## 178   286   <NA> IQ00701-0100-0019    100           FIH      1
## 179   291   <NA> IQ00701-0100-0020    100           FIH      1
## 180   293   <NA> IQ00701-0100-0020    100           FIH      1
## 181   294   <NA> IQ00701-0100-0020    100           FIH      1
## 182   295   <NA> IQ00701-0100-0020    100           FIH      1
## 183   296   <NA> IQ00701-0100-0020    100           FIH      1
## 184   297   <NA> IQ00701-0100-0020    100           FIH      1
## 185   298   <NA> IQ00701-0100-0020    100           FIH      1
## 186   299   <NA> IQ00701-0100-0020    100           FIH      1
## 187   300   <NA> IQ00701-0100-0020    100           FIH      1
## 188   302   <NA> IQ00701-0100-0020    100           FIH      1
## 189   303   <NA> IQ00701-0100-0020    100           FIH      1
## 190   308   <NA> IQ00701-0100-0021    100           FIH      1
## 191   310   <NA> IQ00701-0100-0021    100           FIH      1
## 192   311   <NA> IQ00701-0100-0021    100           FIH      1
## 193   312   <NA> IQ00701-0100-0021    100           FIH      1
## 194   313   <NA> IQ00701-0100-0021    100           FIH      1
## 195   314   <NA> IQ00701-0100-0021    100           FIH      1
## 196   315   <NA> IQ00701-0100-0021    100           FIH      1
## 197   316   <NA> IQ00701-0100-0021    100           FIH      1
## 198   317   <NA> IQ00701-0100-0021    100           FIH      1
## 199   318   <NA> IQ00701-0100-0021    100           FIH      1
## 200   319   <NA> IQ00701-0100-0021    100           FIH      1
## 201   320   <NA> IQ00701-0100-0021    100           FIH      1
## 202   325   <NA> IQ00701-0100-0022    100           FIH      1
## 203   327   <NA> IQ00701-0100-0022    100           FIH      1
## 204   328   <NA> IQ00701-0100-0022    100           FIH      1
## 205   329   <NA> IQ00701-0100-0022    100           FIH      1
## 206   330   <NA> IQ00701-0100-0022    100           FIH      1
## 207   331   <NA> IQ00701-0100-0022    100           FIH      1
## 208   332   <NA> IQ00701-0100-0022    100           FIH      1
## 209   333   <NA> IQ00701-0100-0022    100           FIH      1
## 210   334   <NA> IQ00701-0100-0022    100           FIH      1
## 211   335   <NA> IQ00701-0100-0022    100           FIH      1
## 212   336   <NA> IQ00701-0100-0022    100           FIH      1
## 213   337   <NA> IQ00701-0100-0022    100           FIH      1
## 214   342   <NA> IQ00701-0100-0023    100           FIH      1
## 215   344   <NA> IQ00701-0100-0023    100           FIH      1
## 216   345   <NA> IQ00701-0100-0023    100           FIH      1
## 217   346   <NA> IQ00701-0100-0023    100           FIH      1
## 218   347   <NA> IQ00701-0100-0023    100           FIH      1
## 219   348   <NA> IQ00701-0100-0023    100           FIH      1
## 220   349   <NA> IQ00701-0100-0023    100           FIH      1
## 221   350   <NA> IQ00701-0100-0023    100           FIH      1
## 222   351   <NA> IQ00701-0100-0023    100           FIH      1
## 223   352   <NA> IQ00701-0100-0023    100           FIH      1
## 224   353   <NA> IQ00701-0100-0023    100           FIH      1
## 225   354   <NA> IQ00701-0100-0023    100           FIH      1
## 226   359   <NA> IQ00701-0100-0024    100           FIH      1
## 227   361   <NA> IQ00701-0100-0024    100           FIH      1
## 228   362   <NA> IQ00701-0100-0024    100           FIH      1
## 229   363   <NA> IQ00701-0100-0024    100           FIH      1
## 230   364   <NA> IQ00701-0100-0024    100           FIH      1
## 231   365   <NA> IQ00701-0100-0024    100           FIH      1
## 232   366   <NA> IQ00701-0100-0024    100           FIH      1
## 233   367   <NA> IQ00701-0100-0024    100           FIH      1
## 234   368   <NA> IQ00701-0100-0024    100           FIH      1
## 235   369   <NA> IQ00701-0100-0024    100           FIH      1
## 236   370   <NA> IQ00701-0100-0024    100           FIH      1
## 237   371   <NA> IQ00701-0100-0024    100           FIH      1
## 238   376   <NA> IQ00701-0100-0025    100           FIH      1
## 239   378   <NA> IQ00701-0100-0025    100           FIH      1
## 240   379   <NA> IQ00701-0100-0025    100           FIH      1
## 241   380   <NA> IQ00701-0100-0025    100           FIH      1
## 242   381   <NA> IQ00701-0100-0025    100           FIH      1
## 243   382   <NA> IQ00701-0100-0025    100           FIH      1
## 244   383   <NA> IQ00701-0100-0025    100           FIH      1
## 245   384   <NA> IQ00701-0100-0025    100           FIH      1
## 246   385   <NA> IQ00701-0100-0025    100           FIH      1
## 247   386   <NA> IQ00701-0100-0025    100           FIH      1
## 248   387   <NA> IQ00701-0100-0025    100           FIH      1
## 249   388   <NA> IQ00701-0100-0025    100           FIH      1
## 250   393   <NA> IQ00701-0100-0026    100           FIH      1
## 251   395   <NA> IQ00701-0100-0026    100           FIH      1
## 252   396   <NA> IQ00701-0100-0026    100           FIH      1
## 253   397   <NA> IQ00701-0100-0026    100           FIH      1
## 254   398   <NA> IQ00701-0100-0026    100           FIH      1
## 255   399   <NA> IQ00701-0100-0026    100           FIH      1
## 256   400   <NA> IQ00701-0100-0026    100           FIH      1
## 257   401   <NA> IQ00701-0100-0026    100           FIH      1
## 258   402   <NA> IQ00701-0100-0026    100           FIH      1
## 259   403   <NA> IQ00701-0100-0026    100           FIH      1
## 260   404   <NA> IQ00701-0100-0026    100           FIH      1
## 261   405   <NA> IQ00701-0100-0026    100           FIH      1
## 262   410   <NA> IQ00701-0100-0027    100           FIH      1
## 263   412   <NA> IQ00701-0100-0027    100           FIH      1
## 264   413   <NA> IQ00701-0100-0027    100           FIH      1
## 265   414   <NA> IQ00701-0100-0027    100           FIH      1
## 266   415   <NA> IQ00701-0100-0027    100           FIH      1
## 267   416   <NA> IQ00701-0100-0027    100           FIH      1
## 268   417   <NA> IQ00701-0100-0027    100           FIH      1
## 269   418   <NA> IQ00701-0100-0027    100           FIH      1
## 270   419   <NA> IQ00701-0100-0027    100           FIH      1
## 271   420   <NA> IQ00701-0100-0027    100           FIH      1
## 272   421   <NA> IQ00701-0100-0027    100           FIH      1
## 273   422   <NA> IQ00701-0100-0027    100           FIH      1
## 274   427   <NA> IQ00701-0100-0028    100           FIH      1
## 275   429   <NA> IQ00701-0100-0028    100           FIH      1
## 276   430   <NA> IQ00701-0100-0028    100           FIH      1
## 277   431   <NA> IQ00701-0100-0028    100           FIH      1
## 278   432   <NA> IQ00701-0100-0028    100           FIH      1
## 279   433   <NA> IQ00701-0100-0028    100           FIH      1
## 280   434   <NA> IQ00701-0100-0028    100           FIH      1
## 281   435   <NA> IQ00701-0100-0028    100           FIH      1
## 282   436   <NA> IQ00701-0100-0028    100           FIH      1
## 283   437   <NA> IQ00701-0100-0028    100           FIH      1
## 284   438   <NA> IQ00701-0100-0028    100           FIH      1
## 285   439   <NA> IQ00701-0100-0028    100           FIH      1
## 286   444   <NA> IQ00701-0100-0029    100           FIH      1
## 287   446   <NA> IQ00701-0100-0029    100           FIH      1
## 288   447   <NA> IQ00701-0100-0029    100           FIH      1
## 289   448   <NA> IQ00701-0100-0029    100           FIH      1
## 290   449   <NA> IQ00701-0100-0029    100           FIH      1
## 291   450   <NA> IQ00701-0100-0029    100           FIH      1
## 292   451   <NA> IQ00701-0100-0029    100           FIH      1
## 293   452   <NA> IQ00701-0100-0029    100           FIH      1
## 294   453   <NA> IQ00701-0100-0029    100           FIH      1
## 295   454   <NA> IQ00701-0100-0029    100           FIH      1
## 296   455   <NA> IQ00701-0100-0029    100           FIH      1
## 297   456   <NA> IQ00701-0100-0029    100           FIH      1
## 298   461   <NA> IQ00701-0100-0030    100           FIH      1
## 299   463   <NA> IQ00701-0100-0030    100           FIH      1
## 300   464   <NA> IQ00701-0100-0030    100           FIH      1
## 301   465   <NA> IQ00701-0100-0030    100           FIH      1
## 302   466   <NA> IQ00701-0100-0030    100           FIH      1
## 303   467   <NA> IQ00701-0100-0030    100           FIH      1
## 304   468   <NA> IQ00701-0100-0030    100           FIH      1
## 305   469   <NA> IQ00701-0100-0030    100           FIH      1
## 306   470   <NA> IQ00701-0100-0030    100           FIH      1
## 307   471   <NA> IQ00701-0100-0030    100           FIH      1
## 308   472   <NA> IQ00701-0100-0030    100           FIH      1
## 309   473   <NA> IQ00701-0100-0030    100           FIH      1
## 310   478   <NA> IQ00701-0100-0031    100           FIH      1
## 311   480   <NA> IQ00701-0100-0031    100           FIH      1
## 312   481   <NA> IQ00701-0100-0031    100           FIH      1
## 313   482   <NA> IQ00701-0100-0031    100           FIH      1
## 314   483   <NA> IQ00701-0100-0031    100           FIH      1
## 315   484   <NA> IQ00701-0100-0031    100           FIH      1
## 316   485   <NA> IQ00701-0100-0031    100           FIH      1
## 317   486   <NA> IQ00701-0100-0031    100           FIH      1
## 318   487   <NA> IQ00701-0100-0031    100           FIH      1
## 319   488   <NA> IQ00701-0100-0031    100           FIH      1
## 320   489   <NA> IQ00701-0100-0031    100           FIH      1
## 321   490   <NA> IQ00701-0100-0031    100           FIH      1
## 322   495   <NA> IQ00701-0100-0032    100           FIH      1
## 323   497   <NA> IQ00701-0100-0032    100           FIH      1
## 324   498   <NA> IQ00701-0100-0032    100           FIH      1
## 325   499   <NA> IQ00701-0100-0032    100           FIH      1
## 326   500   <NA> IQ00701-0100-0032    100           FIH      1
## 327   501   <NA> IQ00701-0100-0032    100           FIH      1
## 328   502   <NA> IQ00701-0100-0032    100           FIH      1
## 329   503   <NA> IQ00701-0100-0032    100           FIH      1
## 330   504   <NA> IQ00701-0100-0032    100           FIH      1
## 331   505   <NA> IQ00701-0100-0032    100           FIH      1
## 332   506   <NA> IQ00701-0100-0032    100           FIH      1
## 333   507   <NA> IQ00701-0100-0032    100           FIH      1
## 334   512   <NA> IQ00701-0100-0033    100           FIH      1
## 335   514   <NA> IQ00701-0100-0033    100           FIH      1
## 336   515   <NA> IQ00701-0100-0033    100           FIH      1
## 337   516   <NA> IQ00701-0100-0033    100           FIH      1
## 338   517   <NA> IQ00701-0100-0033    100           FIH      1
## 339   518   <NA> IQ00701-0100-0033    100           FIH      1
## 340   519   <NA> IQ00701-0100-0033    100           FIH      1
## 341   520   <NA> IQ00701-0100-0033    100           FIH      1
## 342   521   <NA> IQ00701-0100-0033    100           FIH      1
## 343   522   <NA> IQ00701-0100-0033    100           FIH      1
## 344   523   <NA> IQ00701-0100-0033    100           FIH      1
## 345   524   <NA> IQ00701-0100-0033    100           FIH      1
## 346   529   <NA> IQ00701-0100-0034    100           FIH      1
## 347   531   <NA> IQ00701-0100-0034    100           FIH      1
## 348   532   <NA> IQ00701-0100-0034    100           FIH      1
## 349   533   <NA> IQ00701-0100-0034    100           FIH      1
## 350   534   <NA> IQ00701-0100-0034    100           FIH      1
## 351   535   <NA> IQ00701-0100-0034    100           FIH      1
## 352   536   <NA> IQ00701-0100-0034    100           FIH      1
## 353   537   <NA> IQ00701-0100-0034    100           FIH      1
## 354   538   <NA> IQ00701-0100-0034    100           FIH      1
## 355   539   <NA> IQ00701-0100-0034    100           FIH      1
## 356   540   <NA> IQ00701-0100-0034    100           FIH      1
## 357   541   <NA> IQ00701-0100-0034    100           FIH      1
## 358   546   <NA> IQ00701-0100-0035    100           FIH      1
## 359   548   <NA> IQ00701-0100-0035    100           FIH      1
## 360   549   <NA> IQ00701-0100-0035    100           FIH      1
## 361   550   <NA> IQ00701-0100-0035    100           FIH      1
## 362   551   <NA> IQ00701-0100-0035    100           FIH      1
## 363   552   <NA> IQ00701-0100-0035    100           FIH      1
## 364   553   <NA> IQ00701-0100-0035    100           FIH      1
## 365   554   <NA> IQ00701-0100-0035    100           FIH      1
## 366   555   <NA> IQ00701-0100-0035    100           FIH      1
## 367   556   <NA> IQ00701-0100-0035    100           FIH      1
## 368   557   <NA> IQ00701-0100-0035    100           FIH      1
## 369   558   <NA> IQ00701-0100-0035    100           FIH      1
## 370   563   <NA> IQ00701-0100-0036    100           FIH      1
## 371   565   <NA> IQ00701-0100-0036    100           FIH      1
## 372   566   <NA> IQ00701-0100-0036    100           FIH      1
## 373   567   <NA> IQ00701-0100-0036    100           FIH      1
## 374   568   <NA> IQ00701-0100-0036    100           FIH      1
## 375   569   <NA> IQ00701-0100-0036    100           FIH      1
## 376   570   <NA> IQ00701-0100-0036    100           FIH      1
## 377   571   <NA> IQ00701-0100-0036    100           FIH      1
## 378   572   <NA> IQ00701-0100-0036    100           FIH      1
## 379   573   <NA> IQ00701-0100-0036    100           FIH      1
## 380   574   <NA> IQ00701-0100-0036    100           FIH      1
## 381   575   <NA> IQ00701-0100-0036    100           FIH      1
## 382   580   <NA> IQ00701-0100-0037    100 FIH extension      2
## 383   582   <NA> IQ00701-0100-0037    100 FIH extension      2
## 384   583   <NA> IQ00701-0100-0037    100 FIH extension      2
## 385   584   <NA> IQ00701-0100-0037    100 FIH extension      2
## 386   585   <NA> IQ00701-0100-0037    100 FIH extension      2
## 387   586   <NA> IQ00701-0100-0037    100 FIH extension      2
## 388   587   <NA> IQ00701-0100-0037    100 FIH extension      2
## 389   588   <NA> IQ00701-0100-0037    100 FIH extension      2
## 390   589   <NA> IQ00701-0100-0037    100 FIH extension      2
## 391   590   <NA> IQ00701-0100-0037    100 FIH extension      2
## 392   591   <NA> IQ00701-0100-0037    100 FIH extension      2
## 393   592   <NA> IQ00701-0100-0037    100 FIH extension      2
## 394   597   <NA> IQ00701-0100-0038    100 FIH extension      2
## 395   599   <NA> IQ00701-0100-0038    100 FIH extension      2
## 396   600   <NA> IQ00701-0100-0038    100 FIH extension      2
## 397   601   <NA> IQ00701-0100-0038    100 FIH extension      2
## 398   602   <NA> IQ00701-0100-0038    100 FIH extension      2
## 399   603   <NA> IQ00701-0100-0038    100 FIH extension      2
## 400   604   <NA> IQ00701-0100-0038    100 FIH extension      2
## 401   605   <NA> IQ00701-0100-0038    100 FIH extension      2
## 402   606   <NA> IQ00701-0100-0038    100 FIH extension      2
## 403   607   <NA> IQ00701-0100-0038    100 FIH extension      2
## 404   608   <NA> IQ00701-0100-0038    100 FIH extension      2
## 405   609   <NA> IQ00701-0100-0038    100 FIH extension      2
## 406   614   <NA> IQ00701-0100-0039    100 FIH extension      2
## 407   616   <NA> IQ00701-0100-0039    100 FIH extension      2
## 408   617   <NA> IQ00701-0100-0039    100 FIH extension      2
## 409   618   <NA> IQ00701-0100-0039    100 FIH extension      2
## 410   619   <NA> IQ00701-0100-0039    100 FIH extension      2
## 411   620   <NA> IQ00701-0100-0039    100 FIH extension      2
## 412   621   <NA> IQ00701-0100-0039    100 FIH extension      2
## 413   622   <NA> IQ00701-0100-0039    100 FIH extension      2
## 414   623   <NA> IQ00701-0100-0039    100 FIH extension      2
## 415   624   <NA> IQ00701-0100-0039    100 FIH extension      2
## 416   625   <NA> IQ00701-0100-0039    100 FIH extension      2
## 417   626   <NA> IQ00701-0100-0039    100 FIH extension      2
## 418   631   <NA> IQ00701-0100-0040    100 FIH extension      2
## 419   633   <NA> IQ00701-0100-0040    100 FIH extension      2
## 420   634   <NA> IQ00701-0100-0040    100 FIH extension      2
## 421   635   <NA> IQ00701-0100-0040    100 FIH extension      2
## 422   636   <NA> IQ00701-0100-0040    100 FIH extension      2
## 423   637   <NA> IQ00701-0100-0040    100 FIH extension      2
## 424   638   <NA> IQ00701-0100-0040    100 FIH extension      2
## 425   639   <NA> IQ00701-0100-0040    100 FIH extension      2
## 426   640   <NA> IQ00701-0100-0040    100 FIH extension      2
## 427   641   <NA> IQ00701-0100-0040    100 FIH extension      2
## 428   642   <NA> IQ00701-0100-0040    100 FIH extension      2
## 429   643   <NA> IQ00701-0100-0040    100 FIH extension      2
## 430   648   <NA> IQ00701-0100-0041    100 FIH extension      2
## 431   650   <NA> IQ00701-0100-0041    100 FIH extension      2
## 432   651   <NA> IQ00701-0100-0041    100 FIH extension      2
## 433   652   <NA> IQ00701-0100-0041    100 FIH extension      2
## 434   653   <NA> IQ00701-0100-0041    100 FIH extension      2
## 435   654   <NA> IQ00701-0100-0041    100 FIH extension      2
## 436   655   <NA> IQ00701-0100-0041    100 FIH extension      2
## 437   656   <NA> IQ00701-0100-0041    100 FIH extension      2
## 438   657   <NA> IQ00701-0100-0041    100 FIH extension      2
## 439   658   <NA> IQ00701-0100-0041    100 FIH extension      2
## 440   659   <NA> IQ00701-0100-0041    100 FIH extension      2
## 441   660   <NA> IQ00701-0100-0041    100 FIH extension      2
## 442   665   <NA> IQ00701-0100-0042    100 FIH extension      2
## 443   667   <NA> IQ00701-0100-0042    100 FIH extension      2
## 444   668   <NA> IQ00701-0100-0042    100 FIH extension      2
## 445   669   <NA> IQ00701-0100-0042    100 FIH extension      2
## 446   670   <NA> IQ00701-0100-0042    100 FIH extension      2
## 447   671   <NA> IQ00701-0100-0042    100 FIH extension      2
## 448   672   <NA> IQ00701-0100-0042    100 FIH extension      2
## 449   673   <NA> IQ00701-0100-0042    100 FIH extension      2
## 450   674   <NA> IQ00701-0100-0042    100 FIH extension      2
## 451   675   <NA> IQ00701-0100-0042    100 FIH extension      2
## 452   676   <NA> IQ00701-0100-0042    100 FIH extension      2
## 453   677   <NA> IQ00701-0100-0042    100 FIH extension      2
## 454   682   <NA> IQ00701-0100-0043    100 FIH extension      2
## 455   684   <NA> IQ00701-0100-0043    100 FIH extension      2
## 456   685   <NA> IQ00701-0100-0043    100 FIH extension      2
## 457   686   <NA> IQ00701-0100-0043    100 FIH extension      2
## 458   687   <NA> IQ00701-0100-0043    100 FIH extension      2
## 459   688   <NA> IQ00701-0100-0043    100 FIH extension      2
## 460   689   <NA> IQ00701-0100-0043    100 FIH extension      2
## 461   690   <NA> IQ00701-0100-0043    100 FIH extension      2
## 462   691   <NA> IQ00701-0100-0043    100 FIH extension      2
## 463   692   <NA> IQ00701-0100-0043    100 FIH extension      2
## 464   693   <NA> IQ00701-0100-0043    100 FIH extension      2
## 465   694   <NA> IQ00701-0100-0043    100 FIH extension      2
## 466   699   <NA> IQ00701-0100-0044    100 FIH extension      2
## 467   701   <NA> IQ00701-0100-0044    100 FIH extension      2
## 468   702   <NA> IQ00701-0100-0044    100 FIH extension      2
## 469   703   <NA> IQ00701-0100-0044    100 FIH extension      2
## 470   704   <NA> IQ00701-0100-0044    100 FIH extension      2
## 471   705   <NA> IQ00701-0100-0044    100 FIH extension      2
## 472   706   <NA> IQ00701-0100-0044    100 FIH extension      2
## 473   707   <NA> IQ00701-0100-0044    100 FIH extension      2
## 474   708   <NA> IQ00701-0100-0044    100 FIH extension      2
## 475   709   <NA> IQ00701-0100-0044    100 FIH extension      2
## 476   710   <NA> IQ00701-0100-0044    100 FIH extension      2
## 477   711   <NA> IQ00701-0100-0044    100 FIH extension      2
## 478   716   <NA> IQ00701-0100-0045    100 FIH extension      2
## 479   718   <NA> IQ00701-0100-0045    100 FIH extension      2
## 480   719   <NA> IQ00701-0100-0045    100 FIH extension      2
## 481   720   <NA> IQ00701-0100-0045    100 FIH extension      2
## 482   721   <NA> IQ00701-0100-0045    100 FIH extension      2
## 483   722   <NA> IQ00701-0100-0045    100 FIH extension      2
## 484   723   <NA> IQ00701-0100-0045    100 FIH extension      2
## 485   724   <NA> IQ00701-0100-0045    100 FIH extension      2
## 486   725   <NA> IQ00701-0100-0045    100 FIH extension      2
## 487   726   <NA> IQ00701-0100-0045    100 FIH extension      2
## 488   727   <NA> IQ00701-0100-0045    100 FIH extension      2
## 489   728   <NA> IQ00701-0100-0045    100 FIH extension      2
## 490   733   <NA> IQ00701-0100-0046    100 FIH extension      2
## 491   735   <NA> IQ00701-0100-0046    100 FIH extension      2
## 492   736   <NA> IQ00701-0100-0046    100 FIH extension      2
## 493   737   <NA> IQ00701-0100-0046    100 FIH extension      2
## 494   738   <NA> IQ00701-0100-0046    100 FIH extension      2
## 495   739   <NA> IQ00701-0100-0046    100 FIH extension      2
## 496   740   <NA> IQ00701-0100-0046    100 FIH extension      2
## 497   741   <NA> IQ00701-0100-0046    100 FIH extension      2
## 498   742   <NA> IQ00701-0100-0046    100 FIH extension      2
## 499   743   <NA> IQ00701-0100-0046    100 FIH extension      2
## 500   744   <NA> IQ00701-0100-0046    100 FIH extension      2
## 501   745   <NA> IQ00701-0100-0046    100 FIH extension      2
## 502   750   <NA> IQ00701-0100-0047    100 FIH extension      2
## 503   752   <NA> IQ00701-0100-0047    100 FIH extension      2
## 504   753   <NA> IQ00701-0100-0047    100 FIH extension      2
## 505   754   <NA> IQ00701-0100-0047    100 FIH extension      2
## 506   755   <NA> IQ00701-0100-0047    100 FIH extension      2
## 507   756   <NA> IQ00701-0100-0047    100 FIH extension      2
## 508   757   <NA> IQ00701-0100-0047    100 FIH extension      2
## 509   758   <NA> IQ00701-0100-0047    100 FIH extension      2
## 510   759   <NA> IQ00701-0100-0047    100 FIH extension      2
## 511   760   <NA> IQ00701-0100-0047    100 FIH extension      2
## 512   761   <NA> IQ00701-0100-0047    100 FIH extension      2
## 513   762   <NA> IQ00701-0100-0047    100 FIH extension      2
## 514   767   <NA> IQ00701-0100-0048    100 FIH extension      2
## 515   769   <NA> IQ00701-0100-0048    100 FIH extension      2
## 516   770   <NA> IQ00701-0100-0048    100 FIH extension      2
## 517   771   <NA> IQ00701-0100-0048    100 FIH extension      2
## 518   772   <NA> IQ00701-0100-0048    100 FIH extension      2
## 519   773   <NA> IQ00701-0100-0048    100 FIH extension      2
## 520   774   <NA> IQ00701-0100-0048    100 FIH extension      2
## 521   775   <NA> IQ00701-0100-0048    100 FIH extension      2
## 522   776   <NA> IQ00701-0100-0048    100 FIH extension      2
## 523   777   <NA> IQ00701-0100-0048    100 FIH extension      2
## 524   778   <NA> IQ00701-0100-0048    100 FIH extension      2
## 525   779   <NA> IQ00701-0100-0048    100 FIH extension      2
##                    TRTNAME TRT VISIT BASE SCREEN TIMEUNIT           NT     TIME
## 1     1mg oral single dose   3     2    0      0    HOURS  -0.08333333  -0.0830
## 2     1mg oral single dose   3     2    0      0    HOURS   0.08333333   0.0830
## 3     1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.2500
## 4     1mg oral single dose   3     2    0      0    HOURS   0.50000000   0.5000
## 5     1mg oral single dose   3     2    0      0    HOURS   1.00000000   1.0000
## 6     1mg oral single dose   3     2    0      0    HOURS   2.00000000   2.0000
## 7     1mg oral single dose   3     2    0      0    HOURS   4.00000000   4.0000
## 8     1mg oral single dose   3     2    0      0    HOURS  12.00000000  12.0000
## 9     1mg oral single dose   3     3    0      0    HOURS  24.00000000  24.0000
## 10    1mg oral single dose   3     4    0      0    HOURS  48.00000000  48.0000
## 11    1mg oral single dose   3     5    0      0    HOURS  96.00000000  96.0000
## 12    1mg oral single dose   3     6    0      0    HOURS 168.00000000 168.0000
## 13    1mg oral single dose   3     2    0      0    HOURS  -0.08333333  -0.0830
## 14    1mg oral single dose   3     2    0      0    HOURS   0.08333333   0.0830
## 15    1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.2500
## 16    1mg oral single dose   3     2    0      0    HOURS   0.50000000   0.5000
## 17    1mg oral single dose   3     2    0      0    HOURS   1.00000000   1.0000
## 18    1mg oral single dose   3     2    0      0    HOURS   2.00000000   2.0000
## 19    1mg oral single dose   3     2    0      0    HOURS   4.00000000   4.0000
## 20    1mg oral single dose   3     2    0      0    HOURS  12.00000000  12.0000
## 21    1mg oral single dose   3     3    0      0    HOURS  24.00000000  24.0000
## 22    1mg oral single dose   3     4    0      0    HOURS  48.00000000  48.0000
## 23    1mg oral single dose   3     5    0      0    HOURS  96.00000000  96.0000
## 24    1mg oral single dose   3     6    0      0    HOURS 168.00000000 168.0000
## 25    1mg oral single dose   3     2    0      0    HOURS  -0.08333333  -0.0830
## 26    1mg oral single dose   3     2    0      0    HOURS   0.08333333   0.0830
## 27    1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.2500
## 28    1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.2501
## 29    1mg oral single dose   3     2    0      0    HOURS   1.00000000   1.0000
## 30    1mg oral single dose   3     2    0      0    HOURS   2.00000000   2.0000
## 31    1mg oral single dose   3     2    0      0    HOURS   4.00000000   4.0000
## 32    1mg oral single dose   3     3    0      0    HOURS  24.00000000  24.0000
## 33    1mg oral single dose   3     4    0      0    HOURS  48.00000000  48.0000
## 34    1mg oral single dose   3     5    0      0    HOURS  96.00000000  96.0000
## 35    1mg oral single dose   3     6    0      0    HOURS 168.00000000 168.0000
## 36    1mg oral single dose   3     2    0      0    HOURS  -0.08333333  -0.0830
## 37    1mg oral single dose   3     2    0      0    HOURS   0.08333333   0.0830
## 38    1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.2500
## 39    1mg oral single dose   3     2    0      0    HOURS   0.50000000   0.5000
## 40    1mg oral single dose   3     2    0      0    HOURS   1.00000000   1.0000
## 41    1mg oral single dose   3     2    0      0    HOURS   2.00000000   2.0000
## 42    1mg oral single dose   3     2    0      0    HOURS   4.00000000   4.0000
## 43    1mg oral single dose   3     2    0      0    HOURS  12.00000000  12.0000
## 44    1mg oral single dose   3     3    0      0    HOURS  24.00000000  24.0000
## 45    1mg oral single dose   3     4    0      0    HOURS  48.00000000  48.0000
## 46    1mg oral single dose   3     5    0      0    HOURS  96.00000000  96.0000
## 47    1mg oral single dose   3     6    0      0    HOURS 168.00000000 168.0000
## 48    2mg oral single dose   6     2    0      0    HOURS  -0.08333333  -0.0830
## 49    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.0830
## 50    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.2500
## 51    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.5000
## 52    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.0000
## 53    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.0000
## 54    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.0000
## 55    2mg oral single dose   6     2    0      0    HOURS  12.00000000  12.0000
## 56    2mg oral single dose   6     3    0      0    HOURS  24.00000000  24.0000
## 57    2mg oral single dose   6     5    0      0    HOURS  96.00000000  96.0000
## 58    2mg oral single dose   6     6    0      0    HOURS 168.00000000 168.0000
## 59    2mg oral single dose   6     2    0      0    HOURS  -0.08333333  -0.0830
## 60    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.0830
## 61    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.2500
## 62    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.5000
## 63    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.0000
## 64    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.0000
## 65    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.0000
## 66    2mg oral single dose   6     2    0      0    HOURS  12.00000000  12.0000
## 67    2mg oral single dose   6     3    0      0    HOURS  24.00000000  24.0000
## 68    2mg oral single dose   6     4    0      0    HOURS  48.00000000  48.0000
## 69    2mg oral single dose   6     5    0      0    HOURS  96.00000000  96.0000
## 70    2mg oral single dose   6     6    0      0    HOURS 168.00000000 168.0000
## 71    2mg oral single dose   6     2    0      0    HOURS  -0.08333333  -0.0830
## 72    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.0830
## 73    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.2500
## 74    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.5000
## 75    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.0000
## 76    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.0000
## 77    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.0000
## 78    2mg oral single dose   6     2    0      0    HOURS  12.00000000  12.0000
## 79    2mg oral single dose   6     3    0      0    HOURS  24.00000000  24.0000
## 80    2mg oral single dose   6     4    0      0    HOURS  48.00000000  48.0000
## 81    2mg oral single dose   6     5    0      0    HOURS  96.00000000  96.0000
## 82    2mg oral single dose   6     6    0      0    HOURS 168.00000000 168.0000
## 83    2mg oral single dose   6     2    0      0    HOURS  -0.08333333  -0.0830
## 84    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.0830
## 85    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.2500
## 86    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.5000
## 87    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.0000
## 88    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.0000
## 89    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.0000
## 90    2mg oral single dose   6     2    0      0    HOURS  12.00000000  12.0000
## 91    2mg oral single dose   6     3    0      0    HOURS  24.00000000  24.0000
## 92    2mg oral single dose   6     4    0      0    HOURS  48.00000000  48.0000
## 93    2mg oral single dose   6     5    0      0    HOURS  96.00000000  96.0000
## 94    2mg oral single dose   6     6    0      0    HOURS 168.00000000 168.0000
## 95    2mg oral single dose   6     2    0      0    HOURS  -0.08333333  -0.0830
## 96    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.0830
## 97    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.2500
## 98    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.5000
## 99    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.0000
## 100   2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.0000
## 101   2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.0000
## 102   2mg oral single dose   6     2    0      0    HOURS  12.00000000  12.0000
## 103   2mg oral single dose   6     3    0      0    HOURS  24.00000000  24.0000
## 104   2mg oral single dose   6     4    0      0    HOURS  48.00000000  48.0000
## 105   2mg oral single dose   6     5    0      0    HOURS  96.00000000  96.0000
## 106   2mg oral single dose   6     6    0      0    HOURS 168.00000000 168.0000
## 107   5mg oral single dose   8     2    0      0    HOURS  -0.08333333  -0.0830
## 108   5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.0830
## 109   5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.2500
## 110   5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.5000
## 111   5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.0000
## 112   5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.0000
## 113   5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.0000
## 114   5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.0000
## 115   5mg oral single dose   8     3    0      0    HOURS  24.00000000  24.0000
## 116   5mg oral single dose   8     4    0      0    HOURS  48.00000000  48.0000
## 117   5mg oral single dose   8     5    0      0    HOURS  96.00000000  96.0000
## 118   5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.0000
## 119   5mg oral single dose   8     2    0      0    HOURS  -0.08333333  -0.0830
## 120   5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.0830
## 121   5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.2500
## 122   5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.5000
## 123   5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.0000
## 124   5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.0000
## 125   5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.0000
## 126   5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.0000
## 127   5mg oral single dose   8     3    0      0    HOURS  24.00000000  24.0000
## 128   5mg oral single dose   8     4    0      0    HOURS  48.00000000  48.0000
## 129   5mg oral single dose   8     5    0      0    HOURS  96.00000000  96.0000
## 130   5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.0000
## 131   5mg oral single dose   8     2    0      0    HOURS  -0.08333333  -0.0830
## 132   5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.0830
## 133   5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.2500
## 134   5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.5000
## 135   5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.0000
## 136   5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.0000
## 137   5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.0000
## 138   5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.0000
## 139   5mg oral single dose   8     3    0      0    HOURS  24.00000000  24.0000
## 140   5mg oral single dose   8     4    0      0    HOURS  48.00000000  48.0000
## 141   5mg oral single dose   8     5    0      0    HOURS  96.00000000  96.0000
## 142   5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.0000
## 143   5mg oral single dose   8     2    0      0    HOURS  -0.08333333  -0.0830
## 144   5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.0830
## 145   5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.2500
## 146   5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.5000
## 147   5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.0000
## 148   5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.0000
## 149   5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.0000
## 150   5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.0000
## 151   5mg oral single dose   8     3    0      0    HOURS  24.00000000  24.0000
## 152   5mg oral single dose   8     4    0      0    HOURS  48.00000000  48.0000
## 153   5mg oral single dose   8     5    0      0    HOURS  96.00000000  96.0000
## 154   5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.0000
## 155   5mg oral single dose   8     2    0      0    HOURS  -0.08333333  -0.0830
## 156   5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.0830
## 157   5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.2500
## 158   5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.5000
## 159   5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.0000
## 160   5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.0000
## 161   5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.0000
## 162   5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.0000
## 163   5mg oral single dose   8     3    0      0    HOURS  24.00000000  24.0000
## 164   5mg oral single dose   8     4    0      0    HOURS  48.00000000  48.0000
## 165   5mg oral single dose   8     5    0      0    HOURS  96.00000000  96.0000
## 166   5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.0000
## 167  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 168  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 169  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 170  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 171  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 172  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 173  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 174  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 175  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 176  10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.0000
## 177  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 178  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 179  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 180  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 181  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 182  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 183  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 184  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 185  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 186  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 187  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 188  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 189  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 190  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 191  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 192  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 193  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 194  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 195  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 196  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 197  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 198  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 199  10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.0000
## 200  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 201  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 202  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 203  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 204  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 205  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 206  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 207  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 208  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 209  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 210  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 211  10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.0000
## 212  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 213  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 214  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 215  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 216  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 217  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 218  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 219  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 220  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 221  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 222  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 223  10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.0000
## 224  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 225  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 226  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 227  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 228  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 229  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 230  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 231  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 232  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 233  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 234  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 235  10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.0000
## 236  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 237  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 238  20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.0830
## 239  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.0830
## 240  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.2500
## 241  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.5000
## 242  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.0000
## 243  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.0000
## 244  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.0000
## 245  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.0000
## 246  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.0000
## 247  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.0000
## 248  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.0000
## 249  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.0000
## 250  20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.0830
## 251  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.0830
## 252  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.2500
## 253  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.5000
## 254  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.0000
## 255  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.0000
## 256  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.0000
## 257  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.0000
## 258  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.0000
## 259  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.0000
## 260  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.0000
## 261  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.0000
## 262  20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.0830
## 263  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.0830
## 264  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.2500
## 265  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.5000
## 266  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.0000
## 267  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.0000
## 268  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.0000
## 269  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.0000
## 270  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.0000
## 271  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.0000
## 272  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.0000
## 273  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.0000
## 274  20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.0830
## 275  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.0830
## 276  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.2500
## 277  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.5000
## 278  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.0000
## 279  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.0000
## 280  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.0000
## 281  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.0000
## 282  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.0000
## 283  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.0000
## 284  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.0000
## 285  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.0000
## 286  20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.0830
## 287  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.0830
## 288  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.2500
## 289  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.5000
## 290  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.0000
## 291  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.0000
## 292  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.0000
## 293  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.0000
## 294  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.0000
## 295  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.0000
## 296  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.0000
## 297  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.0000
## 298  20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.0830
## 299  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.0830
## 300  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.2500
## 301  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.5000
## 302  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.0000
## 303  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.0000
## 304  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.0000
## 305  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.0000
## 306  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.0000
## 307  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.0000
## 308  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.0000
## 309  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.0000
## 310  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.0830
## 311  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.0830
## 312  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.2500
## 313  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.5000
## 314  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.0000
## 315  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.0000
## 316  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.0000
## 317  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.0000
## 318  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.0000
## 319  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.0000
## 320  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.0000
## 321  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.0000
## 322  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.0830
## 323  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.0830
## 324  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.2500
## 325  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.5000
## 326  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.0000
## 327  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.0000
## 328  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.0000
## 329  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.0000
## 330  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.0000
## 331  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.0000
## 332  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.0000
## 333  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.0000
## 334  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.0830
## 335  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.0830
## 336  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.2500
## 337  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.5000
## 338  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.0000
## 339  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.0000
## 340  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.0000
## 341  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.0000
## 342  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.0000
## 343  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.0000
## 344  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.0000
## 345  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.0000
## 346  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.0830
## 347  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.0830
## 348  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.2500
## 349  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.5000
## 350  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.0000
## 351  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.0000
## 352  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.0000
## 353  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.0000
## 354  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.0000
## 355  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.0000
## 356  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.0000
## 357  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.0000
## 358  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.0830
## 359  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.0830
## 360  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.2500
## 361  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.5000
## 362  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.0000
## 363  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.0000
## 364  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.0000
## 365  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.0000
## 366  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.0000
## 367  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.0000
## 368  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.0000
## 369  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.0000
## 370  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.0830
## 371  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.0830
## 372  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.2500
## 373  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.5000
## 374  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.0000
## 375  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.0000
## 376  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.0000
## 377  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.0000
## 378  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.0000
## 379  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.0000
## 380  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.0000
## 381  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.0000
## 382 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.0830
## 383 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.0830
## 384 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.2500
## 385 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.5000
## 386 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.0000
## 387 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.0000
## 388 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.0000
## 389 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.0000
## 390 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.0000
## 391 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.0000
## 392 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.0000
## 393 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.0000
## 394 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.0830
## 395 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.0830
## 396 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.2500
## 397 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.5000
## 398 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.0000
## 399 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.0000
## 400 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.0000
## 401 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.0000
## 402 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.0000
## 403 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.0000
## 404 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.0000
## 405 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.0000
## 406 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.0830
## 407 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.0830
## 408 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.2500
## 409 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.5000
## 410 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.0000
## 411 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.0000
## 412 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.0000
## 413 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.0000
## 414 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.0000
## 415 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.0000
## 416 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.0000
## 417 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.0000
## 418 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.0830
## 419 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.0830
## 420 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.2500
## 421 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.5000
## 422 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.0000
## 423 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.0000
## 424 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.0000
## 425 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.0000
## 426 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.0000
## 427 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.0000
## 428 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.0000
## 429 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.0000
## 430 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.0830
## 431 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.0830
## 432 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.2500
## 433 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.5000
## 434 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.0000
## 435 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.0000
## 436 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.0000
## 437 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.0000
## 438 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.0000
## 439 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.0000
## 440 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.0000
## 441 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.0000
## 442 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.0830
## 443 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.0830
## 444 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.2500
## 445 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.5000
## 446 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.0000
## 447 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.0000
## 448 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.0000
## 449 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.0000
## 450 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.0000
## 451 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.0000
## 452 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.0000
## 453 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.0000
## 454 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.0830
## 455 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.0830
## 456 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.2500
## 457 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.5000
## 458 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.0000
## 459 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.0000
## 460 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.0000
## 461 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.0000
## 462 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.0000
## 463 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.0000
## 464 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.0000
## 465 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.0000
## 466 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.0830
## 467 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.0830
## 468 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.2500
## 469 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.5000
## 470 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.0000
## 471 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.0000
## 472 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.0000
## 473 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.0000
## 474 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.0000
## 475 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.0000
## 476 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.0000
## 477 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.0000
## 478 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.0830
## 479 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.0830
## 480 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.2500
## 481 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.5000
## 482 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.0000
## 483 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.0000
## 484 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.0000
## 485 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.0000
## 486 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.0000
## 487 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.0000
## 488 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.0000
## 489 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.0000
## 490 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.0830
## 491 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.0830
## 492 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.2500
## 493 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.5000
## 494 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.0000
## 495 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.0000
## 496 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.0000
## 497 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.0000
## 498 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.0000
## 499 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.0000
## 500 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.0000
## 501 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.0000
## 502 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.0830
## 503 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.0830
## 504 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.2500
## 505 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.5000
## 506 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.0000
## 507 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.0000
## 508 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.0000
## 509 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.0000
## 510 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.0000
## 511 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.0000
## 512 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.0000
## 513 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.0000
## 514 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.0830
## 515 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.0830
## 516 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.2500
## 517 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.5000
## 518 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.0000
## 519 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.0000
## 520 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.0000
## 521 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.0000
## 522 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.0000
## 523 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.0000
## 524 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.0000
## 525 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.0000
##     DURATION                        NAME   VALUE VALUETXT  UNIT  LLOQ ROUTE II
## 1          0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 2          0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 3          0 Plasma concentration IQ0815 0.00153     <NA> ug/mL 0.001  <NA>  0
## 4          0 Plasma concentration IQ0815 0.00350     <NA> ug/mL 0.001  <NA>  0
## 5          0 Plasma concentration IQ0815 0.00380     <NA> ug/mL 0.001  <NA>  0
## 6          0 Plasma concentration IQ0815 0.00333     <NA> ug/mL 0.001  <NA>  0
## 7          0 Plasma concentration IQ0815 0.00291     <NA> ug/mL 0.001  <NA>  0
## 8          0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 9          0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 10         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 11         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 12         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 13         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 14         0 Plasma concentration IQ0815 0.00138     <NA> ug/mL 0.001  <NA>  0
## 15         0 Plasma concentration IQ0815 0.00212     <NA> ug/mL 0.001  <NA>  0
## 16         0 Plasma concentration IQ0815 0.00359     <NA> ug/mL 0.001  <NA>  0
## 17         0 Plasma concentration IQ0815 0.00542     <NA> ug/mL 0.001  <NA>  0
## 18         0 Plasma concentration IQ0815 0.00526     <NA> ug/mL 0.001  <NA>  0
## 19         0 Plasma concentration IQ0815 0.00391     <NA> ug/mL 0.001  <NA>  0
## 20         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 21         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 22         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 23         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 24         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 25         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 26         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 27         0 Plasma concentration IQ0815 0.00168     <NA> ug/mL 0.001  <NA>  0
## 28         0 Plasma concentration IQ0815 0.00168     <NA> ug/mL 0.001  <NA>  0
## 29         0 Plasma concentration IQ0815 0.00221     <NA> ug/mL 0.001  <NA>  0
## 30         0 Plasma concentration IQ0815 0.00307     <NA> ug/mL 0.001  <NA>  0
## 31         0 Plasma concentration IQ0815 0.00133     <NA> ug/mL 0.001  <NA>  0
## 32         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 33         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 34         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 35         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 36         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 37         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 38         0 Plasma concentration IQ0815 0.00128     <NA> ug/mL 0.001  <NA>  0
## 39         0 Plasma concentration IQ0815 0.00220     <NA> ug/mL 0.001  <NA>  0
## 40         0 Plasma concentration IQ0815 0.00278     <NA> ug/mL 0.001  <NA>  0
## 41         0 Plasma concentration IQ0815 0.00221     <NA> ug/mL 0.001  <NA>  0
## 42         0 Plasma concentration IQ0815 0.00153     <NA> ug/mL 0.001  <NA>  0
## 43         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 44         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 45         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 46         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 47         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 48         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 49         0 Plasma concentration IQ0815 0.00174     <NA> ug/mL 0.001  <NA>  0
## 50         0 Plasma concentration IQ0815 0.00299     <NA> ug/mL 0.001  <NA>  0
## 51         0 Plasma concentration IQ0815 0.00555     <NA> ug/mL 0.001  <NA>  0
## 52         0 Plasma concentration IQ0815 0.00780     <NA> ug/mL 0.001  <NA>  0
## 53         0 Plasma concentration IQ0815 0.00706     <NA> ug/mL 0.001  <NA>  0
## 54         0 Plasma concentration IQ0815 0.00526     <NA> ug/mL 0.001  <NA>  0
## 55         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 56         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 57         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 58         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 59         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 60         0 Plasma concentration IQ0815 0.00123     <NA> ug/mL 0.001  <NA>  0
## 61         0 Plasma concentration IQ0815 0.00238     <NA> ug/mL 0.001  <NA>  0
## 62         0 Plasma concentration IQ0815 0.00480     <NA> ug/mL 0.001  <NA>  0
## 63         0 Plasma concentration IQ0815 0.00672     <NA> ug/mL 0.001  <NA>  0
## 64         0 Plasma concentration IQ0815 0.00509     <NA> ug/mL 0.001  <NA>  0
## 65         0 Plasma concentration IQ0815 0.00396     <NA> ug/mL 0.001  <NA>  0
## 66         0 Plasma concentration IQ0815 0.00160     <NA> ug/mL 0.001  <NA>  0
## 67         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 68         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 69         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 70         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 71         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 72         0 Plasma concentration IQ0815 0.00157     <NA> ug/mL 0.001  <NA>  0
## 73         0 Plasma concentration IQ0815 0.00205     <NA> ug/mL 0.001  <NA>  0
## 74         0 Plasma concentration IQ0815 0.00446     <NA> ug/mL 0.001  <NA>  0
## 75         0 Plasma concentration IQ0815 0.00462     <NA> ug/mL 0.001  <NA>  0
## 76         0 Plasma concentration IQ0815 0.00555     <NA> ug/mL 0.001  <NA>  0
## 77         0 Plasma concentration IQ0815 0.00329     <NA> ug/mL 0.001  <NA>  0
## 78         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 79         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 80         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 81         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 82         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 83         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 84         0 Plasma concentration IQ0815 0.00127     <NA> ug/mL 0.001  <NA>  0
## 85         0 Plasma concentration IQ0815 0.00345     <NA> ug/mL 0.001  <NA>  0
## 86         0 Plasma concentration IQ0815 0.00491     <NA> ug/mL 0.001  <NA>  0
## 87         0 Plasma concentration IQ0815 0.00692     <NA> ug/mL 0.001  <NA>  0
## 88         0 Plasma concentration IQ0815 0.00736     <NA> ug/mL 0.001  <NA>  0
## 89         0 Plasma concentration IQ0815 0.00420     <NA> ug/mL 0.001  <NA>  0
## 90         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 91         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 92         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 93         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 94         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 95         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 96         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 97         0 Plasma concentration IQ0815 0.00380     <NA> ug/mL 0.001  <NA>  0
## 98         0 Plasma concentration IQ0815 0.00510     <NA> ug/mL 0.001  <NA>  0
## 99         0 Plasma concentration IQ0815 0.00396     <NA> ug/mL 0.001  <NA>  0
## 100        0 Plasma concentration IQ0815 0.00596     <NA> ug/mL 0.001  <NA>  0
## 101        0 Plasma concentration IQ0815 0.00445     <NA> ug/mL 0.001  <NA>  0
## 102        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 103        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 104        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 105        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 106        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 107        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 108        0 Plasma concentration IQ0815 0.00593     <NA> ug/mL 0.001  <NA>  0
## 109        0 Plasma concentration IQ0815 0.01100     <NA> ug/mL 0.001  <NA>  0
## 110        0 Plasma concentration IQ0815 0.02130     <NA> ug/mL 0.001  <NA>  0
## 111        0 Plasma concentration IQ0815 0.02640     <NA> ug/mL 0.001  <NA>  0
## 112        0 Plasma concentration IQ0815 0.02360     <NA> ug/mL 0.001  <NA>  0
## 113        0 Plasma concentration IQ0815 0.00808     <NA> ug/mL 0.001  <NA>  0
## 114        0 Plasma concentration IQ0815 0.00128     <NA> ug/mL 0.001  <NA>  0
## 115        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 116        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 117        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 118        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 119        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 120        0 Plasma concentration IQ0815 0.00428     <NA> ug/mL 0.001  <NA>  0
## 121        0 Plasma concentration IQ0815 0.01080     <NA> ug/mL 0.001  <NA>  0
## 122        0 Plasma concentration IQ0815 0.01920     <NA> ug/mL 0.001  <NA>  0
## 123        0 Plasma concentration IQ0815 0.01960     <NA> ug/mL 0.001  <NA>  0
## 124        0 Plasma concentration IQ0815 0.01400     <NA> ug/mL 0.001  <NA>  0
## 125        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 126        0 Plasma concentration IQ0815 0.00112     <NA> ug/mL 0.001  <NA>  0
## 127        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 128        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 129        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 130        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 131        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 132        0 Plasma concentration IQ0815 0.00174     <NA> ug/mL 0.001  <NA>  0
## 133        0 Plasma concentration IQ0815 0.00432     <NA> ug/mL 0.001  <NA>  0
## 134        0 Plasma concentration IQ0815 0.00766     <NA> ug/mL 0.001  <NA>  0
## 135        0 Plasma concentration IQ0815 0.01030     <NA> ug/mL 0.001  <NA>  0
## 136        0 Plasma concentration IQ0815 0.00802     <NA> ug/mL 0.001  <NA>  0
## 137        0 Plasma concentration IQ0815 0.00742     <NA> ug/mL 0.001  <NA>  0
## 138        0 Plasma concentration IQ0815 0.00300     <NA> ug/mL 0.001  <NA>  0
## 139        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 140        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 141        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 142        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 143        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 144        0 Plasma concentration IQ0815 0.00370     <NA> ug/mL 0.001  <NA>  0
## 145        0 Plasma concentration IQ0815 0.00826     <NA> ug/mL 0.001  <NA>  0
## 146        0 Plasma concentration IQ0815 0.01440     <NA> ug/mL 0.001  <NA>  0
## 147        0 Plasma concentration IQ0815 0.01460     <NA> ug/mL 0.001  <NA>  0
## 148        0 Plasma concentration IQ0815 0.01770     <NA> ug/mL 0.001  <NA>  0
## 149        0 Plasma concentration IQ0815 0.00857     <NA> ug/mL 0.001  <NA>  0
## 150        0 Plasma concentration IQ0815 0.00199     <NA> ug/mL 0.001  <NA>  0
## 151        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 152        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 153        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 154        0 Plasma concentration IQ0815 0.00101     <NA> ug/mL 0.001  <NA>  0
## 155        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 156        0 Plasma concentration IQ0815 0.00386     <NA> ug/mL 0.001  <NA>  0
## 157        0 Plasma concentration IQ0815 0.00888     <NA> ug/mL 0.001  <NA>  0
## 158        0 Plasma concentration IQ0815 0.01700     <NA> ug/mL 0.001  <NA>  0
## 159        0 Plasma concentration IQ0815 0.01830     <NA> ug/mL 0.001  <NA>  0
## 160        0 Plasma concentration IQ0815 0.01980     <NA> ug/mL 0.001  <NA>  0
## 161        0 Plasma concentration IQ0815 0.00950     <NA> ug/mL 0.001  <NA>  0
## 162        0 Plasma concentration IQ0815 0.00334     <NA> ug/mL 0.001  <NA>  0
## 163        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 164        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 165        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 166        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 167        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 168        0 Plasma concentration IQ0815 0.00689     <NA> ug/mL 0.001  <NA>  0
## 169        0 Plasma concentration IQ0815 0.01530     <NA> ug/mL 0.001  <NA>  0
## 170        0 Plasma concentration IQ0815 0.02390     <NA> ug/mL 0.001  <NA>  0
## 171        0 Plasma concentration IQ0815 0.04110     <NA> ug/mL 0.001  <NA>  0
## 172        0 Plasma concentration IQ0815 0.03820     <NA> ug/mL 0.001  <NA>  0
## 173        0 Plasma concentration IQ0815 0.02730     <NA> ug/mL 0.001  <NA>  0
## 174        0 Plasma concentration IQ0815 0.00528     <NA> ug/mL 0.001  <NA>  0
## 175        0 Plasma concentration IQ0815 0.00198     <NA> ug/mL 0.001  <NA>  0
## 176        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 177        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 178        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 179        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 180        0 Plasma concentration IQ0815 0.00515     <NA> ug/mL 0.001  <NA>  0
## 181        0 Plasma concentration IQ0815 0.01130     <NA> ug/mL 0.001  <NA>  0
## 182        0 Plasma concentration IQ0815 0.01910     <NA> ug/mL 0.001  <NA>  0
## 183        0 Plasma concentration IQ0815 0.03580     <NA> ug/mL 0.001  <NA>  0
## 184        0 Plasma concentration IQ0815 0.02670     <NA> ug/mL 0.001  <NA>  0
## 185        0 Plasma concentration IQ0815 0.01850     <NA> ug/mL 0.001  <NA>  0
## 186        0 Plasma concentration IQ0815 0.00755     <NA> ug/mL 0.001  <NA>  0
## 187        0 Plasma concentration IQ0815 0.00219     <NA> ug/mL 0.001  <NA>  0
## 188        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 189        0 Plasma concentration IQ0815 0.00101     <NA> ug/mL 0.001  <NA>  0
## 190        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 191        0 Plasma concentration IQ0815 0.00374     <NA> ug/mL 0.001  <NA>  0
## 192        0 Plasma concentration IQ0815 0.00866     <NA> ug/mL 0.001  <NA>  0
## 193        0 Plasma concentration IQ0815 0.01570     <NA> ug/mL 0.001  <NA>  0
## 194        0 Plasma concentration IQ0815 0.01960     <NA> ug/mL 0.001  <NA>  0
## 195        0 Plasma concentration IQ0815 0.02190     <NA> ug/mL 0.001  <NA>  0
## 196        0 Plasma concentration IQ0815 0.02200     <NA> ug/mL 0.001  <NA>  0
## 197        0 Plasma concentration IQ0815 0.00786     <NA> ug/mL 0.001  <NA>  0
## 198        0 Plasma concentration IQ0815 0.00382     <NA> ug/mL 0.001  <NA>  0
## 199        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 200        0 Plasma concentration IQ0815 0.00108     <NA> ug/mL 0.001  <NA>  0
## 201        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 202        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 203        0 Plasma concentration IQ0815 0.00241     <NA> ug/mL 0.001  <NA>  0
## 204        0 Plasma concentration IQ0815 0.01060     <NA> ug/mL 0.001  <NA>  0
## 205        0 Plasma concentration IQ0815 0.01630     <NA> ug/mL 0.001  <NA>  0
## 206        0 Plasma concentration IQ0815 0.02530     <NA> ug/mL 0.001  <NA>  0
## 207        0 Plasma concentration IQ0815 0.20500     <NA> ug/mL 0.001  <NA>  0
## 208        0 Plasma concentration IQ0815 0.01860     <NA> ug/mL 0.001  <NA>  0
## 209        0 Plasma concentration IQ0815 0.00534     <NA> ug/mL 0.001  <NA>  0
## 210        0 Plasma concentration IQ0815 0.00213     <NA> ug/mL 0.001  <NA>  0
## 211        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 212        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 213        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 214        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 215        0 Plasma concentration IQ0815 0.00905     <NA> ug/mL 0.001  <NA>  0
## 216        0 Plasma concentration IQ0815 0.02640     <NA> ug/mL 0.001  <NA>  0
## 217        0 Plasma concentration IQ0815 0.03400     <NA> ug/mL 0.001  <NA>  0
## 218        0 Plasma concentration IQ0815 0.04700     <NA> ug/mL 0.001  <NA>  0
## 219        0 Plasma concentration IQ0815 0.03710     <NA> ug/mL 0.001  <NA>  0
## 220        0 Plasma concentration IQ0815 0.02450     <NA> ug/mL 0.001  <NA>  0
## 221        0 Plasma concentration IQ0815 0.00779     <NA> ug/mL 0.001  <NA>  0
## 222        0 Plasma concentration IQ0815 0.00116     <NA> ug/mL 0.001  <NA>  0
## 223        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 224        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 225        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 226        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 227        0 Plasma concentration IQ0815 0.00433     <NA> ug/mL 0.001  <NA>  0
## 228        0 Plasma concentration IQ0815 0.01200     <NA> ug/mL 0.001  <NA>  0
## 229        0 Plasma concentration IQ0815 0.01940     <NA> ug/mL 0.001  <NA>  0
## 230        0 Plasma concentration IQ0815 0.03030     <NA> ug/mL 0.001  <NA>  0
## 231        0 Plasma concentration IQ0815 0.03300     <NA> ug/mL 0.001  <NA>  0
## 232        0 Plasma concentration IQ0815 0.02270     <NA> ug/mL 0.001  <NA>  0
## 233        0 Plasma concentration IQ0815 0.00835     <NA> ug/mL 0.001  <NA>  0
## 234        0 Plasma concentration IQ0815 0.00266     <NA> ug/mL 0.001  <NA>  0
## 235        0 Plasma concentration IQ0815 0.00241     <NA> ug/mL 0.001  <NA>  0
## 236        0 Plasma concentration IQ0815 0.00127     <NA> ug/mL 0.001  <NA>  0
## 237        0 Plasma concentration IQ0815 0.00124     <NA> ug/mL 0.001  <NA>  0
## 238        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 239        0 Plasma concentration IQ0815 0.01190     <NA> ug/mL 0.001  <NA>  0
## 240        0 Plasma concentration IQ0815 0.03410     <NA> ug/mL 0.001  <NA>  0
## 241        0 Plasma concentration IQ0815 0.05540     <NA> ug/mL 0.001  <NA>  0
## 242        0 Plasma concentration IQ0815 0.05080     <NA> ug/mL 0.001  <NA>  0
## 243        0 Plasma concentration IQ0815 0.05230     <NA> ug/mL 0.001  <NA>  0
## 244        0 Plasma concentration IQ0815 0.03200     <NA> ug/mL 0.001  <NA>  0
## 245        0 Plasma concentration IQ0815 0.01060     <NA> ug/mL 0.001  <NA>  0
## 246        0 Plasma concentration IQ0815 0.00196     <NA> ug/mL 0.001  <NA>  0
## 247        0 Plasma concentration IQ0815 0.00168     <NA> ug/mL 0.001  <NA>  0
## 248        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 249        0 Plasma concentration IQ0815 0.00117     <NA> ug/mL 0.001  <NA>  0
## 250        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 251        0 Plasma concentration IQ0815 0.00936     <NA> ug/mL 0.001  <NA>  0
## 252        0 Plasma concentration IQ0815 0.02200     <NA> ug/mL 0.001  <NA>  0
## 253        0 Plasma concentration IQ0815 0.03310     <NA> ug/mL 0.001  <NA>  0
## 254        0 Plasma concentration IQ0815 0.05420     <NA> ug/mL 0.001  <NA>  0
## 255        0 Plasma concentration IQ0815 0.05030     <NA> ug/mL 0.001  <NA>  0
## 256        0 Plasma concentration IQ0815 0.04100     <NA> ug/mL 0.001  <NA>  0
## 257        0 Plasma concentration IQ0815 0.01170     <NA> ug/mL 0.001  <NA>  0
## 258        0 Plasma concentration IQ0815 0.00311     <NA> ug/mL 0.001  <NA>  0
## 259        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 260        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 261        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 262        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 263        0 Plasma concentration IQ0815 0.01390     <NA> ug/mL 0.001  <NA>  0
## 264        0 Plasma concentration IQ0815 0.03260     <NA> ug/mL 0.001  <NA>  0
## 265        0 Plasma concentration IQ0815 0.05050     <NA> ug/mL 0.001  <NA>  0
## 266        0 Plasma concentration IQ0815 0.06240     <NA> ug/mL 0.001  <NA>  0
## 267        0 Plasma concentration IQ0815 0.05440     <NA> ug/mL 0.001  <NA>  0
## 268        0 Plasma concentration IQ0815 0.03180     <NA> ug/mL 0.001  <NA>  0
## 269        0 Plasma concentration IQ0815 0.00749     <NA> ug/mL 0.001  <NA>  0
## 270        0 Plasma concentration IQ0815 0.00232     <NA> ug/mL 0.001  <NA>  0
## 271        0 Plasma concentration IQ0815 0.00309     <NA> ug/mL 0.001  <NA>  0
## 272        0 Plasma concentration IQ0815 0.00261     <NA> ug/mL 0.001  <NA>  0
## 273        0 Plasma concentration IQ0815 0.00165     <NA> ug/mL 0.001  <NA>  0
## 274        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 275        0 Plasma concentration IQ0815 0.00609     <NA> ug/mL 0.001  <NA>  0
## 276        0 Plasma concentration IQ0815 0.01570     <NA> ug/mL 0.001  <NA>  0
## 277        0 Plasma concentration IQ0815 0.02970     <NA> ug/mL 0.001  <NA>  0
## 278        0 Plasma concentration IQ0815 0.05030     <NA> ug/mL 0.001  <NA>  0
## 279        0 Plasma concentration IQ0815 0.04650     <NA> ug/mL 0.001  <NA>  0
## 280        0 Plasma concentration IQ0815 0.04090     <NA> ug/mL 0.001  <NA>  0
## 281        0 Plasma concentration IQ0815 0.00898     <NA> ug/mL 0.001  <NA>  0
## 282        0 Plasma concentration IQ0815 0.00265     <NA> ug/mL 0.001  <NA>  0
## 283        0 Plasma concentration IQ0815 0.00169     <NA> ug/mL 0.001  <NA>  0
## 284        0 Plasma concentration IQ0815 0.00170     <NA> ug/mL 0.001  <NA>  0
## 285        0 Plasma concentration IQ0815 0.00145     <NA> ug/mL 0.001  <NA>  0
## 286        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 287        0 Plasma concentration IQ0815 0.00971     <NA> ug/mL 0.001  <NA>  0
## 288        0 Plasma concentration IQ0815 0.02690     <NA> ug/mL 0.001  <NA>  0
## 289        0 Plasma concentration IQ0815 0.04840     <NA> ug/mL 0.001  <NA>  0
## 290        0 Plasma concentration IQ0815 0.06530     <NA> ug/mL 0.001  <NA>  0
## 291        0 Plasma concentration IQ0815 0.05790     <NA> ug/mL 0.001  <NA>  0
## 292        0 Plasma concentration IQ0815 0.03360     <NA> ug/mL 0.001  <NA>  0
## 293        0 Plasma concentration IQ0815 0.00991     <NA> ug/mL 0.001  <NA>  0
## 294        0 Plasma concentration IQ0815 0.00188     <NA> ug/mL 0.001  <NA>  0
## 295        0 Plasma concentration IQ0815 0.00296     <NA> ug/mL 0.001  <NA>  0
## 296        0 Plasma concentration IQ0815 0.00149     <NA> ug/mL 0.001  <NA>  0
## 297        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 298        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 299        0 Plasma concentration IQ0815 0.01290     <NA> ug/mL 0.001  <NA>  0
## 300        0 Plasma concentration IQ0815 0.03290     <NA> ug/mL 0.001  <NA>  0
## 301        0 Plasma concentration IQ0815 0.04310     <NA> ug/mL 0.001  <NA>  0
## 302        0 Plasma concentration IQ0815 0.05360     <NA> ug/mL 0.001  <NA>  0
## 303        0 Plasma concentration IQ0815 0.05700     <NA> ug/mL 0.001  <NA>  0
## 304        0 Plasma concentration IQ0815 0.04370     <NA> ug/mL 0.001  <NA>  0
## 305        0 Plasma concentration IQ0815 0.01170     <NA> ug/mL 0.001  <NA>  0
## 306        0 Plasma concentration IQ0815 0.00297     <NA> ug/mL 0.001  <NA>  0
## 307        0 Plasma concentration IQ0815 0.00114     <NA> ug/mL 0.001  <NA>  0
## 308        0 Plasma concentration IQ0815 0.00131     <NA> ug/mL 0.001  <NA>  0
## 309        0 Plasma concentration IQ0815 0.00121     <NA> ug/mL 0.001  <NA>  0
## 310        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 311        0 Plasma concentration IQ0815 0.01480     <NA> ug/mL 0.001  <NA>  0
## 312        0 Plasma concentration IQ0815 0.03720     <NA> ug/mL 0.001  <NA>  0
## 313        0 Plasma concentration IQ0815 0.06000     <NA> ug/mL 0.001  <NA>  0
## 314        0 Plasma concentration IQ0815 0.08750     <NA> ug/mL 0.001  <NA>  0
## 315        0 Plasma concentration IQ0815 0.07030     <NA> ug/mL 0.001  <NA>  0
## 316        0 Plasma concentration IQ0815 0.07920     <NA> ug/mL 0.001  <NA>  0
## 317        0 Plasma concentration IQ0815 0.02850     <NA> ug/mL 0.001  <NA>  0
## 318        0 Plasma concentration IQ0815 0.00963     <NA> ug/mL 0.001  <NA>  0
## 319        0 Plasma concentration IQ0815 0.00283     <NA> ug/mL 0.001  <NA>  0
## 320        0 Plasma concentration IQ0815 0.00248     <NA> ug/mL 0.001  <NA>  0
## 321        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 322        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 323        0 Plasma concentration IQ0815 0.04720     <NA> ug/mL 0.001  <NA>  0
## 324        0 Plasma concentration IQ0815 0.11400     <NA> ug/mL 0.001  <NA>  0
## 325        0 Plasma concentration IQ0815 0.15200     <NA> ug/mL 0.001  <NA>  0
## 326        0 Plasma concentration IQ0815 0.17300     <NA> ug/mL 0.001  <NA>  0
## 327        0 Plasma concentration IQ0815 0.14500     <NA> ug/mL 0.001  <NA>  0
## 328        0 Plasma concentration IQ0815 0.10100     <NA> ug/mL 0.001  <NA>  0
## 329        0 Plasma concentration IQ0815 0.01950     <NA> ug/mL 0.001  <NA>  0
## 330        0 Plasma concentration IQ0815 0.00940     <NA> ug/mL 0.001  <NA>  0
## 331        0 Plasma concentration IQ0815 0.00528     <NA> ug/mL 0.001  <NA>  0
## 332        0 Plasma concentration IQ0815 0.00482     <NA> ug/mL 0.001  <NA>  0
## 333        0 Plasma concentration IQ0815 0.00229     <NA> ug/mL 0.001  <NA>  0
## 334        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 335        0 Plasma concentration IQ0815 0.02670     <NA> ug/mL 0.001  <NA>  0
## 336        0 Plasma concentration IQ0815 0.06480     <NA> ug/mL 0.001  <NA>  0
## 337        0 Plasma concentration IQ0815 0.11000     <NA> ug/mL 0.001  <NA>  0
## 338        0 Plasma concentration IQ0815 0.12500     <NA> ug/mL 0.001  <NA>  0
## 339        0 Plasma concentration IQ0815 0.14300     <NA> ug/mL 0.001  <NA>  0
## 340        0 Plasma concentration IQ0815 0.06950     <NA> ug/mL 0.001  <NA>  0
## 341        0 Plasma concentration IQ0815 0.01640     <NA> ug/mL 0.001  <NA>  0
## 342        0 Plasma concentration IQ0815 0.00447     <NA> ug/mL 0.001  <NA>  0
## 343        0 Plasma concentration IQ0815 0.00313     <NA> ug/mL 0.001  <NA>  0
## 344        0 Plasma concentration IQ0815 0.00299     <NA> ug/mL 0.001  <NA>  0
## 345        0 Plasma concentration IQ0815 0.00201     <NA> ug/mL 0.001  <NA>  0
## 346        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 347        0 Plasma concentration IQ0815 0.01730     <NA> ug/mL 0.001  <NA>  0
## 348        0 Plasma concentration IQ0815 0.04370     <NA> ug/mL 0.001  <NA>  0
## 349        0 Plasma concentration IQ0815 0.07930     <NA> ug/mL 0.001  <NA>  0
## 350        0 Plasma concentration IQ0815 0.08940     <NA> ug/mL 0.001  <NA>  0
## 351        0 Plasma concentration IQ0815 0.09610     <NA> ug/mL 0.001  <NA>  0
## 352        0 Plasma concentration IQ0815 0.07590     <NA> ug/mL 0.001  <NA>  0
## 353        0 Plasma concentration IQ0815 0.01350     <NA> ug/mL 0.001  <NA>  0
## 354        0 Plasma concentration IQ0815 0.00340     <NA> ug/mL 0.001  <NA>  0
## 355        0 Plasma concentration IQ0815 0.00208     <NA> ug/mL 0.001  <NA>  0
## 356        0 Plasma concentration IQ0815 0.00112     <NA> ug/mL 0.001  <NA>  0
## 357        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 358        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 359        0 Plasma concentration IQ0815 0.04720     <NA> ug/mL 0.001  <NA>  0
## 360        0 Plasma concentration IQ0815 0.10600     <NA> ug/mL 0.001  <NA>  0
## 361        0 Plasma concentration IQ0815 0.13700     <NA> ug/mL 0.001  <NA>  0
## 362        0 Plasma concentration IQ0815 0.18200     <NA> ug/mL 0.001  <NA>  0
## 363        0 Plasma concentration IQ0815 0.16700     <NA> ug/mL 0.001  <NA>  0
## 364        0 Plasma concentration IQ0815 0.09100     <NA> ug/mL 0.001  <NA>  0
## 365        0 Plasma concentration IQ0815 0.01220     <NA> ug/mL 0.001  <NA>  0
## 366        0 Plasma concentration IQ0815 0.00554     <NA> ug/mL 0.001  <NA>  0
## 367        0 Plasma concentration IQ0815 0.00404     <NA> ug/mL 0.001  <NA>  0
## 368        0 Plasma concentration IQ0815 0.00415     <NA> ug/mL 0.001  <NA>  0
## 369        0 Plasma concentration IQ0815 0.00204     <NA> ug/mL 0.001  <NA>  0
## 370        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 371        0 Plasma concentration IQ0815 0.03750     <NA> ug/mL 0.001  <NA>  0
## 372        0 Plasma concentration IQ0815 0.08430     <NA> ug/mL 0.001  <NA>  0
## 373        0 Plasma concentration IQ0815 0.13000     <NA> ug/mL 0.001  <NA>  0
## 374        0 Plasma concentration IQ0815 0.22300     <NA> ug/mL 0.001  <NA>  0
## 375        0 Plasma concentration IQ0815 0.19500     <NA> ug/mL 0.001  <NA>  0
## 376        0 Plasma concentration IQ0815 0.14900     <NA> ug/mL 0.001  <NA>  0
## 377        0 Plasma concentration IQ0815 0.02950     <NA> ug/mL 0.001  <NA>  0
## 378        0 Plasma concentration IQ0815 0.00783     <NA> ug/mL 0.001  <NA>  0
## 379        0 Plasma concentration IQ0815 0.00447     <NA> ug/mL 0.001  <NA>  0
## 380        0 Plasma concentration IQ0815 0.00439     <NA> ug/mL 0.001  <NA>  0
## 381        0 Plasma concentration IQ0815 0.00191     <NA> ug/mL 0.001  <NA>  0
## 382        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 383        0 Plasma concentration IQ0815 0.03800     <NA> ug/mL 0.001  <NA>  0
## 384        0 Plasma concentration IQ0815 0.11800     <NA> ug/mL 0.001  <NA>  0
## 385        0 Plasma concentration IQ0815 0.15600     <NA> ug/mL 0.001  <NA>  0
## 386        0 Plasma concentration IQ0815 0.26800     <NA> ug/mL 0.001  <NA>  0
## 387        0 Plasma concentration IQ0815 0.22600     <NA> ug/mL 0.001  <NA>  0
## 388        0 Plasma concentration IQ0815 0.18700     <NA> ug/mL 0.001  <NA>  0
## 389        0 Plasma concentration IQ0815 0.07220     <NA> ug/mL 0.001  <NA>  0
## 390        0 Plasma concentration IQ0815 0.01980     <NA> ug/mL 0.001  <NA>  0
## 391        0 Plasma concentration IQ0815 0.00557     <NA> ug/mL 0.001  <NA>  0
## 392        0 Plasma concentration IQ0815 0.00625     <NA> ug/mL 0.001  <NA>  0
## 393        0 Plasma concentration IQ0815 0.00489     <NA> ug/mL 0.001  <NA>  0
## 394        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 395        0 Plasma concentration IQ0815 0.05450     <NA> ug/mL 0.001  <NA>  0
## 396        0 Plasma concentration IQ0815 0.17100     <NA> ug/mL 0.001  <NA>  0
## 397        0 Plasma concentration IQ0815 0.25400     <NA> ug/mL 0.001  <NA>  0
## 398        0 Plasma concentration IQ0815 0.25600     <NA> ug/mL 0.001  <NA>  0
## 399        0 Plasma concentration IQ0815 0.25300     <NA> ug/mL 0.001  <NA>  0
## 400        0 Plasma concentration IQ0815 0.20200     <NA> ug/mL 0.001  <NA>  0
## 401        0 Plasma concentration IQ0815 0.09480     <NA> ug/mL 0.001  <NA>  0
## 402        0 Plasma concentration IQ0815 0.02510     <NA> ug/mL 0.001  <NA>  0
## 403        0 Plasma concentration IQ0815 0.00726     <NA> ug/mL 0.001  <NA>  0
## 404        0 Plasma concentration IQ0815 0.00550     <NA> ug/mL 0.001  <NA>  0
## 405        0 Plasma concentration IQ0815 0.00584     <NA> ug/mL 0.001  <NA>  0
## 406        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 407        0 Plasma concentration IQ0815 0.07300     <NA> ug/mL 0.001  <NA>  0
## 408        0 Plasma concentration IQ0815 0.19400     <NA> ug/mL 0.001  <NA>  0
## 409        0 Plasma concentration IQ0815 0.25700     <NA> ug/mL 0.001  <NA>  0
## 410        0 Plasma concentration IQ0815 0.41900     <NA> ug/mL 0.001  <NA>  0
## 411        0 Plasma concentration IQ0815 0.43900     <NA> ug/mL 0.001  <NA>  0
## 412        0 Plasma concentration IQ0815 0.32000     <NA> ug/mL 0.001  <NA>  0
## 413        0 Plasma concentration IQ0815 0.05640     <NA> ug/mL 0.001  <NA>  0
## 414        0 Plasma concentration IQ0815 0.01690     <NA> ug/mL 0.001  <NA>  0
## 415        0 Plasma concentration IQ0815 0.01180     <NA> ug/mL 0.001  <NA>  0
## 416        0 Plasma concentration IQ0815 0.00834     <NA> ug/mL 0.001  <NA>  0
## 417        0 Plasma concentration IQ0815 0.00685     <NA> ug/mL 0.001  <NA>  0
## 418        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 419        0 Plasma concentration IQ0815 0.08670     <NA> ug/mL 0.001  <NA>  0
## 420        0 Plasma concentration IQ0815 0.20300     <NA> ug/mL 0.001  <NA>  0
## 421        0 Plasma concentration IQ0815 0.29300     <NA> ug/mL 0.001  <NA>  0
## 422        0 Plasma concentration IQ0815 0.33400     <NA> ug/mL 0.001  <NA>  0
## 423        0 Plasma concentration IQ0815 0.29100     <NA> ug/mL 0.001  <NA>  0
## 424        0 Plasma concentration IQ0815 0.24300     <NA> ug/mL 0.001  <NA>  0
## 425        0 Plasma concentration IQ0815 0.05680     <NA> ug/mL 0.001  <NA>  0
## 426        0 Plasma concentration IQ0815 0.01150     <NA> ug/mL 0.001  <NA>  0
## 427        0 Plasma concentration IQ0815 0.00503     <NA> ug/mL 0.001  <NA>  0
## 428        0 Plasma concentration IQ0815 0.00278     <NA> ug/mL 0.001  <NA>  0
## 429        0 Plasma concentration IQ0815 0.00216     <NA> ug/mL 0.001  <NA>  0
## 430        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 431        0 Plasma concentration IQ0815 0.06290     <NA> ug/mL 0.001  <NA>  0
## 432        0 Plasma concentration IQ0815 0.14200     <NA> ug/mL 0.001  <NA>  0
## 433        0 Plasma concentration IQ0815 0.21500     <NA> ug/mL 0.001  <NA>  0
## 434        0 Plasma concentration IQ0815 0.31800     <NA> ug/mL 0.001  <NA>  0
## 435        0 Plasma concentration IQ0815 0.25400     <NA> ug/mL 0.001  <NA>  0
## 436        0 Plasma concentration IQ0815 0.16900     <NA> ug/mL 0.001  <NA>  0
## 437        0 Plasma concentration IQ0815 0.02870     <NA> ug/mL 0.001  <NA>  0
## 438        0 Plasma concentration IQ0815 0.00977     <NA> ug/mL 0.001  <NA>  0
## 439        0 Plasma concentration IQ0815 0.00555     <NA> ug/mL 0.001  <NA>  0
## 440        0 Plasma concentration IQ0815 0.00413     <NA> ug/mL 0.001  <NA>  0
## 441        0 Plasma concentration IQ0815 0.00196     <NA> ug/mL 0.001  <NA>  0
## 442        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 443        0 Plasma concentration IQ0815 0.08270     <NA> ug/mL 0.001  <NA>  0
## 444        0 Plasma concentration IQ0815 0.20200     <NA> ug/mL 0.001  <NA>  0
## 445        0 Plasma concentration IQ0815 0.28400     <NA> ug/mL 0.001  <NA>  0
## 446        0 Plasma concentration IQ0815 0.31000     <NA> ug/mL 0.001  <NA>  0
## 447        0 Plasma concentration IQ0815 0.25600     <NA> ug/mL 0.001  <NA>  0
## 448        0 Plasma concentration IQ0815 0.18200     <NA> ug/mL 0.001  <NA>  0
## 449        0 Plasma concentration IQ0815 0.02720     <NA> ug/mL 0.001  <NA>  0
## 450        0 Plasma concentration IQ0815 0.01400     <NA> ug/mL 0.001  <NA>  0
## 451        0 Plasma concentration IQ0815 0.01130     <NA> ug/mL 0.001  <NA>  0
## 452        0 Plasma concentration IQ0815 0.00537     <NA> ug/mL 0.001  <NA>  0
## 453        0 Plasma concentration IQ0815 0.00258     <NA> ug/mL 0.001  <NA>  0
## 454        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 455        0 Plasma concentration IQ0815 0.16600     <NA> ug/mL 0.001  <NA>  0
## 456        0 Plasma concentration IQ0815 0.37400     <NA> ug/mL 0.001  <NA>  0
## 457        0 Plasma concentration IQ0815 0.50400     <NA> ug/mL 0.001  <NA>  0
## 458        0 Plasma concentration IQ0815 0.86200     <NA> ug/mL 0.001  <NA>  0
## 459        0 Plasma concentration IQ0815 0.78800     <NA> ug/mL 0.001  <NA>  0
## 460        0 Plasma concentration IQ0815 0.49000     <NA> ug/mL 0.001  <NA>  0
## 461        0 Plasma concentration IQ0815 0.14300     <NA> ug/mL 0.001  <NA>  0
## 462        0 Plasma concentration IQ0815 0.02110     <NA> ug/mL 0.001  <NA>  0
## 463        0 Plasma concentration IQ0815 0.00575     <NA> ug/mL 0.001  <NA>  0
## 464        0 Plasma concentration IQ0815 0.00667     <NA> ug/mL 0.001  <NA>  0
## 465        0 Plasma concentration IQ0815 0.00593     <NA> ug/mL 0.001  <NA>  0
## 466        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 467        0 Plasma concentration IQ0815 0.08550     <NA> ug/mL 0.001  <NA>  0
## 468        0 Plasma concentration IQ0815 0.18200     <NA> ug/mL 0.001  <NA>  0
## 469        0 Plasma concentration IQ0815 0.32300     <NA> ug/mL 0.001  <NA>  0
## 470        0 Plasma concentration IQ0815 0.43400     <NA> ug/mL 0.001  <NA>  0
## 471        0 Plasma concentration IQ0815 0.41700     <NA> ug/mL 0.001  <NA>  0
## 472        0 Plasma concentration IQ0815 0.23200     <NA> ug/mL 0.001  <NA>  0
## 473        0 Plasma concentration IQ0815 0.03960     <NA> ug/mL 0.001  <NA>  0
## 474        0 Plasma concentration IQ0815 0.00877     <NA> ug/mL 0.001  <NA>  0
## 475        0 Plasma concentration IQ0815 0.00778     <NA> ug/mL 0.001  <NA>  0
## 476        0 Plasma concentration IQ0815 0.00419     <NA> ug/mL 0.001  <NA>  0
## 477        0 Plasma concentration IQ0815 0.00410     <NA> ug/mL 0.001  <NA>  0
## 478        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 479        0 Plasma concentration IQ0815 0.17500     <NA> ug/mL 0.001  <NA>  0
## 480        0 Plasma concentration IQ0815 0.37600     <NA> ug/mL 0.001  <NA>  0
## 481        0 Plasma concentration IQ0815 0.59300     <NA> ug/mL 0.001  <NA>  0
## 482        0 Plasma concentration IQ0815 0.63500     <NA> ug/mL 0.001  <NA>  0
## 483        0 Plasma concentration IQ0815 0.51700     <NA> ug/mL 0.001  <NA>  0
## 484        0 Plasma concentration IQ0815 0.42900     <NA> ug/mL 0.001  <NA>  0
## 485        0 Plasma concentration IQ0815 0.09240     <NA> ug/mL 0.001  <NA>  0
## 486        0 Plasma concentration IQ0815 0.01930     <NA> ug/mL 0.001  <NA>  0
## 487        0 Plasma concentration IQ0815 0.01220     <NA> ug/mL 0.001  <NA>  0
## 488        0 Plasma concentration IQ0815 0.00661     <NA> ug/mL 0.001  <NA>  0
## 489        0 Plasma concentration IQ0815 0.00625     <NA> ug/mL 0.001  <NA>  0
## 490        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 491        0 Plasma concentration IQ0815 0.08050     <NA> ug/mL 0.001  <NA>  0
## 492        0 Plasma concentration IQ0815 0.19300     <NA> ug/mL 0.001  <NA>  0
## 493        0 Plasma concentration IQ0815 0.32400     <NA> ug/mL 0.001  <NA>  0
## 494        0 Plasma concentration IQ0815 0.54500     <NA> ug/mL 0.001  <NA>  0
## 495        0 Plasma concentration IQ0815 0.48700     <NA> ug/mL 0.001  <NA>  0
## 496        0 Plasma concentration IQ0815 0.32100     <NA> ug/mL 0.001  <NA>  0
## 497        0 Plasma concentration IQ0815 0.05940     <NA> ug/mL 0.001  <NA>  0
## 498        0 Plasma concentration IQ0815 0.01070     <NA> ug/mL 0.001  <NA>  0
## 499        0 Plasma concentration IQ0815 0.00319     <NA> ug/mL 0.001  <NA>  0
## 500        0 Plasma concentration IQ0815 0.00324     <NA> ug/mL 0.001  <NA>  0
## 501        0 Plasma concentration IQ0815 0.00277     <NA> ug/mL 0.001  <NA>  0
## 502        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 503        0 Plasma concentration IQ0815 0.11000     <NA> ug/mL 0.001  <NA>  0
## 504        0 Plasma concentration IQ0815 0.26500     <NA> ug/mL 0.001  <NA>  0
## 505        0 Plasma concentration IQ0815 0.42700     <NA> ug/mL 0.001  <NA>  0
## 506        0 Plasma concentration IQ0815 0.55200     <NA> ug/mL 0.001  <NA>  0
## 507        0 Plasma concentration IQ0815 0.43200     <NA> ug/mL 0.001  <NA>  0
## 508        0 Plasma concentration IQ0815 0.35400     <NA> ug/mL 0.001  <NA>  0
## 509        0 Plasma concentration IQ0815 0.09750     <NA> ug/mL 0.001  <NA>  0
## 510        0 Plasma concentration IQ0815 0.02520     <NA> ug/mL 0.001  <NA>  0
## 511        0 Plasma concentration IQ0815 0.01240     <NA> ug/mL 0.001  <NA>  0
## 512        0 Plasma concentration IQ0815 0.01140     <NA> ug/mL 0.001  <NA>  0
## 513        0 Plasma concentration IQ0815 0.00855     <NA> ug/mL 0.001  <NA>  0
## 514        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 515        0 Plasma concentration IQ0815 0.18300     <NA> ug/mL 0.001  <NA>  0
## 516        0 Plasma concentration IQ0815 0.50000     <NA> ug/mL 0.001  <NA>  0
## 517        0 Plasma concentration IQ0815 0.70600     <NA> ug/mL 0.001  <NA>  0
## 518        0 Plasma concentration IQ0815 0.98400     <NA> ug/mL 0.001  <NA>  0
## 519        0 Plasma concentration IQ0815 0.83000     <NA> ug/mL 0.001  <NA>  0
## 520        0 Plasma concentration IQ0815 0.59300     <NA> ug/mL 0.001  <NA>  0
## 521        0 Plasma concentration IQ0815 0.19600     <NA> ug/mL 0.001  <NA>  0
## 522        0 Plasma concentration IQ0815 0.05670     <NA> ug/mL 0.001  <NA>  0
## 523        0 Plasma concentration IQ0815 0.01880     <NA> ug/mL 0.001  <NA>  0
## 524        0 Plasma concentration IQ0815 0.01930     <NA> ug/mL 0.001  <NA>  0
## 525        0 Plasma concentration IQ0815 0.01510     <NA> ug/mL 0.001  <NA>  0
##     ADDL ID  TIMEPOS EVID MDV CENS AMT      DV TINF RATE ADM YTYPE      TAD
## 1      0  3 167.5833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 2      0  3 167.7493    0   0    1   0 0.00100    0    0   0     1   0.0830
## 3      0  3 167.9163    0   0    0   0 0.00153    0    0   0     1   0.2500
## 4      0  3 168.1663    0   0    0   0 0.00350    0    0   0     1   0.5000
## 5      0  3 168.6663    0   0    0   0 0.00380    0    0   0     1   1.0000
## 6      0  3 169.6663    0   0    0   0 0.00333    0    0   0     1   2.0000
## 7      0  3 171.6663    0   0    0   0 0.00291    0    0   0     1   4.0000
## 8      0  3 179.6663    0   0    1   0 0.00100    0    0   0     1  12.0000
## 9      0  3 191.6663    0   0    1   0 0.00100    0    0   0     1  24.0000
## 10     0  3 215.6663    0   0    1   0 0.00100    0    0   0     1  48.0000
## 11     0  3 263.6663    0   0    1   0 0.00100    0    0   0     1  96.0000
## 12     0  3 335.6663    0   0    1   0 0.00100    0    0   0     1 168.0000
## 13     0  4 168.0000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 14     0  4 168.1660    0   0    0   0 0.00138    0    0   0     1   0.0830
## 15     0  4 168.3330    0   0    0   0 0.00212    0    0   0     1   0.2500
## 16     0  4 168.5830    0   0    0   0 0.00359    0    0   0     1   0.5000
## 17     0  4 169.0830    0   0    0   0 0.00542    0    0   0     1   1.0000
## 18     0  4 170.0830    0   0    0   0 0.00526    0    0   0     1   2.0000
## 19     0  4 172.0830    0   0    0   0 0.00391    0    0   0     1   4.0000
## 20     0  4 180.0830    0   0    1   0 0.00100    0    0   0     1  12.0000
## 21     0  4 192.0830    0   0    1   0 0.00100    0    0   0     1  24.0000
## 22     0  4 216.0830    0   0    1   0 0.00100    0    0   0     1  48.0000
## 23     0  4 264.0830    0   0    1   0 0.00100    0    0   0     1  96.0000
## 24     0  4 336.0830    0   0    1   0 0.00100    0    0   0     1 168.0000
## 25     0  5 168.0500    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 26     0  5 168.2160    0   0    1   0 0.00100    0    0   0     1   0.0830
## 27     0  5 168.3830    0   0    0   0 0.00168    0    0   0     1   0.2500
## 28     0  5 168.3831    0   0    0   0 0.00168    0    0   0     1   0.2501
## 29     0  5 169.1330    0   0    0   0 0.00221    0    0   0     1   1.0000
## 30     0  5 170.1330    0   0    0   0 0.00307    0    0   0     1   2.0000
## 31     0  5 172.1330    0   0    0   0 0.00133    0    0   0     1   4.0000
## 32     0  5 192.1330    0   0    1   0 0.00100    0    0   0     1  24.0000
## 33     0  5 216.1330    0   0    1   0 0.00100    0    0   0     1  48.0000
## 34     0  5 264.1330    0   0    1   0 0.00100    0    0   0     1  96.0000
## 35     0  5 336.1330    0   0    1   0 0.00100    0    0   0     1 168.0000
## 36     0  6 167.9667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 37     0  6 168.1327    0   0    1   0 0.00100    0    0   0     1   0.0830
## 38     0  6 168.2997    0   0    0   0 0.00128    0    0   0     1   0.2500
## 39     0  6 168.5497    0   0    0   0 0.00220    0    0   0     1   0.5000
## 40     0  6 169.0497    0   0    0   0 0.00278    0    0   0     1   1.0000
## 41     0  6 170.0497    0   0    0   0 0.00221    0    0   0     1   2.0000
## 42     0  6 172.0497    0   0    0   0 0.00153    0    0   0     1   4.0000
## 43     0  6 180.0497    0   0    1   0 0.00100    0    0   0     1  12.0000
## 44     0  6 192.0497    0   0    1   0 0.00100    0    0   0     1  24.0000
## 45     0  6 216.0497    0   0    1   0 0.00100    0    0   0     1  48.0000
## 46     0  6 264.0497    0   0    1   0 0.00100    0    0   0     1  96.0000
## 47     0  6 336.0497    0   0    1   0 0.00100    0    0   0     1 168.0000
## 48     0  7 167.9333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 49     0  7 168.0993    0   0    0   0 0.00174    0    0   0     1   0.0830
## 50     0  7 168.2663    0   0    0   0 0.00299    0    0   0     1   0.2500
## 51     0  7 168.5163    0   0    0   0 0.00555    0    0   0     1   0.5000
## 52     0  7 169.0163    0   0    0   0 0.00780    0    0   0     1   1.0000
## 53     0  7 170.0163    0   0    0   0 0.00706    0    0   0     1   2.0000
## 54     0  7 172.0163    0   0    0   0 0.00526    0    0   0     1   4.0000
## 55     0  7 180.0163    0   0    1   0 0.00100    0    0   0     1  12.0000
## 56     0  7 192.0163    0   0    1   0 0.00100    0    0   0     1  24.0000
## 57     0  7 264.0163    0   0    1   0 0.00100    0    0   0     1  96.0000
## 58     0  7 336.0163    0   0    1   0 0.00100    0    0   0     1 168.0000
## 59     0  9 167.9833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 60     0  9 168.1493    0   0    0   0 0.00123    0    0   0     1   0.0830
## 61     0  9 168.3163    0   0    0   0 0.00238    0    0   0     1   0.2500
## 62     0  9 168.5663    0   0    0   0 0.00480    0    0   0     1   0.5000
## 63     0  9 169.0663    0   0    0   0 0.00672    0    0   0     1   1.0000
## 64     0  9 170.0663    0   0    0   0 0.00509    0    0   0     1   2.0000
## 65     0  9 172.0663    0   0    0   0 0.00396    0    0   0     1   4.0000
## 66     0  9 180.0663    0   0    0   0 0.00160    0    0   0     1  12.0000
## 67     0  9 192.0663    0   0    1   0 0.00100    0    0   0     1  24.0000
## 68     0  9 216.0663    0   0    1   0 0.00100    0    0   0     1  48.0000
## 69     0  9 264.0663    0   0    1   0 0.00100    0    0   0     1  96.0000
## 70     0  9 336.0663    0   0    1   0 0.00100    0    0   0     1 168.0000
## 71     0 10 167.9333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 72     0 10 168.0993    0   0    0   0 0.00157    0    0   0     1   0.0830
## 73     0 10 168.2663    0   0    0   0 0.00205    0    0   0     1   0.2500
## 74     0 10 168.5163    0   0    0   0 0.00446    0    0   0     1   0.5000
## 75     0 10 169.0163    0   0    0   0 0.00462    0    0   0     1   1.0000
## 76     0 10 170.0163    0   0    0   0 0.00555    0    0   0     1   2.0000
## 77     0 10 172.0163    0   0    0   0 0.00329    0    0   0     1   4.0000
## 78     0 10 180.0163    0   0    1   0 0.00100    0    0   0     1  12.0000
## 79     0 10 192.0163    0   0    1   0 0.00100    0    0   0     1  24.0000
## 80     0 10 216.0163    0   0    1   0 0.00100    0    0   0     1  48.0000
## 81     0 10 264.0163    0   0    1   0 0.00100    0    0   0     1  96.0000
## 82     0 10 336.0163    0   0    1   0 0.00100    0    0   0     1 168.0000
## 83     0 11 167.6333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 84     0 11 167.7993    0   0    0   0 0.00127    0    0   0     1   0.0830
## 85     0 11 167.9663    0   0    0   0 0.00345    0    0   0     1   0.2500
## 86     0 11 168.2163    0   0    0   0 0.00491    0    0   0     1   0.5000
## 87     0 11 168.7163    0   0    0   0 0.00692    0    0   0     1   1.0000
## 88     0 11 169.7163    0   0    0   0 0.00736    0    0   0     1   2.0000
## 89     0 11 171.7163    0   0    0   0 0.00420    0    0   0     1   4.0000
## 90     0 11 179.7163    0   0    1   0 0.00100    0    0   0     1  12.0000
## 91     0 11 191.7163    0   0    1   0 0.00100    0    0   0     1  24.0000
## 92     0 11 215.7163    0   0    1   0 0.00100    0    0   0     1  48.0000
## 93     0 11 263.7163    0   0    1   0 0.00100    0    0   0     1  96.0000
## 94     0 11 335.7163    0   0    1   0 0.00100    0    0   0     1 168.0000
## 95     0 12 168.7000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 96     0 12 168.8660    0   0    1   0 0.00100    0    0   0     1   0.0830
## 97     0 12 169.0330    0   0    0   0 0.00380    0    0   0     1   0.2500
## 98     0 12 169.2830    0   0    0   0 0.00510    0    0   0     1   0.5000
## 99     0 12 169.7830    0   0    0   0 0.00396    0    0   0     1   1.0000
## 100    0 12 170.7830    0   0    0   0 0.00596    0    0   0     1   2.0000
## 101    0 12 172.7830    0   0    0   0 0.00445    0    0   0     1   4.0000
## 102    0 12 180.7830    0   0    1   0 0.00100    0    0   0     1  12.0000
## 103    0 12 192.7830    0   0    1   0 0.00100    0    0   0     1  24.0000
## 104    0 12 216.7830    0   0    1   0 0.00100    0    0   0     1  48.0000
## 105    0 12 264.7830    0   0    1   0 0.00100    0    0   0     1  96.0000
## 106    0 12 336.7830    0   0    1   0 0.00100    0    0   0     1 168.0000
## 107    0 13 168.5000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 108    0 13 168.6660    0   0    0   0 0.00593    0    0   0     1   0.0830
## 109    0 13 168.8330    0   0    0   0 0.01100    0    0   0     1   0.2500
## 110    0 13 169.0830    0   0    0   0 0.02130    0    0   0     1   0.5000
## 111    0 13 169.5830    0   0    0   0 0.02640    0    0   0     1   1.0000
## 112    0 13 170.5830    0   0    0   0 0.02360    0    0   0     1   2.0000
## 113    0 13 172.5830    0   0    0   0 0.00808    0    0   0     1   4.0000
## 114    0 13 180.5830    0   0    0   0 0.00128    0    0   0     1  12.0000
## 115    0 13 192.5830    0   0    1   0 0.00100    0    0   0     1  24.0000
## 116    0 13 216.5830    0   0    1   0 0.00100    0    0   0     1  48.0000
## 117    0 13 264.5830    0   0    1   0 0.00100    0    0   0     1  96.0000
## 118    0 13 336.5830    0   0    1   0 0.00100    0    0   0     1 168.0000
## 119    0 14 168.5667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 120    0 14 168.7327    0   0    0   0 0.00428    0    0   0     1   0.0830
## 121    0 14 168.8997    0   0    0   0 0.01080    0    0   0     1   0.2500
## 122    0 14 169.1497    0   0    0   0 0.01920    0    0   0     1   0.5000
## 123    0 14 169.6497    0   0    0   0 0.01960    0    0   0     1   1.0000
## 124    0 14 170.6497    0   0    0   0 0.01400    0    0   0     1   2.0000
## 125    0 14 172.6497    0   0    1   0 0.00100    0    0   0     1   4.0000
## 126    0 14 180.6497    0   0    0   0 0.00112    0    0   0     1  12.0000
## 127    0 14 192.6497    0   0    1   0 0.00100    0    0   0     1  24.0000
## 128    0 14 216.6497    0   0    1   0 0.00100    0    0   0     1  48.0000
## 129    0 14 264.6497    0   0    1   0 0.00100    0    0   0     1  96.0000
## 130    0 14 336.6497    0   0    1   0 0.00100    0    0   0     1 168.0000
## 131    0 15 168.3167    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 132    0 15 168.4827    0   0    0   0 0.00174    0    0   0     1   0.0830
## 133    0 15 168.6497    0   0    0   0 0.00432    0    0   0     1   0.2500
## 134    0 15 168.8997    0   0    0   0 0.00766    0    0   0     1   0.5000
## 135    0 15 169.3997    0   0    0   0 0.01030    0    0   0     1   1.0000
## 136    0 15 170.3997    0   0    0   0 0.00802    0    0   0     1   2.0000
## 137    0 15 172.3997    0   0    0   0 0.00742    0    0   0     1   4.0000
## 138    0 15 180.3997    0   0    0   0 0.00300    0    0   0     1  12.0000
## 139    0 15 192.3997    0   0    1   0 0.00100    0    0   0     1  24.0000
## 140    0 15 216.3997    0   0    1   0 0.00100    0    0   0     1  48.0000
## 141    0 15 264.3997    0   0    1   0 0.00100    0    0   0     1  96.0000
## 142    0 15 336.3997    0   0    1   0 0.00100    0    0   0     1 168.0000
## 143    0 16 167.2833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 144    0 16 167.4493    0   0    0   0 0.00370    0    0   0     1   0.0830
## 145    0 16 167.6163    0   0    0   0 0.00826    0    0   0     1   0.2500
## 146    0 16 167.8663    0   0    0   0 0.01440    0    0   0     1   0.5000
## 147    0 16 168.3663    0   0    0   0 0.01460    0    0   0     1   1.0000
## 148    0 16 169.3663    0   0    0   0 0.01770    0    0   0     1   2.0000
## 149    0 16 171.3663    0   0    0   0 0.00857    0    0   0     1   4.0000
## 150    0 16 179.3663    0   0    0   0 0.00199    0    0   0     1  12.0000
## 151    0 16 191.3663    0   0    1   0 0.00100    0    0   0     1  24.0000
## 152    0 16 215.3663    0   0    1   0 0.00100    0    0   0     1  48.0000
## 153    0 16 263.3663    0   0    1   0 0.00100    0    0   0     1  96.0000
## 154    0 16 335.3663    0   0    0   0 0.00101    0    0   0     1 168.0000
## 155    0 17 168.6667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 156    0 17 168.8327    0   0    0   0 0.00386    0    0   0     1   0.0830
## 157    0 17 168.9997    0   0    0   0 0.00888    0    0   0     1   0.2500
## 158    0 17 169.2497    0   0    0   0 0.01700    0    0   0     1   0.5000
## 159    0 17 169.7497    0   0    0   0 0.01830    0    0   0     1   1.0000
## 160    0 17 170.7497    0   0    0   0 0.01980    0    0   0     1   2.0000
## 161    0 17 172.7497    0   0    0   0 0.00950    0    0   0     1   4.0000
## 162    0 17 180.7497    0   0    0   0 0.00334    0    0   0     1  12.0000
## 163    0 17 192.7497    0   0    1   0 0.00100    0    0   0     1  24.0000
## 164    0 17 216.7497    0   0    1   0 0.00100    0    0   0     1  48.0000
## 165    0 17 264.7497    0   0    1   0 0.00100    0    0   0     1  96.0000
## 166    0 17 336.7497    0   0    1   0 0.00100    0    0   0     1 168.0000
## 167    0 19 169.0833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 168    0 19 169.2493    0   0    0   0 0.00689    0    0   0     1   0.0830
## 169    0 19 169.4163    0   0    0   0 0.01530    0    0   0     1   0.2500
## 170    0 19 169.6663    0   0    0   0 0.02390    0    0   0     1   0.5000
## 171    0 19 170.1663    0   0    0   0 0.04110    0    0   0     1   1.0000
## 172    0 19 171.1663    0   0    0   0 0.03820    0    0   0     1   2.0000
## 173    0 19 173.1663    0   0    0   0 0.02730    0    0   0     1   4.0000
## 174    0 19 181.1663    0   0    0   0 0.00528    0    0   0     1  12.0000
## 175    0 19 193.1663    0   0    0   0 0.00198    0    0   0     1  24.0000
## 176    0 19 217.1663    0   0    1   0 0.00100    0    0   0     1  48.0000
## 177    0 19 265.1663    0   0    1   0 0.00100    0    0   0     1  96.0000
## 178    0 19 337.1663    0   0    1   0 0.00100    0    0   0     1 168.0000
## 179    0 20 168.3667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 180    0 20 168.5327    0   0    0   0 0.00515    0    0   0     1   0.0830
## 181    0 20 168.6997    0   0    0   0 0.01130    0    0   0     1   0.2500
## 182    0 20 168.9497    0   0    0   0 0.01910    0    0   0     1   0.5000
## 183    0 20 169.4497    0   0    0   0 0.03580    0    0   0     1   1.0000
## 184    0 20 170.4497    0   0    0   0 0.02670    0    0   0     1   2.0000
## 185    0 20 172.4497    0   0    0   0 0.01850    0    0   0     1   4.0000
## 186    0 20 180.4497    0   0    0   0 0.00755    0    0   0     1  12.0000
## 187    0 20 192.4497    0   0    0   0 0.00219    0    0   0     1  24.0000
## 188    0 20 264.4497    0   0    1   0 0.00100    0    0   0     1  96.0000
## 189    0 20 336.4497    0   0    0   0 0.00101    0    0   0     1 168.0000
## 190    0 21 167.6000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 191    0 21 167.7660    0   0    0   0 0.00374    0    0   0     1   0.0830
## 192    0 21 167.9330    0   0    0   0 0.00866    0    0   0     1   0.2500
## 193    0 21 168.1830    0   0    0   0 0.01570    0    0   0     1   0.5000
## 194    0 21 168.6830    0   0    0   0 0.01960    0    0   0     1   1.0000
## 195    0 21 169.6830    0   0    0   0 0.02190    0    0   0     1   2.0000
## 196    0 21 171.6830    0   0    0   0 0.02200    0    0   0     1   4.0000
## 197    0 21 179.6830    0   0    0   0 0.00786    0    0   0     1  12.0000
## 198    0 21 191.6830    0   0    0   0 0.00382    0    0   0     1  24.0000
## 199    0 21 215.6830    0   0    1   0 0.00100    0    0   0     1  48.0000
## 200    0 21 263.6830    0   0    0   0 0.00108    0    0   0     1  96.0000
## 201    0 21 335.6830    0   0    1   0 0.00100    0    0   0     1 168.0000
## 202    0 22 167.4500    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 203    0 22 167.6160    0   0    0   0 0.00241    0    0   0     1   0.0830
## 204    0 22 167.7830    0   0    0   0 0.01060    0    0   0     1   0.2500
## 205    0 22 168.0330    0   0    0   0 0.01630    0    0   0     1   0.5000
## 206    0 22 168.5330    0   0    0   0 0.02530    0    0   0     1   1.0000
## 207    0 22 169.5330    0   0    0   0 0.20500    0    0   0     1   2.0000
## 208    0 22 171.5330    0   0    0   0 0.01860    0    0   0     1   4.0000
## 209    0 22 179.5330    0   0    0   0 0.00534    0    0   0     1  12.0000
## 210    0 22 191.5330    0   0    0   0 0.00213    0    0   0     1  24.0000
## 211    0 22 215.5330    0   0    1   0 0.00100    0    0   0     1  48.0000
## 212    0 22 263.5330    0   0    1   0 0.00100    0    0   0     1  96.0000
## 213    0 22 335.5330    0   0    1   0 0.00100    0    0   0     1 168.0000
## 214    0 23 167.7667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 215    0 23 167.9327    0   0    0   0 0.00905    0    0   0     1   0.0830
## 216    0 23 168.0997    0   0    0   0 0.02640    0    0   0     1   0.2500
## 217    0 23 168.3497    0   0    0   0 0.03400    0    0   0     1   0.5000
## 218    0 23 168.8497    0   0    0   0 0.04700    0    0   0     1   1.0000
## 219    0 23 169.8497    0   0    0   0 0.03710    0    0   0     1   2.0000
## 220    0 23 171.8497    0   0    0   0 0.02450    0    0   0     1   4.0000
## 221    0 23 179.8497    0   0    0   0 0.00779    0    0   0     1  12.0000
## 222    0 23 191.8497    0   0    0   0 0.00116    0    0   0     1  24.0000
## 223    0 23 215.8497    0   0    1   0 0.00100    0    0   0     1  48.0000
## 224    0 23 263.8497    0   0    1   0 0.00100    0    0   0     1  96.0000
## 225    0 23 335.8497    0   0    1   0 0.00100    0    0   0     1 168.0000
## 226    0 24 168.1333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 227    0 24 168.2993    0   0    0   0 0.00433    0    0   0     1   0.0830
## 228    0 24 168.4663    0   0    0   0 0.01200    0    0   0     1   0.2500
## 229    0 24 168.7163    0   0    0   0 0.01940    0    0   0     1   0.5000
## 230    0 24 169.2163    0   0    0   0 0.03030    0    0   0     1   1.0000
## 231    0 24 170.2163    0   0    0   0 0.03300    0    0   0     1   2.0000
## 232    0 24 172.2163    0   0    0   0 0.02270    0    0   0     1   4.0000
## 233    0 24 180.2163    0   0    0   0 0.00835    0    0   0     1  12.0000
## 234    0 24 192.2163    0   0    0   0 0.00266    0    0   0     1  24.0000
## 235    0 24 216.2163    0   0    0   0 0.00241    0    0   0     1  48.0000
## 236    0 24 264.2163    0   0    0   0 0.00127    0    0   0     1  96.0000
## 237    0 24 336.2163    0   0    0   0 0.00124    0    0   0     1 168.0000
## 238    0 25 167.5000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 239    0 25 167.6660    0   0    0   0 0.01190    0    0   0     1   0.0830
## 240    0 25 167.8330    0   0    0   0 0.03410    0    0   0     1   0.2500
## 241    0 25 168.0830    0   0    0   0 0.05540    0    0   0     1   0.5000
## 242    0 25 168.5830    0   0    0   0 0.05080    0    0   0     1   1.0000
## 243    0 25 169.5830    0   0    0   0 0.05230    0    0   0     1   2.0000
## 244    0 25 171.5830    0   0    0   0 0.03200    0    0   0     1   4.0000
## 245    0 25 179.5830    0   0    0   0 0.01060    0    0   0     1  12.0000
## 246    0 25 191.5830    0   0    0   0 0.00196    0    0   0     1  24.0000
## 247    0 25 215.5830    0   0    0   0 0.00168    0    0   0     1  48.0000
## 248    0 25 263.5830    0   0    1   0 0.00100    0    0   0     1  96.0000
## 249    0 25 335.5830    0   0    0   0 0.00117    0    0   0     1 168.0000
## 250    0 26 167.4833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 251    0 26 167.6493    0   0    0   0 0.00936    0    0   0     1   0.0830
## 252    0 26 167.8163    0   0    0   0 0.02200    0    0   0     1   0.2500
## 253    0 26 168.0663    0   0    0   0 0.03310    0    0   0     1   0.5000
## 254    0 26 168.5663    0   0    0   0 0.05420    0    0   0     1   1.0000
## 255    0 26 169.5663    0   0    0   0 0.05030    0    0   0     1   2.0000
## 256    0 26 171.5663    0   0    0   0 0.04100    0    0   0     1   4.0000
## 257    0 26 179.5663    0   0    0   0 0.01170    0    0   0     1  12.0000
## 258    0 26 191.5663    0   0    0   0 0.00311    0    0   0     1  24.0000
## 259    0 26 215.5663    0   0    1   0 0.00100    0    0   0     1  48.0000
## 260    0 26 263.5663    0   0    1   0 0.00100    0    0   0     1  96.0000
## 261    0 26 335.5663    0   0    1   0 0.00100    0    0   0     1 168.0000
## 262    0 27 168.8000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 263    0 27 168.9660    0   0    0   0 0.01390    0    0   0     1   0.0830
## 264    0 27 169.1330    0   0    0   0 0.03260    0    0   0     1   0.2500
## 265    0 27 169.3830    0   0    0   0 0.05050    0    0   0     1   0.5000
## 266    0 27 169.8830    0   0    0   0 0.06240    0    0   0     1   1.0000
## 267    0 27 170.8830    0   0    0   0 0.05440    0    0   0     1   2.0000
## 268    0 27 172.8830    0   0    0   0 0.03180    0    0   0     1   4.0000
## 269    0 27 180.8830    0   0    0   0 0.00749    0    0   0     1  12.0000
## 270    0 27 192.8830    0   0    0   0 0.00232    0    0   0     1  24.0000
## 271    0 27 216.8830    0   0    0   0 0.00309    0    0   0     1  48.0000
## 272    0 27 264.8830    0   0    0   0 0.00261    0    0   0     1  96.0000
## 273    0 27 336.8830    0   0    0   0 0.00165    0    0   0     1 168.0000
## 274    0 28 167.8667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 275    0 28 168.0327    0   0    0   0 0.00609    0    0   0     1   0.0830
## 276    0 28 168.1997    0   0    0   0 0.01570    0    0   0     1   0.2500
## 277    0 28 168.4497    0   0    0   0 0.02970    0    0   0     1   0.5000
## 278    0 28 168.9497    0   0    0   0 0.05030    0    0   0     1   1.0000
## 279    0 28 169.9497    0   0    0   0 0.04650    0    0   0     1   2.0000
## 280    0 28 171.9497    0   0    0   0 0.04090    0    0   0     1   4.0000
## 281    0 28 179.9497    0   0    0   0 0.00898    0    0   0     1  12.0000
## 282    0 28 191.9497    0   0    0   0 0.00265    0    0   0     1  24.0000
## 283    0 28 215.9497    0   0    0   0 0.00169    0    0   0     1  48.0000
## 284    0 28 263.9497    0   0    0   0 0.00170    0    0   0     1  96.0000
## 285    0 28 335.9497    0   0    0   0 0.00145    0    0   0     1 168.0000
## 286    0 29 167.8000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 287    0 29 167.9660    0   0    0   0 0.00971    0    0   0     1   0.0830
## 288    0 29 168.1330    0   0    0   0 0.02690    0    0   0     1   0.2500
## 289    0 29 168.3830    0   0    0   0 0.04840    0    0   0     1   0.5000
## 290    0 29 168.8830    0   0    0   0 0.06530    0    0   0     1   1.0000
## 291    0 29 169.8830    0   0    0   0 0.05790    0    0   0     1   2.0000
## 292    0 29 171.8830    0   0    0   0 0.03360    0    0   0     1   4.0000
## 293    0 29 179.8830    0   0    0   0 0.00991    0    0   0     1  12.0000
## 294    0 29 191.8830    0   0    0   0 0.00188    0    0   0     1  24.0000
## 295    0 29 215.8830    0   0    0   0 0.00296    0    0   0     1  48.0000
## 296    0 29 263.8830    0   0    0   0 0.00149    0    0   0     1  96.0000
## 297    0 29 335.8830    0   0    1   0 0.00100    0    0   0     1 168.0000
## 298    0 30 167.6333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 299    0 30 167.7993    0   0    0   0 0.01290    0    0   0     1   0.0830
## 300    0 30 167.9663    0   0    0   0 0.03290    0    0   0     1   0.2500
## 301    0 30 168.2163    0   0    0   0 0.04310    0    0   0     1   0.5000
## 302    0 30 168.7163    0   0    0   0 0.05360    0    0   0     1   1.0000
## 303    0 30 169.7163    0   0    0   0 0.05700    0    0   0     1   2.0000
## 304    0 30 171.7163    0   0    0   0 0.04370    0    0   0     1   4.0000
## 305    0 30 179.7163    0   0    0   0 0.01170    0    0   0     1  12.0000
## 306    0 30 191.7163    0   0    0   0 0.00297    0    0   0     1  24.0000
## 307    0 30 215.7163    0   0    0   0 0.00114    0    0   0     1  48.0000
## 308    0 30 263.7163    0   0    0   0 0.00131    0    0   0     1  96.0000
## 309    0 30 335.7163    0   0    0   0 0.00121    0    0   0     1 168.0000
## 310    0 31 168.0833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 311    0 31 168.2493    0   0    0   0 0.01480    0    0   0     1   0.0830
## 312    0 31 168.4163    0   0    0   0 0.03720    0    0   0     1   0.2500
## 313    0 31 168.6663    0   0    0   0 0.06000    0    0   0     1   0.5000
## 314    0 31 169.1663    0   0    0   0 0.08750    0    0   0     1   1.0000
## 315    0 31 170.1663    0   0    0   0 0.07030    0    0   0     1   2.0000
## 316    0 31 172.1663    0   0    0   0 0.07920    0    0   0     1   4.0000
## 317    0 31 180.1663    0   0    0   0 0.02850    0    0   0     1  12.0000
## 318    0 31 192.1663    0   0    0   0 0.00963    0    0   0     1  24.0000
## 319    0 31 216.1663    0   0    0   0 0.00283    0    0   0     1  48.0000
## 320    0 31 264.1663    0   0    0   0 0.00248    0    0   0     1  96.0000
## 321    0 31 336.1663    0   0    1   0 0.00100    0    0   0     1 168.0000
## 322    0 32 168.1333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 323    0 32 168.2993    0   0    0   0 0.04720    0    0   0     1   0.0830
## 324    0 32 168.4663    0   0    0   0 0.11400    0    0   0     1   0.2500
## 325    0 32 168.7163    0   0    0   0 0.15200    0    0   0     1   0.5000
## 326    0 32 169.2163    0   0    0   0 0.17300    0    0   0     1   1.0000
## 327    0 32 170.2163    0   0    0   0 0.14500    0    0   0     1   2.0000
## 328    0 32 172.2163    0   0    0   0 0.10100    0    0   0     1   4.0000
## 329    0 32 180.2163    0   0    0   0 0.01950    0    0   0     1  12.0000
## 330    0 32 192.2163    0   0    0   0 0.00940    0    0   0     1  24.0000
## 331    0 32 216.2163    0   0    0   0 0.00528    0    0   0     1  48.0000
## 332    0 32 264.2163    0   0    0   0 0.00482    0    0   0     1  96.0000
## 333    0 32 336.2163    0   0    0   0 0.00229    0    0   0     1 168.0000
## 334    0 33 168.5167    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 335    0 33 168.6827    0   0    0   0 0.02670    0    0   0     1   0.0830
## 336    0 33 168.8497    0   0    0   0 0.06480    0    0   0     1   0.2500
## 337    0 33 169.0997    0   0    0   0 0.11000    0    0   0     1   0.5000
## 338    0 33 169.5997    0   0    0   0 0.12500    0    0   0     1   1.0000
## 339    0 33 170.5997    0   0    0   0 0.14300    0    0   0     1   2.0000
## 340    0 33 172.5997    0   0    0   0 0.06950    0    0   0     1   4.0000
## 341    0 33 180.5997    0   0    0   0 0.01640    0    0   0     1  12.0000
## 342    0 33 192.5997    0   0    0   0 0.00447    0    0   0     1  24.0000
## 343    0 33 216.5997    0   0    0   0 0.00313    0    0   0     1  48.0000
## 344    0 33 264.5997    0   0    0   0 0.00299    0    0   0     1  96.0000
## 345    0 33 336.5997    0   0    0   0 0.00201    0    0   0     1 168.0000
## 346    0 34 167.8667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 347    0 34 168.0327    0   0    0   0 0.01730    0    0   0     1   0.0830
## 348    0 34 168.1997    0   0    0   0 0.04370    0    0   0     1   0.2500
## 349    0 34 168.4497    0   0    0   0 0.07930    0    0   0     1   0.5000
## 350    0 34 168.9497    0   0    0   0 0.08940    0    0   0     1   1.0000
## 351    0 34 169.9497    0   0    0   0 0.09610    0    0   0     1   2.0000
## 352    0 34 171.9497    0   0    0   0 0.07590    0    0   0     1   4.0000
## 353    0 34 179.9497    0   0    0   0 0.01350    0    0   0     1  12.0000
## 354    0 34 191.9497    0   0    0   0 0.00340    0    0   0     1  24.0000
## 355    0 34 215.9497    0   0    0   0 0.00208    0    0   0     1  48.0000
## 356    0 34 263.9497    0   0    0   0 0.00112    0    0   0     1  96.0000
## 357    0 34 335.9497    0   0    1   0 0.00100    0    0   0     1 168.0000
## 358    0 35 168.2833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 359    0 35 168.4493    0   0    0   0 0.04720    0    0   0     1   0.0830
## 360    0 35 168.6163    0   0    0   0 0.10600    0    0   0     1   0.2500
## 361    0 35 168.8663    0   0    0   0 0.13700    0    0   0     1   0.5000
## 362    0 35 169.3663    0   0    0   0 0.18200    0    0   0     1   1.0000
## 363    0 35 170.3663    0   0    0   0 0.16700    0    0   0     1   2.0000
## 364    0 35 172.3663    0   0    0   0 0.09100    0    0   0     1   4.0000
## 365    0 35 180.3663    0   0    0   0 0.01220    0    0   0     1  12.0000
## 366    0 35 192.3663    0   0    0   0 0.00554    0    0   0     1  24.0000
## 367    0 35 216.3663    0   0    0   0 0.00404    0    0   0     1  48.0000
## 368    0 35 264.3663    0   0    0   0 0.00415    0    0   0     1  96.0000
## 369    0 35 336.3663    0   0    0   0 0.00204    0    0   0     1 168.0000
## 370    0 36 168.5833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 371    0 36 168.7493    0   0    0   0 0.03750    0    0   0     1   0.0830
## 372    0 36 168.9163    0   0    0   0 0.08430    0    0   0     1   0.2500
## 373    0 36 169.1663    0   0    0   0 0.13000    0    0   0     1   0.5000
## 374    0 36 169.6663    0   0    0   0 0.22300    0    0   0     1   1.0000
## 375    0 36 170.6663    0   0    0   0 0.19500    0    0   0     1   2.0000
## 376    0 36 172.6663    0   0    0   0 0.14900    0    0   0     1   4.0000
## 377    0 36 180.6663    0   0    0   0 0.02950    0    0   0     1  12.0000
## 378    0 36 192.6663    0   0    0   0 0.00783    0    0   0     1  24.0000
## 379    0 36 216.6663    0   0    0   0 0.00447    0    0   0     1  48.0000
## 380    0 36 264.6663    0   0    0   0 0.00439    0    0   0     1  96.0000
## 381    0 36 336.6663    0   0    0   0 0.00191    0    0   0     1 168.0000
## 382    0 37 167.9000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 383    0 37 168.0660    0   0    0   0 0.03800    0    0   0     1   0.0830
## 384    0 37 168.2330    0   0    0   0 0.11800    0    0   0     1   0.2500
## 385    0 37 168.4830    0   0    0   0 0.15600    0    0   0     1   0.5000
## 386    0 37 168.9830    0   0    0   0 0.26800    0    0   0     1   1.0000
## 387    0 37 169.9830    0   0    0   0 0.22600    0    0   0     1   2.0000
## 388    0 37 171.9830    0   0    0   0 0.18700    0    0   0     1   4.0000
## 389    0 37 179.9830    0   0    0   0 0.07220    0    0   0     1  12.0000
## 390    0 37 191.9830    0   0    0   0 0.01980    0    0   0     1  24.0000
## 391    0 37 215.9830    0   0    0   0 0.00557    0    0   0     1  48.0000
## 392    0 37 263.9830    0   0    0   0 0.00625    0    0   0     1  96.0000
## 393    0 37 335.9830    0   0    0   0 0.00489    0    0   0     1 168.0000
## 394    0 38 167.1833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 395    0 38 167.3493    0   0    0   0 0.05450    0    0   0     1   0.0830
## 396    0 38 167.5163    0   0    0   0 0.17100    0    0   0     1   0.2500
## 397    0 38 167.7663    0   0    0   0 0.25400    0    0   0     1   0.5000
## 398    0 38 168.2663    0   0    0   0 0.25600    0    0   0     1   1.0000
## 399    0 38 169.2663    0   0    0   0 0.25300    0    0   0     1   2.0000
## 400    0 38 171.2663    0   0    0   0 0.20200    0    0   0     1   4.0000
## 401    0 38 179.2663    0   0    0   0 0.09480    0    0   0     1  12.0000
## 402    0 38 191.2663    0   0    0   0 0.02510    0    0   0     1  24.0000
## 403    0 38 215.2663    0   0    0   0 0.00726    0    0   0     1  48.0000
## 404    0 38 263.2663    0   0    0   0 0.00550    0    0   0     1  96.0000
## 405    0 38 335.2663    0   0    0   0 0.00584    0    0   0     1 168.0000
## 406    0 39 167.9000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 407    0 39 168.0660    0   0    0   0 0.07300    0    0   0     1   0.0830
## 408    0 39 168.2330    0   0    0   0 0.19400    0    0   0     1   0.2500
## 409    0 39 168.4830    0   0    0   0 0.25700    0    0   0     1   0.5000
## 410    0 39 168.9830    0   0    0   0 0.41900    0    0   0     1   1.0000
## 411    0 39 169.9830    0   0    0   0 0.43900    0    0   0     1   2.0000
## 412    0 39 171.9830    0   0    0   0 0.32000    0    0   0     1   4.0000
## 413    0 39 179.9830    0   0    0   0 0.05640    0    0   0     1  12.0000
## 414    0 39 191.9830    0   0    0   0 0.01690    0    0   0     1  24.0000
## 415    0 39 215.9830    0   0    0   0 0.01180    0    0   0     1  48.0000
## 416    0 39 263.9830    0   0    0   0 0.00834    0    0   0     1  96.0000
## 417    0 39 335.9830    0   0    0   0 0.00685    0    0   0     1 168.0000
## 418    0 40 168.2000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 419    0 40 168.3660    0   0    0   0 0.08670    0    0   0     1   0.0830
## 420    0 40 168.5330    0   0    0   0 0.20300    0    0   0     1   0.2500
## 421    0 40 168.7830    0   0    0   0 0.29300    0    0   0     1   0.5000
## 422    0 40 169.2830    0   0    0   0 0.33400    0    0   0     1   1.0000
## 423    0 40 170.2830    0   0    0   0 0.29100    0    0   0     1   2.0000
## 424    0 40 172.2830    0   0    0   0 0.24300    0    0   0     1   4.0000
## 425    0 40 180.2830    0   0    0   0 0.05680    0    0   0     1  12.0000
## 426    0 40 192.2830    0   0    0   0 0.01150    0    0   0     1  24.0000
## 427    0 40 216.2830    0   0    0   0 0.00503    0    0   0     1  48.0000
## 428    0 40 264.2830    0   0    0   0 0.00278    0    0   0     1  96.0000
## 429    0 40 336.2830    0   0    0   0 0.00216    0    0   0     1 168.0000
## 430    0 41 168.2333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 431    0 41 168.3993    0   0    0   0 0.06290    0    0   0     1   0.0830
## 432    0 41 168.5663    0   0    0   0 0.14200    0    0   0     1   0.2500
## 433    0 41 168.8163    0   0    0   0 0.21500    0    0   0     1   0.5000
## 434    0 41 169.3163    0   0    0   0 0.31800    0    0   0     1   1.0000
## 435    0 41 170.3163    0   0    0   0 0.25400    0    0   0     1   2.0000
## 436    0 41 172.3163    0   0    0   0 0.16900    0    0   0     1   4.0000
## 437    0 41 180.3163    0   0    0   0 0.02870    0    0   0     1  12.0000
## 438    0 41 192.3163    0   0    0   0 0.00977    0    0   0     1  24.0000
## 439    0 41 216.3163    0   0    0   0 0.00555    0    0   0     1  48.0000
## 440    0 41 264.3163    0   0    0   0 0.00413    0    0   0     1  96.0000
## 441    0 41 336.3163    0   0    0   0 0.00196    0    0   0     1 168.0000
## 442    0 42 168.9000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 443    0 42 169.0660    0   0    0   0 0.08270    0    0   0     1   0.0830
## 444    0 42 169.2330    0   0    0   0 0.20200    0    0   0     1   0.2500
## 445    0 42 169.4830    0   0    0   0 0.28400    0    0   0     1   0.5000
## 446    0 42 169.9830    0   0    0   0 0.31000    0    0   0     1   1.0000
## 447    0 42 170.9830    0   0    0   0 0.25600    0    0   0     1   2.0000
## 448    0 42 172.9830    0   0    0   0 0.18200    0    0   0     1   4.0000
## 449    0 42 180.9830    0   0    0   0 0.02720    0    0   0     1  12.0000
## 450    0 42 192.9830    0   0    0   0 0.01400    0    0   0     1  24.0000
## 451    0 42 216.9830    0   0    0   0 0.01130    0    0   0     1  48.0000
## 452    0 42 264.9830    0   0    0   0 0.00537    0    0   0     1  96.0000
## 453    0 42 336.9830    0   0    0   0 0.00258    0    0   0     1 168.0000
## 454    0 43 168.6833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 455    0 43 168.8493    0   0    0   0 0.16600    0    0   0     1   0.0830
## 456    0 43 169.0163    0   0    0   0 0.37400    0    0   0     1   0.2500
## 457    0 43 169.2663    0   0    0   0 0.50400    0    0   0     1   0.5000
## 458    0 43 169.7663    0   0    0   0 0.86200    0    0   0     1   1.0000
## 459    0 43 170.7663    0   0    0   0 0.78800    0    0   0     1   2.0000
## 460    0 43 172.7663    0   0    0   0 0.49000    0    0   0     1   4.0000
## 461    0 43 180.7663    0   0    0   0 0.14300    0    0   0     1  12.0000
## 462    0 43 192.7663    0   0    0   0 0.02110    0    0   0     1  24.0000
## 463    0 43 216.7663    0   0    0   0 0.00575    0    0   0     1  48.0000
## 464    0 43 264.7663    0   0    0   0 0.00667    0    0   0     1  96.0000
## 465    0 43 336.7663    0   0    0   0 0.00593    0    0   0     1 168.0000
## 466    0 44 168.2833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 467    0 44 168.4493    0   0    0   0 0.08550    0    0   0     1   0.0830
## 468    0 44 168.6163    0   0    0   0 0.18200    0    0   0     1   0.2500
## 469    0 44 168.8663    0   0    0   0 0.32300    0    0   0     1   0.5000
## 470    0 44 169.3663    0   0    0   0 0.43400    0    0   0     1   1.0000
## 471    0 44 170.3663    0   0    0   0 0.41700    0    0   0     1   2.0000
## 472    0 44 172.3663    0   0    0   0 0.23200    0    0   0     1   4.0000
## 473    0 44 180.3663    0   0    0   0 0.03960    0    0   0     1  12.0000
## 474    0 44 192.3663    0   0    0   0 0.00877    0    0   0     1  24.0000
## 475    0 44 216.3663    0   0    0   0 0.00778    0    0   0     1  48.0000
## 476    0 44 264.3663    0   0    0   0 0.00419    0    0   0     1  96.0000
## 477    0 44 336.3663    0   0    0   0 0.00410    0    0   0     1 168.0000
## 478    0 45 168.4667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 479    0 45 168.6327    0   0    0   0 0.17500    0    0   0     1   0.0830
## 480    0 45 168.7997    0   0    0   0 0.37600    0    0   0     1   0.2500
## 481    0 45 169.0497    0   0    0   0 0.59300    0    0   0     1   0.5000
## 482    0 45 169.5497    0   0    0   0 0.63500    0    0   0     1   1.0000
## 483    0 45 170.5497    0   0    0   0 0.51700    0    0   0     1   2.0000
## 484    0 45 172.5497    0   0    0   0 0.42900    0    0   0     1   4.0000
## 485    0 45 180.5497    0   0    0   0 0.09240    0    0   0     1  12.0000
## 486    0 45 192.5497    0   0    0   0 0.01930    0    0   0     1  24.0000
## 487    0 45 216.5497    0   0    0   0 0.01220    0    0   0     1  48.0000
## 488    0 45 264.5497    0   0    0   0 0.00661    0    0   0     1  96.0000
## 489    0 45 336.5497    0   0    0   0 0.00625    0    0   0     1 168.0000
## 490    0 46 167.9000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 491    0 46 168.0660    0   0    0   0 0.08050    0    0   0     1   0.0830
## 492    0 46 168.2330    0   0    0   0 0.19300    0    0   0     1   0.2500
## 493    0 46 168.4830    0   0    0   0 0.32400    0    0   0     1   0.5000
## 494    0 46 168.9830    0   0    0   0 0.54500    0    0   0     1   1.0000
## 495    0 46 169.9830    0   0    0   0 0.48700    0    0   0     1   2.0000
## 496    0 46 171.9830    0   0    0   0 0.32100    0    0   0     1   4.0000
## 497    0 46 179.9830    0   0    0   0 0.05940    0    0   0     1  12.0000
## 498    0 46 191.9830    0   0    0   0 0.01070    0    0   0     1  24.0000
## 499    0 46 215.9830    0   0    0   0 0.00319    0    0   0     1  48.0000
## 500    0 46 263.9830    0   0    0   0 0.00324    0    0   0     1  96.0000
## 501    0 46 335.9830    0   0    0   0 0.00277    0    0   0     1 168.0000
## 502    0 47 168.1333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 503    0 47 168.2993    0   0    0   0 0.11000    0    0   0     1   0.0830
## 504    0 47 168.4663    0   0    0   0 0.26500    0    0   0     1   0.2500
## 505    0 47 168.7163    0   0    0   0 0.42700    0    0   0     1   0.5000
## 506    0 47 169.2163    0   0    0   0 0.55200    0    0   0     1   1.0000
## 507    0 47 170.2163    0   0    0   0 0.43200    0    0   0     1   2.0000
## 508    0 47 172.2163    0   0    0   0 0.35400    0    0   0     1   4.0000
## 509    0 47 180.2163    0   0    0   0 0.09750    0    0   0     1  12.0000
## 510    0 47 192.2163    0   0    0   0 0.02520    0    0   0     1  24.0000
## 511    0 47 216.2163    0   0    0   0 0.01240    0    0   0     1  48.0000
## 512    0 47 264.2163    0   0    0   0 0.01140    0    0   0     1  96.0000
## 513    0 47 336.2163    0   0    0   0 0.00855    0    0   0     1 168.0000
## 514    0 48 167.6000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 515    0 48 167.7660    0   0    0   0 0.18300    0    0   0     1   0.0830
## 516    0 48 167.9330    0   0    0   0 0.50000    0    0   0     1   0.2500
## 517    0 48 168.1830    0   0    0   0 0.70600    0    0   0     1   0.5000
## 518    0 48 168.6830    0   0    0   0 0.98400    0    0   0     1   1.0000
## 519    0 48 169.6830    0   0    0   0 0.83000    0    0   0     1   2.0000
## 520    0 48 171.6830    0   0    0   0 0.59300    0    0   0     1   4.0000
## 521    0 48 179.6830    0   0    0   0 0.19600    0    0   0     1  12.0000
## 522    0 48 191.6830    0   0    0   0 0.05670    0    0   0     1  24.0000
## 523    0 48 215.6830    0   0    0   0 0.01880    0    0   0     1  48.0000
## 524    0 48 263.6830    0   0    0   0 0.01930    0    0   0     1  96.0000
## 525    0 48 335.6830    0   0    0   0 0.01510    0    0   0     1 168.0000
##     DOSE WT0 AGE0 HT0 SEX BLOQ           TRTNAMElabel
## 1      0  80   28 180   1  yes   1mg oral single dose
## 2      1  80   28 180   1  yes   1mg oral single dose
## 3      1  80   28 180   1   no   1mg oral single dose
## 4      1  80   28 180   1   no   1mg oral single dose
## 5      1  80   28 180   1   no   1mg oral single dose
## 6      1  80   28 180   1   no   1mg oral single dose
## 7      1  80   28 180   1   no   1mg oral single dose
## 8      1  80   28 180   1  yes   1mg oral single dose
## 9      1  80   28 180   1  yes   1mg oral single dose
## 10     1  80   28 180   1  yes   1mg oral single dose
## 11     1  80   28 180   1  yes   1mg oral single dose
## 12     1  80   28 180   1  yes   1mg oral single dose
## 13     0  68   25 166   1  yes   1mg oral single dose
## 14     1  68   25 166   1   no   1mg oral single dose
## 15     1  68   25 166   1   no   1mg oral single dose
## 16     1  68   25 166   1   no   1mg oral single dose
## 17     1  68   25 166   1   no   1mg oral single dose
## 18     1  68   25 166   1   no   1mg oral single dose
## 19     1  68   25 166   1   no   1mg oral single dose
## 20     1  68   25 166   1  yes   1mg oral single dose
## 21     1  68   25 166   1  yes   1mg oral single dose
## 22     1  68   25 166   1  yes   1mg oral single dose
## 23     1  68   25 166   1  yes   1mg oral single dose
## 24     1  68   25 166   1  yes   1mg oral single dose
## 25     0  86   29 183   1  yes   1mg oral single dose
## 26     1  86   29 183   1  yes   1mg oral single dose
## 27     1  86   29 183   1   no   1mg oral single dose
## 28     1  86   29 183   1   no   1mg oral single dose
## 29     1  86   29 183   1   no   1mg oral single dose
## 30     1  86   29 183   1   no   1mg oral single dose
## 31     1  86   29 183   1   no   1mg oral single dose
## 32     1  86   29 183   1  yes   1mg oral single dose
## 33     1  86   29 183   1  yes   1mg oral single dose
## 34     1  86   29 183   1  yes   1mg oral single dose
## 35     1  86   29 183   1  yes   1mg oral single dose
## 36     0  70   35 181   1  yes   1mg oral single dose
## 37     1  70   35 181   1  yes   1mg oral single dose
## 38     1  70   35 181   1   no   1mg oral single dose
## 39     1  70   35 181   1   no   1mg oral single dose
## 40     1  70   35 181   1   no   1mg oral single dose
## 41     1  70   35 181   1   no   1mg oral single dose
## 42     1  70   35 181   1   no   1mg oral single dose
## 43     1  70   35 181   1  yes   1mg oral single dose
## 44     1  70   35 181   1  yes   1mg oral single dose
## 45     1  70   35 181   1  yes   1mg oral single dose
## 46     1  70   35 181   1  yes   1mg oral single dose
## 47     1  70   35 181   1  yes   1mg oral single dose
## 48     0  88   28 181   1  yes   2mg oral single dose
## 49     2  88   28 181   1   no   2mg oral single dose
## 50     2  88   28 181   1   no   2mg oral single dose
## 51     2  88   28 181   1   no   2mg oral single dose
## 52     2  88   28 181   1   no   2mg oral single dose
## 53     2  88   28 181   1   no   2mg oral single dose
## 54     2  88   28 181   1   no   2mg oral single dose
## 55     2  88   28 181   1  yes   2mg oral single dose
## 56     2  88   28 181   1  yes   2mg oral single dose
## 57     2  88   28 181   1  yes   2mg oral single dose
## 58     2  88   28 181   1  yes   2mg oral single dose
## 59     0  79   29 175   1  yes   2mg oral single dose
## 60     2  79   29 175   1   no   2mg oral single dose
## 61     2  79   29 175   1   no   2mg oral single dose
## 62     2  79   29 175   1   no   2mg oral single dose
## 63     2  79   29 175   1   no   2mg oral single dose
## 64     2  79   29 175   1   no   2mg oral single dose
## 65     2  79   29 175   1   no   2mg oral single dose
## 66     2  79   29 175   1   no   2mg oral single dose
## 67     2  79   29 175   1  yes   2mg oral single dose
## 68     2  79   29 175   1  yes   2mg oral single dose
## 69     2  79   29 175   1  yes   2mg oral single dose
## 70     2  79   29 175   1  yes   2mg oral single dose
## 71     0  87   32 174   1  yes   2mg oral single dose
## 72     2  87   32 174   1   no   2mg oral single dose
## 73     2  87   32 174   1   no   2mg oral single dose
## 74     2  87   32 174   1   no   2mg oral single dose
## 75     2  87   32 174   1   no   2mg oral single dose
## 76     2  87   32 174   1   no   2mg oral single dose
## 77     2  87   32 174   1   no   2mg oral single dose
## 78     2  87   32 174   1  yes   2mg oral single dose
## 79     2  87   32 174   1  yes   2mg oral single dose
## 80     2  87   32 174   1  yes   2mg oral single dose
## 81     2  87   32 174   1  yes   2mg oral single dose
## 82     2  87   32 174   1  yes   2mg oral single dose
## 83     0  79   30 177   1  yes   2mg oral single dose
## 84     2  79   30 177   1   no   2mg oral single dose
## 85     2  79   30 177   1   no   2mg oral single dose
## 86     2  79   30 177   1   no   2mg oral single dose
## 87     2  79   30 177   1   no   2mg oral single dose
## 88     2  79   30 177   1   no   2mg oral single dose
## 89     2  79   30 177   1   no   2mg oral single dose
## 90     2  79   30 177   1  yes   2mg oral single dose
## 91     2  79   30 177   1  yes   2mg oral single dose
## 92     2  79   30 177   1  yes   2mg oral single dose
## 93     2  79   30 177   1  yes   2mg oral single dose
## 94     2  79   30 177   1  yes   2mg oral single dose
## 95     0  68   28 178   1  yes   2mg oral single dose
## 96     2  68   28 178   1  yes   2mg oral single dose
## 97     2  68   28 178   1   no   2mg oral single dose
## 98     2  68   28 178   1   no   2mg oral single dose
## 99     2  68   28 178   1   no   2mg oral single dose
## 100    2  68   28 178   1   no   2mg oral single dose
## 101    2  68   28 178   1   no   2mg oral single dose
## 102    2  68   28 178   1  yes   2mg oral single dose
## 103    2  68   28 178   1  yes   2mg oral single dose
## 104    2  68   28 178   1  yes   2mg oral single dose
## 105    2  68   28 178   1  yes   2mg oral single dose
## 106    2  68   28 178   1  yes   2mg oral single dose
## 107    0  66   36 178   1  yes   5mg oral single dose
## 108    5  66   36 178   1   no   5mg oral single dose
## 109    5  66   36 178   1   no   5mg oral single dose
## 110    5  66   36 178   1   no   5mg oral single dose
## 111    5  66   36 178   1   no   5mg oral single dose
## 112    5  66   36 178   1   no   5mg oral single dose
## 113    5  66   36 178   1   no   5mg oral single dose
## 114    5  66   36 178   1   no   5mg oral single dose
## 115    5  66   36 178   1  yes   5mg oral single dose
## 116    5  66   36 178   1  yes   5mg oral single dose
## 117    5  66   36 178   1  yes   5mg oral single dose
## 118    5  66   36 178   1  yes   5mg oral single dose
## 119    0  71   34 176   1  yes   5mg oral single dose
## 120    5  71   34 176   1   no   5mg oral single dose
## 121    5  71   34 176   1   no   5mg oral single dose
## 122    5  71   34 176   1   no   5mg oral single dose
## 123    5  71   34 176   1   no   5mg oral single dose
## 124    5  71   34 176   1   no   5mg oral single dose
## 125    5  71   34 176   1  yes   5mg oral single dose
## 126    5  71   34 176   1   no   5mg oral single dose
## 127    5  71   34 176   1  yes   5mg oral single dose
## 128    5  71   34 176   1  yes   5mg oral single dose
## 129    5  71   34 176   1  yes   5mg oral single dose
## 130    5  71   34 176   1  yes   5mg oral single dose
## 131    0  65   29 171   1  yes   5mg oral single dose
## 132    5  65   29 171   1   no   5mg oral single dose
## 133    5  65   29 171   1   no   5mg oral single dose
## 134    5  65   29 171   1   no   5mg oral single dose
## 135    5  65   29 171   1   no   5mg oral single dose
## 136    5  65   29 171   1   no   5mg oral single dose
## 137    5  65   29 171   1   no   5mg oral single dose
## 138    5  65   29 171   1   no   5mg oral single dose
## 139    5  65   29 171   1  yes   5mg oral single dose
## 140    5  65   29 171   1  yes   5mg oral single dose
## 141    5  65   29 171   1  yes   5mg oral single dose
## 142    5  65   29 171   1  yes   5mg oral single dose
## 143    0  74   24 174   1  yes   5mg oral single dose
## 144    5  74   24 174   1   no   5mg oral single dose
## 145    5  74   24 174   1   no   5mg oral single dose
## 146    5  74   24 174   1   no   5mg oral single dose
## 147    5  74   24 174   1   no   5mg oral single dose
## 148    5  74   24 174   1   no   5mg oral single dose
## 149    5  74   24 174   1   no   5mg oral single dose
## 150    5  74   24 174   1   no   5mg oral single dose
## 151    5  74   24 174   1  yes   5mg oral single dose
## 152    5  74   24 174   1  yes   5mg oral single dose
## 153    5  74   24 174   1  yes   5mg oral single dose
## 154    5  74   24 174   1   no   5mg oral single dose
## 155    0  90   25 176   1  yes   5mg oral single dose
## 156    5  90   25 176   1   no   5mg oral single dose
## 157    5  90   25 176   1   no   5mg oral single dose
## 158    5  90   25 176   1   no   5mg oral single dose
## 159    5  90   25 176   1   no   5mg oral single dose
## 160    5  90   25 176   1   no   5mg oral single dose
## 161    5  90   25 176   1   no   5mg oral single dose
## 162    5  90   25 176   1   no   5mg oral single dose
## 163    5  90   25 176   1  yes   5mg oral single dose
## 164    5  90   25 176   1  yes   5mg oral single dose
## 165    5  90   25 176   1  yes   5mg oral single dose
## 166    5  90   25 176   1  yes   5mg oral single dose
## 167    0  83   27 178   1  yes  10mg oral single dose
## 168   10  83   27 178   1   no  10mg oral single dose
## 169   10  83   27 178   1   no  10mg oral single dose
## 170   10  83   27 178   1   no  10mg oral single dose
## 171   10  83   27 178   1   no  10mg oral single dose
## 172   10  83   27 178   1   no  10mg oral single dose
## 173   10  83   27 178   1   no  10mg oral single dose
## 174   10  83   27 178   1   no  10mg oral single dose
## 175   10  83   27 178   1   no  10mg oral single dose
## 176   10  83   27 178   1  yes  10mg oral single dose
## 177   10  83   27 178   1  yes  10mg oral single dose
## 178   10  83   27 178   1  yes  10mg oral single dose
## 179    0  77   29 175   1  yes  10mg oral single dose
## 180   10  77   29 175   1   no  10mg oral single dose
## 181   10  77   29 175   1   no  10mg oral single dose
## 182   10  77   29 175   1   no  10mg oral single dose
## 183   10  77   29 175   1   no  10mg oral single dose
## 184   10  77   29 175   1   no  10mg oral single dose
## 185   10  77   29 175   1   no  10mg oral single dose
## 186   10  77   29 175   1   no  10mg oral single dose
## 187   10  77   29 175   1   no  10mg oral single dose
## 188   10  77   29 175   1  yes  10mg oral single dose
## 189   10  77   29 175   1   no  10mg oral single dose
## 190    0  78   34 181   1  yes  10mg oral single dose
## 191   10  78   34 181   1   no  10mg oral single dose
## 192   10  78   34 181   1   no  10mg oral single dose
## 193   10  78   34 181   1   no  10mg oral single dose
## 194   10  78   34 181   1   no  10mg oral single dose
## 195   10  78   34 181   1   no  10mg oral single dose
## 196   10  78   34 181   1   no  10mg oral single dose
## 197   10  78   34 181   1   no  10mg oral single dose
## 198   10  78   34 181   1   no  10mg oral single dose
## 199   10  78   34 181   1  yes  10mg oral single dose
## 200   10  78   34 181   1   no  10mg oral single dose
## 201   10  78   34 181   1  yes  10mg oral single dose
## 202    0  88   26 183   1  yes  10mg oral single dose
## 203   10  88   26 183   1   no  10mg oral single dose
## 204   10  88   26 183   1   no  10mg oral single dose
## 205   10  88   26 183   1   no  10mg oral single dose
## 206   10  88   26 183   1   no  10mg oral single dose
## 207   10  88   26 183   1   no  10mg oral single dose
## 208   10  88   26 183   1   no  10mg oral single dose
## 209   10  88   26 183   1   no  10mg oral single dose
## 210   10  88   26 183   1   no  10mg oral single dose
## 211   10  88   26 183   1  yes  10mg oral single dose
## 212   10  88   26 183   1  yes  10mg oral single dose
## 213   10  88   26 183   1  yes  10mg oral single dose
## 214    0  85   24 176   1  yes  10mg oral single dose
## 215   10  85   24 176   1   no  10mg oral single dose
## 216   10  85   24 176   1   no  10mg oral single dose
## 217   10  85   24 176   1   no  10mg oral single dose
## 218   10  85   24 176   1   no  10mg oral single dose
## 219   10  85   24 176   1   no  10mg oral single dose
## 220   10  85   24 176   1   no  10mg oral single dose
## 221   10  85   24 176   1   no  10mg oral single dose
## 222   10  85   24 176   1   no  10mg oral single dose
## 223   10  85   24 176   1  yes  10mg oral single dose
## 224   10  85   24 176   1  yes  10mg oral single dose
## 225   10  85   24 176   1  yes  10mg oral single dose
## 226    0  75   18 183   1  yes  10mg oral single dose
## 227   10  75   18 183   1   no  10mg oral single dose
## 228   10  75   18 183   1   no  10mg oral single dose
## 229   10  75   18 183   1   no  10mg oral single dose
## 230   10  75   18 183   1   no  10mg oral single dose
## 231   10  75   18 183   1   no  10mg oral single dose
## 232   10  75   18 183   1   no  10mg oral single dose
## 233   10  75   18 183   1   no  10mg oral single dose
## 234   10  75   18 183   1   no  10mg oral single dose
## 235   10  75   18 183   1   no  10mg oral single dose
## 236   10  75   18 183   1   no  10mg oral single dose
## 237   10  75   18 183   1   no  10mg oral single dose
## 238    0  78   32 186   1  yes  20mg oral single dose
## 239   20  78   32 186   1   no  20mg oral single dose
## 240   20  78   32 186   1   no  20mg oral single dose
## 241   20  78   32 186   1   no  20mg oral single dose
## 242   20  78   32 186   1   no  20mg oral single dose
## 243   20  78   32 186   1   no  20mg oral single dose
## 244   20  78   32 186   1   no  20mg oral single dose
## 245   20  78   32 186   1   no  20mg oral single dose
## 246   20  78   32 186   1   no  20mg oral single dose
## 247   20  78   32 186   1   no  20mg oral single dose
## 248   20  78   32 186   1  yes  20mg oral single dose
## 249   20  78   32 186   1   no  20mg oral single dose
## 250    0  87   23 179   1  yes  20mg oral single dose
## 251   20  87   23 179   1   no  20mg oral single dose
## 252   20  87   23 179   1   no  20mg oral single dose
## 253   20  87   23 179   1   no  20mg oral single dose
## 254   20  87   23 179   1   no  20mg oral single dose
## 255   20  87   23 179   1   no  20mg oral single dose
## 256   20  87   23 179   1   no  20mg oral single dose
## 257   20  87   23 179   1   no  20mg oral single dose
## 258   20  87   23 179   1   no  20mg oral single dose
## 259   20  87   23 179   1  yes  20mg oral single dose
## 260   20  87   23 179   1  yes  20mg oral single dose
## 261   20  87   23 179   1  yes  20mg oral single dose
## 262    0  68   28 184   1  yes  20mg oral single dose
## 263   20  68   28 184   1   no  20mg oral single dose
## 264   20  68   28 184   1   no  20mg oral single dose
## 265   20  68   28 184   1   no  20mg oral single dose
## 266   20  68   28 184   1   no  20mg oral single dose
## 267   20  68   28 184   1   no  20mg oral single dose
## 268   20  68   28 184   1   no  20mg oral single dose
## 269   20  68   28 184   1   no  20mg oral single dose
## 270   20  68   28 184   1   no  20mg oral single dose
## 271   20  68   28 184   1   no  20mg oral single dose
## 272   20  68   28 184   1   no  20mg oral single dose
## 273   20  68   28 184   1   no  20mg oral single dose
## 274    0  77   32 168   1  yes  20mg oral single dose
## 275   20  77   32 168   1   no  20mg oral single dose
## 276   20  77   32 168   1   no  20mg oral single dose
## 277   20  77   32 168   1   no  20mg oral single dose
## 278   20  77   32 168   1   no  20mg oral single dose
## 279   20  77   32 168   1   no  20mg oral single dose
## 280   20  77   32 168   1   no  20mg oral single dose
## 281   20  77   32 168   1   no  20mg oral single dose
## 282   20  77   32 168   1   no  20mg oral single dose
## 283   20  77   32 168   1   no  20mg oral single dose
## 284   20  77   32 168   1   no  20mg oral single dose
## 285   20  77   32 168   1   no  20mg oral single dose
## 286    0  74   31 181   1  yes  20mg oral single dose
## 287   20  74   31 181   1   no  20mg oral single dose
## 288   20  74   31 181   1   no  20mg oral single dose
## 289   20  74   31 181   1   no  20mg oral single dose
## 290   20  74   31 181   1   no  20mg oral single dose
## 291   20  74   31 181   1   no  20mg oral single dose
## 292   20  74   31 181   1   no  20mg oral single dose
## 293   20  74   31 181   1   no  20mg oral single dose
## 294   20  74   31 181   1   no  20mg oral single dose
## 295   20  74   31 181   1   no  20mg oral single dose
## 296   20  74   31 181   1   no  20mg oral single dose
## 297   20  74   31 181   1  yes  20mg oral single dose
## 298    0  78   27 181   1  yes  20mg oral single dose
## 299   20  78   27 181   1   no  20mg oral single dose
## 300   20  78   27 181   1   no  20mg oral single dose
## 301   20  78   27 181   1   no  20mg oral single dose
## 302   20  78   27 181   1   no  20mg oral single dose
## 303   20  78   27 181   1   no  20mg oral single dose
## 304   20  78   27 181   1   no  20mg oral single dose
## 305   20  78   27 181   1   no  20mg oral single dose
## 306   20  78   27 181   1   no  20mg oral single dose
## 307   20  78   27 181   1   no  20mg oral single dose
## 308   20  78   27 181   1   no  20mg oral single dose
## 309   20  78   27 181   1   no  20mg oral single dose
## 310    0  74   23 176   1  yes  50mg oral single dose
## 311   50  74   23 176   1   no  50mg oral single dose
## 312   50  74   23 176   1   no  50mg oral single dose
## 313   50  74   23 176   1   no  50mg oral single dose
## 314   50  74   23 176   1   no  50mg oral single dose
## 315   50  74   23 176   1   no  50mg oral single dose
## 316   50  74   23 176   1   no  50mg oral single dose
## 317   50  74   23 176   1   no  50mg oral single dose
## 318   50  74   23 176   1   no  50mg oral single dose
## 319   50  74   23 176   1   no  50mg oral single dose
## 320   50  74   23 176   1   no  50mg oral single dose
## 321   50  74   23 176   1  yes  50mg oral single dose
## 322    0  85   29 180   1  yes  50mg oral single dose
## 323   50  85   29 180   1   no  50mg oral single dose
## 324   50  85   29 180   1   no  50mg oral single dose
## 325   50  85   29 180   1   no  50mg oral single dose
## 326   50  85   29 180   1   no  50mg oral single dose
## 327   50  85   29 180   1   no  50mg oral single dose
## 328   50  85   29 180   1   no  50mg oral single dose
## 329   50  85   29 180   1   no  50mg oral single dose
## 330   50  85   29 180   1   no  50mg oral single dose
## 331   50  85   29 180   1   no  50mg oral single dose
## 332   50  85   29 180   1   no  50mg oral single dose
## 333   50  85   29 180   1   no  50mg oral single dose
## 334    0  76   35 174   1  yes  50mg oral single dose
## 335   50  76   35 174   1   no  50mg oral single dose
## 336   50  76   35 174   1   no  50mg oral single dose
## 337   50  76   35 174   1   no  50mg oral single dose
## 338   50  76   35 174   1   no  50mg oral single dose
## 339   50  76   35 174   1   no  50mg oral single dose
## 340   50  76   35 174   1   no  50mg oral single dose
## 341   50  76   35 174   1   no  50mg oral single dose
## 342   50  76   35 174   1   no  50mg oral single dose
## 343   50  76   35 174   1   no  50mg oral single dose
## 344   50  76   35 174   1   no  50mg oral single dose
## 345   50  76   35 174   1   no  50mg oral single dose
## 346    0  84   27 181   1  yes  50mg oral single dose
## 347   50  84   27 181   1   no  50mg oral single dose
## 348   50  84   27 181   1   no  50mg oral single dose
## 349   50  84   27 181   1   no  50mg oral single dose
## 350   50  84   27 181   1   no  50mg oral single dose
## 351   50  84   27 181   1   no  50mg oral single dose
## 352   50  84   27 181   1   no  50mg oral single dose
## 353   50  84   27 181   1   no  50mg oral single dose
## 354   50  84   27 181   1   no  50mg oral single dose
## 355   50  84   27 181   1   no  50mg oral single dose
## 356   50  84   27 181   1   no  50mg oral single dose
## 357   50  84   27 181   1  yes  50mg oral single dose
## 358    0  94   34 181   1  yes  50mg oral single dose
## 359   50  94   34 181   1   no  50mg oral single dose
## 360   50  94   34 181   1   no  50mg oral single dose
## 361   50  94   34 181   1   no  50mg oral single dose
## 362   50  94   34 181   1   no  50mg oral single dose
## 363   50  94   34 181   1   no  50mg oral single dose
## 364   50  94   34 181   1   no  50mg oral single dose
## 365   50  94   34 181   1   no  50mg oral single dose
## 366   50  94   34 181   1   no  50mg oral single dose
## 367   50  94   34 181   1   no  50mg oral single dose
## 368   50  94   34 181   1   no  50mg oral single dose
## 369   50  94   34 181   1   no  50mg oral single dose
## 370    0  75   34 182   1  yes  50mg oral single dose
## 371   50  75   34 182   1   no  50mg oral single dose
## 372   50  75   34 182   1   no  50mg oral single dose
## 373   50  75   34 182   1   no  50mg oral single dose
## 374   50  75   34 182   1   no  50mg oral single dose
## 375   50  75   34 182   1   no  50mg oral single dose
## 376   50  75   34 182   1   no  50mg oral single dose
## 377   50  75   34 182   1   no  50mg oral single dose
## 378   50  75   34 182   1   no  50mg oral single dose
## 379   50  75   34 182   1   no  50mg oral single dose
## 380   50  75   34 182   1   no  50mg oral single dose
## 381   50  75   34 182   1   no  50mg oral single dose
## 382    0  78   22 178   1  yes 100mg oral single dose
## 383  100  78   22 178   1   no 100mg oral single dose
## 384  100  78   22 178   1   no 100mg oral single dose
## 385  100  78   22 178   1   no 100mg oral single dose
## 386  100  78   22 178   1   no 100mg oral single dose
## 387  100  78   22 178   1   no 100mg oral single dose
## 388  100  78   22 178   1   no 100mg oral single dose
## 389  100  78   22 178   1   no 100mg oral single dose
## 390  100  78   22 178   1   no 100mg oral single dose
## 391  100  78   22 178   1   no 100mg oral single dose
## 392  100  78   22 178   1   no 100mg oral single dose
## 393  100  78   22 178   1   no 100mg oral single dose
## 394    0  80   21 184   1  yes 100mg oral single dose
## 395  100  80   21 184   1   no 100mg oral single dose
## 396  100  80   21 184   1   no 100mg oral single dose
## 397  100  80   21 184   1   no 100mg oral single dose
## 398  100  80   21 184   1   no 100mg oral single dose
## 399  100  80   21 184   1   no 100mg oral single dose
## 400  100  80   21 184   1   no 100mg oral single dose
## 401  100  80   21 184   1   no 100mg oral single dose
## 402  100  80   21 184   1   no 100mg oral single dose
## 403  100  80   21 184   1   no 100mg oral single dose
## 404  100  80   21 184   1   no 100mg oral single dose
## 405  100  80   21 184   1   no 100mg oral single dose
## 406    0  85   32 179   1  yes 100mg oral single dose
## 407  100  85   32 179   1   no 100mg oral single dose
## 408  100  85   32 179   1   no 100mg oral single dose
## 409  100  85   32 179   1   no 100mg oral single dose
## 410  100  85   32 179   1   no 100mg oral single dose
## 411  100  85   32 179   1   no 100mg oral single dose
## 412  100  85   32 179   1   no 100mg oral single dose
## 413  100  85   32 179   1   no 100mg oral single dose
## 414  100  85   32 179   1   no 100mg oral single dose
## 415  100  85   32 179   1   no 100mg oral single dose
## 416  100  85   32 179   1   no 100mg oral single dose
## 417  100  85   32 179   1   no 100mg oral single dose
## 418    0  92   33 179   1  yes 100mg oral single dose
## 419  100  92   33 179   1   no 100mg oral single dose
## 420  100  92   33 179   1   no 100mg oral single dose
## 421  100  92   33 179   1   no 100mg oral single dose
## 422  100  92   33 179   1   no 100mg oral single dose
## 423  100  92   33 179   1   no 100mg oral single dose
## 424  100  92   33 179   1   no 100mg oral single dose
## 425  100  92   33 179   1   no 100mg oral single dose
## 426  100  92   33 179   1   no 100mg oral single dose
## 427  100  92   33 179   1   no 100mg oral single dose
## 428  100  92   33 179   1   no 100mg oral single dose
## 429  100  92   33 179   1   no 100mg oral single dose
## 430    0  88   34 178   1  yes 100mg oral single dose
## 431  100  88   34 178   1   no 100mg oral single dose
## 432  100  88   34 178   1   no 100mg oral single dose
## 433  100  88   34 178   1   no 100mg oral single dose
## 434  100  88   34 178   1   no 100mg oral single dose
## 435  100  88   34 178   1   no 100mg oral single dose
## 436  100  88   34 178   1   no 100mg oral single dose
## 437  100  88   34 178   1   no 100mg oral single dose
## 438  100  88   34 178   1   no 100mg oral single dose
## 439  100  88   34 178   1   no 100mg oral single dose
## 440  100  88   34 178   1   no 100mg oral single dose
## 441  100  88   34 178   1   no 100mg oral single dose
## 442    0  90   31 188   1  yes 100mg oral single dose
## 443  100  90   31 188   1   no 100mg oral single dose
## 444  100  90   31 188   1   no 100mg oral single dose
## 445  100  90   31 188   1   no 100mg oral single dose
## 446  100  90   31 188   1   no 100mg oral single dose
## 447  100  90   31 188   1   no 100mg oral single dose
## 448  100  90   31 188   1   no 100mg oral single dose
## 449  100  90   31 188   1   no 100mg oral single dose
## 450  100  90   31 188   1   no 100mg oral single dose
## 451  100  90   31 188   1   no 100mg oral single dose
## 452  100  90   31 188   1   no 100mg oral single dose
## 453  100  90   31 188   1   no 100mg oral single dose
## 454    0  73   31 176   1  yes 200mg oral single dose
## 455  200  73   31 176   1   no 200mg oral single dose
## 456  200  73   31 176   1   no 200mg oral single dose
## 457  200  73   31 176   1   no 200mg oral single dose
## 458  200  73   31 176   1   no 200mg oral single dose
## 459  200  73   31 176   1   no 200mg oral single dose
## 460  200  73   31 176   1   no 200mg oral single dose
## 461  200  73   31 176   1   no 200mg oral single dose
## 462  200  73   31 176   1   no 200mg oral single dose
## 463  200  73   31 176   1   no 200mg oral single dose
## 464  200  73   31 176   1   no 200mg oral single dose
## 465  200  73   31 176   1   no 200mg oral single dose
## 466    0  78   28 183   1  yes 200mg oral single dose
## 467  200  78   28 183   1   no 200mg oral single dose
## 468  200  78   28 183   1   no 200mg oral single dose
## 469  200  78   28 183   1   no 200mg oral single dose
## 470  200  78   28 183   1   no 200mg oral single dose
## 471  200  78   28 183   1   no 200mg oral single dose
## 472  200  78   28 183   1   no 200mg oral single dose
## 473  200  78   28 183   1   no 200mg oral single dose
## 474  200  78   28 183   1   no 200mg oral single dose
## 475  200  78   28 183   1   no 200mg oral single dose
## 476  200  78   28 183   1   no 200mg oral single dose
## 477  200  78   28 183   1   no 200mg oral single dose
## 478    0  67   31 172   1  yes 200mg oral single dose
## 479  200  67   31 172   1   no 200mg oral single dose
## 480  200  67   31 172   1   no 200mg oral single dose
## 481  200  67   31 172   1   no 200mg oral single dose
## 482  200  67   31 172   1   no 200mg oral single dose
## 483  200  67   31 172   1   no 200mg oral single dose
## 484  200  67   31 172   1   no 200mg oral single dose
## 485  200  67   31 172   1   no 200mg oral single dose
## 486  200  67   31 172   1   no 200mg oral single dose
## 487  200  67   31 172   1   no 200mg oral single dose
## 488  200  67   31 172   1   no 200mg oral single dose
## 489  200  67   31 172   1   no 200mg oral single dose
## 490    0  77   32 178   1  yes 200mg oral single dose
## 491  200  77   32 178   1   no 200mg oral single dose
## 492  200  77   32 178   1   no 200mg oral single dose
## 493  200  77   32 178   1   no 200mg oral single dose
## 494  200  77   32 178   1   no 200mg oral single dose
## 495  200  77   32 178   1   no 200mg oral single dose
## 496  200  77   32 178   1   no 200mg oral single dose
## 497  200  77   32 178   1   no 200mg oral single dose
## 498  200  77   32 178   1   no 200mg oral single dose
## 499  200  77   32 178   1   no 200mg oral single dose
## 500  200  77   32 178   1   no 200mg oral single dose
## 501  200  77   32 178   1   no 200mg oral single dose
## 502    0  91   38 174   1  yes 200mg oral single dose
## 503  200  91   38 174   1   no 200mg oral single dose
## 504  200  91   38 174   1   no 200mg oral single dose
## 505  200  91   38 174   1   no 200mg oral single dose
## 506  200  91   38 174   1   no 200mg oral single dose
## 507  200  91   38 174   1   no 200mg oral single dose
## 508  200  91   38 174   1   no 200mg oral single dose
## 509  200  91   38 174   1   no 200mg oral single dose
## 510  200  91   38 174   1   no 200mg oral single dose
## 511  200  91   38 174   1   no 200mg oral single dose
## 512  200  91   38 174   1   no 200mg oral single dose
## 513  200  91   38 174   1   no 200mg oral single dose
## 514    0  77   22 176   1  yes 200mg oral single dose
## 515  200  77   22 176   1   no 200mg oral single dose
## 516  200  77   22 176   1   no 200mg oral single dose
## 517  200  77   22 176   1   no 200mg oral single dose
## 518  200  77   22 176   1   no 200mg oral single dose
## 519  200  77   22 176   1   no 200mg oral single dose
## 520  200  77   22 176   1   no 200mg oral single dose
## 521  200  77   22 176   1   no 200mg oral single dose
## 522  200  77   22 176   1   no 200mg oral single dose
## 523  200  77   22 176   1   no 200mg oral single dose
## 524  200  77   22 176   1   no 200mg oral single dose
## 525  200  77   22 176   1   no 200mg oral single dose
# Lines per idividual
plotSpaghetti_IQRdataGENERAL(data1CleanM3, stratify = "AGE0")
## $unstratified
## $unstratified$`Plasma concentration IQ0815`

## 
## attr(,"split_type")
## [1] "data.frame"
## attr(,"split_labels")
##                          NAME
## 1 Plasma concentration IQ0815
## 
## $stratified
## $stratified$`Plasma concentration IQ0815.AGE0CAT::1`

## 
## $stratified$`Plasma concentration IQ0815.AGE0CAT::2`

## 
## attr(,"strat_info")
##                          NAME VALUE   STRAT
## 1 Plasma concentration IQ0815     1 AGE0CAT
## 2 Plasma concentration IQ0815     2 AGE0CAT
## 
## attr(,"data")
## attr(,"data")$unstratified
## attr(,"data")$unstratified$`Plasma concentration IQ0815`
##     IXGDF IGNORE           USUBJID CENTER         STUDY STUDYN
## 1      20   <NA> IQ00701-0100-0003    100           FIH      1
## 2      22   <NA> IQ00701-0100-0003    100           FIH      1
## 3      23   <NA> IQ00701-0100-0003    100           FIH      1
## 4      24   <NA> IQ00701-0100-0003    100           FIH      1
## 5      25   <NA> IQ00701-0100-0003    100           FIH      1
## 6      26   <NA> IQ00701-0100-0003    100           FIH      1
## 7      27   <NA> IQ00701-0100-0003    100           FIH      1
## 8      28   <NA> IQ00701-0100-0003    100           FIH      1
## 9      29   <NA> IQ00701-0100-0003    100           FIH      1
## 10     30   <NA> IQ00701-0100-0003    100           FIH      1
## 11     31   <NA> IQ00701-0100-0003    100           FIH      1
## 12     32   <NA> IQ00701-0100-0003    100           FIH      1
## 13     37   <NA> IQ00701-0100-0004    100           FIH      1
## 14     39   <NA> IQ00701-0100-0004    100           FIH      1
## 15     40   <NA> IQ00701-0100-0004    100           FIH      1
## 16     41   <NA> IQ00701-0100-0004    100           FIH      1
## 17     42   <NA> IQ00701-0100-0004    100           FIH      1
## 18     43   <NA> IQ00701-0100-0004    100           FIH      1
## 19     44   <NA> IQ00701-0100-0004    100           FIH      1
## 20     45   <NA> IQ00701-0100-0004    100           FIH      1
## 21     46   <NA> IQ00701-0100-0004    100           FIH      1
## 22     47   <NA> IQ00701-0100-0004    100           FIH      1
## 23     48   <NA> IQ00701-0100-0004    100           FIH      1
## 24     49   <NA> IQ00701-0100-0004    100           FIH      1
## 25     54   <NA> IQ00701-0100-0005    100           FIH      1
## 26     56   <NA> IQ00701-0100-0005    100           FIH      1
## 27     57   <NA> IQ00701-0100-0005    100           FIH      1
## 28     58   <NA> IQ00701-0100-0005    100           FIH      1
## 29     60   <NA> IQ00701-0100-0005    100           FIH      1
## 30     61   <NA> IQ00701-0100-0005    100           FIH      1
## 31     62   <NA> IQ00701-0100-0005    100           FIH      1
## 32     63   <NA> IQ00701-0100-0005    100           FIH      1
## 33     64   <NA> IQ00701-0100-0005    100           FIH      1
## 34     65   <NA> IQ00701-0100-0005    100           FIH      1
## 35     66   <NA> IQ00701-0100-0005    100           FIH      1
## 36     71   <NA> IQ00701-0100-0006    100           FIH      1
## 37     73   <NA> IQ00701-0100-0006    100           FIH      1
## 38     74   <NA> IQ00701-0100-0006    100           FIH      1
## 39     75   <NA> IQ00701-0100-0006    100           FIH      1
## 40     76   <NA> IQ00701-0100-0006    100           FIH      1
## 41     77   <NA> IQ00701-0100-0006    100           FIH      1
## 42     78   <NA> IQ00701-0100-0006    100           FIH      1
## 43     79   <NA> IQ00701-0100-0006    100           FIH      1
## 44     80   <NA> IQ00701-0100-0006    100           FIH      1
## 45     81   <NA> IQ00701-0100-0006    100           FIH      1
## 46     82   <NA> IQ00701-0100-0006    100           FIH      1
## 47     83   <NA> IQ00701-0100-0006    100           FIH      1
## 48     88   <NA> IQ00701-0100-0007    100           FIH      1
## 49     90   <NA> IQ00701-0100-0007    100           FIH      1
## 50     91   <NA> IQ00701-0100-0007    100           FIH      1
## 51     92   <NA> IQ00701-0100-0007    100           FIH      1
## 52     93   <NA> IQ00701-0100-0007    100           FIH      1
## 53     94   <NA> IQ00701-0100-0007    100           FIH      1
## 54     95   <NA> IQ00701-0100-0007    100           FIH      1
## 55     96   <NA> IQ00701-0100-0007    100           FIH      1
## 56     97   <NA> IQ00701-0100-0007    100           FIH      1
## 57     99   <NA> IQ00701-0100-0007    100           FIH      1
## 58    100   <NA> IQ00701-0100-0007    100           FIH      1
## 59    106   <NA> IQ00701-0100-0009    100           FIH      1
## 60    108   <NA> IQ00701-0100-0009    100           FIH      1
## 61    109   <NA> IQ00701-0100-0009    100           FIH      1
## 62    110   <NA> IQ00701-0100-0009    100           FIH      1
## 63    111   <NA> IQ00701-0100-0009    100           FIH      1
## 64    112   <NA> IQ00701-0100-0009    100           FIH      1
## 65    113   <NA> IQ00701-0100-0009    100           FIH      1
## 66    114   <NA> IQ00701-0100-0009    100           FIH      1
## 67    115   <NA> IQ00701-0100-0009    100           FIH      1
## 68    116   <NA> IQ00701-0100-0009    100           FIH      1
## 69    117   <NA> IQ00701-0100-0009    100           FIH      1
## 70    118   <NA> IQ00701-0100-0009    100           FIH      1
## 71    123   <NA> IQ00701-0100-0010    100           FIH      1
## 72    125   <NA> IQ00701-0100-0010    100           FIH      1
## 73    126   <NA> IQ00701-0100-0010    100           FIH      1
## 74    127   <NA> IQ00701-0100-0010    100           FIH      1
## 75    128   <NA> IQ00701-0100-0010    100           FIH      1
## 76    129   <NA> IQ00701-0100-0010    100           FIH      1
## 77    130   <NA> IQ00701-0100-0010    100           FIH      1
## 78    131   <NA> IQ00701-0100-0010    100           FIH      1
## 79    132   <NA> IQ00701-0100-0010    100           FIH      1
## 80    133   <NA> IQ00701-0100-0010    100           FIH      1
## 81    134   <NA> IQ00701-0100-0010    100           FIH      1
## 82    135   <NA> IQ00701-0100-0010    100           FIH      1
## 83    139   <NA> IQ00701-0100-0011    100           FIH      1
## 84    141   <NA> IQ00701-0100-0011    100           FIH      1
## 85    142   <NA> IQ00701-0100-0011    100           FIH      1
## 86    143   <NA> IQ00701-0100-0011    100           FIH      1
## 87    144   <NA> IQ00701-0100-0011    100           FIH      1
## 88    145   <NA> IQ00701-0100-0011    100           FIH      1
## 89    146   <NA> IQ00701-0100-0011    100           FIH      1
## 90    147   <NA> IQ00701-0100-0011    100           FIH      1
## 91    148   <NA> IQ00701-0100-0011    100           FIH      1
## 92    149   <NA> IQ00701-0100-0011    100           FIH      1
## 93    150   <NA> IQ00701-0100-0011    100           FIH      1
## 94    151   <NA> IQ00701-0100-0011    100           FIH      1
## 95    156   <NA> IQ00701-0100-0012    100           FIH      1
## 96    158   <NA> IQ00701-0100-0012    100           FIH      1
## 97    159   <NA> IQ00701-0100-0012    100           FIH      1
## 98    160   <NA> IQ00701-0100-0012    100           FIH      1
## 99    161   <NA> IQ00701-0100-0012    100           FIH      1
## 100   162   <NA> IQ00701-0100-0012    100           FIH      1
## 101   163   <NA> IQ00701-0100-0012    100           FIH      1
## 102   164   <NA> IQ00701-0100-0012    100           FIH      1
## 103   165   <NA> IQ00701-0100-0012    100           FIH      1
## 104   166   <NA> IQ00701-0100-0012    100           FIH      1
## 105   167   <NA> IQ00701-0100-0012    100           FIH      1
## 106   168   <NA> IQ00701-0100-0012    100           FIH      1
## 107   172   <NA> IQ00701-0100-0013    100           FIH      1
## 108   174   <NA> IQ00701-0100-0013    100           FIH      1
## 109   175   <NA> IQ00701-0100-0013    100           FIH      1
## 110   176   <NA> IQ00701-0100-0013    100           FIH      1
## 111   177   <NA> IQ00701-0100-0013    100           FIH      1
## 112   178   <NA> IQ00701-0100-0013    100           FIH      1
## 113   179   <NA> IQ00701-0100-0013    100           FIH      1
## 114   180   <NA> IQ00701-0100-0013    100           FIH      1
## 115   181   <NA> IQ00701-0100-0013    100           FIH      1
## 116   182   <NA> IQ00701-0100-0013    100           FIH      1
## 117   183   <NA> IQ00701-0100-0013    100           FIH      1
## 118   184   <NA> IQ00701-0100-0013    100           FIH      1
## 119   189   <NA> IQ00701-0100-0014    100           FIH      1
## 120   191   <NA> IQ00701-0100-0014    100           FIH      1
## 121   192   <NA> IQ00701-0100-0014    100           FIH      1
## 122   193   <NA> IQ00701-0100-0014    100           FIH      1
## 123   194   <NA> IQ00701-0100-0014    100           FIH      1
## 124   195   <NA> IQ00701-0100-0014    100           FIH      1
## 125   196   <NA> IQ00701-0100-0014    100           FIH      1
## 126   197   <NA> IQ00701-0100-0014    100           FIH      1
## 127   198   <NA> IQ00701-0100-0014    100           FIH      1
## 128   199   <NA> IQ00701-0100-0014    100           FIH      1
## 129   200   <NA> IQ00701-0100-0014    100           FIH      1
## 130   201   <NA> IQ00701-0100-0014    100           FIH      1
## 131   206   <NA> IQ00701-0100-0015    100           FIH      1
## 132   208   <NA> IQ00701-0100-0015    100           FIH      1
## 133   209   <NA> IQ00701-0100-0015    100           FIH      1
## 134   210   <NA> IQ00701-0100-0015    100           FIH      1
## 135   211   <NA> IQ00701-0100-0015    100           FIH      1
## 136   212   <NA> IQ00701-0100-0015    100           FIH      1
## 137   213   <NA> IQ00701-0100-0015    100           FIH      1
## 138   214   <NA> IQ00701-0100-0015    100           FIH      1
## 139   215   <NA> IQ00701-0100-0015    100           FIH      1
## 140   216   <NA> IQ00701-0100-0015    100           FIH      1
## 141   217   <NA> IQ00701-0100-0015    100           FIH      1
## 142   218   <NA> IQ00701-0100-0015    100           FIH      1
## 143   223   <NA> IQ00701-0100-0016    100           FIH      1
## 144   225   <NA> IQ00701-0100-0016    100           FIH      1
## 145   226   <NA> IQ00701-0100-0016    100           FIH      1
## 146   227   <NA> IQ00701-0100-0016    100           FIH      1
## 147   228   <NA> IQ00701-0100-0016    100           FIH      1
## 148   229   <NA> IQ00701-0100-0016    100           FIH      1
## 149   230   <NA> IQ00701-0100-0016    100           FIH      1
## 150   231   <NA> IQ00701-0100-0016    100           FIH      1
## 151   232   <NA> IQ00701-0100-0016    100           FIH      1
## 152   233   <NA> IQ00701-0100-0016    100           FIH      1
## 153   234   <NA> IQ00701-0100-0016    100           FIH      1
## 154   235   <NA> IQ00701-0100-0016    100           FIH      1
## 155   240   <NA> IQ00701-0100-0017    100           FIH      1
## 156   242   <NA> IQ00701-0100-0017    100           FIH      1
## 157   243   <NA> IQ00701-0100-0017    100           FIH      1
## 158   244   <NA> IQ00701-0100-0017    100           FIH      1
## 159   245   <NA> IQ00701-0100-0017    100           FIH      1
## 160   246   <NA> IQ00701-0100-0017    100           FIH      1
## 161   247   <NA> IQ00701-0100-0017    100           FIH      1
## 162   248   <NA> IQ00701-0100-0017    100           FIH      1
## 163   249   <NA> IQ00701-0100-0017    100           FIH      1
## 164   250   <NA> IQ00701-0100-0017    100           FIH      1
## 165   251   <NA> IQ00701-0100-0017    100           FIH      1
## 166   252   <NA> IQ00701-0100-0017    100           FIH      1
## 167   274   <NA> IQ00701-0100-0019    100           FIH      1
## 168   276   <NA> IQ00701-0100-0019    100           FIH      1
## 169   277   <NA> IQ00701-0100-0019    100           FIH      1
## 170   278   <NA> IQ00701-0100-0019    100           FIH      1
## 171   279   <NA> IQ00701-0100-0019    100           FIH      1
## 172   280   <NA> IQ00701-0100-0019    100           FIH      1
## 173   281   <NA> IQ00701-0100-0019    100           FIH      1
## 174   282   <NA> IQ00701-0100-0019    100           FIH      1
## 175   283   <NA> IQ00701-0100-0019    100           FIH      1
## 176   284   <NA> IQ00701-0100-0019    100           FIH      1
## 177   285   <NA> IQ00701-0100-0019    100           FIH      1
## 178   286   <NA> IQ00701-0100-0019    100           FIH      1
## 179   291   <NA> IQ00701-0100-0020    100           FIH      1
## 180   293   <NA> IQ00701-0100-0020    100           FIH      1
## 181   294   <NA> IQ00701-0100-0020    100           FIH      1
## 182   295   <NA> IQ00701-0100-0020    100           FIH      1
## 183   296   <NA> IQ00701-0100-0020    100           FIH      1
## 184   297   <NA> IQ00701-0100-0020    100           FIH      1
## 185   298   <NA> IQ00701-0100-0020    100           FIH      1
## 186   299   <NA> IQ00701-0100-0020    100           FIH      1
## 187   300   <NA> IQ00701-0100-0020    100           FIH      1
## 188   302   <NA> IQ00701-0100-0020    100           FIH      1
## 189   303   <NA> IQ00701-0100-0020    100           FIH      1
## 190   308   <NA> IQ00701-0100-0021    100           FIH      1
## 191   310   <NA> IQ00701-0100-0021    100           FIH      1
## 192   311   <NA> IQ00701-0100-0021    100           FIH      1
## 193   312   <NA> IQ00701-0100-0021    100           FIH      1
## 194   313   <NA> IQ00701-0100-0021    100           FIH      1
## 195   314   <NA> IQ00701-0100-0021    100           FIH      1
## 196   315   <NA> IQ00701-0100-0021    100           FIH      1
## 197   316   <NA> IQ00701-0100-0021    100           FIH      1
## 198   317   <NA> IQ00701-0100-0021    100           FIH      1
## 199   318   <NA> IQ00701-0100-0021    100           FIH      1
## 200   319   <NA> IQ00701-0100-0021    100           FIH      1
## 201   320   <NA> IQ00701-0100-0021    100           FIH      1
## 202   325   <NA> IQ00701-0100-0022    100           FIH      1
## 203   327   <NA> IQ00701-0100-0022    100           FIH      1
## 204   328   <NA> IQ00701-0100-0022    100           FIH      1
## 205   329   <NA> IQ00701-0100-0022    100           FIH      1
## 206   330   <NA> IQ00701-0100-0022    100           FIH      1
## 207   331   <NA> IQ00701-0100-0022    100           FIH      1
## 208   332   <NA> IQ00701-0100-0022    100           FIH      1
## 209   333   <NA> IQ00701-0100-0022    100           FIH      1
## 210   334   <NA> IQ00701-0100-0022    100           FIH      1
## 211   335   <NA> IQ00701-0100-0022    100           FIH      1
## 212   336   <NA> IQ00701-0100-0022    100           FIH      1
## 213   337   <NA> IQ00701-0100-0022    100           FIH      1
## 214   342   <NA> IQ00701-0100-0023    100           FIH      1
## 215   344   <NA> IQ00701-0100-0023    100           FIH      1
## 216   345   <NA> IQ00701-0100-0023    100           FIH      1
## 217   346   <NA> IQ00701-0100-0023    100           FIH      1
## 218   347   <NA> IQ00701-0100-0023    100           FIH      1
## 219   348   <NA> IQ00701-0100-0023    100           FIH      1
## 220   349   <NA> IQ00701-0100-0023    100           FIH      1
## 221   350   <NA> IQ00701-0100-0023    100           FIH      1
## 222   351   <NA> IQ00701-0100-0023    100           FIH      1
## 223   352   <NA> IQ00701-0100-0023    100           FIH      1
## 224   353   <NA> IQ00701-0100-0023    100           FIH      1
## 225   354   <NA> IQ00701-0100-0023    100           FIH      1
## 226   359   <NA> IQ00701-0100-0024    100           FIH      1
## 227   361   <NA> IQ00701-0100-0024    100           FIH      1
## 228   362   <NA> IQ00701-0100-0024    100           FIH      1
## 229   363   <NA> IQ00701-0100-0024    100           FIH      1
## 230   364   <NA> IQ00701-0100-0024    100           FIH      1
## 231   365   <NA> IQ00701-0100-0024    100           FIH      1
## 232   366   <NA> IQ00701-0100-0024    100           FIH      1
## 233   367   <NA> IQ00701-0100-0024    100           FIH      1
## 234   368   <NA> IQ00701-0100-0024    100           FIH      1
## 235   369   <NA> IQ00701-0100-0024    100           FIH      1
## 236   370   <NA> IQ00701-0100-0024    100           FIH      1
## 237   371   <NA> IQ00701-0100-0024    100           FIH      1
## 238   376   <NA> IQ00701-0100-0025    100           FIH      1
## 239   378   <NA> IQ00701-0100-0025    100           FIH      1
## 240   379   <NA> IQ00701-0100-0025    100           FIH      1
## 241   380   <NA> IQ00701-0100-0025    100           FIH      1
## 242   381   <NA> IQ00701-0100-0025    100           FIH      1
## 243   382   <NA> IQ00701-0100-0025    100           FIH      1
## 244   383   <NA> IQ00701-0100-0025    100           FIH      1
## 245   384   <NA> IQ00701-0100-0025    100           FIH      1
## 246   385   <NA> IQ00701-0100-0025    100           FIH      1
## 247   386   <NA> IQ00701-0100-0025    100           FIH      1
## 248   387   <NA> IQ00701-0100-0025    100           FIH      1
## 249   388   <NA> IQ00701-0100-0025    100           FIH      1
## 250   393   <NA> IQ00701-0100-0026    100           FIH      1
## 251   395   <NA> IQ00701-0100-0026    100           FIH      1
## 252   396   <NA> IQ00701-0100-0026    100           FIH      1
## 253   397   <NA> IQ00701-0100-0026    100           FIH      1
## 254   398   <NA> IQ00701-0100-0026    100           FIH      1
## 255   399   <NA> IQ00701-0100-0026    100           FIH      1
## 256   400   <NA> IQ00701-0100-0026    100           FIH      1
## 257   401   <NA> IQ00701-0100-0026    100           FIH      1
## 258   402   <NA> IQ00701-0100-0026    100           FIH      1
## 259   403   <NA> IQ00701-0100-0026    100           FIH      1
## 260   404   <NA> IQ00701-0100-0026    100           FIH      1
## 261   405   <NA> IQ00701-0100-0026    100           FIH      1
## 262   410   <NA> IQ00701-0100-0027    100           FIH      1
## 263   412   <NA> IQ00701-0100-0027    100           FIH      1
## 264   413   <NA> IQ00701-0100-0027    100           FIH      1
## 265   414   <NA> IQ00701-0100-0027    100           FIH      1
## 266   415   <NA> IQ00701-0100-0027    100           FIH      1
## 267   416   <NA> IQ00701-0100-0027    100           FIH      1
## 268   417   <NA> IQ00701-0100-0027    100           FIH      1
## 269   418   <NA> IQ00701-0100-0027    100           FIH      1
## 270   419   <NA> IQ00701-0100-0027    100           FIH      1
## 271   420   <NA> IQ00701-0100-0027    100           FIH      1
## 272   421   <NA> IQ00701-0100-0027    100           FIH      1
## 273   422   <NA> IQ00701-0100-0027    100           FIH      1
## 274   427   <NA> IQ00701-0100-0028    100           FIH      1
## 275   429   <NA> IQ00701-0100-0028    100           FIH      1
## 276   430   <NA> IQ00701-0100-0028    100           FIH      1
## 277   431   <NA> IQ00701-0100-0028    100           FIH      1
## 278   432   <NA> IQ00701-0100-0028    100           FIH      1
## 279   433   <NA> IQ00701-0100-0028    100           FIH      1
## 280   434   <NA> IQ00701-0100-0028    100           FIH      1
## 281   435   <NA> IQ00701-0100-0028    100           FIH      1
## 282   436   <NA> IQ00701-0100-0028    100           FIH      1
## 283   437   <NA> IQ00701-0100-0028    100           FIH      1
## 284   438   <NA> IQ00701-0100-0028    100           FIH      1
## 285   439   <NA> IQ00701-0100-0028    100           FIH      1
## 286   444   <NA> IQ00701-0100-0029    100           FIH      1
## 287   446   <NA> IQ00701-0100-0029    100           FIH      1
## 288   447   <NA> IQ00701-0100-0029    100           FIH      1
## 289   448   <NA> IQ00701-0100-0029    100           FIH      1
## 290   449   <NA> IQ00701-0100-0029    100           FIH      1
## 291   450   <NA> IQ00701-0100-0029    100           FIH      1
## 292   451   <NA> IQ00701-0100-0029    100           FIH      1
## 293   452   <NA> IQ00701-0100-0029    100           FIH      1
## 294   453   <NA> IQ00701-0100-0029    100           FIH      1
## 295   454   <NA> IQ00701-0100-0029    100           FIH      1
## 296   455   <NA> IQ00701-0100-0029    100           FIH      1
## 297   456   <NA> IQ00701-0100-0029    100           FIH      1
## 298   461   <NA> IQ00701-0100-0030    100           FIH      1
## 299   463   <NA> IQ00701-0100-0030    100           FIH      1
## 300   464   <NA> IQ00701-0100-0030    100           FIH      1
## 301   465   <NA> IQ00701-0100-0030    100           FIH      1
## 302   466   <NA> IQ00701-0100-0030    100           FIH      1
## 303   467   <NA> IQ00701-0100-0030    100           FIH      1
## 304   468   <NA> IQ00701-0100-0030    100           FIH      1
## 305   469   <NA> IQ00701-0100-0030    100           FIH      1
## 306   470   <NA> IQ00701-0100-0030    100           FIH      1
## 307   471   <NA> IQ00701-0100-0030    100           FIH      1
## 308   472   <NA> IQ00701-0100-0030    100           FIH      1
## 309   473   <NA> IQ00701-0100-0030    100           FIH      1
## 310   478   <NA> IQ00701-0100-0031    100           FIH      1
## 311   480   <NA> IQ00701-0100-0031    100           FIH      1
## 312   481   <NA> IQ00701-0100-0031    100           FIH      1
## 313   482   <NA> IQ00701-0100-0031    100           FIH      1
## 314   483   <NA> IQ00701-0100-0031    100           FIH      1
## 315   484   <NA> IQ00701-0100-0031    100           FIH      1
## 316   485   <NA> IQ00701-0100-0031    100           FIH      1
## 317   486   <NA> IQ00701-0100-0031    100           FIH      1
## 318   487   <NA> IQ00701-0100-0031    100           FIH      1
## 319   488   <NA> IQ00701-0100-0031    100           FIH      1
## 320   489   <NA> IQ00701-0100-0031    100           FIH      1
## 321   490   <NA> IQ00701-0100-0031    100           FIH      1
## 322   495   <NA> IQ00701-0100-0032    100           FIH      1
## 323   497   <NA> IQ00701-0100-0032    100           FIH      1
## 324   498   <NA> IQ00701-0100-0032    100           FIH      1
## 325   499   <NA> IQ00701-0100-0032    100           FIH      1
## 326   500   <NA> IQ00701-0100-0032    100           FIH      1
## 327   501   <NA> IQ00701-0100-0032    100           FIH      1
## 328   502   <NA> IQ00701-0100-0032    100           FIH      1
## 329   503   <NA> IQ00701-0100-0032    100           FIH      1
## 330   504   <NA> IQ00701-0100-0032    100           FIH      1
## 331   505   <NA> IQ00701-0100-0032    100           FIH      1
## 332   506   <NA> IQ00701-0100-0032    100           FIH      1
## 333   507   <NA> IQ00701-0100-0032    100           FIH      1
## 334   512   <NA> IQ00701-0100-0033    100           FIH      1
## 335   514   <NA> IQ00701-0100-0033    100           FIH      1
## 336   515   <NA> IQ00701-0100-0033    100           FIH      1
## 337   516   <NA> IQ00701-0100-0033    100           FIH      1
## 338   517   <NA> IQ00701-0100-0033    100           FIH      1
## 339   518   <NA> IQ00701-0100-0033    100           FIH      1
## 340   519   <NA> IQ00701-0100-0033    100           FIH      1
## 341   520   <NA> IQ00701-0100-0033    100           FIH      1
## 342   521   <NA> IQ00701-0100-0033    100           FIH      1
## 343   522   <NA> IQ00701-0100-0033    100           FIH      1
## 344   523   <NA> IQ00701-0100-0033    100           FIH      1
## 345   524   <NA> IQ00701-0100-0033    100           FIH      1
## 346   529   <NA> IQ00701-0100-0034    100           FIH      1
## 347   531   <NA> IQ00701-0100-0034    100           FIH      1
## 348   532   <NA> IQ00701-0100-0034    100           FIH      1
## 349   533   <NA> IQ00701-0100-0034    100           FIH      1
## 350   534   <NA> IQ00701-0100-0034    100           FIH      1
## 351   535   <NA> IQ00701-0100-0034    100           FIH      1
## 352   536   <NA> IQ00701-0100-0034    100           FIH      1
## 353   537   <NA> IQ00701-0100-0034    100           FIH      1
## 354   538   <NA> IQ00701-0100-0034    100           FIH      1
## 355   539   <NA> IQ00701-0100-0034    100           FIH      1
## 356   540   <NA> IQ00701-0100-0034    100           FIH      1
## 357   541   <NA> IQ00701-0100-0034    100           FIH      1
## 358   546   <NA> IQ00701-0100-0035    100           FIH      1
## 359   548   <NA> IQ00701-0100-0035    100           FIH      1
## 360   549   <NA> IQ00701-0100-0035    100           FIH      1
## 361   550   <NA> IQ00701-0100-0035    100           FIH      1
## 362   551   <NA> IQ00701-0100-0035    100           FIH      1
## 363   552   <NA> IQ00701-0100-0035    100           FIH      1
## 364   553   <NA> IQ00701-0100-0035    100           FIH      1
## 365   554   <NA> IQ00701-0100-0035    100           FIH      1
## 366   555   <NA> IQ00701-0100-0035    100           FIH      1
## 367   556   <NA> IQ00701-0100-0035    100           FIH      1
## 368   557   <NA> IQ00701-0100-0035    100           FIH      1
## 369   558   <NA> IQ00701-0100-0035    100           FIH      1
## 370   563   <NA> IQ00701-0100-0036    100           FIH      1
## 371   565   <NA> IQ00701-0100-0036    100           FIH      1
## 372   566   <NA> IQ00701-0100-0036    100           FIH      1
## 373   567   <NA> IQ00701-0100-0036    100           FIH      1
## 374   568   <NA> IQ00701-0100-0036    100           FIH      1
## 375   569   <NA> IQ00701-0100-0036    100           FIH      1
## 376   570   <NA> IQ00701-0100-0036    100           FIH      1
## 377   571   <NA> IQ00701-0100-0036    100           FIH      1
## 378   572   <NA> IQ00701-0100-0036    100           FIH      1
## 379   573   <NA> IQ00701-0100-0036    100           FIH      1
## 380   574   <NA> IQ00701-0100-0036    100           FIH      1
## 381   575   <NA> IQ00701-0100-0036    100           FIH      1
## 382   580   <NA> IQ00701-0100-0037    100 FIH extension      2
## 383   582   <NA> IQ00701-0100-0037    100 FIH extension      2
## 384   583   <NA> IQ00701-0100-0037    100 FIH extension      2
## 385   584   <NA> IQ00701-0100-0037    100 FIH extension      2
## 386   585   <NA> IQ00701-0100-0037    100 FIH extension      2
## 387   586   <NA> IQ00701-0100-0037    100 FIH extension      2
## 388   587   <NA> IQ00701-0100-0037    100 FIH extension      2
## 389   588   <NA> IQ00701-0100-0037    100 FIH extension      2
## 390   589   <NA> IQ00701-0100-0037    100 FIH extension      2
## 391   590   <NA> IQ00701-0100-0037    100 FIH extension      2
## 392   591   <NA> IQ00701-0100-0037    100 FIH extension      2
## 393   592   <NA> IQ00701-0100-0037    100 FIH extension      2
## 394   597   <NA> IQ00701-0100-0038    100 FIH extension      2
## 395   599   <NA> IQ00701-0100-0038    100 FIH extension      2
## 396   600   <NA> IQ00701-0100-0038    100 FIH extension      2
## 397   601   <NA> IQ00701-0100-0038    100 FIH extension      2
## 398   602   <NA> IQ00701-0100-0038    100 FIH extension      2
## 399   603   <NA> IQ00701-0100-0038    100 FIH extension      2
## 400   604   <NA> IQ00701-0100-0038    100 FIH extension      2
## 401   605   <NA> IQ00701-0100-0038    100 FIH extension      2
## 402   606   <NA> IQ00701-0100-0038    100 FIH extension      2
## 403   607   <NA> IQ00701-0100-0038    100 FIH extension      2
## 404   608   <NA> IQ00701-0100-0038    100 FIH extension      2
## 405   609   <NA> IQ00701-0100-0038    100 FIH extension      2
## 406   614   <NA> IQ00701-0100-0039    100 FIH extension      2
## 407   616   <NA> IQ00701-0100-0039    100 FIH extension      2
## 408   617   <NA> IQ00701-0100-0039    100 FIH extension      2
## 409   618   <NA> IQ00701-0100-0039    100 FIH extension      2
## 410   619   <NA> IQ00701-0100-0039    100 FIH extension      2
## 411   620   <NA> IQ00701-0100-0039    100 FIH extension      2
## 412   621   <NA> IQ00701-0100-0039    100 FIH extension      2
## 413   622   <NA> IQ00701-0100-0039    100 FIH extension      2
## 414   623   <NA> IQ00701-0100-0039    100 FIH extension      2
## 415   624   <NA> IQ00701-0100-0039    100 FIH extension      2
## 416   625   <NA> IQ00701-0100-0039    100 FIH extension      2
## 417   626   <NA> IQ00701-0100-0039    100 FIH extension      2
## 418   631   <NA> IQ00701-0100-0040    100 FIH extension      2
## 419   633   <NA> IQ00701-0100-0040    100 FIH extension      2
## 420   634   <NA> IQ00701-0100-0040    100 FIH extension      2
## 421   635   <NA> IQ00701-0100-0040    100 FIH extension      2
## 422   636   <NA> IQ00701-0100-0040    100 FIH extension      2
## 423   637   <NA> IQ00701-0100-0040    100 FIH extension      2
## 424   638   <NA> IQ00701-0100-0040    100 FIH extension      2
## 425   639   <NA> IQ00701-0100-0040    100 FIH extension      2
## 426   640   <NA> IQ00701-0100-0040    100 FIH extension      2
## 427   641   <NA> IQ00701-0100-0040    100 FIH extension      2
## 428   642   <NA> IQ00701-0100-0040    100 FIH extension      2
## 429   643   <NA> IQ00701-0100-0040    100 FIH extension      2
## 430   648   <NA> IQ00701-0100-0041    100 FIH extension      2
## 431   650   <NA> IQ00701-0100-0041    100 FIH extension      2
## 432   651   <NA> IQ00701-0100-0041    100 FIH extension      2
## 433   652   <NA> IQ00701-0100-0041    100 FIH extension      2
## 434   653   <NA> IQ00701-0100-0041    100 FIH extension      2
## 435   654   <NA> IQ00701-0100-0041    100 FIH extension      2
## 436   655   <NA> IQ00701-0100-0041    100 FIH extension      2
## 437   656   <NA> IQ00701-0100-0041    100 FIH extension      2
## 438   657   <NA> IQ00701-0100-0041    100 FIH extension      2
## 439   658   <NA> IQ00701-0100-0041    100 FIH extension      2
## 440   659   <NA> IQ00701-0100-0041    100 FIH extension      2
## 441   660   <NA> IQ00701-0100-0041    100 FIH extension      2
## 442   665   <NA> IQ00701-0100-0042    100 FIH extension      2
## 443   667   <NA> IQ00701-0100-0042    100 FIH extension      2
## 444   668   <NA> IQ00701-0100-0042    100 FIH extension      2
## 445   669   <NA> IQ00701-0100-0042    100 FIH extension      2
## 446   670   <NA> IQ00701-0100-0042    100 FIH extension      2
## 447   671   <NA> IQ00701-0100-0042    100 FIH extension      2
## 448   672   <NA> IQ00701-0100-0042    100 FIH extension      2
## 449   673   <NA> IQ00701-0100-0042    100 FIH extension      2
## 450   674   <NA> IQ00701-0100-0042    100 FIH extension      2
## 451   675   <NA> IQ00701-0100-0042    100 FIH extension      2
## 452   676   <NA> IQ00701-0100-0042    100 FIH extension      2
## 453   677   <NA> IQ00701-0100-0042    100 FIH extension      2
## 454   682   <NA> IQ00701-0100-0043    100 FIH extension      2
## 455   684   <NA> IQ00701-0100-0043    100 FIH extension      2
## 456   685   <NA> IQ00701-0100-0043    100 FIH extension      2
## 457   686   <NA> IQ00701-0100-0043    100 FIH extension      2
## 458   687   <NA> IQ00701-0100-0043    100 FIH extension      2
## 459   688   <NA> IQ00701-0100-0043    100 FIH extension      2
## 460   689   <NA> IQ00701-0100-0043    100 FIH extension      2
## 461   690   <NA> IQ00701-0100-0043    100 FIH extension      2
## 462   691   <NA> IQ00701-0100-0043    100 FIH extension      2
## 463   692   <NA> IQ00701-0100-0043    100 FIH extension      2
## 464   693   <NA> IQ00701-0100-0043    100 FIH extension      2
## 465   694   <NA> IQ00701-0100-0043    100 FIH extension      2
## 466   699   <NA> IQ00701-0100-0044    100 FIH extension      2
## 467   701   <NA> IQ00701-0100-0044    100 FIH extension      2
## 468   702   <NA> IQ00701-0100-0044    100 FIH extension      2
## 469   703   <NA> IQ00701-0100-0044    100 FIH extension      2
## 470   704   <NA> IQ00701-0100-0044    100 FIH extension      2
## 471   705   <NA> IQ00701-0100-0044    100 FIH extension      2
## 472   706   <NA> IQ00701-0100-0044    100 FIH extension      2
## 473   707   <NA> IQ00701-0100-0044    100 FIH extension      2
## 474   708   <NA> IQ00701-0100-0044    100 FIH extension      2
## 475   709   <NA> IQ00701-0100-0044    100 FIH extension      2
## 476   710   <NA> IQ00701-0100-0044    100 FIH extension      2
## 477   711   <NA> IQ00701-0100-0044    100 FIH extension      2
## 478   716   <NA> IQ00701-0100-0045    100 FIH extension      2
## 479   718   <NA> IQ00701-0100-0045    100 FIH extension      2
## 480   719   <NA> IQ00701-0100-0045    100 FIH extension      2
## 481   720   <NA> IQ00701-0100-0045    100 FIH extension      2
## 482   721   <NA> IQ00701-0100-0045    100 FIH extension      2
## 483   722   <NA> IQ00701-0100-0045    100 FIH extension      2
## 484   723   <NA> IQ00701-0100-0045    100 FIH extension      2
## 485   724   <NA> IQ00701-0100-0045    100 FIH extension      2
## 486   725   <NA> IQ00701-0100-0045    100 FIH extension      2
## 487   726   <NA> IQ00701-0100-0045    100 FIH extension      2
## 488   727   <NA> IQ00701-0100-0045    100 FIH extension      2
## 489   728   <NA> IQ00701-0100-0045    100 FIH extension      2
## 490   733   <NA> IQ00701-0100-0046    100 FIH extension      2
## 491   735   <NA> IQ00701-0100-0046    100 FIH extension      2
## 492   736   <NA> IQ00701-0100-0046    100 FIH extension      2
## 493   737   <NA> IQ00701-0100-0046    100 FIH extension      2
## 494   738   <NA> IQ00701-0100-0046    100 FIH extension      2
## 495   739   <NA> IQ00701-0100-0046    100 FIH extension      2
## 496   740   <NA> IQ00701-0100-0046    100 FIH extension      2
## 497   741   <NA> IQ00701-0100-0046    100 FIH extension      2
## 498   742   <NA> IQ00701-0100-0046    100 FIH extension      2
## 499   743   <NA> IQ00701-0100-0046    100 FIH extension      2
## 500   744   <NA> IQ00701-0100-0046    100 FIH extension      2
## 501   745   <NA> IQ00701-0100-0046    100 FIH extension      2
## 502   750   <NA> IQ00701-0100-0047    100 FIH extension      2
## 503   752   <NA> IQ00701-0100-0047    100 FIH extension      2
## 504   753   <NA> IQ00701-0100-0047    100 FIH extension      2
## 505   754   <NA> IQ00701-0100-0047    100 FIH extension      2
## 506   755   <NA> IQ00701-0100-0047    100 FIH extension      2
## 507   756   <NA> IQ00701-0100-0047    100 FIH extension      2
## 508   757   <NA> IQ00701-0100-0047    100 FIH extension      2
## 509   758   <NA> IQ00701-0100-0047    100 FIH extension      2
## 510   759   <NA> IQ00701-0100-0047    100 FIH extension      2
## 511   760   <NA> IQ00701-0100-0047    100 FIH extension      2
## 512   761   <NA> IQ00701-0100-0047    100 FIH extension      2
## 513   762   <NA> IQ00701-0100-0047    100 FIH extension      2
## 514   767   <NA> IQ00701-0100-0048    100 FIH extension      2
## 515   769   <NA> IQ00701-0100-0048    100 FIH extension      2
## 516   770   <NA> IQ00701-0100-0048    100 FIH extension      2
## 517   771   <NA> IQ00701-0100-0048    100 FIH extension      2
## 518   772   <NA> IQ00701-0100-0048    100 FIH extension      2
## 519   773   <NA> IQ00701-0100-0048    100 FIH extension      2
## 520   774   <NA> IQ00701-0100-0048    100 FIH extension      2
## 521   775   <NA> IQ00701-0100-0048    100 FIH extension      2
## 522   776   <NA> IQ00701-0100-0048    100 FIH extension      2
## 523   777   <NA> IQ00701-0100-0048    100 FIH extension      2
## 524   778   <NA> IQ00701-0100-0048    100 FIH extension      2
## 525   779   <NA> IQ00701-0100-0048    100 FIH extension      2
##                    TRTNAME TRT VISIT BASE SCREEN TIMEUNIT           NT     TIME
## 1     1mg oral single dose   3     2    0      0    HOURS  -0.08333333  -0.0830
## 2     1mg oral single dose   3     2    0      0    HOURS   0.08333333   0.0830
## 3     1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.2500
## 4     1mg oral single dose   3     2    0      0    HOURS   0.50000000   0.5000
## 5     1mg oral single dose   3     2    0      0    HOURS   1.00000000   1.0000
## 6     1mg oral single dose   3     2    0      0    HOURS   2.00000000   2.0000
## 7     1mg oral single dose   3     2    0      0    HOURS   4.00000000   4.0000
## 8     1mg oral single dose   3     2    0      0    HOURS  12.00000000  12.0000
## 9     1mg oral single dose   3     3    0      0    HOURS  24.00000000  24.0000
## 10    1mg oral single dose   3     4    0      0    HOURS  48.00000000  48.0000
## 11    1mg oral single dose   3     5    0      0    HOURS  96.00000000  96.0000
## 12    1mg oral single dose   3     6    0      0    HOURS 168.00000000 168.0000
## 13    1mg oral single dose   3     2    0      0    HOURS  -0.08333333  -0.0830
## 14    1mg oral single dose   3     2    0      0    HOURS   0.08333333   0.0830
## 15    1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.2500
## 16    1mg oral single dose   3     2    0      0    HOURS   0.50000000   0.5000
## 17    1mg oral single dose   3     2    0      0    HOURS   1.00000000   1.0000
## 18    1mg oral single dose   3     2    0      0    HOURS   2.00000000   2.0000
## 19    1mg oral single dose   3     2    0      0    HOURS   4.00000000   4.0000
## 20    1mg oral single dose   3     2    0      0    HOURS  12.00000000  12.0000
## 21    1mg oral single dose   3     3    0      0    HOURS  24.00000000  24.0000
## 22    1mg oral single dose   3     4    0      0    HOURS  48.00000000  48.0000
## 23    1mg oral single dose   3     5    0      0    HOURS  96.00000000  96.0000
## 24    1mg oral single dose   3     6    0      0    HOURS 168.00000000 168.0000
## 25    1mg oral single dose   3     2    0      0    HOURS  -0.08333333  -0.0830
## 26    1mg oral single dose   3     2    0      0    HOURS   0.08333333   0.0830
## 27    1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.2500
## 28    1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.2501
## 29    1mg oral single dose   3     2    0      0    HOURS   1.00000000   1.0000
## 30    1mg oral single dose   3     2    0      0    HOURS   2.00000000   2.0000
## 31    1mg oral single dose   3     2    0      0    HOURS   4.00000000   4.0000
## 32    1mg oral single dose   3     3    0      0    HOURS  24.00000000  24.0000
## 33    1mg oral single dose   3     4    0      0    HOURS  48.00000000  48.0000
## 34    1mg oral single dose   3     5    0      0    HOURS  96.00000000  96.0000
## 35    1mg oral single dose   3     6    0      0    HOURS 168.00000000 168.0000
## 36    1mg oral single dose   3     2    0      0    HOURS  -0.08333333  -0.0830
## 37    1mg oral single dose   3     2    0      0    HOURS   0.08333333   0.0830
## 38    1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.2500
## 39    1mg oral single dose   3     2    0      0    HOURS   0.50000000   0.5000
## 40    1mg oral single dose   3     2    0      0    HOURS   1.00000000   1.0000
## 41    1mg oral single dose   3     2    0      0    HOURS   2.00000000   2.0000
## 42    1mg oral single dose   3     2    0      0    HOURS   4.00000000   4.0000
## 43    1mg oral single dose   3     2    0      0    HOURS  12.00000000  12.0000
## 44    1mg oral single dose   3     3    0      0    HOURS  24.00000000  24.0000
## 45    1mg oral single dose   3     4    0      0    HOURS  48.00000000  48.0000
## 46    1mg oral single dose   3     5    0      0    HOURS  96.00000000  96.0000
## 47    1mg oral single dose   3     6    0      0    HOURS 168.00000000 168.0000
## 48    2mg oral single dose   6     2    0      0    HOURS  -0.08333333  -0.0830
## 49    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.0830
## 50    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.2500
## 51    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.5000
## 52    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.0000
## 53    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.0000
## 54    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.0000
## 55    2mg oral single dose   6     2    0      0    HOURS  12.00000000  12.0000
## 56    2mg oral single dose   6     3    0      0    HOURS  24.00000000  24.0000
## 57    2mg oral single dose   6     5    0      0    HOURS  96.00000000  96.0000
## 58    2mg oral single dose   6     6    0      0    HOURS 168.00000000 168.0000
## 59    2mg oral single dose   6     2    0      0    HOURS  -0.08333333  -0.0830
## 60    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.0830
## 61    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.2500
## 62    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.5000
## 63    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.0000
## 64    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.0000
## 65    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.0000
## 66    2mg oral single dose   6     2    0      0    HOURS  12.00000000  12.0000
## 67    2mg oral single dose   6     3    0      0    HOURS  24.00000000  24.0000
## 68    2mg oral single dose   6     4    0      0    HOURS  48.00000000  48.0000
## 69    2mg oral single dose   6     5    0      0    HOURS  96.00000000  96.0000
## 70    2mg oral single dose   6     6    0      0    HOURS 168.00000000 168.0000
## 71    2mg oral single dose   6     2    0      0    HOURS  -0.08333333  -0.0830
## 72    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.0830
## 73    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.2500
## 74    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.5000
## 75    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.0000
## 76    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.0000
## 77    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.0000
## 78    2mg oral single dose   6     2    0      0    HOURS  12.00000000  12.0000
## 79    2mg oral single dose   6     3    0      0    HOURS  24.00000000  24.0000
## 80    2mg oral single dose   6     4    0      0    HOURS  48.00000000  48.0000
## 81    2mg oral single dose   6     5    0      0    HOURS  96.00000000  96.0000
## 82    2mg oral single dose   6     6    0      0    HOURS 168.00000000 168.0000
## 83    2mg oral single dose   6     2    0      0    HOURS  -0.08333333  -0.0830
## 84    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.0830
## 85    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.2500
## 86    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.5000
## 87    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.0000
## 88    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.0000
## 89    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.0000
## 90    2mg oral single dose   6     2    0      0    HOURS  12.00000000  12.0000
## 91    2mg oral single dose   6     3    0      0    HOURS  24.00000000  24.0000
## 92    2mg oral single dose   6     4    0      0    HOURS  48.00000000  48.0000
## 93    2mg oral single dose   6     5    0      0    HOURS  96.00000000  96.0000
## 94    2mg oral single dose   6     6    0      0    HOURS 168.00000000 168.0000
## 95    2mg oral single dose   6     2    0      0    HOURS  -0.08333333  -0.0830
## 96    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.0830
## 97    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.2500
## 98    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.5000
## 99    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.0000
## 100   2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.0000
## 101   2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.0000
## 102   2mg oral single dose   6     2    0      0    HOURS  12.00000000  12.0000
## 103   2mg oral single dose   6     3    0      0    HOURS  24.00000000  24.0000
## 104   2mg oral single dose   6     4    0      0    HOURS  48.00000000  48.0000
## 105   2mg oral single dose   6     5    0      0    HOURS  96.00000000  96.0000
## 106   2mg oral single dose   6     6    0      0    HOURS 168.00000000 168.0000
## 107   5mg oral single dose   8     2    0      0    HOURS  -0.08333333  -0.0830
## 108   5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.0830
## 109   5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.2500
## 110   5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.5000
## 111   5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.0000
## 112   5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.0000
## 113   5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.0000
## 114   5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.0000
## 115   5mg oral single dose   8     3    0      0    HOURS  24.00000000  24.0000
## 116   5mg oral single dose   8     4    0      0    HOURS  48.00000000  48.0000
## 117   5mg oral single dose   8     5    0      0    HOURS  96.00000000  96.0000
## 118   5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.0000
## 119   5mg oral single dose   8     2    0      0    HOURS  -0.08333333  -0.0830
## 120   5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.0830
## 121   5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.2500
## 122   5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.5000
## 123   5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.0000
## 124   5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.0000
## 125   5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.0000
## 126   5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.0000
## 127   5mg oral single dose   8     3    0      0    HOURS  24.00000000  24.0000
## 128   5mg oral single dose   8     4    0      0    HOURS  48.00000000  48.0000
## 129   5mg oral single dose   8     5    0      0    HOURS  96.00000000  96.0000
## 130   5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.0000
## 131   5mg oral single dose   8     2    0      0    HOURS  -0.08333333  -0.0830
## 132   5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.0830
## 133   5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.2500
## 134   5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.5000
## 135   5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.0000
## 136   5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.0000
## 137   5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.0000
## 138   5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.0000
## 139   5mg oral single dose   8     3    0      0    HOURS  24.00000000  24.0000
## 140   5mg oral single dose   8     4    0      0    HOURS  48.00000000  48.0000
## 141   5mg oral single dose   8     5    0      0    HOURS  96.00000000  96.0000
## 142   5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.0000
## 143   5mg oral single dose   8     2    0      0    HOURS  -0.08333333  -0.0830
## 144   5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.0830
## 145   5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.2500
## 146   5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.5000
## 147   5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.0000
## 148   5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.0000
## 149   5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.0000
## 150   5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.0000
## 151   5mg oral single dose   8     3    0      0    HOURS  24.00000000  24.0000
## 152   5mg oral single dose   8     4    0      0    HOURS  48.00000000  48.0000
## 153   5mg oral single dose   8     5    0      0    HOURS  96.00000000  96.0000
## 154   5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.0000
## 155   5mg oral single dose   8     2    0      0    HOURS  -0.08333333  -0.0830
## 156   5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.0830
## 157   5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.2500
## 158   5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.5000
## 159   5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.0000
## 160   5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.0000
## 161   5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.0000
## 162   5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.0000
## 163   5mg oral single dose   8     3    0      0    HOURS  24.00000000  24.0000
## 164   5mg oral single dose   8     4    0      0    HOURS  48.00000000  48.0000
## 165   5mg oral single dose   8     5    0      0    HOURS  96.00000000  96.0000
## 166   5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.0000
## 167  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 168  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 169  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 170  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 171  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 172  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 173  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 174  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 175  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 176  10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.0000
## 177  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 178  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 179  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 180  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 181  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 182  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 183  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 184  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 185  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 186  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 187  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 188  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 189  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 190  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 191  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 192  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 193  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 194  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 195  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 196  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 197  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 198  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 199  10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.0000
## 200  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 201  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 202  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 203  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 204  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 205  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 206  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 207  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 208  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 209  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 210  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 211  10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.0000
## 212  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 213  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 214  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 215  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 216  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 217  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 218  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 219  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 220  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 221  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 222  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 223  10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.0000
## 224  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 225  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 226  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 227  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 228  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 229  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 230  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 231  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 232  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 233  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 234  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 235  10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.0000
## 236  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 237  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 238  20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.0830
## 239  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.0830
## 240  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.2500
## 241  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.5000
## 242  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.0000
## 243  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.0000
## 244  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.0000
## 245  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.0000
## 246  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.0000
## 247  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.0000
## 248  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.0000
## 249  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.0000
## 250  20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.0830
## 251  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.0830
## 252  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.2500
## 253  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.5000
## 254  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.0000
## 255  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.0000
## 256  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.0000
## 257  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.0000
## 258  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.0000
## 259  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.0000
## 260  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.0000
## 261  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.0000
## 262  20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.0830
## 263  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.0830
## 264  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.2500
## 265  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.5000
## 266  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.0000
## 267  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.0000
## 268  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.0000
## 269  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.0000
## 270  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.0000
## 271  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.0000
## 272  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.0000
## 273  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.0000
## 274  20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.0830
## 275  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.0830
## 276  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.2500
## 277  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.5000
## 278  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.0000
## 279  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.0000
## 280  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.0000
## 281  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.0000
## 282  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.0000
## 283  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.0000
## 284  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.0000
## 285  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.0000
## 286  20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.0830
## 287  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.0830
## 288  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.2500
## 289  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.5000
## 290  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.0000
## 291  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.0000
## 292  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.0000
## 293  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.0000
## 294  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.0000
## 295  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.0000
## 296  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.0000
## 297  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.0000
## 298  20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.0830
## 299  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.0830
## 300  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.2500
## 301  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.5000
## 302  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.0000
## 303  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.0000
## 304  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.0000
## 305  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.0000
## 306  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.0000
## 307  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.0000
## 308  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.0000
## 309  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.0000
## 310  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.0830
## 311  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.0830
## 312  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.2500
## 313  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.5000
## 314  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.0000
## 315  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.0000
## 316  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.0000
## 317  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.0000
## 318  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.0000
## 319  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.0000
## 320  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.0000
## 321  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.0000
## 322  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.0830
## 323  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.0830
## 324  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.2500
## 325  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.5000
## 326  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.0000
## 327  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.0000
## 328  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.0000
## 329  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.0000
## 330  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.0000
## 331  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.0000
## 332  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.0000
## 333  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.0000
## 334  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.0830
## 335  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.0830
## 336  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.2500
## 337  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.5000
## 338  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.0000
## 339  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.0000
## 340  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.0000
## 341  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.0000
## 342  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.0000
## 343  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.0000
## 344  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.0000
## 345  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.0000
## 346  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.0830
## 347  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.0830
## 348  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.2500
## 349  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.5000
## 350  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.0000
## 351  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.0000
## 352  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.0000
## 353  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.0000
## 354  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.0000
## 355  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.0000
## 356  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.0000
## 357  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.0000
## 358  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.0830
## 359  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.0830
## 360  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.2500
## 361  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.5000
## 362  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.0000
## 363  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.0000
## 364  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.0000
## 365  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.0000
## 366  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.0000
## 367  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.0000
## 368  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.0000
## 369  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.0000
## 370  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.0830
## 371  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.0830
## 372  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.2500
## 373  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.5000
## 374  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.0000
## 375  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.0000
## 376  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.0000
## 377  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.0000
## 378  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.0000
## 379  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.0000
## 380  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.0000
## 381  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.0000
## 382 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.0830
## 383 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.0830
## 384 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.2500
## 385 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.5000
## 386 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.0000
## 387 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.0000
## 388 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.0000
## 389 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.0000
## 390 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.0000
## 391 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.0000
## 392 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.0000
## 393 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.0000
## 394 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.0830
## 395 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.0830
## 396 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.2500
## 397 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.5000
## 398 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.0000
## 399 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.0000
## 400 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.0000
## 401 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.0000
## 402 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.0000
## 403 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.0000
## 404 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.0000
## 405 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.0000
## 406 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.0830
## 407 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.0830
## 408 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.2500
## 409 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.5000
## 410 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.0000
## 411 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.0000
## 412 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.0000
## 413 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.0000
## 414 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.0000
## 415 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.0000
## 416 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.0000
## 417 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.0000
## 418 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.0830
## 419 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.0830
## 420 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.2500
## 421 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.5000
## 422 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.0000
## 423 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.0000
## 424 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.0000
## 425 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.0000
## 426 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.0000
## 427 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.0000
## 428 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.0000
## 429 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.0000
## 430 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.0830
## 431 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.0830
## 432 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.2500
## 433 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.5000
## 434 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.0000
## 435 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.0000
## 436 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.0000
## 437 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.0000
## 438 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.0000
## 439 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.0000
## 440 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.0000
## 441 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.0000
## 442 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.0830
## 443 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.0830
## 444 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.2500
## 445 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.5000
## 446 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.0000
## 447 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.0000
## 448 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.0000
## 449 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.0000
## 450 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.0000
## 451 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.0000
## 452 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.0000
## 453 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.0000
## 454 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.0830
## 455 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.0830
## 456 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.2500
## 457 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.5000
## 458 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.0000
## 459 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.0000
## 460 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.0000
## 461 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.0000
## 462 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.0000
## 463 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.0000
## 464 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.0000
## 465 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.0000
## 466 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.0830
## 467 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.0830
## 468 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.2500
## 469 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.5000
## 470 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.0000
## 471 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.0000
## 472 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.0000
## 473 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.0000
## 474 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.0000
## 475 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.0000
## 476 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.0000
## 477 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.0000
## 478 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.0830
## 479 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.0830
## 480 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.2500
## 481 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.5000
## 482 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.0000
## 483 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.0000
## 484 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.0000
## 485 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.0000
## 486 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.0000
## 487 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.0000
## 488 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.0000
## 489 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.0000
## 490 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.0830
## 491 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.0830
## 492 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.2500
## 493 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.5000
## 494 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.0000
## 495 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.0000
## 496 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.0000
## 497 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.0000
## 498 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.0000
## 499 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.0000
## 500 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.0000
## 501 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.0000
## 502 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.0830
## 503 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.0830
## 504 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.2500
## 505 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.5000
## 506 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.0000
## 507 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.0000
## 508 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.0000
## 509 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.0000
## 510 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.0000
## 511 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.0000
## 512 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.0000
## 513 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.0000
## 514 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.0830
## 515 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.0830
## 516 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.2500
## 517 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.5000
## 518 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.0000
## 519 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.0000
## 520 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.0000
## 521 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.0000
## 522 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.0000
## 523 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.0000
## 524 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.0000
## 525 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.0000
##     DURATION                        NAME   VALUE VALUETXT  UNIT  LLOQ ROUTE II
## 1          0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 2          0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 3          0 Plasma concentration IQ0815 0.00153     <NA> ug/mL 0.001  <NA>  0
## 4          0 Plasma concentration IQ0815 0.00350     <NA> ug/mL 0.001  <NA>  0
## 5          0 Plasma concentration IQ0815 0.00380     <NA> ug/mL 0.001  <NA>  0
## 6          0 Plasma concentration IQ0815 0.00333     <NA> ug/mL 0.001  <NA>  0
## 7          0 Plasma concentration IQ0815 0.00291     <NA> ug/mL 0.001  <NA>  0
## 8          0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 9          0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 10         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 11         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 12         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 13         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 14         0 Plasma concentration IQ0815 0.00138     <NA> ug/mL 0.001  <NA>  0
## 15         0 Plasma concentration IQ0815 0.00212     <NA> ug/mL 0.001  <NA>  0
## 16         0 Plasma concentration IQ0815 0.00359     <NA> ug/mL 0.001  <NA>  0
## 17         0 Plasma concentration IQ0815 0.00542     <NA> ug/mL 0.001  <NA>  0
## 18         0 Plasma concentration IQ0815 0.00526     <NA> ug/mL 0.001  <NA>  0
## 19         0 Plasma concentration IQ0815 0.00391     <NA> ug/mL 0.001  <NA>  0
## 20         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 21         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 22         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 23         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 24         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 25         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 26         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 27         0 Plasma concentration IQ0815 0.00168     <NA> ug/mL 0.001  <NA>  0
## 28         0 Plasma concentration IQ0815 0.00168     <NA> ug/mL 0.001  <NA>  0
## 29         0 Plasma concentration IQ0815 0.00221     <NA> ug/mL 0.001  <NA>  0
## 30         0 Plasma concentration IQ0815 0.00307     <NA> ug/mL 0.001  <NA>  0
## 31         0 Plasma concentration IQ0815 0.00133     <NA> ug/mL 0.001  <NA>  0
## 32         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 33         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 34         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 35         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 36         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 37         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 38         0 Plasma concentration IQ0815 0.00128     <NA> ug/mL 0.001  <NA>  0
## 39         0 Plasma concentration IQ0815 0.00220     <NA> ug/mL 0.001  <NA>  0
## 40         0 Plasma concentration IQ0815 0.00278     <NA> ug/mL 0.001  <NA>  0
## 41         0 Plasma concentration IQ0815 0.00221     <NA> ug/mL 0.001  <NA>  0
## 42         0 Plasma concentration IQ0815 0.00153     <NA> ug/mL 0.001  <NA>  0
## 43         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 44         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 45         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 46         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 47         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 48         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 49         0 Plasma concentration IQ0815 0.00174     <NA> ug/mL 0.001  <NA>  0
## 50         0 Plasma concentration IQ0815 0.00299     <NA> ug/mL 0.001  <NA>  0
## 51         0 Plasma concentration IQ0815 0.00555     <NA> ug/mL 0.001  <NA>  0
## 52         0 Plasma concentration IQ0815 0.00780     <NA> ug/mL 0.001  <NA>  0
## 53         0 Plasma concentration IQ0815 0.00706     <NA> ug/mL 0.001  <NA>  0
## 54         0 Plasma concentration IQ0815 0.00526     <NA> ug/mL 0.001  <NA>  0
## 55         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 56         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 57         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 58         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 59         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 60         0 Plasma concentration IQ0815 0.00123     <NA> ug/mL 0.001  <NA>  0
## 61         0 Plasma concentration IQ0815 0.00238     <NA> ug/mL 0.001  <NA>  0
## 62         0 Plasma concentration IQ0815 0.00480     <NA> ug/mL 0.001  <NA>  0
## 63         0 Plasma concentration IQ0815 0.00672     <NA> ug/mL 0.001  <NA>  0
## 64         0 Plasma concentration IQ0815 0.00509     <NA> ug/mL 0.001  <NA>  0
## 65         0 Plasma concentration IQ0815 0.00396     <NA> ug/mL 0.001  <NA>  0
## 66         0 Plasma concentration IQ0815 0.00160     <NA> ug/mL 0.001  <NA>  0
## 67         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 68         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 69         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 70         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 71         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 72         0 Plasma concentration IQ0815 0.00157     <NA> ug/mL 0.001  <NA>  0
## 73         0 Plasma concentration IQ0815 0.00205     <NA> ug/mL 0.001  <NA>  0
## 74         0 Plasma concentration IQ0815 0.00446     <NA> ug/mL 0.001  <NA>  0
## 75         0 Plasma concentration IQ0815 0.00462     <NA> ug/mL 0.001  <NA>  0
## 76         0 Plasma concentration IQ0815 0.00555     <NA> ug/mL 0.001  <NA>  0
## 77         0 Plasma concentration IQ0815 0.00329     <NA> ug/mL 0.001  <NA>  0
## 78         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 79         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 80         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 81         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 82         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 83         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 84         0 Plasma concentration IQ0815 0.00127     <NA> ug/mL 0.001  <NA>  0
## 85         0 Plasma concentration IQ0815 0.00345     <NA> ug/mL 0.001  <NA>  0
## 86         0 Plasma concentration IQ0815 0.00491     <NA> ug/mL 0.001  <NA>  0
## 87         0 Plasma concentration IQ0815 0.00692     <NA> ug/mL 0.001  <NA>  0
## 88         0 Plasma concentration IQ0815 0.00736     <NA> ug/mL 0.001  <NA>  0
## 89         0 Plasma concentration IQ0815 0.00420     <NA> ug/mL 0.001  <NA>  0
## 90         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 91         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 92         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 93         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 94         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 95         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 96         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 97         0 Plasma concentration IQ0815 0.00380     <NA> ug/mL 0.001  <NA>  0
## 98         0 Plasma concentration IQ0815 0.00510     <NA> ug/mL 0.001  <NA>  0
## 99         0 Plasma concentration IQ0815 0.00396     <NA> ug/mL 0.001  <NA>  0
## 100        0 Plasma concentration IQ0815 0.00596     <NA> ug/mL 0.001  <NA>  0
## 101        0 Plasma concentration IQ0815 0.00445     <NA> ug/mL 0.001  <NA>  0
## 102        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 103        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 104        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 105        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 106        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 107        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 108        0 Plasma concentration IQ0815 0.00593     <NA> ug/mL 0.001  <NA>  0
## 109        0 Plasma concentration IQ0815 0.01100     <NA> ug/mL 0.001  <NA>  0
## 110        0 Plasma concentration IQ0815 0.02130     <NA> ug/mL 0.001  <NA>  0
## 111        0 Plasma concentration IQ0815 0.02640     <NA> ug/mL 0.001  <NA>  0
## 112        0 Plasma concentration IQ0815 0.02360     <NA> ug/mL 0.001  <NA>  0
## 113        0 Plasma concentration IQ0815 0.00808     <NA> ug/mL 0.001  <NA>  0
## 114        0 Plasma concentration IQ0815 0.00128     <NA> ug/mL 0.001  <NA>  0
## 115        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 116        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 117        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 118        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 119        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 120        0 Plasma concentration IQ0815 0.00428     <NA> ug/mL 0.001  <NA>  0
## 121        0 Plasma concentration IQ0815 0.01080     <NA> ug/mL 0.001  <NA>  0
## 122        0 Plasma concentration IQ0815 0.01920     <NA> ug/mL 0.001  <NA>  0
## 123        0 Plasma concentration IQ0815 0.01960     <NA> ug/mL 0.001  <NA>  0
## 124        0 Plasma concentration IQ0815 0.01400     <NA> ug/mL 0.001  <NA>  0
## 125        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 126        0 Plasma concentration IQ0815 0.00112     <NA> ug/mL 0.001  <NA>  0
## 127        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 128        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 129        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 130        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 131        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 132        0 Plasma concentration IQ0815 0.00174     <NA> ug/mL 0.001  <NA>  0
## 133        0 Plasma concentration IQ0815 0.00432     <NA> ug/mL 0.001  <NA>  0
## 134        0 Plasma concentration IQ0815 0.00766     <NA> ug/mL 0.001  <NA>  0
## 135        0 Plasma concentration IQ0815 0.01030     <NA> ug/mL 0.001  <NA>  0
## 136        0 Plasma concentration IQ0815 0.00802     <NA> ug/mL 0.001  <NA>  0
## 137        0 Plasma concentration IQ0815 0.00742     <NA> ug/mL 0.001  <NA>  0
## 138        0 Plasma concentration IQ0815 0.00300     <NA> ug/mL 0.001  <NA>  0
## 139        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 140        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 141        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 142        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 143        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 144        0 Plasma concentration IQ0815 0.00370     <NA> ug/mL 0.001  <NA>  0
## 145        0 Plasma concentration IQ0815 0.00826     <NA> ug/mL 0.001  <NA>  0
## 146        0 Plasma concentration IQ0815 0.01440     <NA> ug/mL 0.001  <NA>  0
## 147        0 Plasma concentration IQ0815 0.01460     <NA> ug/mL 0.001  <NA>  0
## 148        0 Plasma concentration IQ0815 0.01770     <NA> ug/mL 0.001  <NA>  0
## 149        0 Plasma concentration IQ0815 0.00857     <NA> ug/mL 0.001  <NA>  0
## 150        0 Plasma concentration IQ0815 0.00199     <NA> ug/mL 0.001  <NA>  0
## 151        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 152        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 153        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 154        0 Plasma concentration IQ0815 0.00101     <NA> ug/mL 0.001  <NA>  0
## 155        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 156        0 Plasma concentration IQ0815 0.00386     <NA> ug/mL 0.001  <NA>  0
## 157        0 Plasma concentration IQ0815 0.00888     <NA> ug/mL 0.001  <NA>  0
## 158        0 Plasma concentration IQ0815 0.01700     <NA> ug/mL 0.001  <NA>  0
## 159        0 Plasma concentration IQ0815 0.01830     <NA> ug/mL 0.001  <NA>  0
## 160        0 Plasma concentration IQ0815 0.01980     <NA> ug/mL 0.001  <NA>  0
## 161        0 Plasma concentration IQ0815 0.00950     <NA> ug/mL 0.001  <NA>  0
## 162        0 Plasma concentration IQ0815 0.00334     <NA> ug/mL 0.001  <NA>  0
## 163        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 164        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 165        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 166        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 167        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 168        0 Plasma concentration IQ0815 0.00689     <NA> ug/mL 0.001  <NA>  0
## 169        0 Plasma concentration IQ0815 0.01530     <NA> ug/mL 0.001  <NA>  0
## 170        0 Plasma concentration IQ0815 0.02390     <NA> ug/mL 0.001  <NA>  0
## 171        0 Plasma concentration IQ0815 0.04110     <NA> ug/mL 0.001  <NA>  0
## 172        0 Plasma concentration IQ0815 0.03820     <NA> ug/mL 0.001  <NA>  0
## 173        0 Plasma concentration IQ0815 0.02730     <NA> ug/mL 0.001  <NA>  0
## 174        0 Plasma concentration IQ0815 0.00528     <NA> ug/mL 0.001  <NA>  0
## 175        0 Plasma concentration IQ0815 0.00198     <NA> ug/mL 0.001  <NA>  0
## 176        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 177        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 178        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 179        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 180        0 Plasma concentration IQ0815 0.00515     <NA> ug/mL 0.001  <NA>  0
## 181        0 Plasma concentration IQ0815 0.01130     <NA> ug/mL 0.001  <NA>  0
## 182        0 Plasma concentration IQ0815 0.01910     <NA> ug/mL 0.001  <NA>  0
## 183        0 Plasma concentration IQ0815 0.03580     <NA> ug/mL 0.001  <NA>  0
## 184        0 Plasma concentration IQ0815 0.02670     <NA> ug/mL 0.001  <NA>  0
## 185        0 Plasma concentration IQ0815 0.01850     <NA> ug/mL 0.001  <NA>  0
## 186        0 Plasma concentration IQ0815 0.00755     <NA> ug/mL 0.001  <NA>  0
## 187        0 Plasma concentration IQ0815 0.00219     <NA> ug/mL 0.001  <NA>  0
## 188        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 189        0 Plasma concentration IQ0815 0.00101     <NA> ug/mL 0.001  <NA>  0
## 190        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 191        0 Plasma concentration IQ0815 0.00374     <NA> ug/mL 0.001  <NA>  0
## 192        0 Plasma concentration IQ0815 0.00866     <NA> ug/mL 0.001  <NA>  0
## 193        0 Plasma concentration IQ0815 0.01570     <NA> ug/mL 0.001  <NA>  0
## 194        0 Plasma concentration IQ0815 0.01960     <NA> ug/mL 0.001  <NA>  0
## 195        0 Plasma concentration IQ0815 0.02190     <NA> ug/mL 0.001  <NA>  0
## 196        0 Plasma concentration IQ0815 0.02200     <NA> ug/mL 0.001  <NA>  0
## 197        0 Plasma concentration IQ0815 0.00786     <NA> ug/mL 0.001  <NA>  0
## 198        0 Plasma concentration IQ0815 0.00382     <NA> ug/mL 0.001  <NA>  0
## 199        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 200        0 Plasma concentration IQ0815 0.00108     <NA> ug/mL 0.001  <NA>  0
## 201        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 202        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 203        0 Plasma concentration IQ0815 0.00241     <NA> ug/mL 0.001  <NA>  0
## 204        0 Plasma concentration IQ0815 0.01060     <NA> ug/mL 0.001  <NA>  0
## 205        0 Plasma concentration IQ0815 0.01630     <NA> ug/mL 0.001  <NA>  0
## 206        0 Plasma concentration IQ0815 0.02530     <NA> ug/mL 0.001  <NA>  0
## 207        0 Plasma concentration IQ0815 0.20500     <NA> ug/mL 0.001  <NA>  0
## 208        0 Plasma concentration IQ0815 0.01860     <NA> ug/mL 0.001  <NA>  0
## 209        0 Plasma concentration IQ0815 0.00534     <NA> ug/mL 0.001  <NA>  0
## 210        0 Plasma concentration IQ0815 0.00213     <NA> ug/mL 0.001  <NA>  0
## 211        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 212        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 213        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 214        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 215        0 Plasma concentration IQ0815 0.00905     <NA> ug/mL 0.001  <NA>  0
## 216        0 Plasma concentration IQ0815 0.02640     <NA> ug/mL 0.001  <NA>  0
## 217        0 Plasma concentration IQ0815 0.03400     <NA> ug/mL 0.001  <NA>  0
## 218        0 Plasma concentration IQ0815 0.04700     <NA> ug/mL 0.001  <NA>  0
## 219        0 Plasma concentration IQ0815 0.03710     <NA> ug/mL 0.001  <NA>  0
## 220        0 Plasma concentration IQ0815 0.02450     <NA> ug/mL 0.001  <NA>  0
## 221        0 Plasma concentration IQ0815 0.00779     <NA> ug/mL 0.001  <NA>  0
## 222        0 Plasma concentration IQ0815 0.00116     <NA> ug/mL 0.001  <NA>  0
## 223        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 224        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 225        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 226        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 227        0 Plasma concentration IQ0815 0.00433     <NA> ug/mL 0.001  <NA>  0
## 228        0 Plasma concentration IQ0815 0.01200     <NA> ug/mL 0.001  <NA>  0
## 229        0 Plasma concentration IQ0815 0.01940     <NA> ug/mL 0.001  <NA>  0
## 230        0 Plasma concentration IQ0815 0.03030     <NA> ug/mL 0.001  <NA>  0
## 231        0 Plasma concentration IQ0815 0.03300     <NA> ug/mL 0.001  <NA>  0
## 232        0 Plasma concentration IQ0815 0.02270     <NA> ug/mL 0.001  <NA>  0
## 233        0 Plasma concentration IQ0815 0.00835     <NA> ug/mL 0.001  <NA>  0
## 234        0 Plasma concentration IQ0815 0.00266     <NA> ug/mL 0.001  <NA>  0
## 235        0 Plasma concentration IQ0815 0.00241     <NA> ug/mL 0.001  <NA>  0
## 236        0 Plasma concentration IQ0815 0.00127     <NA> ug/mL 0.001  <NA>  0
## 237        0 Plasma concentration IQ0815 0.00124     <NA> ug/mL 0.001  <NA>  0
## 238        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 239        0 Plasma concentration IQ0815 0.01190     <NA> ug/mL 0.001  <NA>  0
## 240        0 Plasma concentration IQ0815 0.03410     <NA> ug/mL 0.001  <NA>  0
## 241        0 Plasma concentration IQ0815 0.05540     <NA> ug/mL 0.001  <NA>  0
## 242        0 Plasma concentration IQ0815 0.05080     <NA> ug/mL 0.001  <NA>  0
## 243        0 Plasma concentration IQ0815 0.05230     <NA> ug/mL 0.001  <NA>  0
## 244        0 Plasma concentration IQ0815 0.03200     <NA> ug/mL 0.001  <NA>  0
## 245        0 Plasma concentration IQ0815 0.01060     <NA> ug/mL 0.001  <NA>  0
## 246        0 Plasma concentration IQ0815 0.00196     <NA> ug/mL 0.001  <NA>  0
## 247        0 Plasma concentration IQ0815 0.00168     <NA> ug/mL 0.001  <NA>  0
## 248        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 249        0 Plasma concentration IQ0815 0.00117     <NA> ug/mL 0.001  <NA>  0
## 250        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 251        0 Plasma concentration IQ0815 0.00936     <NA> ug/mL 0.001  <NA>  0
## 252        0 Plasma concentration IQ0815 0.02200     <NA> ug/mL 0.001  <NA>  0
## 253        0 Plasma concentration IQ0815 0.03310     <NA> ug/mL 0.001  <NA>  0
## 254        0 Plasma concentration IQ0815 0.05420     <NA> ug/mL 0.001  <NA>  0
## 255        0 Plasma concentration IQ0815 0.05030     <NA> ug/mL 0.001  <NA>  0
## 256        0 Plasma concentration IQ0815 0.04100     <NA> ug/mL 0.001  <NA>  0
## 257        0 Plasma concentration IQ0815 0.01170     <NA> ug/mL 0.001  <NA>  0
## 258        0 Plasma concentration IQ0815 0.00311     <NA> ug/mL 0.001  <NA>  0
## 259        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 260        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 261        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 262        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 263        0 Plasma concentration IQ0815 0.01390     <NA> ug/mL 0.001  <NA>  0
## 264        0 Plasma concentration IQ0815 0.03260     <NA> ug/mL 0.001  <NA>  0
## 265        0 Plasma concentration IQ0815 0.05050     <NA> ug/mL 0.001  <NA>  0
## 266        0 Plasma concentration IQ0815 0.06240     <NA> ug/mL 0.001  <NA>  0
## 267        0 Plasma concentration IQ0815 0.05440     <NA> ug/mL 0.001  <NA>  0
## 268        0 Plasma concentration IQ0815 0.03180     <NA> ug/mL 0.001  <NA>  0
## 269        0 Plasma concentration IQ0815 0.00749     <NA> ug/mL 0.001  <NA>  0
## 270        0 Plasma concentration IQ0815 0.00232     <NA> ug/mL 0.001  <NA>  0
## 271        0 Plasma concentration IQ0815 0.00309     <NA> ug/mL 0.001  <NA>  0
## 272        0 Plasma concentration IQ0815 0.00261     <NA> ug/mL 0.001  <NA>  0
## 273        0 Plasma concentration IQ0815 0.00165     <NA> ug/mL 0.001  <NA>  0
## 274        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 275        0 Plasma concentration IQ0815 0.00609     <NA> ug/mL 0.001  <NA>  0
## 276        0 Plasma concentration IQ0815 0.01570     <NA> ug/mL 0.001  <NA>  0
## 277        0 Plasma concentration IQ0815 0.02970     <NA> ug/mL 0.001  <NA>  0
## 278        0 Plasma concentration IQ0815 0.05030     <NA> ug/mL 0.001  <NA>  0
## 279        0 Plasma concentration IQ0815 0.04650     <NA> ug/mL 0.001  <NA>  0
## 280        0 Plasma concentration IQ0815 0.04090     <NA> ug/mL 0.001  <NA>  0
## 281        0 Plasma concentration IQ0815 0.00898     <NA> ug/mL 0.001  <NA>  0
## 282        0 Plasma concentration IQ0815 0.00265     <NA> ug/mL 0.001  <NA>  0
## 283        0 Plasma concentration IQ0815 0.00169     <NA> ug/mL 0.001  <NA>  0
## 284        0 Plasma concentration IQ0815 0.00170     <NA> ug/mL 0.001  <NA>  0
## 285        0 Plasma concentration IQ0815 0.00145     <NA> ug/mL 0.001  <NA>  0
## 286        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 287        0 Plasma concentration IQ0815 0.00971     <NA> ug/mL 0.001  <NA>  0
## 288        0 Plasma concentration IQ0815 0.02690     <NA> ug/mL 0.001  <NA>  0
## 289        0 Plasma concentration IQ0815 0.04840     <NA> ug/mL 0.001  <NA>  0
## 290        0 Plasma concentration IQ0815 0.06530     <NA> ug/mL 0.001  <NA>  0
## 291        0 Plasma concentration IQ0815 0.05790     <NA> ug/mL 0.001  <NA>  0
## 292        0 Plasma concentration IQ0815 0.03360     <NA> ug/mL 0.001  <NA>  0
## 293        0 Plasma concentration IQ0815 0.00991     <NA> ug/mL 0.001  <NA>  0
## 294        0 Plasma concentration IQ0815 0.00188     <NA> ug/mL 0.001  <NA>  0
## 295        0 Plasma concentration IQ0815 0.00296     <NA> ug/mL 0.001  <NA>  0
## 296        0 Plasma concentration IQ0815 0.00149     <NA> ug/mL 0.001  <NA>  0
## 297        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 298        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 299        0 Plasma concentration IQ0815 0.01290     <NA> ug/mL 0.001  <NA>  0
## 300        0 Plasma concentration IQ0815 0.03290     <NA> ug/mL 0.001  <NA>  0
## 301        0 Plasma concentration IQ0815 0.04310     <NA> ug/mL 0.001  <NA>  0
## 302        0 Plasma concentration IQ0815 0.05360     <NA> ug/mL 0.001  <NA>  0
## 303        0 Plasma concentration IQ0815 0.05700     <NA> ug/mL 0.001  <NA>  0
## 304        0 Plasma concentration IQ0815 0.04370     <NA> ug/mL 0.001  <NA>  0
## 305        0 Plasma concentration IQ0815 0.01170     <NA> ug/mL 0.001  <NA>  0
## 306        0 Plasma concentration IQ0815 0.00297     <NA> ug/mL 0.001  <NA>  0
## 307        0 Plasma concentration IQ0815 0.00114     <NA> ug/mL 0.001  <NA>  0
## 308        0 Plasma concentration IQ0815 0.00131     <NA> ug/mL 0.001  <NA>  0
## 309        0 Plasma concentration IQ0815 0.00121     <NA> ug/mL 0.001  <NA>  0
## 310        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 311        0 Plasma concentration IQ0815 0.01480     <NA> ug/mL 0.001  <NA>  0
## 312        0 Plasma concentration IQ0815 0.03720     <NA> ug/mL 0.001  <NA>  0
## 313        0 Plasma concentration IQ0815 0.06000     <NA> ug/mL 0.001  <NA>  0
## 314        0 Plasma concentration IQ0815 0.08750     <NA> ug/mL 0.001  <NA>  0
## 315        0 Plasma concentration IQ0815 0.07030     <NA> ug/mL 0.001  <NA>  0
## 316        0 Plasma concentration IQ0815 0.07920     <NA> ug/mL 0.001  <NA>  0
## 317        0 Plasma concentration IQ0815 0.02850     <NA> ug/mL 0.001  <NA>  0
## 318        0 Plasma concentration IQ0815 0.00963     <NA> ug/mL 0.001  <NA>  0
## 319        0 Plasma concentration IQ0815 0.00283     <NA> ug/mL 0.001  <NA>  0
## 320        0 Plasma concentration IQ0815 0.00248     <NA> ug/mL 0.001  <NA>  0
## 321        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 322        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 323        0 Plasma concentration IQ0815 0.04720     <NA> ug/mL 0.001  <NA>  0
## 324        0 Plasma concentration IQ0815 0.11400     <NA> ug/mL 0.001  <NA>  0
## 325        0 Plasma concentration IQ0815 0.15200     <NA> ug/mL 0.001  <NA>  0
## 326        0 Plasma concentration IQ0815 0.17300     <NA> ug/mL 0.001  <NA>  0
## 327        0 Plasma concentration IQ0815 0.14500     <NA> ug/mL 0.001  <NA>  0
## 328        0 Plasma concentration IQ0815 0.10100     <NA> ug/mL 0.001  <NA>  0
## 329        0 Plasma concentration IQ0815 0.01950     <NA> ug/mL 0.001  <NA>  0
## 330        0 Plasma concentration IQ0815 0.00940     <NA> ug/mL 0.001  <NA>  0
## 331        0 Plasma concentration IQ0815 0.00528     <NA> ug/mL 0.001  <NA>  0
## 332        0 Plasma concentration IQ0815 0.00482     <NA> ug/mL 0.001  <NA>  0
## 333        0 Plasma concentration IQ0815 0.00229     <NA> ug/mL 0.001  <NA>  0
## 334        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 335        0 Plasma concentration IQ0815 0.02670     <NA> ug/mL 0.001  <NA>  0
## 336        0 Plasma concentration IQ0815 0.06480     <NA> ug/mL 0.001  <NA>  0
## 337        0 Plasma concentration IQ0815 0.11000     <NA> ug/mL 0.001  <NA>  0
## 338        0 Plasma concentration IQ0815 0.12500     <NA> ug/mL 0.001  <NA>  0
## 339        0 Plasma concentration IQ0815 0.14300     <NA> ug/mL 0.001  <NA>  0
## 340        0 Plasma concentration IQ0815 0.06950     <NA> ug/mL 0.001  <NA>  0
## 341        0 Plasma concentration IQ0815 0.01640     <NA> ug/mL 0.001  <NA>  0
## 342        0 Plasma concentration IQ0815 0.00447     <NA> ug/mL 0.001  <NA>  0
## 343        0 Plasma concentration IQ0815 0.00313     <NA> ug/mL 0.001  <NA>  0
## 344        0 Plasma concentration IQ0815 0.00299     <NA> ug/mL 0.001  <NA>  0
## 345        0 Plasma concentration IQ0815 0.00201     <NA> ug/mL 0.001  <NA>  0
## 346        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 347        0 Plasma concentration IQ0815 0.01730     <NA> ug/mL 0.001  <NA>  0
## 348        0 Plasma concentration IQ0815 0.04370     <NA> ug/mL 0.001  <NA>  0
## 349        0 Plasma concentration IQ0815 0.07930     <NA> ug/mL 0.001  <NA>  0
## 350        0 Plasma concentration IQ0815 0.08940     <NA> ug/mL 0.001  <NA>  0
## 351        0 Plasma concentration IQ0815 0.09610     <NA> ug/mL 0.001  <NA>  0
## 352        0 Plasma concentration IQ0815 0.07590     <NA> ug/mL 0.001  <NA>  0
## 353        0 Plasma concentration IQ0815 0.01350     <NA> ug/mL 0.001  <NA>  0
## 354        0 Plasma concentration IQ0815 0.00340     <NA> ug/mL 0.001  <NA>  0
## 355        0 Plasma concentration IQ0815 0.00208     <NA> ug/mL 0.001  <NA>  0
## 356        0 Plasma concentration IQ0815 0.00112     <NA> ug/mL 0.001  <NA>  0
## 357        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 358        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 359        0 Plasma concentration IQ0815 0.04720     <NA> ug/mL 0.001  <NA>  0
## 360        0 Plasma concentration IQ0815 0.10600     <NA> ug/mL 0.001  <NA>  0
## 361        0 Plasma concentration IQ0815 0.13700     <NA> ug/mL 0.001  <NA>  0
## 362        0 Plasma concentration IQ0815 0.18200     <NA> ug/mL 0.001  <NA>  0
## 363        0 Plasma concentration IQ0815 0.16700     <NA> ug/mL 0.001  <NA>  0
## 364        0 Plasma concentration IQ0815 0.09100     <NA> ug/mL 0.001  <NA>  0
## 365        0 Plasma concentration IQ0815 0.01220     <NA> ug/mL 0.001  <NA>  0
## 366        0 Plasma concentration IQ0815 0.00554     <NA> ug/mL 0.001  <NA>  0
## 367        0 Plasma concentration IQ0815 0.00404     <NA> ug/mL 0.001  <NA>  0
## 368        0 Plasma concentration IQ0815 0.00415     <NA> ug/mL 0.001  <NA>  0
## 369        0 Plasma concentration IQ0815 0.00204     <NA> ug/mL 0.001  <NA>  0
## 370        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 371        0 Plasma concentration IQ0815 0.03750     <NA> ug/mL 0.001  <NA>  0
## 372        0 Plasma concentration IQ0815 0.08430     <NA> ug/mL 0.001  <NA>  0
## 373        0 Plasma concentration IQ0815 0.13000     <NA> ug/mL 0.001  <NA>  0
## 374        0 Plasma concentration IQ0815 0.22300     <NA> ug/mL 0.001  <NA>  0
## 375        0 Plasma concentration IQ0815 0.19500     <NA> ug/mL 0.001  <NA>  0
## 376        0 Plasma concentration IQ0815 0.14900     <NA> ug/mL 0.001  <NA>  0
## 377        0 Plasma concentration IQ0815 0.02950     <NA> ug/mL 0.001  <NA>  0
## 378        0 Plasma concentration IQ0815 0.00783     <NA> ug/mL 0.001  <NA>  0
## 379        0 Plasma concentration IQ0815 0.00447     <NA> ug/mL 0.001  <NA>  0
## 380        0 Plasma concentration IQ0815 0.00439     <NA> ug/mL 0.001  <NA>  0
## 381        0 Plasma concentration IQ0815 0.00191     <NA> ug/mL 0.001  <NA>  0
## 382        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 383        0 Plasma concentration IQ0815 0.03800     <NA> ug/mL 0.001  <NA>  0
## 384        0 Plasma concentration IQ0815 0.11800     <NA> ug/mL 0.001  <NA>  0
## 385        0 Plasma concentration IQ0815 0.15600     <NA> ug/mL 0.001  <NA>  0
## 386        0 Plasma concentration IQ0815 0.26800     <NA> ug/mL 0.001  <NA>  0
## 387        0 Plasma concentration IQ0815 0.22600     <NA> ug/mL 0.001  <NA>  0
## 388        0 Plasma concentration IQ0815 0.18700     <NA> ug/mL 0.001  <NA>  0
## 389        0 Plasma concentration IQ0815 0.07220     <NA> ug/mL 0.001  <NA>  0
## 390        0 Plasma concentration IQ0815 0.01980     <NA> ug/mL 0.001  <NA>  0
## 391        0 Plasma concentration IQ0815 0.00557     <NA> ug/mL 0.001  <NA>  0
## 392        0 Plasma concentration IQ0815 0.00625     <NA> ug/mL 0.001  <NA>  0
## 393        0 Plasma concentration IQ0815 0.00489     <NA> ug/mL 0.001  <NA>  0
## 394        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 395        0 Plasma concentration IQ0815 0.05450     <NA> ug/mL 0.001  <NA>  0
## 396        0 Plasma concentration IQ0815 0.17100     <NA> ug/mL 0.001  <NA>  0
## 397        0 Plasma concentration IQ0815 0.25400     <NA> ug/mL 0.001  <NA>  0
## 398        0 Plasma concentration IQ0815 0.25600     <NA> ug/mL 0.001  <NA>  0
## 399        0 Plasma concentration IQ0815 0.25300     <NA> ug/mL 0.001  <NA>  0
## 400        0 Plasma concentration IQ0815 0.20200     <NA> ug/mL 0.001  <NA>  0
## 401        0 Plasma concentration IQ0815 0.09480     <NA> ug/mL 0.001  <NA>  0
## 402        0 Plasma concentration IQ0815 0.02510     <NA> ug/mL 0.001  <NA>  0
## 403        0 Plasma concentration IQ0815 0.00726     <NA> ug/mL 0.001  <NA>  0
## 404        0 Plasma concentration IQ0815 0.00550     <NA> ug/mL 0.001  <NA>  0
## 405        0 Plasma concentration IQ0815 0.00584     <NA> ug/mL 0.001  <NA>  0
## 406        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 407        0 Plasma concentration IQ0815 0.07300     <NA> ug/mL 0.001  <NA>  0
## 408        0 Plasma concentration IQ0815 0.19400     <NA> ug/mL 0.001  <NA>  0
## 409        0 Plasma concentration IQ0815 0.25700     <NA> ug/mL 0.001  <NA>  0
## 410        0 Plasma concentration IQ0815 0.41900     <NA> ug/mL 0.001  <NA>  0
## 411        0 Plasma concentration IQ0815 0.43900     <NA> ug/mL 0.001  <NA>  0
## 412        0 Plasma concentration IQ0815 0.32000     <NA> ug/mL 0.001  <NA>  0
## 413        0 Plasma concentration IQ0815 0.05640     <NA> ug/mL 0.001  <NA>  0
## 414        0 Plasma concentration IQ0815 0.01690     <NA> ug/mL 0.001  <NA>  0
## 415        0 Plasma concentration IQ0815 0.01180     <NA> ug/mL 0.001  <NA>  0
## 416        0 Plasma concentration IQ0815 0.00834     <NA> ug/mL 0.001  <NA>  0
## 417        0 Plasma concentration IQ0815 0.00685     <NA> ug/mL 0.001  <NA>  0
## 418        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 419        0 Plasma concentration IQ0815 0.08670     <NA> ug/mL 0.001  <NA>  0
## 420        0 Plasma concentration IQ0815 0.20300     <NA> ug/mL 0.001  <NA>  0
## 421        0 Plasma concentration IQ0815 0.29300     <NA> ug/mL 0.001  <NA>  0
## 422        0 Plasma concentration IQ0815 0.33400     <NA> ug/mL 0.001  <NA>  0
## 423        0 Plasma concentration IQ0815 0.29100     <NA> ug/mL 0.001  <NA>  0
## 424        0 Plasma concentration IQ0815 0.24300     <NA> ug/mL 0.001  <NA>  0
## 425        0 Plasma concentration IQ0815 0.05680     <NA> ug/mL 0.001  <NA>  0
## 426        0 Plasma concentration IQ0815 0.01150     <NA> ug/mL 0.001  <NA>  0
## 427        0 Plasma concentration IQ0815 0.00503     <NA> ug/mL 0.001  <NA>  0
## 428        0 Plasma concentration IQ0815 0.00278     <NA> ug/mL 0.001  <NA>  0
## 429        0 Plasma concentration IQ0815 0.00216     <NA> ug/mL 0.001  <NA>  0
## 430        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 431        0 Plasma concentration IQ0815 0.06290     <NA> ug/mL 0.001  <NA>  0
## 432        0 Plasma concentration IQ0815 0.14200     <NA> ug/mL 0.001  <NA>  0
## 433        0 Plasma concentration IQ0815 0.21500     <NA> ug/mL 0.001  <NA>  0
## 434        0 Plasma concentration IQ0815 0.31800     <NA> ug/mL 0.001  <NA>  0
## 435        0 Plasma concentration IQ0815 0.25400     <NA> ug/mL 0.001  <NA>  0
## 436        0 Plasma concentration IQ0815 0.16900     <NA> ug/mL 0.001  <NA>  0
## 437        0 Plasma concentration IQ0815 0.02870     <NA> ug/mL 0.001  <NA>  0
## 438        0 Plasma concentration IQ0815 0.00977     <NA> ug/mL 0.001  <NA>  0
## 439        0 Plasma concentration IQ0815 0.00555     <NA> ug/mL 0.001  <NA>  0
## 440        0 Plasma concentration IQ0815 0.00413     <NA> ug/mL 0.001  <NA>  0
## 441        0 Plasma concentration IQ0815 0.00196     <NA> ug/mL 0.001  <NA>  0
## 442        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 443        0 Plasma concentration IQ0815 0.08270     <NA> ug/mL 0.001  <NA>  0
## 444        0 Plasma concentration IQ0815 0.20200     <NA> ug/mL 0.001  <NA>  0
## 445        0 Plasma concentration IQ0815 0.28400     <NA> ug/mL 0.001  <NA>  0
## 446        0 Plasma concentration IQ0815 0.31000     <NA> ug/mL 0.001  <NA>  0
## 447        0 Plasma concentration IQ0815 0.25600     <NA> ug/mL 0.001  <NA>  0
## 448        0 Plasma concentration IQ0815 0.18200     <NA> ug/mL 0.001  <NA>  0
## 449        0 Plasma concentration IQ0815 0.02720     <NA> ug/mL 0.001  <NA>  0
## 450        0 Plasma concentration IQ0815 0.01400     <NA> ug/mL 0.001  <NA>  0
## 451        0 Plasma concentration IQ0815 0.01130     <NA> ug/mL 0.001  <NA>  0
## 452        0 Plasma concentration IQ0815 0.00537     <NA> ug/mL 0.001  <NA>  0
## 453        0 Plasma concentration IQ0815 0.00258     <NA> ug/mL 0.001  <NA>  0
## 454        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 455        0 Plasma concentration IQ0815 0.16600     <NA> ug/mL 0.001  <NA>  0
## 456        0 Plasma concentration IQ0815 0.37400     <NA> ug/mL 0.001  <NA>  0
## 457        0 Plasma concentration IQ0815 0.50400     <NA> ug/mL 0.001  <NA>  0
## 458        0 Plasma concentration IQ0815 0.86200     <NA> ug/mL 0.001  <NA>  0
## 459        0 Plasma concentration IQ0815 0.78800     <NA> ug/mL 0.001  <NA>  0
## 460        0 Plasma concentration IQ0815 0.49000     <NA> ug/mL 0.001  <NA>  0
## 461        0 Plasma concentration IQ0815 0.14300     <NA> ug/mL 0.001  <NA>  0
## 462        0 Plasma concentration IQ0815 0.02110     <NA> ug/mL 0.001  <NA>  0
## 463        0 Plasma concentration IQ0815 0.00575     <NA> ug/mL 0.001  <NA>  0
## 464        0 Plasma concentration IQ0815 0.00667     <NA> ug/mL 0.001  <NA>  0
## 465        0 Plasma concentration IQ0815 0.00593     <NA> ug/mL 0.001  <NA>  0
## 466        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 467        0 Plasma concentration IQ0815 0.08550     <NA> ug/mL 0.001  <NA>  0
## 468        0 Plasma concentration IQ0815 0.18200     <NA> ug/mL 0.001  <NA>  0
## 469        0 Plasma concentration IQ0815 0.32300     <NA> ug/mL 0.001  <NA>  0
## 470        0 Plasma concentration IQ0815 0.43400     <NA> ug/mL 0.001  <NA>  0
## 471        0 Plasma concentration IQ0815 0.41700     <NA> ug/mL 0.001  <NA>  0
## 472        0 Plasma concentration IQ0815 0.23200     <NA> ug/mL 0.001  <NA>  0
## 473        0 Plasma concentration IQ0815 0.03960     <NA> ug/mL 0.001  <NA>  0
## 474        0 Plasma concentration IQ0815 0.00877     <NA> ug/mL 0.001  <NA>  0
## 475        0 Plasma concentration IQ0815 0.00778     <NA> ug/mL 0.001  <NA>  0
## 476        0 Plasma concentration IQ0815 0.00419     <NA> ug/mL 0.001  <NA>  0
## 477        0 Plasma concentration IQ0815 0.00410     <NA> ug/mL 0.001  <NA>  0
## 478        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 479        0 Plasma concentration IQ0815 0.17500     <NA> ug/mL 0.001  <NA>  0
## 480        0 Plasma concentration IQ0815 0.37600     <NA> ug/mL 0.001  <NA>  0
## 481        0 Plasma concentration IQ0815 0.59300     <NA> ug/mL 0.001  <NA>  0
## 482        0 Plasma concentration IQ0815 0.63500     <NA> ug/mL 0.001  <NA>  0
## 483        0 Plasma concentration IQ0815 0.51700     <NA> ug/mL 0.001  <NA>  0
## 484        0 Plasma concentration IQ0815 0.42900     <NA> ug/mL 0.001  <NA>  0
## 485        0 Plasma concentration IQ0815 0.09240     <NA> ug/mL 0.001  <NA>  0
## 486        0 Plasma concentration IQ0815 0.01930     <NA> ug/mL 0.001  <NA>  0
## 487        0 Plasma concentration IQ0815 0.01220     <NA> ug/mL 0.001  <NA>  0
## 488        0 Plasma concentration IQ0815 0.00661     <NA> ug/mL 0.001  <NA>  0
## 489        0 Plasma concentration IQ0815 0.00625     <NA> ug/mL 0.001  <NA>  0
## 490        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 491        0 Plasma concentration IQ0815 0.08050     <NA> ug/mL 0.001  <NA>  0
## 492        0 Plasma concentration IQ0815 0.19300     <NA> ug/mL 0.001  <NA>  0
## 493        0 Plasma concentration IQ0815 0.32400     <NA> ug/mL 0.001  <NA>  0
## 494        0 Plasma concentration IQ0815 0.54500     <NA> ug/mL 0.001  <NA>  0
## 495        0 Plasma concentration IQ0815 0.48700     <NA> ug/mL 0.001  <NA>  0
## 496        0 Plasma concentration IQ0815 0.32100     <NA> ug/mL 0.001  <NA>  0
## 497        0 Plasma concentration IQ0815 0.05940     <NA> ug/mL 0.001  <NA>  0
## 498        0 Plasma concentration IQ0815 0.01070     <NA> ug/mL 0.001  <NA>  0
## 499        0 Plasma concentration IQ0815 0.00319     <NA> ug/mL 0.001  <NA>  0
## 500        0 Plasma concentration IQ0815 0.00324     <NA> ug/mL 0.001  <NA>  0
## 501        0 Plasma concentration IQ0815 0.00277     <NA> ug/mL 0.001  <NA>  0
## 502        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 503        0 Plasma concentration IQ0815 0.11000     <NA> ug/mL 0.001  <NA>  0
## 504        0 Plasma concentration IQ0815 0.26500     <NA> ug/mL 0.001  <NA>  0
## 505        0 Plasma concentration IQ0815 0.42700     <NA> ug/mL 0.001  <NA>  0
## 506        0 Plasma concentration IQ0815 0.55200     <NA> ug/mL 0.001  <NA>  0
## 507        0 Plasma concentration IQ0815 0.43200     <NA> ug/mL 0.001  <NA>  0
## 508        0 Plasma concentration IQ0815 0.35400     <NA> ug/mL 0.001  <NA>  0
## 509        0 Plasma concentration IQ0815 0.09750     <NA> ug/mL 0.001  <NA>  0
## 510        0 Plasma concentration IQ0815 0.02520     <NA> ug/mL 0.001  <NA>  0
## 511        0 Plasma concentration IQ0815 0.01240     <NA> ug/mL 0.001  <NA>  0
## 512        0 Plasma concentration IQ0815 0.01140     <NA> ug/mL 0.001  <NA>  0
## 513        0 Plasma concentration IQ0815 0.00855     <NA> ug/mL 0.001  <NA>  0
## 514        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 515        0 Plasma concentration IQ0815 0.18300     <NA> ug/mL 0.001  <NA>  0
## 516        0 Plasma concentration IQ0815 0.50000     <NA> ug/mL 0.001  <NA>  0
## 517        0 Plasma concentration IQ0815 0.70600     <NA> ug/mL 0.001  <NA>  0
## 518        0 Plasma concentration IQ0815 0.98400     <NA> ug/mL 0.001  <NA>  0
## 519        0 Plasma concentration IQ0815 0.83000     <NA> ug/mL 0.001  <NA>  0
## 520        0 Plasma concentration IQ0815 0.59300     <NA> ug/mL 0.001  <NA>  0
## 521        0 Plasma concentration IQ0815 0.19600     <NA> ug/mL 0.001  <NA>  0
## 522        0 Plasma concentration IQ0815 0.05670     <NA> ug/mL 0.001  <NA>  0
## 523        0 Plasma concentration IQ0815 0.01880     <NA> ug/mL 0.001  <NA>  0
## 524        0 Plasma concentration IQ0815 0.01930     <NA> ug/mL 0.001  <NA>  0
## 525        0 Plasma concentration IQ0815 0.01510     <NA> ug/mL 0.001  <NA>  0
##     ADDL ID  TIMEPOS EVID MDV CENS AMT      DV TINF RATE ADM YTYPE      TAD
## 1      0  3 167.5833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 2      0  3 167.7493    0   0    1   0 0.00100    0    0   0     1   0.0830
## 3      0  3 167.9163    0   0    0   0 0.00153    0    0   0     1   0.2500
## 4      0  3 168.1663    0   0    0   0 0.00350    0    0   0     1   0.5000
## 5      0  3 168.6663    0   0    0   0 0.00380    0    0   0     1   1.0000
## 6      0  3 169.6663    0   0    0   0 0.00333    0    0   0     1   2.0000
## 7      0  3 171.6663    0   0    0   0 0.00291    0    0   0     1   4.0000
## 8      0  3 179.6663    0   0    1   0 0.00100    0    0   0     1  12.0000
## 9      0  3 191.6663    0   0    1   0 0.00100    0    0   0     1  24.0000
## 10     0  3 215.6663    0   0    1   0 0.00100    0    0   0     1  48.0000
## 11     0  3 263.6663    0   0    1   0 0.00100    0    0   0     1  96.0000
## 12     0  3 335.6663    0   0    1   0 0.00100    0    0   0     1 168.0000
## 13     0  4 168.0000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 14     0  4 168.1660    0   0    0   0 0.00138    0    0   0     1   0.0830
## 15     0  4 168.3330    0   0    0   0 0.00212    0    0   0     1   0.2500
## 16     0  4 168.5830    0   0    0   0 0.00359    0    0   0     1   0.5000
## 17     0  4 169.0830    0   0    0   0 0.00542    0    0   0     1   1.0000
## 18     0  4 170.0830    0   0    0   0 0.00526    0    0   0     1   2.0000
## 19     0  4 172.0830    0   0    0   0 0.00391    0    0   0     1   4.0000
## 20     0  4 180.0830    0   0    1   0 0.00100    0    0   0     1  12.0000
## 21     0  4 192.0830    0   0    1   0 0.00100    0    0   0     1  24.0000
## 22     0  4 216.0830    0   0    1   0 0.00100    0    0   0     1  48.0000
## 23     0  4 264.0830    0   0    1   0 0.00100    0    0   0     1  96.0000
## 24     0  4 336.0830    0   0    1   0 0.00100    0    0   0     1 168.0000
## 25     0  5 168.0500    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 26     0  5 168.2160    0   0    1   0 0.00100    0    0   0     1   0.0830
## 27     0  5 168.3830    0   0    0   0 0.00168    0    0   0     1   0.2500
## 28     0  5 168.3831    0   0    0   0 0.00168    0    0   0     1   0.2501
## 29     0  5 169.1330    0   0    0   0 0.00221    0    0   0     1   1.0000
## 30     0  5 170.1330    0   0    0   0 0.00307    0    0   0     1   2.0000
## 31     0  5 172.1330    0   0    0   0 0.00133    0    0   0     1   4.0000
## 32     0  5 192.1330    0   0    1   0 0.00100    0    0   0     1  24.0000
## 33     0  5 216.1330    0   0    1   0 0.00100    0    0   0     1  48.0000
## 34     0  5 264.1330    0   0    1   0 0.00100    0    0   0     1  96.0000
## 35     0  5 336.1330    0   0    1   0 0.00100    0    0   0     1 168.0000
## 36     0  6 167.9667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 37     0  6 168.1327    0   0    1   0 0.00100    0    0   0     1   0.0830
## 38     0  6 168.2997    0   0    0   0 0.00128    0    0   0     1   0.2500
## 39     0  6 168.5497    0   0    0   0 0.00220    0    0   0     1   0.5000
## 40     0  6 169.0497    0   0    0   0 0.00278    0    0   0     1   1.0000
## 41     0  6 170.0497    0   0    0   0 0.00221    0    0   0     1   2.0000
## 42     0  6 172.0497    0   0    0   0 0.00153    0    0   0     1   4.0000
## 43     0  6 180.0497    0   0    1   0 0.00100    0    0   0     1  12.0000
## 44     0  6 192.0497    0   0    1   0 0.00100    0    0   0     1  24.0000
## 45     0  6 216.0497    0   0    1   0 0.00100    0    0   0     1  48.0000
## 46     0  6 264.0497    0   0    1   0 0.00100    0    0   0     1  96.0000
## 47     0  6 336.0497    0   0    1   0 0.00100    0    0   0     1 168.0000
## 48     0  7 167.9333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 49     0  7 168.0993    0   0    0   0 0.00174    0    0   0     1   0.0830
## 50     0  7 168.2663    0   0    0   0 0.00299    0    0   0     1   0.2500
## 51     0  7 168.5163    0   0    0   0 0.00555    0    0   0     1   0.5000
## 52     0  7 169.0163    0   0    0   0 0.00780    0    0   0     1   1.0000
## 53     0  7 170.0163    0   0    0   0 0.00706    0    0   0     1   2.0000
## 54     0  7 172.0163    0   0    0   0 0.00526    0    0   0     1   4.0000
## 55     0  7 180.0163    0   0    1   0 0.00100    0    0   0     1  12.0000
## 56     0  7 192.0163    0   0    1   0 0.00100    0    0   0     1  24.0000
## 57     0  7 264.0163    0   0    1   0 0.00100    0    0   0     1  96.0000
## 58     0  7 336.0163    0   0    1   0 0.00100    0    0   0     1 168.0000
## 59     0  9 167.9833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 60     0  9 168.1493    0   0    0   0 0.00123    0    0   0     1   0.0830
## 61     0  9 168.3163    0   0    0   0 0.00238    0    0   0     1   0.2500
## 62     0  9 168.5663    0   0    0   0 0.00480    0    0   0     1   0.5000
## 63     0  9 169.0663    0   0    0   0 0.00672    0    0   0     1   1.0000
## 64     0  9 170.0663    0   0    0   0 0.00509    0    0   0     1   2.0000
## 65     0  9 172.0663    0   0    0   0 0.00396    0    0   0     1   4.0000
## 66     0  9 180.0663    0   0    0   0 0.00160    0    0   0     1  12.0000
## 67     0  9 192.0663    0   0    1   0 0.00100    0    0   0     1  24.0000
## 68     0  9 216.0663    0   0    1   0 0.00100    0    0   0     1  48.0000
## 69     0  9 264.0663    0   0    1   0 0.00100    0    0   0     1  96.0000
## 70     0  9 336.0663    0   0    1   0 0.00100    0    0   0     1 168.0000
## 71     0 10 167.9333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 72     0 10 168.0993    0   0    0   0 0.00157    0    0   0     1   0.0830
## 73     0 10 168.2663    0   0    0   0 0.00205    0    0   0     1   0.2500
## 74     0 10 168.5163    0   0    0   0 0.00446    0    0   0     1   0.5000
## 75     0 10 169.0163    0   0    0   0 0.00462    0    0   0     1   1.0000
## 76     0 10 170.0163    0   0    0   0 0.00555    0    0   0     1   2.0000
## 77     0 10 172.0163    0   0    0   0 0.00329    0    0   0     1   4.0000
## 78     0 10 180.0163    0   0    1   0 0.00100    0    0   0     1  12.0000
## 79     0 10 192.0163    0   0    1   0 0.00100    0    0   0     1  24.0000
## 80     0 10 216.0163    0   0    1   0 0.00100    0    0   0     1  48.0000
## 81     0 10 264.0163    0   0    1   0 0.00100    0    0   0     1  96.0000
## 82     0 10 336.0163    0   0    1   0 0.00100    0    0   0     1 168.0000
## 83     0 11 167.6333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 84     0 11 167.7993    0   0    0   0 0.00127    0    0   0     1   0.0830
## 85     0 11 167.9663    0   0    0   0 0.00345    0    0   0     1   0.2500
## 86     0 11 168.2163    0   0    0   0 0.00491    0    0   0     1   0.5000
## 87     0 11 168.7163    0   0    0   0 0.00692    0    0   0     1   1.0000
## 88     0 11 169.7163    0   0    0   0 0.00736    0    0   0     1   2.0000
## 89     0 11 171.7163    0   0    0   0 0.00420    0    0   0     1   4.0000
## 90     0 11 179.7163    0   0    1   0 0.00100    0    0   0     1  12.0000
## 91     0 11 191.7163    0   0    1   0 0.00100    0    0   0     1  24.0000
## 92     0 11 215.7163    0   0    1   0 0.00100    0    0   0     1  48.0000
## 93     0 11 263.7163    0   0    1   0 0.00100    0    0   0     1  96.0000
## 94     0 11 335.7163    0   0    1   0 0.00100    0    0   0     1 168.0000
## 95     0 12 168.7000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 96     0 12 168.8660    0   0    1   0 0.00100    0    0   0     1   0.0830
## 97     0 12 169.0330    0   0    0   0 0.00380    0    0   0     1   0.2500
## 98     0 12 169.2830    0   0    0   0 0.00510    0    0   0     1   0.5000
## 99     0 12 169.7830    0   0    0   0 0.00396    0    0   0     1   1.0000
## 100    0 12 170.7830    0   0    0   0 0.00596    0    0   0     1   2.0000
## 101    0 12 172.7830    0   0    0   0 0.00445    0    0   0     1   4.0000
## 102    0 12 180.7830    0   0    1   0 0.00100    0    0   0     1  12.0000
## 103    0 12 192.7830    0   0    1   0 0.00100    0    0   0     1  24.0000
## 104    0 12 216.7830    0   0    1   0 0.00100    0    0   0     1  48.0000
## 105    0 12 264.7830    0   0    1   0 0.00100    0    0   0     1  96.0000
## 106    0 12 336.7830    0   0    1   0 0.00100    0    0   0     1 168.0000
## 107    0 13 168.5000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 108    0 13 168.6660    0   0    0   0 0.00593    0    0   0     1   0.0830
## 109    0 13 168.8330    0   0    0   0 0.01100    0    0   0     1   0.2500
## 110    0 13 169.0830    0   0    0   0 0.02130    0    0   0     1   0.5000
## 111    0 13 169.5830    0   0    0   0 0.02640    0    0   0     1   1.0000
## 112    0 13 170.5830    0   0    0   0 0.02360    0    0   0     1   2.0000
## 113    0 13 172.5830    0   0    0   0 0.00808    0    0   0     1   4.0000
## 114    0 13 180.5830    0   0    0   0 0.00128    0    0   0     1  12.0000
## 115    0 13 192.5830    0   0    1   0 0.00100    0    0   0     1  24.0000
## 116    0 13 216.5830    0   0    1   0 0.00100    0    0   0     1  48.0000
## 117    0 13 264.5830    0   0    1   0 0.00100    0    0   0     1  96.0000
## 118    0 13 336.5830    0   0    1   0 0.00100    0    0   0     1 168.0000
## 119    0 14 168.5667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 120    0 14 168.7327    0   0    0   0 0.00428    0    0   0     1   0.0830
## 121    0 14 168.8997    0   0    0   0 0.01080    0    0   0     1   0.2500
## 122    0 14 169.1497    0   0    0   0 0.01920    0    0   0     1   0.5000
## 123    0 14 169.6497    0   0    0   0 0.01960    0    0   0     1   1.0000
## 124    0 14 170.6497    0   0    0   0 0.01400    0    0   0     1   2.0000
## 125    0 14 172.6497    0   0    1   0 0.00100    0    0   0     1   4.0000
## 126    0 14 180.6497    0   0    0   0 0.00112    0    0   0     1  12.0000
## 127    0 14 192.6497    0   0    1   0 0.00100    0    0   0     1  24.0000
## 128    0 14 216.6497    0   0    1   0 0.00100    0    0   0     1  48.0000
## 129    0 14 264.6497    0   0    1   0 0.00100    0    0   0     1  96.0000
## 130    0 14 336.6497    0   0    1   0 0.00100    0    0   0     1 168.0000
## 131    0 15 168.3167    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 132    0 15 168.4827    0   0    0   0 0.00174    0    0   0     1   0.0830
## 133    0 15 168.6497    0   0    0   0 0.00432    0    0   0     1   0.2500
## 134    0 15 168.8997    0   0    0   0 0.00766    0    0   0     1   0.5000
## 135    0 15 169.3997    0   0    0   0 0.01030    0    0   0     1   1.0000
## 136    0 15 170.3997    0   0    0   0 0.00802    0    0   0     1   2.0000
## 137    0 15 172.3997    0   0    0   0 0.00742    0    0   0     1   4.0000
## 138    0 15 180.3997    0   0    0   0 0.00300    0    0   0     1  12.0000
## 139    0 15 192.3997    0   0    1   0 0.00100    0    0   0     1  24.0000
## 140    0 15 216.3997    0   0    1   0 0.00100    0    0   0     1  48.0000
## 141    0 15 264.3997    0   0    1   0 0.00100    0    0   0     1  96.0000
## 142    0 15 336.3997    0   0    1   0 0.00100    0    0   0     1 168.0000
## 143    0 16 167.2833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 144    0 16 167.4493    0   0    0   0 0.00370    0    0   0     1   0.0830
## 145    0 16 167.6163    0   0    0   0 0.00826    0    0   0     1   0.2500
## 146    0 16 167.8663    0   0    0   0 0.01440    0    0   0     1   0.5000
## 147    0 16 168.3663    0   0    0   0 0.01460    0    0   0     1   1.0000
## 148    0 16 169.3663    0   0    0   0 0.01770    0    0   0     1   2.0000
## 149    0 16 171.3663    0   0    0   0 0.00857    0    0   0     1   4.0000
## 150    0 16 179.3663    0   0    0   0 0.00199    0    0   0     1  12.0000
## 151    0 16 191.3663    0   0    1   0 0.00100    0    0   0     1  24.0000
## 152    0 16 215.3663    0   0    1   0 0.00100    0    0   0     1  48.0000
## 153    0 16 263.3663    0   0    1   0 0.00100    0    0   0     1  96.0000
## 154    0 16 335.3663    0   0    0   0 0.00101    0    0   0     1 168.0000
## 155    0 17 168.6667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 156    0 17 168.8327    0   0    0   0 0.00386    0    0   0     1   0.0830
## 157    0 17 168.9997    0   0    0   0 0.00888    0    0   0     1   0.2500
## 158    0 17 169.2497    0   0    0   0 0.01700    0    0   0     1   0.5000
## 159    0 17 169.7497    0   0    0   0 0.01830    0    0   0     1   1.0000
## 160    0 17 170.7497    0   0    0   0 0.01980    0    0   0     1   2.0000
## 161    0 17 172.7497    0   0    0   0 0.00950    0    0   0     1   4.0000
## 162    0 17 180.7497    0   0    0   0 0.00334    0    0   0     1  12.0000
## 163    0 17 192.7497    0   0    1   0 0.00100    0    0   0     1  24.0000
## 164    0 17 216.7497    0   0    1   0 0.00100    0    0   0     1  48.0000
## 165    0 17 264.7497    0   0    1   0 0.00100    0    0   0     1  96.0000
## 166    0 17 336.7497    0   0    1   0 0.00100    0    0   0     1 168.0000
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## 169    0 19 169.4163    0   0    0   0 0.01530    0    0   0     1   0.2500
## 170    0 19 169.6663    0   0    0   0 0.02390    0    0   0     1   0.5000
## 171    0 19 170.1663    0   0    0   0 0.04110    0    0   0     1   1.0000
## 172    0 19 171.1663    0   0    0   0 0.03820    0    0   0     1   2.0000
## 173    0 19 173.1663    0   0    0   0 0.02730    0    0   0     1   4.0000
## 174    0 19 181.1663    0   0    0   0 0.00528    0    0   0     1  12.0000
## 175    0 19 193.1663    0   0    0   0 0.00198    0    0   0     1  24.0000
## 176    0 19 217.1663    0   0    1   0 0.00100    0    0   0     1  48.0000
## 177    0 19 265.1663    0   0    1   0 0.00100    0    0   0     1  96.0000
## 178    0 19 337.1663    0   0    1   0 0.00100    0    0   0     1 168.0000
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## 180    0 20 168.5327    0   0    0   0 0.00515    0    0   0     1   0.0830
## 181    0 20 168.6997    0   0    0   0 0.01130    0    0   0     1   0.2500
## 182    0 20 168.9497    0   0    0   0 0.01910    0    0   0     1   0.5000
## 183    0 20 169.4497    0   0    0   0 0.03580    0    0   0     1   1.0000
## 184    0 20 170.4497    0   0    0   0 0.02670    0    0   0     1   2.0000
## 185    0 20 172.4497    0   0    0   0 0.01850    0    0   0     1   4.0000
## 186    0 20 180.4497    0   0    0   0 0.00755    0    0   0     1  12.0000
## 187    0 20 192.4497    0   0    0   0 0.00219    0    0   0     1  24.0000
## 188    0 20 264.4497    0   0    1   0 0.00100    0    0   0     1  96.0000
## 189    0 20 336.4497    0   0    0   0 0.00101    0    0   0     1 168.0000
## 190    0 21 167.6000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 191    0 21 167.7660    0   0    0   0 0.00374    0    0   0     1   0.0830
## 192    0 21 167.9330    0   0    0   0 0.00866    0    0   0     1   0.2500
## 193    0 21 168.1830    0   0    0   0 0.01570    0    0   0     1   0.5000
## 194    0 21 168.6830    0   0    0   0 0.01960    0    0   0     1   1.0000
## 195    0 21 169.6830    0   0    0   0 0.02190    0    0   0     1   2.0000
## 196    0 21 171.6830    0   0    0   0 0.02200    0    0   0     1   4.0000
## 197    0 21 179.6830    0   0    0   0 0.00786    0    0   0     1  12.0000
## 198    0 21 191.6830    0   0    0   0 0.00382    0    0   0     1  24.0000
## 199    0 21 215.6830    0   0    1   0 0.00100    0    0   0     1  48.0000
## 200    0 21 263.6830    0   0    0   0 0.00108    0    0   0     1  96.0000
## 201    0 21 335.6830    0   0    1   0 0.00100    0    0   0     1 168.0000
## 202    0 22 167.4500    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 203    0 22 167.6160    0   0    0   0 0.00241    0    0   0     1   0.0830
## 204    0 22 167.7830    0   0    0   0 0.01060    0    0   0     1   0.2500
## 205    0 22 168.0330    0   0    0   0 0.01630    0    0   0     1   0.5000
## 206    0 22 168.5330    0   0    0   0 0.02530    0    0   0     1   1.0000
## 207    0 22 169.5330    0   0    0   0 0.20500    0    0   0     1   2.0000
## 208    0 22 171.5330    0   0    0   0 0.01860    0    0   0     1   4.0000
## 209    0 22 179.5330    0   0    0   0 0.00534    0    0   0     1  12.0000
## 210    0 22 191.5330    0   0    0   0 0.00213    0    0   0     1  24.0000
## 211    0 22 215.5330    0   0    1   0 0.00100    0    0   0     1  48.0000
## 212    0 22 263.5330    0   0    1   0 0.00100    0    0   0     1  96.0000
## 213    0 22 335.5330    0   0    1   0 0.00100    0    0   0     1 168.0000
## 214    0 23 167.7667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 215    0 23 167.9327    0   0    0   0 0.00905    0    0   0     1   0.0830
## 216    0 23 168.0997    0   0    0   0 0.02640    0    0   0     1   0.2500
## 217    0 23 168.3497    0   0    0   0 0.03400    0    0   0     1   0.5000
## 218    0 23 168.8497    0   0    0   0 0.04700    0    0   0     1   1.0000
## 219    0 23 169.8497    0   0    0   0 0.03710    0    0   0     1   2.0000
## 220    0 23 171.8497    0   0    0   0 0.02450    0    0   0     1   4.0000
## 221    0 23 179.8497    0   0    0   0 0.00779    0    0   0     1  12.0000
## 222    0 23 191.8497    0   0    0   0 0.00116    0    0   0     1  24.0000
## 223    0 23 215.8497    0   0    1   0 0.00100    0    0   0     1  48.0000
## 224    0 23 263.8497    0   0    1   0 0.00100    0    0   0     1  96.0000
## 225    0 23 335.8497    0   0    1   0 0.00100    0    0   0     1 168.0000
## 226    0 24 168.1333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 227    0 24 168.2993    0   0    0   0 0.00433    0    0   0     1   0.0830
## 228    0 24 168.4663    0   0    0   0 0.01200    0    0   0     1   0.2500
## 229    0 24 168.7163    0   0    0   0 0.01940    0    0   0     1   0.5000
## 230    0 24 169.2163    0   0    0   0 0.03030    0    0   0     1   1.0000
## 231    0 24 170.2163    0   0    0   0 0.03300    0    0   0     1   2.0000
## 232    0 24 172.2163    0   0    0   0 0.02270    0    0   0     1   4.0000
## 233    0 24 180.2163    0   0    0   0 0.00835    0    0   0     1  12.0000
## 234    0 24 192.2163    0   0    0   0 0.00266    0    0   0     1  24.0000
## 235    0 24 216.2163    0   0    0   0 0.00241    0    0   0     1  48.0000
## 236    0 24 264.2163    0   0    0   0 0.00127    0    0   0     1  96.0000
## 237    0 24 336.2163    0   0    0   0 0.00124    0    0   0     1 168.0000
## 238    0 25 167.5000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 239    0 25 167.6660    0   0    0   0 0.01190    0    0   0     1   0.0830
## 240    0 25 167.8330    0   0    0   0 0.03410    0    0   0     1   0.2500
## 241    0 25 168.0830    0   0    0   0 0.05540    0    0   0     1   0.5000
## 242    0 25 168.5830    0   0    0   0 0.05080    0    0   0     1   1.0000
## 243    0 25 169.5830    0   0    0   0 0.05230    0    0   0     1   2.0000
## 244    0 25 171.5830    0   0    0   0 0.03200    0    0   0     1   4.0000
## 245    0 25 179.5830    0   0    0   0 0.01060    0    0   0     1  12.0000
## 246    0 25 191.5830    0   0    0   0 0.00196    0    0   0     1  24.0000
## 247    0 25 215.5830    0   0    0   0 0.00168    0    0   0     1  48.0000
## 248    0 25 263.5830    0   0    1   0 0.00100    0    0   0     1  96.0000
## 249    0 25 335.5830    0   0    0   0 0.00117    0    0   0     1 168.0000
## 250    0 26 167.4833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 251    0 26 167.6493    0   0    0   0 0.00936    0    0   0     1   0.0830
## 252    0 26 167.8163    0   0    0   0 0.02200    0    0   0     1   0.2500
## 253    0 26 168.0663    0   0    0   0 0.03310    0    0   0     1   0.5000
## 254    0 26 168.5663    0   0    0   0 0.05420    0    0   0     1   1.0000
## 255    0 26 169.5663    0   0    0   0 0.05030    0    0   0     1   2.0000
## 256    0 26 171.5663    0   0    0   0 0.04100    0    0   0     1   4.0000
## 257    0 26 179.5663    0   0    0   0 0.01170    0    0   0     1  12.0000
## 258    0 26 191.5663    0   0    0   0 0.00311    0    0   0     1  24.0000
## 259    0 26 215.5663    0   0    1   0 0.00100    0    0   0     1  48.0000
## 260    0 26 263.5663    0   0    1   0 0.00100    0    0   0     1  96.0000
## 261    0 26 335.5663    0   0    1   0 0.00100    0    0   0     1 168.0000
## 262    0 27 168.8000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 263    0 27 168.9660    0   0    0   0 0.01390    0    0   0     1   0.0830
## 264    0 27 169.1330    0   0    0   0 0.03260    0    0   0     1   0.2500
## 265    0 27 169.3830    0   0    0   0 0.05050    0    0   0     1   0.5000
## 266    0 27 169.8830    0   0    0   0 0.06240    0    0   0     1   1.0000
## 267    0 27 170.8830    0   0    0   0 0.05440    0    0   0     1   2.0000
## 268    0 27 172.8830    0   0    0   0 0.03180    0    0   0     1   4.0000
## 269    0 27 180.8830    0   0    0   0 0.00749    0    0   0     1  12.0000
## 270    0 27 192.8830    0   0    0   0 0.00232    0    0   0     1  24.0000
## 271    0 27 216.8830    0   0    0   0 0.00309    0    0   0     1  48.0000
## 272    0 27 264.8830    0   0    0   0 0.00261    0    0   0     1  96.0000
## 273    0 27 336.8830    0   0    0   0 0.00165    0    0   0     1 168.0000
## 274    0 28 167.8667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 275    0 28 168.0327    0   0    0   0 0.00609    0    0   0     1   0.0830
## 276    0 28 168.1997    0   0    0   0 0.01570    0    0   0     1   0.2500
## 277    0 28 168.4497    0   0    0   0 0.02970    0    0   0     1   0.5000
## 278    0 28 168.9497    0   0    0   0 0.05030    0    0   0     1   1.0000
## 279    0 28 169.9497    0   0    0   0 0.04650    0    0   0     1   2.0000
## 280    0 28 171.9497    0   0    0   0 0.04090    0    0   0     1   4.0000
## 281    0 28 179.9497    0   0    0   0 0.00898    0    0   0     1  12.0000
## 282    0 28 191.9497    0   0    0   0 0.00265    0    0   0     1  24.0000
## 283    0 28 215.9497    0   0    0   0 0.00169    0    0   0     1  48.0000
## 284    0 28 263.9497    0   0    0   0 0.00170    0    0   0     1  96.0000
## 285    0 28 335.9497    0   0    0   0 0.00145    0    0   0     1 168.0000
## 286    0 29 167.8000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 287    0 29 167.9660    0   0    0   0 0.00971    0    0   0     1   0.0830
## 288    0 29 168.1330    0   0    0   0 0.02690    0    0   0     1   0.2500
## 289    0 29 168.3830    0   0    0   0 0.04840    0    0   0     1   0.5000
## 290    0 29 168.8830    0   0    0   0 0.06530    0    0   0     1   1.0000
## 291    0 29 169.8830    0   0    0   0 0.05790    0    0   0     1   2.0000
## 292    0 29 171.8830    0   0    0   0 0.03360    0    0   0     1   4.0000
## 293    0 29 179.8830    0   0    0   0 0.00991    0    0   0     1  12.0000
## 294    0 29 191.8830    0   0    0   0 0.00188    0    0   0     1  24.0000
## 295    0 29 215.8830    0   0    0   0 0.00296    0    0   0     1  48.0000
## 296    0 29 263.8830    0   0    0   0 0.00149    0    0   0     1  96.0000
## 297    0 29 335.8830    0   0    1   0 0.00100    0    0   0     1 168.0000
## 298    0 30 167.6333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 299    0 30 167.7993    0   0    0   0 0.01290    0    0   0     1   0.0830
## 300    0 30 167.9663    0   0    0   0 0.03290    0    0   0     1   0.2500
## 301    0 30 168.2163    0   0    0   0 0.04310    0    0   0     1   0.5000
## 302    0 30 168.7163    0   0    0   0 0.05360    0    0   0     1   1.0000
## 303    0 30 169.7163    0   0    0   0 0.05700    0    0   0     1   2.0000
## 304    0 30 171.7163    0   0    0   0 0.04370    0    0   0     1   4.0000
## 305    0 30 179.7163    0   0    0   0 0.01170    0    0   0     1  12.0000
## 306    0 30 191.7163    0   0    0   0 0.00297    0    0   0     1  24.0000
## 307    0 30 215.7163    0   0    0   0 0.00114    0    0   0     1  48.0000
## 308    0 30 263.7163    0   0    0   0 0.00131    0    0   0     1  96.0000
## 309    0 30 335.7163    0   0    0   0 0.00121    0    0   0     1 168.0000
## 310    0 31 168.0833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 311    0 31 168.2493    0   0    0   0 0.01480    0    0   0     1   0.0830
## 312    0 31 168.4163    0   0    0   0 0.03720    0    0   0     1   0.2500
## 313    0 31 168.6663    0   0    0   0 0.06000    0    0   0     1   0.5000
## 314    0 31 169.1663    0   0    0   0 0.08750    0    0   0     1   1.0000
## 315    0 31 170.1663    0   0    0   0 0.07030    0    0   0     1   2.0000
## 316    0 31 172.1663    0   0    0   0 0.07920    0    0   0     1   4.0000
## 317    0 31 180.1663    0   0    0   0 0.02850    0    0   0     1  12.0000
## 318    0 31 192.1663    0   0    0   0 0.00963    0    0   0     1  24.0000
## 319    0 31 216.1663    0   0    0   0 0.00283    0    0   0     1  48.0000
## 320    0 31 264.1663    0   0    0   0 0.00248    0    0   0     1  96.0000
## 321    0 31 336.1663    0   0    1   0 0.00100    0    0   0     1 168.0000
## 322    0 32 168.1333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 323    0 32 168.2993    0   0    0   0 0.04720    0    0   0     1   0.0830
## 324    0 32 168.4663    0   0    0   0 0.11400    0    0   0     1   0.2500
## 325    0 32 168.7163    0   0    0   0 0.15200    0    0   0     1   0.5000
## 326    0 32 169.2163    0   0    0   0 0.17300    0    0   0     1   1.0000
## 327    0 32 170.2163    0   0    0   0 0.14500    0    0   0     1   2.0000
## 328    0 32 172.2163    0   0    0   0 0.10100    0    0   0     1   4.0000
## 329    0 32 180.2163    0   0    0   0 0.01950    0    0   0     1  12.0000
## 330    0 32 192.2163    0   0    0   0 0.00940    0    0   0     1  24.0000
## 331    0 32 216.2163    0   0    0   0 0.00528    0    0   0     1  48.0000
## 332    0 32 264.2163    0   0    0   0 0.00482    0    0   0     1  96.0000
## 333    0 32 336.2163    0   0    0   0 0.00229    0    0   0     1 168.0000
## 334    0 33 168.5167    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 335    0 33 168.6827    0   0    0   0 0.02670    0    0   0     1   0.0830
## 336    0 33 168.8497    0   0    0   0 0.06480    0    0   0     1   0.2500
## 337    0 33 169.0997    0   0    0   0 0.11000    0    0   0     1   0.5000
## 338    0 33 169.5997    0   0    0   0 0.12500    0    0   0     1   1.0000
## 339    0 33 170.5997    0   0    0   0 0.14300    0    0   0     1   2.0000
## 340    0 33 172.5997    0   0    0   0 0.06950    0    0   0     1   4.0000
## 341    0 33 180.5997    0   0    0   0 0.01640    0    0   0     1  12.0000
## 342    0 33 192.5997    0   0    0   0 0.00447    0    0   0     1  24.0000
## 343    0 33 216.5997    0   0    0   0 0.00313    0    0   0     1  48.0000
## 344    0 33 264.5997    0   0    0   0 0.00299    0    0   0     1  96.0000
## 345    0 33 336.5997    0   0    0   0 0.00201    0    0   0     1 168.0000
## 346    0 34 167.8667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 347    0 34 168.0327    0   0    0   0 0.01730    0    0   0     1   0.0830
## 348    0 34 168.1997    0   0    0   0 0.04370    0    0   0     1   0.2500
## 349    0 34 168.4497    0   0    0   0 0.07930    0    0   0     1   0.5000
## 350    0 34 168.9497    0   0    0   0 0.08940    0    0   0     1   1.0000
## 351    0 34 169.9497    0   0    0   0 0.09610    0    0   0     1   2.0000
## 352    0 34 171.9497    0   0    0   0 0.07590    0    0   0     1   4.0000
## 353    0 34 179.9497    0   0    0   0 0.01350    0    0   0     1  12.0000
## 354    0 34 191.9497    0   0    0   0 0.00340    0    0   0     1  24.0000
## 355    0 34 215.9497    0   0    0   0 0.00208    0    0   0     1  48.0000
## 356    0 34 263.9497    0   0    0   0 0.00112    0    0   0     1  96.0000
## 357    0 34 335.9497    0   0    1   0 0.00100    0    0   0     1 168.0000
## 358    0 35 168.2833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 359    0 35 168.4493    0   0    0   0 0.04720    0    0   0     1   0.0830
## 360    0 35 168.6163    0   0    0   0 0.10600    0    0   0     1   0.2500
## 361    0 35 168.8663    0   0    0   0 0.13700    0    0   0     1   0.5000
## 362    0 35 169.3663    0   0    0   0 0.18200    0    0   0     1   1.0000
## 363    0 35 170.3663    0   0    0   0 0.16700    0    0   0     1   2.0000
## 364    0 35 172.3663    0   0    0   0 0.09100    0    0   0     1   4.0000
## 365    0 35 180.3663    0   0    0   0 0.01220    0    0   0     1  12.0000
## 366    0 35 192.3663    0   0    0   0 0.00554    0    0   0     1  24.0000
## 367    0 35 216.3663    0   0    0   0 0.00404    0    0   0     1  48.0000
## 368    0 35 264.3663    0   0    0   0 0.00415    0    0   0     1  96.0000
## 369    0 35 336.3663    0   0    0   0 0.00204    0    0   0     1 168.0000
## 370    0 36 168.5833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 371    0 36 168.7493    0   0    0   0 0.03750    0    0   0     1   0.0830
## 372    0 36 168.9163    0   0    0   0 0.08430    0    0   0     1   0.2500
## 373    0 36 169.1663    0   0    0   0 0.13000    0    0   0     1   0.5000
## 374    0 36 169.6663    0   0    0   0 0.22300    0    0   0     1   1.0000
## 375    0 36 170.6663    0   0    0   0 0.19500    0    0   0     1   2.0000
## 376    0 36 172.6663    0   0    0   0 0.14900    0    0   0     1   4.0000
## 377    0 36 180.6663    0   0    0   0 0.02950    0    0   0     1  12.0000
## 378    0 36 192.6663    0   0    0   0 0.00783    0    0   0     1  24.0000
## 379    0 36 216.6663    0   0    0   0 0.00447    0    0   0     1  48.0000
## 380    0 36 264.6663    0   0    0   0 0.00439    0    0   0     1  96.0000
## 381    0 36 336.6663    0   0    0   0 0.00191    0    0   0     1 168.0000
## 382    0 37 167.9000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 383    0 37 168.0660    0   0    0   0 0.03800    0    0   0     1   0.0830
## 384    0 37 168.2330    0   0    0   0 0.11800    0    0   0     1   0.2500
## 385    0 37 168.4830    0   0    0   0 0.15600    0    0   0     1   0.5000
## 386    0 37 168.9830    0   0    0   0 0.26800    0    0   0     1   1.0000
## 387    0 37 169.9830    0   0    0   0 0.22600    0    0   0     1   2.0000
## 388    0 37 171.9830    0   0    0   0 0.18700    0    0   0     1   4.0000
## 389    0 37 179.9830    0   0    0   0 0.07220    0    0   0     1  12.0000
## 390    0 37 191.9830    0   0    0   0 0.01980    0    0   0     1  24.0000
## 391    0 37 215.9830    0   0    0   0 0.00557    0    0   0     1  48.0000
## 392    0 37 263.9830    0   0    0   0 0.00625    0    0   0     1  96.0000
## 393    0 37 335.9830    0   0    0   0 0.00489    0    0   0     1 168.0000
## 394    0 38 167.1833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 395    0 38 167.3493    0   0    0   0 0.05450    0    0   0     1   0.0830
## 396    0 38 167.5163    0   0    0   0 0.17100    0    0   0     1   0.2500
## 397    0 38 167.7663    0   0    0   0 0.25400    0    0   0     1   0.5000
## 398    0 38 168.2663    0   0    0   0 0.25600    0    0   0     1   1.0000
## 399    0 38 169.2663    0   0    0   0 0.25300    0    0   0     1   2.0000
## 400    0 38 171.2663    0   0    0   0 0.20200    0    0   0     1   4.0000
## 401    0 38 179.2663    0   0    0   0 0.09480    0    0   0     1  12.0000
## 402    0 38 191.2663    0   0    0   0 0.02510    0    0   0     1  24.0000
## 403    0 38 215.2663    0   0    0   0 0.00726    0    0   0     1  48.0000
## 404    0 38 263.2663    0   0    0   0 0.00550    0    0   0     1  96.0000
## 405    0 38 335.2663    0   0    0   0 0.00584    0    0   0     1 168.0000
## 406    0 39 167.9000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 407    0 39 168.0660    0   0    0   0 0.07300    0    0   0     1   0.0830
## 408    0 39 168.2330    0   0    0   0 0.19400    0    0   0     1   0.2500
## 409    0 39 168.4830    0   0    0   0 0.25700    0    0   0     1   0.5000
## 410    0 39 168.9830    0   0    0   0 0.41900    0    0   0     1   1.0000
## 411    0 39 169.9830    0   0    0   0 0.43900    0    0   0     1   2.0000
## 412    0 39 171.9830    0   0    0   0 0.32000    0    0   0     1   4.0000
## 413    0 39 179.9830    0   0    0   0 0.05640    0    0   0     1  12.0000
## 414    0 39 191.9830    0   0    0   0 0.01690    0    0   0     1  24.0000
## 415    0 39 215.9830    0   0    0   0 0.01180    0    0   0     1  48.0000
## 416    0 39 263.9830    0   0    0   0 0.00834    0    0   0     1  96.0000
## 417    0 39 335.9830    0   0    0   0 0.00685    0    0   0     1 168.0000
## 418    0 40 168.2000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 419    0 40 168.3660    0   0    0   0 0.08670    0    0   0     1   0.0830
## 420    0 40 168.5330    0   0    0   0 0.20300    0    0   0     1   0.2500
## 421    0 40 168.7830    0   0    0   0 0.29300    0    0   0     1   0.5000
## 422    0 40 169.2830    0   0    0   0 0.33400    0    0   0     1   1.0000
## 423    0 40 170.2830    0   0    0   0 0.29100    0    0   0     1   2.0000
## 424    0 40 172.2830    0   0    0   0 0.24300    0    0   0     1   4.0000
## 425    0 40 180.2830    0   0    0   0 0.05680    0    0   0     1  12.0000
## 426    0 40 192.2830    0   0    0   0 0.01150    0    0   0     1  24.0000
## 427    0 40 216.2830    0   0    0   0 0.00503    0    0   0     1  48.0000
## 428    0 40 264.2830    0   0    0   0 0.00278    0    0   0     1  96.0000
## 429    0 40 336.2830    0   0    0   0 0.00216    0    0   0     1 168.0000
## 430    0 41 168.2333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 431    0 41 168.3993    0   0    0   0 0.06290    0    0   0     1   0.0830
## 432    0 41 168.5663    0   0    0   0 0.14200    0    0   0     1   0.2500
## 433    0 41 168.8163    0   0    0   0 0.21500    0    0   0     1   0.5000
## 434    0 41 169.3163    0   0    0   0 0.31800    0    0   0     1   1.0000
## 435    0 41 170.3163    0   0    0   0 0.25400    0    0   0     1   2.0000
## 436    0 41 172.3163    0   0    0   0 0.16900    0    0   0     1   4.0000
## 437    0 41 180.3163    0   0    0   0 0.02870    0    0   0     1  12.0000
## 438    0 41 192.3163    0   0    0   0 0.00977    0    0   0     1  24.0000
## 439    0 41 216.3163    0   0    0   0 0.00555    0    0   0     1  48.0000
## 440    0 41 264.3163    0   0    0   0 0.00413    0    0   0     1  96.0000
## 441    0 41 336.3163    0   0    0   0 0.00196    0    0   0     1 168.0000
## 442    0 42 168.9000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 443    0 42 169.0660    0   0    0   0 0.08270    0    0   0     1   0.0830
## 444    0 42 169.2330    0   0    0   0 0.20200    0    0   0     1   0.2500
## 445    0 42 169.4830    0   0    0   0 0.28400    0    0   0     1   0.5000
## 446    0 42 169.9830    0   0    0   0 0.31000    0    0   0     1   1.0000
## 447    0 42 170.9830    0   0    0   0 0.25600    0    0   0     1   2.0000
## 448    0 42 172.9830    0   0    0   0 0.18200    0    0   0     1   4.0000
## 449    0 42 180.9830    0   0    0   0 0.02720    0    0   0     1  12.0000
## 450    0 42 192.9830    0   0    0   0 0.01400    0    0   0     1  24.0000
## 451    0 42 216.9830    0   0    0   0 0.01130    0    0   0     1  48.0000
## 452    0 42 264.9830    0   0    0   0 0.00537    0    0   0     1  96.0000
## 453    0 42 336.9830    0   0    0   0 0.00258    0    0   0     1 168.0000
## 454    0 43 168.6833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 455    0 43 168.8493    0   0    0   0 0.16600    0    0   0     1   0.0830
## 456    0 43 169.0163    0   0    0   0 0.37400    0    0   0     1   0.2500
## 457    0 43 169.2663    0   0    0   0 0.50400    0    0   0     1   0.5000
## 458    0 43 169.7663    0   0    0   0 0.86200    0    0   0     1   1.0000
## 459    0 43 170.7663    0   0    0   0 0.78800    0    0   0     1   2.0000
## 460    0 43 172.7663    0   0    0   0 0.49000    0    0   0     1   4.0000
## 461    0 43 180.7663    0   0    0   0 0.14300    0    0   0     1  12.0000
## 462    0 43 192.7663    0   0    0   0 0.02110    0    0   0     1  24.0000
## 463    0 43 216.7663    0   0    0   0 0.00575    0    0   0     1  48.0000
## 464    0 43 264.7663    0   0    0   0 0.00667    0    0   0     1  96.0000
## 465    0 43 336.7663    0   0    0   0 0.00593    0    0   0     1 168.0000
## 466    0 44 168.2833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 467    0 44 168.4493    0   0    0   0 0.08550    0    0   0     1   0.0830
## 468    0 44 168.6163    0   0    0   0 0.18200    0    0   0     1   0.2500
## 469    0 44 168.8663    0   0    0   0 0.32300    0    0   0     1   0.5000
## 470    0 44 169.3663    0   0    0   0 0.43400    0    0   0     1   1.0000
## 471    0 44 170.3663    0   0    0   0 0.41700    0    0   0     1   2.0000
## 472    0 44 172.3663    0   0    0   0 0.23200    0    0   0     1   4.0000
## 473    0 44 180.3663    0   0    0   0 0.03960    0    0   0     1  12.0000
## 474    0 44 192.3663    0   0    0   0 0.00877    0    0   0     1  24.0000
## 475    0 44 216.3663    0   0    0   0 0.00778    0    0   0     1  48.0000
## 476    0 44 264.3663    0   0    0   0 0.00419    0    0   0     1  96.0000
## 477    0 44 336.3663    0   0    0   0 0.00410    0    0   0     1 168.0000
## 478    0 45 168.4667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 479    0 45 168.6327    0   0    0   0 0.17500    0    0   0     1   0.0830
## 480    0 45 168.7997    0   0    0   0 0.37600    0    0   0     1   0.2500
## 481    0 45 169.0497    0   0    0   0 0.59300    0    0   0     1   0.5000
## 482    0 45 169.5497    0   0    0   0 0.63500    0    0   0     1   1.0000
## 483    0 45 170.5497    0   0    0   0 0.51700    0    0   0     1   2.0000
## 484    0 45 172.5497    0   0    0   0 0.42900    0    0   0     1   4.0000
## 485    0 45 180.5497    0   0    0   0 0.09240    0    0   0     1  12.0000
## 486    0 45 192.5497    0   0    0   0 0.01930    0    0   0     1  24.0000
## 487    0 45 216.5497    0   0    0   0 0.01220    0    0   0     1  48.0000
## 488    0 45 264.5497    0   0    0   0 0.00661    0    0   0     1  96.0000
## 489    0 45 336.5497    0   0    0   0 0.00625    0    0   0     1 168.0000
## 490    0 46 167.9000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 491    0 46 168.0660    0   0    0   0 0.08050    0    0   0     1   0.0830
## 492    0 46 168.2330    0   0    0   0 0.19300    0    0   0     1   0.2500
## 493    0 46 168.4830    0   0    0   0 0.32400    0    0   0     1   0.5000
## 494    0 46 168.9830    0   0    0   0 0.54500    0    0   0     1   1.0000
## 495    0 46 169.9830    0   0    0   0 0.48700    0    0   0     1   2.0000
## 496    0 46 171.9830    0   0    0   0 0.32100    0    0   0     1   4.0000
## 497    0 46 179.9830    0   0    0   0 0.05940    0    0   0     1  12.0000
## 498    0 46 191.9830    0   0    0   0 0.01070    0    0   0     1  24.0000
## 499    0 46 215.9830    0   0    0   0 0.00319    0    0   0     1  48.0000
## 500    0 46 263.9830    0   0    0   0 0.00324    0    0   0     1  96.0000
## 501    0 46 335.9830    0   0    0   0 0.00277    0    0   0     1 168.0000
## 502    0 47 168.1333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 503    0 47 168.2993    0   0    0   0 0.11000    0    0   0     1   0.0830
## 504    0 47 168.4663    0   0    0   0 0.26500    0    0   0     1   0.2500
## 505    0 47 168.7163    0   0    0   0 0.42700    0    0   0     1   0.5000
## 506    0 47 169.2163    0   0    0   0 0.55200    0    0   0     1   1.0000
## 507    0 47 170.2163    0   0    0   0 0.43200    0    0   0     1   2.0000
## 508    0 47 172.2163    0   0    0   0 0.35400    0    0   0     1   4.0000
## 509    0 47 180.2163    0   0    0   0 0.09750    0    0   0     1  12.0000
## 510    0 47 192.2163    0   0    0   0 0.02520    0    0   0     1  24.0000
## 511    0 47 216.2163    0   0    0   0 0.01240    0    0   0     1  48.0000
## 512    0 47 264.2163    0   0    0   0 0.01140    0    0   0     1  96.0000
## 513    0 47 336.2163    0   0    0   0 0.00855    0    0   0     1 168.0000
## 514    0 48 167.6000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 515    0 48 167.7660    0   0    0   0 0.18300    0    0   0     1   0.0830
## 516    0 48 167.9330    0   0    0   0 0.50000    0    0   0     1   0.2500
## 517    0 48 168.1830    0   0    0   0 0.70600    0    0   0     1   0.5000
## 518    0 48 168.6830    0   0    0   0 0.98400    0    0   0     1   1.0000
## 519    0 48 169.6830    0   0    0   0 0.83000    0    0   0     1   2.0000
## 520    0 48 171.6830    0   0    0   0 0.59300    0    0   0     1   4.0000
## 521    0 48 179.6830    0   0    0   0 0.19600    0    0   0     1  12.0000
## 522    0 48 191.6830    0   0    0   0 0.05670    0    0   0     1  24.0000
## 523    0 48 215.6830    0   0    0   0 0.01880    0    0   0     1  48.0000
## 524    0 48 263.6830    0   0    0   0 0.01930    0    0   0     1  96.0000
## 525    0 48 335.6830    0   0    0   0 0.01510    0    0   0     1 168.0000
##     DOSE WT0 AGE0 HT0 SEX BLOQ           TRTNAMElabel
## 1      0  80   28 180   1  yes   1mg oral single dose
## 2      1  80   28 180   1  yes   1mg oral single dose
## 3      1  80   28 180   1   no   1mg oral single dose
## 4      1  80   28 180   1   no   1mg oral single dose
## 5      1  80   28 180   1   no   1mg oral single dose
## 6      1  80   28 180   1   no   1mg oral single dose
## 7      1  80   28 180   1   no   1mg oral single dose
## 8      1  80   28 180   1  yes   1mg oral single dose
## 9      1  80   28 180   1  yes   1mg oral single dose
## 10     1  80   28 180   1  yes   1mg oral single dose
## 11     1  80   28 180   1  yes   1mg oral single dose
## 12     1  80   28 180   1  yes   1mg oral single dose
## 13     0  68   25 166   1  yes   1mg oral single dose
## 14     1  68   25 166   1   no   1mg oral single dose
## 15     1  68   25 166   1   no   1mg oral single dose
## 16     1  68   25 166   1   no   1mg oral single dose
## 17     1  68   25 166   1   no   1mg oral single dose
## 18     1  68   25 166   1   no   1mg oral single dose
## 19     1  68   25 166   1   no   1mg oral single dose
## 20     1  68   25 166   1  yes   1mg oral single dose
## 21     1  68   25 166   1  yes   1mg oral single dose
## 22     1  68   25 166   1  yes   1mg oral single dose
## 23     1  68   25 166   1  yes   1mg oral single dose
## 24     1  68   25 166   1  yes   1mg oral single dose
## 25     0  86   29 183   1  yes   1mg oral single dose
## 26     1  86   29 183   1  yes   1mg oral single dose
## 27     1  86   29 183   1   no   1mg oral single dose
## 28     1  86   29 183   1   no   1mg oral single dose
## 29     1  86   29 183   1   no   1mg oral single dose
## 30     1  86   29 183   1   no   1mg oral single dose
## 31     1  86   29 183   1   no   1mg oral single dose
## 32     1  86   29 183   1  yes   1mg oral single dose
## 33     1  86   29 183   1  yes   1mg oral single dose
## 34     1  86   29 183   1  yes   1mg oral single dose
## 35     1  86   29 183   1  yes   1mg oral single dose
## 36     0  70   35 181   1  yes   1mg oral single dose
## 37     1  70   35 181   1  yes   1mg oral single dose
## 38     1  70   35 181   1   no   1mg oral single dose
## 39     1  70   35 181   1   no   1mg oral single dose
## 40     1  70   35 181   1   no   1mg oral single dose
## 41     1  70   35 181   1   no   1mg oral single dose
## 42     1  70   35 181   1   no   1mg oral single dose
## 43     1  70   35 181   1  yes   1mg oral single dose
## 44     1  70   35 181   1  yes   1mg oral single dose
## 45     1  70   35 181   1  yes   1mg oral single dose
## 46     1  70   35 181   1  yes   1mg oral single dose
## 47     1  70   35 181   1  yes   1mg oral single dose
## 48     0  88   28 181   1  yes   2mg oral single dose
## 49     2  88   28 181   1   no   2mg oral single dose
## 50     2  88   28 181   1   no   2mg oral single dose
## 51     2  88   28 181   1   no   2mg oral single dose
## 52     2  88   28 181   1   no   2mg oral single dose
## 53     2  88   28 181   1   no   2mg oral single dose
## 54     2  88   28 181   1   no   2mg oral single dose
## 55     2  88   28 181   1  yes   2mg oral single dose
## 56     2  88   28 181   1  yes   2mg oral single dose
## 57     2  88   28 181   1  yes   2mg oral single dose
## 58     2  88   28 181   1  yes   2mg oral single dose
## 59     0  79   29 175   1  yes   2mg oral single dose
## 60     2  79   29 175   1   no   2mg oral single dose
## 61     2  79   29 175   1   no   2mg oral single dose
## 62     2  79   29 175   1   no   2mg oral single dose
## 63     2  79   29 175   1   no   2mg oral single dose
## 64     2  79   29 175   1   no   2mg oral single dose
## 65     2  79   29 175   1   no   2mg oral single dose
## 66     2  79   29 175   1   no   2mg oral single dose
## 67     2  79   29 175   1  yes   2mg oral single dose
## 68     2  79   29 175   1  yes   2mg oral single dose
## 69     2  79   29 175   1  yes   2mg oral single dose
## 70     2  79   29 175   1  yes   2mg oral single dose
## 71     0  87   32 174   1  yes   2mg oral single dose
## 72     2  87   32 174   1   no   2mg oral single dose
## 73     2  87   32 174   1   no   2mg oral single dose
## 74     2  87   32 174   1   no   2mg oral single dose
## 75     2  87   32 174   1   no   2mg oral single dose
## 76     2  87   32 174   1   no   2mg oral single dose
## 77     2  87   32 174   1   no   2mg oral single dose
## 78     2  87   32 174   1  yes   2mg oral single dose
## 79     2  87   32 174   1  yes   2mg oral single dose
## 80     2  87   32 174   1  yes   2mg oral single dose
## 81     2  87   32 174   1  yes   2mg oral single dose
## 82     2  87   32 174   1  yes   2mg oral single dose
## 83     0  79   30 177   1  yes   2mg oral single dose
## 84     2  79   30 177   1   no   2mg oral single dose
## 85     2  79   30 177   1   no   2mg oral single dose
## 86     2  79   30 177   1   no   2mg oral single dose
## 87     2  79   30 177   1   no   2mg oral single dose
## 88     2  79   30 177   1   no   2mg oral single dose
## 89     2  79   30 177   1   no   2mg oral single dose
## 90     2  79   30 177   1  yes   2mg oral single dose
## 91     2  79   30 177   1  yes   2mg oral single dose
## 92     2  79   30 177   1  yes   2mg oral single dose
## 93     2  79   30 177   1  yes   2mg oral single dose
## 94     2  79   30 177   1  yes   2mg oral single dose
## 95     0  68   28 178   1  yes   2mg oral single dose
## 96     2  68   28 178   1  yes   2mg oral single dose
## 97     2  68   28 178   1   no   2mg oral single dose
## 98     2  68   28 178   1   no   2mg oral single dose
## 99     2  68   28 178   1   no   2mg oral single dose
## 100    2  68   28 178   1   no   2mg oral single dose
## 101    2  68   28 178   1   no   2mg oral single dose
## 102    2  68   28 178   1  yes   2mg oral single dose
## 103    2  68   28 178   1  yes   2mg oral single dose
## 104    2  68   28 178   1  yes   2mg oral single dose
## 105    2  68   28 178   1  yes   2mg oral single dose
## 106    2  68   28 178   1  yes   2mg oral single dose
## 107    0  66   36 178   1  yes   5mg oral single dose
## 108    5  66   36 178   1   no   5mg oral single dose
## 109    5  66   36 178   1   no   5mg oral single dose
## 110    5  66   36 178   1   no   5mg oral single dose
## 111    5  66   36 178   1   no   5mg oral single dose
## 112    5  66   36 178   1   no   5mg oral single dose
## 113    5  66   36 178   1   no   5mg oral single dose
## 114    5  66   36 178   1   no   5mg oral single dose
## 115    5  66   36 178   1  yes   5mg oral single dose
## 116    5  66   36 178   1  yes   5mg oral single dose
## 117    5  66   36 178   1  yes   5mg oral single dose
## 118    5  66   36 178   1  yes   5mg oral single dose
## 119    0  71   34 176   1  yes   5mg oral single dose
## 120    5  71   34 176   1   no   5mg oral single dose
## 121    5  71   34 176   1   no   5mg oral single dose
## 122    5  71   34 176   1   no   5mg oral single dose
## 123    5  71   34 176   1   no   5mg oral single dose
## 124    5  71   34 176   1   no   5mg oral single dose
## 125    5  71   34 176   1  yes   5mg oral single dose
## 126    5  71   34 176   1   no   5mg oral single dose
## 127    5  71   34 176   1  yes   5mg oral single dose
## 128    5  71   34 176   1  yes   5mg oral single dose
## 129    5  71   34 176   1  yes   5mg oral single dose
## 130    5  71   34 176   1  yes   5mg oral single dose
## 131    0  65   29 171   1  yes   5mg oral single dose
## 132    5  65   29 171   1   no   5mg oral single dose
## 133    5  65   29 171   1   no   5mg oral single dose
## 134    5  65   29 171   1   no   5mg oral single dose
## 135    5  65   29 171   1   no   5mg oral single dose
## 136    5  65   29 171   1   no   5mg oral single dose
## 137    5  65   29 171   1   no   5mg oral single dose
## 138    5  65   29 171   1   no   5mg oral single dose
## 139    5  65   29 171   1  yes   5mg oral single dose
## 140    5  65   29 171   1  yes   5mg oral single dose
## 141    5  65   29 171   1  yes   5mg oral single dose
## 142    5  65   29 171   1  yes   5mg oral single dose
## 143    0  74   24 174   1  yes   5mg oral single dose
## 144    5  74   24 174   1   no   5mg oral single dose
## 145    5  74   24 174   1   no   5mg oral single dose
## 146    5  74   24 174   1   no   5mg oral single dose
## 147    5  74   24 174   1   no   5mg oral single dose
## 148    5  74   24 174   1   no   5mg oral single dose
## 149    5  74   24 174   1   no   5mg oral single dose
## 150    5  74   24 174   1   no   5mg oral single dose
## 151    5  74   24 174   1  yes   5mg oral single dose
## 152    5  74   24 174   1  yes   5mg oral single dose
## 153    5  74   24 174   1  yes   5mg oral single dose
## 154    5  74   24 174   1   no   5mg oral single dose
## 155    0  90   25 176   1  yes   5mg oral single dose
## 156    5  90   25 176   1   no   5mg oral single dose
## 157    5  90   25 176   1   no   5mg oral single dose
## 158    5  90   25 176   1   no   5mg oral single dose
## 159    5  90   25 176   1   no   5mg oral single dose
## 160    5  90   25 176   1   no   5mg oral single dose
## 161    5  90   25 176   1   no   5mg oral single dose
## 162    5  90   25 176   1   no   5mg oral single dose
## 163    5  90   25 176   1  yes   5mg oral single dose
## 164    5  90   25 176   1  yes   5mg oral single dose
## 165    5  90   25 176   1  yes   5mg oral single dose
## 166    5  90   25 176   1  yes   5mg oral single dose
## 167    0  83   27 178   1  yes  10mg oral single dose
## 168   10  83   27 178   1   no  10mg oral single dose
## 169   10  83   27 178   1   no  10mg oral single dose
## 170   10  83   27 178   1   no  10mg oral single dose
## 171   10  83   27 178   1   no  10mg oral single dose
## 172   10  83   27 178   1   no  10mg oral single dose
## 173   10  83   27 178   1   no  10mg oral single dose
## 174   10  83   27 178   1   no  10mg oral single dose
## 175   10  83   27 178   1   no  10mg oral single dose
## 176   10  83   27 178   1  yes  10mg oral single dose
## 177   10  83   27 178   1  yes  10mg oral single dose
## 178   10  83   27 178   1  yes  10mg oral single dose
## 179    0  77   29 175   1  yes  10mg oral single dose
## 180   10  77   29 175   1   no  10mg oral single dose
## 181   10  77   29 175   1   no  10mg oral single dose
## 182   10  77   29 175   1   no  10mg oral single dose
## 183   10  77   29 175   1   no  10mg oral single dose
## 184   10  77   29 175   1   no  10mg oral single dose
## 185   10  77   29 175   1   no  10mg oral single dose
## 186   10  77   29 175   1   no  10mg oral single dose
## 187   10  77   29 175   1   no  10mg oral single dose
## 188   10  77   29 175   1  yes  10mg oral single dose
## 189   10  77   29 175   1   no  10mg oral single dose
## 190    0  78   34 181   1  yes  10mg oral single dose
## 191   10  78   34 181   1   no  10mg oral single dose
## 192   10  78   34 181   1   no  10mg oral single dose
## 193   10  78   34 181   1   no  10mg oral single dose
## 194   10  78   34 181   1   no  10mg oral single dose
## 195   10  78   34 181   1   no  10mg oral single dose
## 196   10  78   34 181   1   no  10mg oral single dose
## 197   10  78   34 181   1   no  10mg oral single dose
## 198   10  78   34 181   1   no  10mg oral single dose
## 199   10  78   34 181   1  yes  10mg oral single dose
## 200   10  78   34 181   1   no  10mg oral single dose
## 201   10  78   34 181   1  yes  10mg oral single dose
## 202    0  88   26 183   1  yes  10mg oral single dose
## 203   10  88   26 183   1   no  10mg oral single dose
## 204   10  88   26 183   1   no  10mg oral single dose
## 205   10  88   26 183   1   no  10mg oral single dose
## 206   10  88   26 183   1   no  10mg oral single dose
## 207   10  88   26 183   1   no  10mg oral single dose
## 208   10  88   26 183   1   no  10mg oral single dose
## 209   10  88   26 183   1   no  10mg oral single dose
## 210   10  88   26 183   1   no  10mg oral single dose
## 211   10  88   26 183   1  yes  10mg oral single dose
## 212   10  88   26 183   1  yes  10mg oral single dose
## 213   10  88   26 183   1  yes  10mg oral single dose
## 214    0  85   24 176   1  yes  10mg oral single dose
## 215   10  85   24 176   1   no  10mg oral single dose
## 216   10  85   24 176   1   no  10mg oral single dose
## 217   10  85   24 176   1   no  10mg oral single dose
## 218   10  85   24 176   1   no  10mg oral single dose
## 219   10  85   24 176   1   no  10mg oral single dose
## 220   10  85   24 176   1   no  10mg oral single dose
## 221   10  85   24 176   1   no  10mg oral single dose
## 222   10  85   24 176   1   no  10mg oral single dose
## 223   10  85   24 176   1  yes  10mg oral single dose
## 224   10  85   24 176   1  yes  10mg oral single dose
## 225   10  85   24 176   1  yes  10mg oral single dose
## 226    0  75   18 183   1  yes  10mg oral single dose
## 227   10  75   18 183   1   no  10mg oral single dose
## 228   10  75   18 183   1   no  10mg oral single dose
## 229   10  75   18 183   1   no  10mg oral single dose
## 230   10  75   18 183   1   no  10mg oral single dose
## 231   10  75   18 183   1   no  10mg oral single dose
## 232   10  75   18 183   1   no  10mg oral single dose
## 233   10  75   18 183   1   no  10mg oral single dose
## 234   10  75   18 183   1   no  10mg oral single dose
## 235   10  75   18 183   1   no  10mg oral single dose
## 236   10  75   18 183   1   no  10mg oral single dose
## 237   10  75   18 183   1   no  10mg oral single dose
## 238    0  78   32 186   1  yes  20mg oral single dose
## 239   20  78   32 186   1   no  20mg oral single dose
## 240   20  78   32 186   1   no  20mg oral single dose
## 241   20  78   32 186   1   no  20mg oral single dose
## 242   20  78   32 186   1   no  20mg oral single dose
## 243   20  78   32 186   1   no  20mg oral single dose
## 244   20  78   32 186   1   no  20mg oral single dose
## 245   20  78   32 186   1   no  20mg oral single dose
## 246   20  78   32 186   1   no  20mg oral single dose
## 247   20  78   32 186   1   no  20mg oral single dose
## 248   20  78   32 186   1  yes  20mg oral single dose
## 249   20  78   32 186   1   no  20mg oral single dose
## 250    0  87   23 179   1  yes  20mg oral single dose
## 251   20  87   23 179   1   no  20mg oral single dose
## 252   20  87   23 179   1   no  20mg oral single dose
## 253   20  87   23 179   1   no  20mg oral single dose
## 254   20  87   23 179   1   no  20mg oral single dose
## 255   20  87   23 179   1   no  20mg oral single dose
## 256   20  87   23 179   1   no  20mg oral single dose
## 257   20  87   23 179   1   no  20mg oral single dose
## 258   20  87   23 179   1   no  20mg oral single dose
## 259   20  87   23 179   1  yes  20mg oral single dose
## 260   20  87   23 179   1  yes  20mg oral single dose
## 261   20  87   23 179   1  yes  20mg oral single dose
## 262    0  68   28 184   1  yes  20mg oral single dose
## 263   20  68   28 184   1   no  20mg oral single dose
## 264   20  68   28 184   1   no  20mg oral single dose
## 265   20  68   28 184   1   no  20mg oral single dose
## 266   20  68   28 184   1   no  20mg oral single dose
## 267   20  68   28 184   1   no  20mg oral single dose
## 268   20  68   28 184   1   no  20mg oral single dose
## 269   20  68   28 184   1   no  20mg oral single dose
## 270   20  68   28 184   1   no  20mg oral single dose
## 271   20  68   28 184   1   no  20mg oral single dose
## 272   20  68   28 184   1   no  20mg oral single dose
## 273   20  68   28 184   1   no  20mg oral single dose
## 274    0  77   32 168   1  yes  20mg oral single dose
## 275   20  77   32 168   1   no  20mg oral single dose
## 276   20  77   32 168   1   no  20mg oral single dose
## 277   20  77   32 168   1   no  20mg oral single dose
## 278   20  77   32 168   1   no  20mg oral single dose
## 279   20  77   32 168   1   no  20mg oral single dose
## 280   20  77   32 168   1   no  20mg oral single dose
## 281   20  77   32 168   1   no  20mg oral single dose
## 282   20  77   32 168   1   no  20mg oral single dose
## 283   20  77   32 168   1   no  20mg oral single dose
## 284   20  77   32 168   1   no  20mg oral single dose
## 285   20  77   32 168   1   no  20mg oral single dose
## 286    0  74   31 181   1  yes  20mg oral single dose
## 287   20  74   31 181   1   no  20mg oral single dose
## 288   20  74   31 181   1   no  20mg oral single dose
## 289   20  74   31 181   1   no  20mg oral single dose
## 290   20  74   31 181   1   no  20mg oral single dose
## 291   20  74   31 181   1   no  20mg oral single dose
## 292   20  74   31 181   1   no  20mg oral single dose
## 293   20  74   31 181   1   no  20mg oral single dose
## 294   20  74   31 181   1   no  20mg oral single dose
## 295   20  74   31 181   1   no  20mg oral single dose
## 296   20  74   31 181   1   no  20mg oral single dose
## 297   20  74   31 181   1  yes  20mg oral single dose
## 298    0  78   27 181   1  yes  20mg oral single dose
## 299   20  78   27 181   1   no  20mg oral single dose
## 300   20  78   27 181   1   no  20mg oral single dose
## 301   20  78   27 181   1   no  20mg oral single dose
## 302   20  78   27 181   1   no  20mg oral single dose
## 303   20  78   27 181   1   no  20mg oral single dose
## 304   20  78   27 181   1   no  20mg oral single dose
## 305   20  78   27 181   1   no  20mg oral single dose
## 306   20  78   27 181   1   no  20mg oral single dose
## 307   20  78   27 181   1   no  20mg oral single dose
## 308   20  78   27 181   1   no  20mg oral single dose
## 309   20  78   27 181   1   no  20mg oral single dose
## 310    0  74   23 176   1  yes  50mg oral single dose
## 311   50  74   23 176   1   no  50mg oral single dose
## 312   50  74   23 176   1   no  50mg oral single dose
## 313   50  74   23 176   1   no  50mg oral single dose
## 314   50  74   23 176   1   no  50mg oral single dose
## 315   50  74   23 176   1   no  50mg oral single dose
## 316   50  74   23 176   1   no  50mg oral single dose
## 317   50  74   23 176   1   no  50mg oral single dose
## 318   50  74   23 176   1   no  50mg oral single dose
## 319   50  74   23 176   1   no  50mg oral single dose
## 320   50  74   23 176   1   no  50mg oral single dose
## 321   50  74   23 176   1  yes  50mg oral single dose
## 322    0  85   29 180   1  yes  50mg oral single dose
## 323   50  85   29 180   1   no  50mg oral single dose
## 324   50  85   29 180   1   no  50mg oral single dose
## 325   50  85   29 180   1   no  50mg oral single dose
## 326   50  85   29 180   1   no  50mg oral single dose
## 327   50  85   29 180   1   no  50mg oral single dose
## 328   50  85   29 180   1   no  50mg oral single dose
## 329   50  85   29 180   1   no  50mg oral single dose
## 330   50  85   29 180   1   no  50mg oral single dose
## 331   50  85   29 180   1   no  50mg oral single dose
## 332   50  85   29 180   1   no  50mg oral single dose
## 333   50  85   29 180   1   no  50mg oral single dose
## 334    0  76   35 174   1  yes  50mg oral single dose
## 335   50  76   35 174   1   no  50mg oral single dose
## 336   50  76   35 174   1   no  50mg oral single dose
## 337   50  76   35 174   1   no  50mg oral single dose
## 338   50  76   35 174   1   no  50mg oral single dose
## 339   50  76   35 174   1   no  50mg oral single dose
## 340   50  76   35 174   1   no  50mg oral single dose
## 341   50  76   35 174   1   no  50mg oral single dose
## 342   50  76   35 174   1   no  50mg oral single dose
## 343   50  76   35 174   1   no  50mg oral single dose
## 344   50  76   35 174   1   no  50mg oral single dose
## 345   50  76   35 174   1   no  50mg oral single dose
## 346    0  84   27 181   1  yes  50mg oral single dose
## 347   50  84   27 181   1   no  50mg oral single dose
## 348   50  84   27 181   1   no  50mg oral single dose
## 349   50  84   27 181   1   no  50mg oral single dose
## 350   50  84   27 181   1   no  50mg oral single dose
## 351   50  84   27 181   1   no  50mg oral single dose
## 352   50  84   27 181   1   no  50mg oral single dose
## 353   50  84   27 181   1   no  50mg oral single dose
## 354   50  84   27 181   1   no  50mg oral single dose
## 355   50  84   27 181   1   no  50mg oral single dose
## 356   50  84   27 181   1   no  50mg oral single dose
## 357   50  84   27 181   1  yes  50mg oral single dose
## 358    0  94   34 181   1  yes  50mg oral single dose
## 359   50  94   34 181   1   no  50mg oral single dose
## 360   50  94   34 181   1   no  50mg oral single dose
## 361   50  94   34 181   1   no  50mg oral single dose
## 362   50  94   34 181   1   no  50mg oral single dose
## 363   50  94   34 181   1   no  50mg oral single dose
## 364   50  94   34 181   1   no  50mg oral single dose
## 365   50  94   34 181   1   no  50mg oral single dose
## 366   50  94   34 181   1   no  50mg oral single dose
## 367   50  94   34 181   1   no  50mg oral single dose
## 368   50  94   34 181   1   no  50mg oral single dose
## 369   50  94   34 181   1   no  50mg oral single dose
## 370    0  75   34 182   1  yes  50mg oral single dose
## 371   50  75   34 182   1   no  50mg oral single dose
## 372   50  75   34 182   1   no  50mg oral single dose
## 373   50  75   34 182   1   no  50mg oral single dose
## 374   50  75   34 182   1   no  50mg oral single dose
## 375   50  75   34 182   1   no  50mg oral single dose
## 376   50  75   34 182   1   no  50mg oral single dose
## 377   50  75   34 182   1   no  50mg oral single dose
## 378   50  75   34 182   1   no  50mg oral single dose
## 379   50  75   34 182   1   no  50mg oral single dose
## 380   50  75   34 182   1   no  50mg oral single dose
## 381   50  75   34 182   1   no  50mg oral single dose
## 382    0  78   22 178   1  yes 100mg oral single dose
## 383  100  78   22 178   1   no 100mg oral single dose
## 384  100  78   22 178   1   no 100mg oral single dose
## 385  100  78   22 178   1   no 100mg oral single dose
## 386  100  78   22 178   1   no 100mg oral single dose
## 387  100  78   22 178   1   no 100mg oral single dose
## 388  100  78   22 178   1   no 100mg oral single dose
## 389  100  78   22 178   1   no 100mg oral single dose
## 390  100  78   22 178   1   no 100mg oral single dose
## 391  100  78   22 178   1   no 100mg oral single dose
## 392  100  78   22 178   1   no 100mg oral single dose
## 393  100  78   22 178   1   no 100mg oral single dose
## 394    0  80   21 184   1  yes 100mg oral single dose
## 395  100  80   21 184   1   no 100mg oral single dose
## 396  100  80   21 184   1   no 100mg oral single dose
## 397  100  80   21 184   1   no 100mg oral single dose
## 398  100  80   21 184   1   no 100mg oral single dose
## 399  100  80   21 184   1   no 100mg oral single dose
## 400  100  80   21 184   1   no 100mg oral single dose
## 401  100  80   21 184   1   no 100mg oral single dose
## 402  100  80   21 184   1   no 100mg oral single dose
## 403  100  80   21 184   1   no 100mg oral single dose
## 404  100  80   21 184   1   no 100mg oral single dose
## 405  100  80   21 184   1   no 100mg oral single dose
## 406    0  85   32 179   1  yes 100mg oral single dose
## 407  100  85   32 179   1   no 100mg oral single dose
## 408  100  85   32 179   1   no 100mg oral single dose
## 409  100  85   32 179   1   no 100mg oral single dose
## 410  100  85   32 179   1   no 100mg oral single dose
## 411  100  85   32 179   1   no 100mg oral single dose
## 412  100  85   32 179   1   no 100mg oral single dose
## 413  100  85   32 179   1   no 100mg oral single dose
## 414  100  85   32 179   1   no 100mg oral single dose
## 415  100  85   32 179   1   no 100mg oral single dose
## 416  100  85   32 179   1   no 100mg oral single dose
## 417  100  85   32 179   1   no 100mg oral single dose
## 418    0  92   33 179   1  yes 100mg oral single dose
## 419  100  92   33 179   1   no 100mg oral single dose
## 420  100  92   33 179   1   no 100mg oral single dose
## 421  100  92   33 179   1   no 100mg oral single dose
## 422  100  92   33 179   1   no 100mg oral single dose
## 423  100  92   33 179   1   no 100mg oral single dose
## 424  100  92   33 179   1   no 100mg oral single dose
## 425  100  92   33 179   1   no 100mg oral single dose
## 426  100  92   33 179   1   no 100mg oral single dose
## 427  100  92   33 179   1   no 100mg oral single dose
## 428  100  92   33 179   1   no 100mg oral single dose
## 429  100  92   33 179   1   no 100mg oral single dose
## 430    0  88   34 178   1  yes 100mg oral single dose
## 431  100  88   34 178   1   no 100mg oral single dose
## 432  100  88   34 178   1   no 100mg oral single dose
## 433  100  88   34 178   1   no 100mg oral single dose
## 434  100  88   34 178   1   no 100mg oral single dose
## 435  100  88   34 178   1   no 100mg oral single dose
## 436  100  88   34 178   1   no 100mg oral single dose
## 437  100  88   34 178   1   no 100mg oral single dose
## 438  100  88   34 178   1   no 100mg oral single dose
## 439  100  88   34 178   1   no 100mg oral single dose
## 440  100  88   34 178   1   no 100mg oral single dose
## 441  100  88   34 178   1   no 100mg oral single dose
## 442    0  90   31 188   1  yes 100mg oral single dose
## 443  100  90   31 188   1   no 100mg oral single dose
## 444  100  90   31 188   1   no 100mg oral single dose
## 445  100  90   31 188   1   no 100mg oral single dose
## 446  100  90   31 188   1   no 100mg oral single dose
## 447  100  90   31 188   1   no 100mg oral single dose
## 448  100  90   31 188   1   no 100mg oral single dose
## 449  100  90   31 188   1   no 100mg oral single dose
## 450  100  90   31 188   1   no 100mg oral single dose
## 451  100  90   31 188   1   no 100mg oral single dose
## 452  100  90   31 188   1   no 100mg oral single dose
## 453  100  90   31 188   1   no 100mg oral single dose
## 454    0  73   31 176   1  yes 200mg oral single dose
## 455  200  73   31 176   1   no 200mg oral single dose
## 456  200  73   31 176   1   no 200mg oral single dose
## 457  200  73   31 176   1   no 200mg oral single dose
## 458  200  73   31 176   1   no 200mg oral single dose
## 459  200  73   31 176   1   no 200mg oral single dose
## 460  200  73   31 176   1   no 200mg oral single dose
## 461  200  73   31 176   1   no 200mg oral single dose
## 462  200  73   31 176   1   no 200mg oral single dose
## 463  200  73   31 176   1   no 200mg oral single dose
## 464  200  73   31 176   1   no 200mg oral single dose
## 465  200  73   31 176   1   no 200mg oral single dose
## 466    0  78   28 183   1  yes 200mg oral single dose
## 467  200  78   28 183   1   no 200mg oral single dose
## 468  200  78   28 183   1   no 200mg oral single dose
## 469  200  78   28 183   1   no 200mg oral single dose
## 470  200  78   28 183   1   no 200mg oral single dose
## 471  200  78   28 183   1   no 200mg oral single dose
## 472  200  78   28 183   1   no 200mg oral single dose
## 473  200  78   28 183   1   no 200mg oral single dose
## 474  200  78   28 183   1   no 200mg oral single dose
## 475  200  78   28 183   1   no 200mg oral single dose
## 476  200  78   28 183   1   no 200mg oral single dose
## 477  200  78   28 183   1   no 200mg oral single dose
## 478    0  67   31 172   1  yes 200mg oral single dose
## 479  200  67   31 172   1   no 200mg oral single dose
## 480  200  67   31 172   1   no 200mg oral single dose
## 481  200  67   31 172   1   no 200mg oral single dose
## 482  200  67   31 172   1   no 200mg oral single dose
## 483  200  67   31 172   1   no 200mg oral single dose
## 484  200  67   31 172   1   no 200mg oral single dose
## 485  200  67   31 172   1   no 200mg oral single dose
## 486  200  67   31 172   1   no 200mg oral single dose
## 487  200  67   31 172   1   no 200mg oral single dose
## 488  200  67   31 172   1   no 200mg oral single dose
## 489  200  67   31 172   1   no 200mg oral single dose
## 490    0  77   32 178   1  yes 200mg oral single dose
## 491  200  77   32 178   1   no 200mg oral single dose
## 492  200  77   32 178   1   no 200mg oral single dose
## 493  200  77   32 178   1   no 200mg oral single dose
## 494  200  77   32 178   1   no 200mg oral single dose
## 495  200  77   32 178   1   no 200mg oral single dose
## 496  200  77   32 178   1   no 200mg oral single dose
## 497  200  77   32 178   1   no 200mg oral single dose
## 498  200  77   32 178   1   no 200mg oral single dose
## 499  200  77   32 178   1   no 200mg oral single dose
## 500  200  77   32 178   1   no 200mg oral single dose
## 501  200  77   32 178   1   no 200mg oral single dose
## 502    0  91   38 174   1  yes 200mg oral single dose
## 503  200  91   38 174   1   no 200mg oral single dose
## 504  200  91   38 174   1   no 200mg oral single dose
## 505  200  91   38 174   1   no 200mg oral single dose
## 506  200  91   38 174   1   no 200mg oral single dose
## 507  200  91   38 174   1   no 200mg oral single dose
## 508  200  91   38 174   1   no 200mg oral single dose
## 509  200  91   38 174   1   no 200mg oral single dose
## 510  200  91   38 174   1   no 200mg oral single dose
## 511  200  91   38 174   1   no 200mg oral single dose
## 512  200  91   38 174   1   no 200mg oral single dose
## 513  200  91   38 174   1   no 200mg oral single dose
## 514    0  77   22 176   1  yes 200mg oral single dose
## 515  200  77   22 176   1   no 200mg oral single dose
## 516  200  77   22 176   1   no 200mg oral single dose
## 517  200  77   22 176   1   no 200mg oral single dose
## 518  200  77   22 176   1   no 200mg oral single dose
## 519  200  77   22 176   1   no 200mg oral single dose
## 520  200  77   22 176   1   no 200mg oral single dose
## 521  200  77   22 176   1   no 200mg oral single dose
## 522  200  77   22 176   1   no 200mg oral single dose
## 523  200  77   22 176   1   no 200mg oral single dose
## 524  200  77   22 176   1   no 200mg oral single dose
## 525  200  77   22 176   1   no 200mg oral single dose
## 
## 
## attr(,"data")$stratified
## attr(,"data")$stratified$`Plasma concentration IQ0815_1`
##     IXGDF IGNORE           USUBJID CENTER         STUDY STUDYN
## 1      20   <NA> IQ00701-0100-0003    100           FIH      1
## 2      22   <NA> IQ00701-0100-0003    100           FIH      1
## 3      23   <NA> IQ00701-0100-0003    100           FIH      1
## 4      24   <NA> IQ00701-0100-0003    100           FIH      1
## 5      25   <NA> IQ00701-0100-0003    100           FIH      1
## 6      26   <NA> IQ00701-0100-0003    100           FIH      1
## 7      27   <NA> IQ00701-0100-0003    100           FIH      1
## 8      28   <NA> IQ00701-0100-0003    100           FIH      1
## 9      29   <NA> IQ00701-0100-0003    100           FIH      1
## 10     30   <NA> IQ00701-0100-0003    100           FIH      1
## 11     31   <NA> IQ00701-0100-0003    100           FIH      1
## 12     32   <NA> IQ00701-0100-0003    100           FIH      1
## 13     37   <NA> IQ00701-0100-0004    100           FIH      1
## 14     39   <NA> IQ00701-0100-0004    100           FIH      1
## 15     40   <NA> IQ00701-0100-0004    100           FIH      1
## 16     41   <NA> IQ00701-0100-0004    100           FIH      1
## 17     42   <NA> IQ00701-0100-0004    100           FIH      1
## 18     43   <NA> IQ00701-0100-0004    100           FIH      1
## 19     44   <NA> IQ00701-0100-0004    100           FIH      1
## 20     45   <NA> IQ00701-0100-0004    100           FIH      1
## 21     46   <NA> IQ00701-0100-0004    100           FIH      1
## 22     47   <NA> IQ00701-0100-0004    100           FIH      1
## 23     48   <NA> IQ00701-0100-0004    100           FIH      1
## 24     49   <NA> IQ00701-0100-0004    100           FIH      1
## 25     54   <NA> IQ00701-0100-0005    100           FIH      1
## 26     56   <NA> IQ00701-0100-0005    100           FIH      1
## 27     57   <NA> IQ00701-0100-0005    100           FIH      1
## 28     58   <NA> IQ00701-0100-0005    100           FIH      1
## 29     60   <NA> IQ00701-0100-0005    100           FIH      1
## 30     61   <NA> IQ00701-0100-0005    100           FIH      1
## 31     62   <NA> IQ00701-0100-0005    100           FIH      1
## 32     63   <NA> IQ00701-0100-0005    100           FIH      1
## 33     64   <NA> IQ00701-0100-0005    100           FIH      1
## 34     65   <NA> IQ00701-0100-0005    100           FIH      1
## 35     66   <NA> IQ00701-0100-0005    100           FIH      1
## 36     88   <NA> IQ00701-0100-0007    100           FIH      1
## 37     90   <NA> IQ00701-0100-0007    100           FIH      1
## 38     91   <NA> IQ00701-0100-0007    100           FIH      1
## 39     92   <NA> IQ00701-0100-0007    100           FIH      1
## 40     93   <NA> IQ00701-0100-0007    100           FIH      1
## 41     94   <NA> IQ00701-0100-0007    100           FIH      1
## 42     95   <NA> IQ00701-0100-0007    100           FIH      1
## 43     96   <NA> IQ00701-0100-0007    100           FIH      1
## 44     97   <NA> IQ00701-0100-0007    100           FIH      1
## 45     99   <NA> IQ00701-0100-0007    100           FIH      1
## 46    100   <NA> IQ00701-0100-0007    100           FIH      1
## 47    106   <NA> IQ00701-0100-0009    100           FIH      1
## 48    108   <NA> IQ00701-0100-0009    100           FIH      1
## 49    109   <NA> IQ00701-0100-0009    100           FIH      1
## 50    110   <NA> IQ00701-0100-0009    100           FIH      1
## 51    111   <NA> IQ00701-0100-0009    100           FIH      1
## 52    112   <NA> IQ00701-0100-0009    100           FIH      1
## 53    113   <NA> IQ00701-0100-0009    100           FIH      1
## 54    114   <NA> IQ00701-0100-0009    100           FIH      1
## 55    115   <NA> IQ00701-0100-0009    100           FIH      1
## 56    116   <NA> IQ00701-0100-0009    100           FIH      1
## 57    117   <NA> IQ00701-0100-0009    100           FIH      1
## 58    118   <NA> IQ00701-0100-0009    100           FIH      1
## 59    156   <NA> IQ00701-0100-0012    100           FIH      1
## 60    158   <NA> IQ00701-0100-0012    100           FIH      1
## 61    159   <NA> IQ00701-0100-0012    100           FIH      1
## 62    160   <NA> IQ00701-0100-0012    100           FIH      1
## 63    161   <NA> IQ00701-0100-0012    100           FIH      1
## 64    162   <NA> IQ00701-0100-0012    100           FIH      1
## 65    163   <NA> IQ00701-0100-0012    100           FIH      1
## 66    164   <NA> IQ00701-0100-0012    100           FIH      1
## 67    165   <NA> IQ00701-0100-0012    100           FIH      1
## 68    166   <NA> IQ00701-0100-0012    100           FIH      1
## 69    167   <NA> IQ00701-0100-0012    100           FIH      1
## 70    168   <NA> IQ00701-0100-0012    100           FIH      1
## 71    206   <NA> IQ00701-0100-0015    100           FIH      1
## 72    208   <NA> IQ00701-0100-0015    100           FIH      1
## 73    209   <NA> IQ00701-0100-0015    100           FIH      1
## 74    210   <NA> IQ00701-0100-0015    100           FIH      1
## 75    211   <NA> IQ00701-0100-0015    100           FIH      1
## 76    212   <NA> IQ00701-0100-0015    100           FIH      1
## 77    213   <NA> IQ00701-0100-0015    100           FIH      1
## 78    214   <NA> IQ00701-0100-0015    100           FIH      1
## 79    215   <NA> IQ00701-0100-0015    100           FIH      1
## 80    216   <NA> IQ00701-0100-0015    100           FIH      1
## 81    217   <NA> IQ00701-0100-0015    100           FIH      1
## 82    218   <NA> IQ00701-0100-0015    100           FIH      1
## 83    223   <NA> IQ00701-0100-0016    100           FIH      1
## 84    225   <NA> IQ00701-0100-0016    100           FIH      1
## 85    226   <NA> IQ00701-0100-0016    100           FIH      1
## 86    227   <NA> IQ00701-0100-0016    100           FIH      1
## 87    228   <NA> IQ00701-0100-0016    100           FIH      1
## 88    229   <NA> IQ00701-0100-0016    100           FIH      1
## 89    230   <NA> IQ00701-0100-0016    100           FIH      1
## 90    231   <NA> IQ00701-0100-0016    100           FIH      1
## 91    232   <NA> IQ00701-0100-0016    100           FIH      1
## 92    233   <NA> IQ00701-0100-0016    100           FIH      1
## 93    234   <NA> IQ00701-0100-0016    100           FIH      1
## 94    235   <NA> IQ00701-0100-0016    100           FIH      1
## 95    240   <NA> IQ00701-0100-0017    100           FIH      1
## 96    242   <NA> IQ00701-0100-0017    100           FIH      1
## 97    243   <NA> IQ00701-0100-0017    100           FIH      1
## 98    244   <NA> IQ00701-0100-0017    100           FIH      1
## 99    245   <NA> IQ00701-0100-0017    100           FIH      1
## 100   246   <NA> IQ00701-0100-0017    100           FIH      1
## 101   247   <NA> IQ00701-0100-0017    100           FIH      1
## 102   248   <NA> IQ00701-0100-0017    100           FIH      1
## 103   249   <NA> IQ00701-0100-0017    100           FIH      1
## 104   250   <NA> IQ00701-0100-0017    100           FIH      1
## 105   251   <NA> IQ00701-0100-0017    100           FIH      1
## 106   252   <NA> IQ00701-0100-0017    100           FIH      1
## 107   274   <NA> IQ00701-0100-0019    100           FIH      1
## 108   276   <NA> IQ00701-0100-0019    100           FIH      1
## 109   277   <NA> IQ00701-0100-0019    100           FIH      1
## 110   278   <NA> IQ00701-0100-0019    100           FIH      1
## 111   279   <NA> IQ00701-0100-0019    100           FIH      1
## 112   280   <NA> IQ00701-0100-0019    100           FIH      1
## 113   281   <NA> IQ00701-0100-0019    100           FIH      1
## 114   282   <NA> IQ00701-0100-0019    100           FIH      1
## 115   283   <NA> IQ00701-0100-0019    100           FIH      1
## 116   284   <NA> IQ00701-0100-0019    100           FIH      1
## 117   285   <NA> IQ00701-0100-0019    100           FIH      1
## 118   286   <NA> IQ00701-0100-0019    100           FIH      1
## 119   291   <NA> IQ00701-0100-0020    100           FIH      1
## 120   293   <NA> IQ00701-0100-0020    100           FIH      1
## 121   294   <NA> IQ00701-0100-0020    100           FIH      1
## 122   295   <NA> IQ00701-0100-0020    100           FIH      1
## 123   296   <NA> IQ00701-0100-0020    100           FIH      1
## 124   297   <NA> IQ00701-0100-0020    100           FIH      1
## 125   298   <NA> IQ00701-0100-0020    100           FIH      1
## 126   299   <NA> IQ00701-0100-0020    100           FIH      1
## 127   300   <NA> IQ00701-0100-0020    100           FIH      1
## 128   302   <NA> IQ00701-0100-0020    100           FIH      1
## 129   303   <NA> IQ00701-0100-0020    100           FIH      1
## 130   325   <NA> IQ00701-0100-0022    100           FIH      1
## 131   327   <NA> IQ00701-0100-0022    100           FIH      1
## 132   328   <NA> IQ00701-0100-0022    100           FIH      1
## 133   329   <NA> IQ00701-0100-0022    100           FIH      1
## 134   330   <NA> IQ00701-0100-0022    100           FIH      1
## 135   331   <NA> IQ00701-0100-0022    100           FIH      1
## 136   332   <NA> IQ00701-0100-0022    100           FIH      1
## 137   333   <NA> IQ00701-0100-0022    100           FIH      1
## 138   334   <NA> IQ00701-0100-0022    100           FIH      1
## 139   335   <NA> IQ00701-0100-0022    100           FIH      1
## 140   336   <NA> IQ00701-0100-0022    100           FIH      1
## 141   337   <NA> IQ00701-0100-0022    100           FIH      1
## 142   342   <NA> IQ00701-0100-0023    100           FIH      1
## 143   344   <NA> IQ00701-0100-0023    100           FIH      1
## 144   345   <NA> IQ00701-0100-0023    100           FIH      1
## 145   346   <NA> IQ00701-0100-0023    100           FIH      1
## 146   347   <NA> IQ00701-0100-0023    100           FIH      1
## 147   348   <NA> IQ00701-0100-0023    100           FIH      1
## 148   349   <NA> IQ00701-0100-0023    100           FIH      1
## 149   350   <NA> IQ00701-0100-0023    100           FIH      1
## 150   351   <NA> IQ00701-0100-0023    100           FIH      1
## 151   352   <NA> IQ00701-0100-0023    100           FIH      1
## 152   353   <NA> IQ00701-0100-0023    100           FIH      1
## 153   354   <NA> IQ00701-0100-0023    100           FIH      1
## 154   359   <NA> IQ00701-0100-0024    100           FIH      1
## 155   361   <NA> IQ00701-0100-0024    100           FIH      1
## 156   362   <NA> IQ00701-0100-0024    100           FIH      1
## 157   363   <NA> IQ00701-0100-0024    100           FIH      1
## 158   364   <NA> IQ00701-0100-0024    100           FIH      1
## 159   365   <NA> IQ00701-0100-0024    100           FIH      1
## 160   366   <NA> IQ00701-0100-0024    100           FIH      1
## 161   367   <NA> IQ00701-0100-0024    100           FIH      1
## 162   368   <NA> IQ00701-0100-0024    100           FIH      1
## 163   369   <NA> IQ00701-0100-0024    100           FIH      1
## 164   370   <NA> IQ00701-0100-0024    100           FIH      1
## 165   371   <NA> IQ00701-0100-0024    100           FIH      1
## 166   393   <NA> IQ00701-0100-0026    100           FIH      1
## 167   395   <NA> IQ00701-0100-0026    100           FIH      1
## 168   396   <NA> IQ00701-0100-0026    100           FIH      1
## 169   397   <NA> IQ00701-0100-0026    100           FIH      1
## 170   398   <NA> IQ00701-0100-0026    100           FIH      1
## 171   399   <NA> IQ00701-0100-0026    100           FIH      1
## 172   400   <NA> IQ00701-0100-0026    100           FIH      1
## 173   401   <NA> IQ00701-0100-0026    100           FIH      1
## 174   402   <NA> IQ00701-0100-0026    100           FIH      1
## 175   403   <NA> IQ00701-0100-0026    100           FIH      1
## 176   404   <NA> IQ00701-0100-0026    100           FIH      1
## 177   405   <NA> IQ00701-0100-0026    100           FIH      1
## 178   410   <NA> IQ00701-0100-0027    100           FIH      1
## 179   412   <NA> IQ00701-0100-0027    100           FIH      1
## 180   413   <NA> IQ00701-0100-0027    100           FIH      1
## 181   414   <NA> IQ00701-0100-0027    100           FIH      1
## 182   415   <NA> IQ00701-0100-0027    100           FIH      1
## 183   416   <NA> IQ00701-0100-0027    100           FIH      1
## 184   417   <NA> IQ00701-0100-0027    100           FIH      1
## 185   418   <NA> IQ00701-0100-0027    100           FIH      1
## 186   419   <NA> IQ00701-0100-0027    100           FIH      1
## 187   420   <NA> IQ00701-0100-0027    100           FIH      1
## 188   421   <NA> IQ00701-0100-0027    100           FIH      1
## 189   422   <NA> IQ00701-0100-0027    100           FIH      1
## 190   461   <NA> IQ00701-0100-0030    100           FIH      1
## 191   463   <NA> IQ00701-0100-0030    100           FIH      1
## 192   464   <NA> IQ00701-0100-0030    100           FIH      1
## 193   465   <NA> IQ00701-0100-0030    100           FIH      1
## 194   466   <NA> IQ00701-0100-0030    100           FIH      1
## 195   467   <NA> IQ00701-0100-0030    100           FIH      1
## 196   468   <NA> IQ00701-0100-0030    100           FIH      1
## 197   469   <NA> IQ00701-0100-0030    100           FIH      1
## 198   470   <NA> IQ00701-0100-0030    100           FIH      1
## 199   471   <NA> IQ00701-0100-0030    100           FIH      1
## 200   472   <NA> IQ00701-0100-0030    100           FIH      1
## 201   473   <NA> IQ00701-0100-0030    100           FIH      1
## 202   478   <NA> IQ00701-0100-0031    100           FIH      1
## 203   480   <NA> IQ00701-0100-0031    100           FIH      1
## 204   481   <NA> IQ00701-0100-0031    100           FIH      1
## 205   482   <NA> IQ00701-0100-0031    100           FIH      1
## 206   483   <NA> IQ00701-0100-0031    100           FIH      1
## 207   484   <NA> IQ00701-0100-0031    100           FIH      1
## 208   485   <NA> IQ00701-0100-0031    100           FIH      1
## 209   486   <NA> IQ00701-0100-0031    100           FIH      1
## 210   487   <NA> IQ00701-0100-0031    100           FIH      1
## 211   488   <NA> IQ00701-0100-0031    100           FIH      1
## 212   489   <NA> IQ00701-0100-0031    100           FIH      1
## 213   490   <NA> IQ00701-0100-0031    100           FIH      1
## 214   495   <NA> IQ00701-0100-0032    100           FIH      1
## 215   497   <NA> IQ00701-0100-0032    100           FIH      1
## 216   498   <NA> IQ00701-0100-0032    100           FIH      1
## 217   499   <NA> IQ00701-0100-0032    100           FIH      1
## 218   500   <NA> IQ00701-0100-0032    100           FIH      1
## 219   501   <NA> IQ00701-0100-0032    100           FIH      1
## 220   502   <NA> IQ00701-0100-0032    100           FIH      1
## 221   503   <NA> IQ00701-0100-0032    100           FIH      1
## 222   504   <NA> IQ00701-0100-0032    100           FIH      1
## 223   505   <NA> IQ00701-0100-0032    100           FIH      1
## 224   506   <NA> IQ00701-0100-0032    100           FIH      1
## 225   507   <NA> IQ00701-0100-0032    100           FIH      1
## 226   529   <NA> IQ00701-0100-0034    100           FIH      1
## 227   531   <NA> IQ00701-0100-0034    100           FIH      1
## 228   532   <NA> IQ00701-0100-0034    100           FIH      1
## 229   533   <NA> IQ00701-0100-0034    100           FIH      1
## 230   534   <NA> IQ00701-0100-0034    100           FIH      1
## 231   535   <NA> IQ00701-0100-0034    100           FIH      1
## 232   536   <NA> IQ00701-0100-0034    100           FIH      1
## 233   537   <NA> IQ00701-0100-0034    100           FIH      1
## 234   538   <NA> IQ00701-0100-0034    100           FIH      1
## 235   539   <NA> IQ00701-0100-0034    100           FIH      1
## 236   540   <NA> IQ00701-0100-0034    100           FIH      1
## 237   541   <NA> IQ00701-0100-0034    100           FIH      1
## 238   580   <NA> IQ00701-0100-0037    100 FIH extension      2
## 239   582   <NA> IQ00701-0100-0037    100 FIH extension      2
## 240   583   <NA> IQ00701-0100-0037    100 FIH extension      2
## 241   584   <NA> IQ00701-0100-0037    100 FIH extension      2
## 242   585   <NA> IQ00701-0100-0037    100 FIH extension      2
## 243   586   <NA> IQ00701-0100-0037    100 FIH extension      2
## 244   587   <NA> IQ00701-0100-0037    100 FIH extension      2
## 245   588   <NA> IQ00701-0100-0037    100 FIH extension      2
## 246   589   <NA> IQ00701-0100-0037    100 FIH extension      2
## 247   590   <NA> IQ00701-0100-0037    100 FIH extension      2
## 248   591   <NA> IQ00701-0100-0037    100 FIH extension      2
## 249   592   <NA> IQ00701-0100-0037    100 FIH extension      2
## 250   597   <NA> IQ00701-0100-0038    100 FIH extension      2
## 251   599   <NA> IQ00701-0100-0038    100 FIH extension      2
## 252   600   <NA> IQ00701-0100-0038    100 FIH extension      2
## 253   601   <NA> IQ00701-0100-0038    100 FIH extension      2
## 254   602   <NA> IQ00701-0100-0038    100 FIH extension      2
## 255   603   <NA> IQ00701-0100-0038    100 FIH extension      2
## 256   604   <NA> IQ00701-0100-0038    100 FIH extension      2
## 257   605   <NA> IQ00701-0100-0038    100 FIH extension      2
## 258   606   <NA> IQ00701-0100-0038    100 FIH extension      2
## 259   607   <NA> IQ00701-0100-0038    100 FIH extension      2
## 260   608   <NA> IQ00701-0100-0038    100 FIH extension      2
## 261   609   <NA> IQ00701-0100-0038    100 FIH extension      2
## 262   699   <NA> IQ00701-0100-0044    100 FIH extension      2
## 263   701   <NA> IQ00701-0100-0044    100 FIH extension      2
## 264   702   <NA> IQ00701-0100-0044    100 FIH extension      2
## 265   703   <NA> IQ00701-0100-0044    100 FIH extension      2
## 266   704   <NA> IQ00701-0100-0044    100 FIH extension      2
## 267   705   <NA> IQ00701-0100-0044    100 FIH extension      2
## 268   706   <NA> IQ00701-0100-0044    100 FIH extension      2
## 269   707   <NA> IQ00701-0100-0044    100 FIH extension      2
## 270   708   <NA> IQ00701-0100-0044    100 FIH extension      2
## 271   709   <NA> IQ00701-0100-0044    100 FIH extension      2
## 272   710   <NA> IQ00701-0100-0044    100 FIH extension      2
## 273   711   <NA> IQ00701-0100-0044    100 FIH extension      2
## 274   767   <NA> IQ00701-0100-0048    100 FIH extension      2
## 275   769   <NA> IQ00701-0100-0048    100 FIH extension      2
## 276   770   <NA> IQ00701-0100-0048    100 FIH extension      2
## 277   771   <NA> IQ00701-0100-0048    100 FIH extension      2
## 278   772   <NA> IQ00701-0100-0048    100 FIH extension      2
## 279   773   <NA> IQ00701-0100-0048    100 FIH extension      2
## 280   774   <NA> IQ00701-0100-0048    100 FIH extension      2
## 281   775   <NA> IQ00701-0100-0048    100 FIH extension      2
## 282   776   <NA> IQ00701-0100-0048    100 FIH extension      2
## 283   777   <NA> IQ00701-0100-0048    100 FIH extension      2
## 284   778   <NA> IQ00701-0100-0048    100 FIH extension      2
## 285   779   <NA> IQ00701-0100-0048    100 FIH extension      2
##                    TRTNAME TRT VISIT BASE SCREEN TIMEUNIT           NT     TIME
## 1     1mg oral single dose   3     2    0      0    HOURS  -0.08333333  -0.0830
## 2     1mg oral single dose   3     2    0      0    HOURS   0.08333333   0.0830
## 3     1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.2500
## 4     1mg oral single dose   3     2    0      0    HOURS   0.50000000   0.5000
## 5     1mg oral single dose   3     2    0      0    HOURS   1.00000000   1.0000
## 6     1mg oral single dose   3     2    0      0    HOURS   2.00000000   2.0000
## 7     1mg oral single dose   3     2    0      0    HOURS   4.00000000   4.0000
## 8     1mg oral single dose   3     2    0      0    HOURS  12.00000000  12.0000
## 9     1mg oral single dose   3     3    0      0    HOURS  24.00000000  24.0000
## 10    1mg oral single dose   3     4    0      0    HOURS  48.00000000  48.0000
## 11    1mg oral single dose   3     5    0      0    HOURS  96.00000000  96.0000
## 12    1mg oral single dose   3     6    0      0    HOURS 168.00000000 168.0000
## 13    1mg oral single dose   3     2    0      0    HOURS  -0.08333333  -0.0830
## 14    1mg oral single dose   3     2    0      0    HOURS   0.08333333   0.0830
## 15    1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.2500
## 16    1mg oral single dose   3     2    0      0    HOURS   0.50000000   0.5000
## 17    1mg oral single dose   3     2    0      0    HOURS   1.00000000   1.0000
## 18    1mg oral single dose   3     2    0      0    HOURS   2.00000000   2.0000
## 19    1mg oral single dose   3     2    0      0    HOURS   4.00000000   4.0000
## 20    1mg oral single dose   3     2    0      0    HOURS  12.00000000  12.0000
## 21    1mg oral single dose   3     3    0      0    HOURS  24.00000000  24.0000
## 22    1mg oral single dose   3     4    0      0    HOURS  48.00000000  48.0000
## 23    1mg oral single dose   3     5    0      0    HOURS  96.00000000  96.0000
## 24    1mg oral single dose   3     6    0      0    HOURS 168.00000000 168.0000
## 25    1mg oral single dose   3     2    0      0    HOURS  -0.08333333  -0.0830
## 26    1mg oral single dose   3     2    0      0    HOURS   0.08333333   0.0830
## 27    1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.2500
## 28    1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.2501
## 29    1mg oral single dose   3     2    0      0    HOURS   1.00000000   1.0000
## 30    1mg oral single dose   3     2    0      0    HOURS   2.00000000   2.0000
## 31    1mg oral single dose   3     2    0      0    HOURS   4.00000000   4.0000
## 32    1mg oral single dose   3     3    0      0    HOURS  24.00000000  24.0000
## 33    1mg oral single dose   3     4    0      0    HOURS  48.00000000  48.0000
## 34    1mg oral single dose   3     5    0      0    HOURS  96.00000000  96.0000
## 35    1mg oral single dose   3     6    0      0    HOURS 168.00000000 168.0000
## 36    2mg oral single dose   6     2    0      0    HOURS  -0.08333333  -0.0830
## 37    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.0830
## 38    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.2500
## 39    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.5000
## 40    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.0000
## 41    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.0000
## 42    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.0000
## 43    2mg oral single dose   6     2    0      0    HOURS  12.00000000  12.0000
## 44    2mg oral single dose   6     3    0      0    HOURS  24.00000000  24.0000
## 45    2mg oral single dose   6     5    0      0    HOURS  96.00000000  96.0000
## 46    2mg oral single dose   6     6    0      0    HOURS 168.00000000 168.0000
## 47    2mg oral single dose   6     2    0      0    HOURS  -0.08333333  -0.0830
## 48    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.0830
## 49    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.2500
## 50    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.5000
## 51    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.0000
## 52    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.0000
## 53    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.0000
## 54    2mg oral single dose   6     2    0      0    HOURS  12.00000000  12.0000
## 55    2mg oral single dose   6     3    0      0    HOURS  24.00000000  24.0000
## 56    2mg oral single dose   6     4    0      0    HOURS  48.00000000  48.0000
## 57    2mg oral single dose   6     5    0      0    HOURS  96.00000000  96.0000
## 58    2mg oral single dose   6     6    0      0    HOURS 168.00000000 168.0000
## 59    2mg oral single dose   6     2    0      0    HOURS  -0.08333333  -0.0830
## 60    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.0830
## 61    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.2500
## 62    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.5000
## 63    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.0000
## 64    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.0000
## 65    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.0000
## 66    2mg oral single dose   6     2    0      0    HOURS  12.00000000  12.0000
## 67    2mg oral single dose   6     3    0      0    HOURS  24.00000000  24.0000
## 68    2mg oral single dose   6     4    0      0    HOURS  48.00000000  48.0000
## 69    2mg oral single dose   6     5    0      0    HOURS  96.00000000  96.0000
## 70    2mg oral single dose   6     6    0      0    HOURS 168.00000000 168.0000
## 71    5mg oral single dose   8     2    0      0    HOURS  -0.08333333  -0.0830
## 72    5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.0830
## 73    5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.2500
## 74    5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.5000
## 75    5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.0000
## 76    5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.0000
## 77    5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.0000
## 78    5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.0000
## 79    5mg oral single dose   8     3    0      0    HOURS  24.00000000  24.0000
## 80    5mg oral single dose   8     4    0      0    HOURS  48.00000000  48.0000
## 81    5mg oral single dose   8     5    0      0    HOURS  96.00000000  96.0000
## 82    5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.0000
## 83    5mg oral single dose   8     2    0      0    HOURS  -0.08333333  -0.0830
## 84    5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.0830
## 85    5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.2500
## 86    5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.5000
## 87    5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.0000
## 88    5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.0000
## 89    5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.0000
## 90    5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.0000
## 91    5mg oral single dose   8     3    0      0    HOURS  24.00000000  24.0000
## 92    5mg oral single dose   8     4    0      0    HOURS  48.00000000  48.0000
## 93    5mg oral single dose   8     5    0      0    HOURS  96.00000000  96.0000
## 94    5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.0000
## 95    5mg oral single dose   8     2    0      0    HOURS  -0.08333333  -0.0830
## 96    5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.0830
## 97    5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.2500
## 98    5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.5000
## 99    5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.0000
## 100   5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.0000
## 101   5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.0000
## 102   5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.0000
## 103   5mg oral single dose   8     3    0      0    HOURS  24.00000000  24.0000
## 104   5mg oral single dose   8     4    0      0    HOURS  48.00000000  48.0000
## 105   5mg oral single dose   8     5    0      0    HOURS  96.00000000  96.0000
## 106   5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.0000
## 107  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 108  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 109  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 110  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 111  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 112  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 113  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 114  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 115  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 116  10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.0000
## 117  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 118  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 119  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 120  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 121  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 122  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 123  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 124  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 125  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 126  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 127  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 128  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 129  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 130  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 131  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 132  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 133  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 134  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 135  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 136  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 137  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 138  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 139  10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.0000
## 140  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 141  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 142  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 143  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 144  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 145  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 146  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 147  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 148  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 149  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 150  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 151  10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.0000
## 152  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 153  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 154  10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.0830
## 155  10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.0830
## 156  10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.2500
## 157  10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.5000
## 158  10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.0000
## 159  10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.0000
## 160  10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.0000
## 161  10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.0000
## 162  10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.0000
## 163  10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.0000
## 164  10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.0000
## 165  10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.0000
## 166  20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.0830
## 167  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.0830
## 168  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.2500
## 169  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.5000
## 170  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.0000
## 171  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.0000
## 172  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.0000
## 173  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.0000
## 174  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.0000
## 175  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.0000
## 176  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.0000
## 177  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.0000
## 178  20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.0830
## 179  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.0830
## 180  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.2500
## 181  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.5000
## 182  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.0000
## 183  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.0000
## 184  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.0000
## 185  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.0000
## 186  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.0000
## 187  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.0000
## 188  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.0000
## 189  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.0000
## 190  20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.0830
## 191  20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.0830
## 192  20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.2500
## 193  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.5000
## 194  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.0000
## 195  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.0000
## 196  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.0000
## 197  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.0000
## 198  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.0000
## 199  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.0000
## 200  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.0000
## 201  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.0000
## 202  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.0830
## 203  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.0830
## 204  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.2500
## 205  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.5000
## 206  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.0000
## 207  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.0000
## 208  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.0000
## 209  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.0000
## 210  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.0000
## 211  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.0000
## 212  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.0000
## 213  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.0000
## 214  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.0830
## 215  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.0830
## 216  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.2500
## 217  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.5000
## 218  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.0000
## 219  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.0000
## 220  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.0000
## 221  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.0000
## 222  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.0000
## 223  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.0000
## 224  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.0000
## 225  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.0000
## 226  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.0830
## 227  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.0830
## 228  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.2500
## 229  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.5000
## 230  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.0000
## 231  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.0000
## 232  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.0000
## 233  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.0000
## 234  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.0000
## 235  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.0000
## 236  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.0000
## 237  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.0000
## 238 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.0830
## 239 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.0830
## 240 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.2500
## 241 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.5000
## 242 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.0000
## 243 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.0000
## 244 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.0000
## 245 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.0000
## 246 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.0000
## 247 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.0000
## 248 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.0000
## 249 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.0000
## 250 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.0830
## 251 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.0830
## 252 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.2500
## 253 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.5000
## 254 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.0000
## 255 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.0000
## 256 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.0000
## 257 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.0000
## 258 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.0000
## 259 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.0000
## 260 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.0000
## 261 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.0000
## 262 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.0830
## 263 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.0830
## 264 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.2500
## 265 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.5000
## 266 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.0000
## 267 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.0000
## 268 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.0000
## 269 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.0000
## 270 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.0000
## 271 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.0000
## 272 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.0000
## 273 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.0000
## 274 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.0830
## 275 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.0830
## 276 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.2500
## 277 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.5000
## 278 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.0000
## 279 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.0000
## 280 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.0000
## 281 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.0000
## 282 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.0000
## 283 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.0000
## 284 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.0000
## 285 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.0000
##     DURATION                        NAME   VALUE VALUETXT  UNIT  LLOQ ROUTE II
## 1          0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 2          0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 3          0 Plasma concentration IQ0815 0.00153     <NA> ug/mL 0.001  <NA>  0
## 4          0 Plasma concentration IQ0815 0.00350     <NA> ug/mL 0.001  <NA>  0
## 5          0 Plasma concentration IQ0815 0.00380     <NA> ug/mL 0.001  <NA>  0
## 6          0 Plasma concentration IQ0815 0.00333     <NA> ug/mL 0.001  <NA>  0
## 7          0 Plasma concentration IQ0815 0.00291     <NA> ug/mL 0.001  <NA>  0
## 8          0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 9          0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 10         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 11         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 12         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 13         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 14         0 Plasma concentration IQ0815 0.00138     <NA> ug/mL 0.001  <NA>  0
## 15         0 Plasma concentration IQ0815 0.00212     <NA> ug/mL 0.001  <NA>  0
## 16         0 Plasma concentration IQ0815 0.00359     <NA> ug/mL 0.001  <NA>  0
## 17         0 Plasma concentration IQ0815 0.00542     <NA> ug/mL 0.001  <NA>  0
## 18         0 Plasma concentration IQ0815 0.00526     <NA> ug/mL 0.001  <NA>  0
## 19         0 Plasma concentration IQ0815 0.00391     <NA> ug/mL 0.001  <NA>  0
## 20         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 21         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 22         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 23         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 24         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 25         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 26         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 27         0 Plasma concentration IQ0815 0.00168     <NA> ug/mL 0.001  <NA>  0
## 28         0 Plasma concentration IQ0815 0.00168     <NA> ug/mL 0.001  <NA>  0
## 29         0 Plasma concentration IQ0815 0.00221     <NA> ug/mL 0.001  <NA>  0
## 30         0 Plasma concentration IQ0815 0.00307     <NA> ug/mL 0.001  <NA>  0
## 31         0 Plasma concentration IQ0815 0.00133     <NA> ug/mL 0.001  <NA>  0
## 32         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 33         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 34         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 35         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 36         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 37         0 Plasma concentration IQ0815 0.00174     <NA> ug/mL 0.001  <NA>  0
## 38         0 Plasma concentration IQ0815 0.00299     <NA> ug/mL 0.001  <NA>  0
## 39         0 Plasma concentration IQ0815 0.00555     <NA> ug/mL 0.001  <NA>  0
## 40         0 Plasma concentration IQ0815 0.00780     <NA> ug/mL 0.001  <NA>  0
## 41         0 Plasma concentration IQ0815 0.00706     <NA> ug/mL 0.001  <NA>  0
## 42         0 Plasma concentration IQ0815 0.00526     <NA> ug/mL 0.001  <NA>  0
## 43         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 44         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 45         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 46         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 47         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 48         0 Plasma concentration IQ0815 0.00123     <NA> ug/mL 0.001  <NA>  0
## 49         0 Plasma concentration IQ0815 0.00238     <NA> ug/mL 0.001  <NA>  0
## 50         0 Plasma concentration IQ0815 0.00480     <NA> ug/mL 0.001  <NA>  0
## 51         0 Plasma concentration IQ0815 0.00672     <NA> ug/mL 0.001  <NA>  0
## 52         0 Plasma concentration IQ0815 0.00509     <NA> ug/mL 0.001  <NA>  0
## 53         0 Plasma concentration IQ0815 0.00396     <NA> ug/mL 0.001  <NA>  0
## 54         0 Plasma concentration IQ0815 0.00160     <NA> ug/mL 0.001  <NA>  0
## 55         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 56         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 57         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 58         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 59         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 60         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 61         0 Plasma concentration IQ0815 0.00380     <NA> ug/mL 0.001  <NA>  0
## 62         0 Plasma concentration IQ0815 0.00510     <NA> ug/mL 0.001  <NA>  0
## 63         0 Plasma concentration IQ0815 0.00396     <NA> ug/mL 0.001  <NA>  0
## 64         0 Plasma concentration IQ0815 0.00596     <NA> ug/mL 0.001  <NA>  0
## 65         0 Plasma concentration IQ0815 0.00445     <NA> ug/mL 0.001  <NA>  0
## 66         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 67         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 68         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 69         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 70         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 71         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 72         0 Plasma concentration IQ0815 0.00174     <NA> ug/mL 0.001  <NA>  0
## 73         0 Plasma concentration IQ0815 0.00432     <NA> ug/mL 0.001  <NA>  0
## 74         0 Plasma concentration IQ0815 0.00766     <NA> ug/mL 0.001  <NA>  0
## 75         0 Plasma concentration IQ0815 0.01030     <NA> ug/mL 0.001  <NA>  0
## 76         0 Plasma concentration IQ0815 0.00802     <NA> ug/mL 0.001  <NA>  0
## 77         0 Plasma concentration IQ0815 0.00742     <NA> ug/mL 0.001  <NA>  0
## 78         0 Plasma concentration IQ0815 0.00300     <NA> ug/mL 0.001  <NA>  0
## 79         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 80         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 81         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 82         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 83         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 84         0 Plasma concentration IQ0815 0.00370     <NA> ug/mL 0.001  <NA>  0
## 85         0 Plasma concentration IQ0815 0.00826     <NA> ug/mL 0.001  <NA>  0
## 86         0 Plasma concentration IQ0815 0.01440     <NA> ug/mL 0.001  <NA>  0
## 87         0 Plasma concentration IQ0815 0.01460     <NA> ug/mL 0.001  <NA>  0
## 88         0 Plasma concentration IQ0815 0.01770     <NA> ug/mL 0.001  <NA>  0
## 89         0 Plasma concentration IQ0815 0.00857     <NA> ug/mL 0.001  <NA>  0
## 90         0 Plasma concentration IQ0815 0.00199     <NA> ug/mL 0.001  <NA>  0
## 91         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 92         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 93         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 94         0 Plasma concentration IQ0815 0.00101     <NA> ug/mL 0.001  <NA>  0
## 95         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 96         0 Plasma concentration IQ0815 0.00386     <NA> ug/mL 0.001  <NA>  0
## 97         0 Plasma concentration IQ0815 0.00888     <NA> ug/mL 0.001  <NA>  0
## 98         0 Plasma concentration IQ0815 0.01700     <NA> ug/mL 0.001  <NA>  0
## 99         0 Plasma concentration IQ0815 0.01830     <NA> ug/mL 0.001  <NA>  0
## 100        0 Plasma concentration IQ0815 0.01980     <NA> ug/mL 0.001  <NA>  0
## 101        0 Plasma concentration IQ0815 0.00950     <NA> ug/mL 0.001  <NA>  0
## 102        0 Plasma concentration IQ0815 0.00334     <NA> ug/mL 0.001  <NA>  0
## 103        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 104        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 105        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 106        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 107        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 108        0 Plasma concentration IQ0815 0.00689     <NA> ug/mL 0.001  <NA>  0
## 109        0 Plasma concentration IQ0815 0.01530     <NA> ug/mL 0.001  <NA>  0
## 110        0 Plasma concentration IQ0815 0.02390     <NA> ug/mL 0.001  <NA>  0
## 111        0 Plasma concentration IQ0815 0.04110     <NA> ug/mL 0.001  <NA>  0
## 112        0 Plasma concentration IQ0815 0.03820     <NA> ug/mL 0.001  <NA>  0
## 113        0 Plasma concentration IQ0815 0.02730     <NA> ug/mL 0.001  <NA>  0
## 114        0 Plasma concentration IQ0815 0.00528     <NA> ug/mL 0.001  <NA>  0
## 115        0 Plasma concentration IQ0815 0.00198     <NA> ug/mL 0.001  <NA>  0
## 116        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 117        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 118        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 119        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 120        0 Plasma concentration IQ0815 0.00515     <NA> ug/mL 0.001  <NA>  0
## 121        0 Plasma concentration IQ0815 0.01130     <NA> ug/mL 0.001  <NA>  0
## 122        0 Plasma concentration IQ0815 0.01910     <NA> ug/mL 0.001  <NA>  0
## 123        0 Plasma concentration IQ0815 0.03580     <NA> ug/mL 0.001  <NA>  0
## 124        0 Plasma concentration IQ0815 0.02670     <NA> ug/mL 0.001  <NA>  0
## 125        0 Plasma concentration IQ0815 0.01850     <NA> ug/mL 0.001  <NA>  0
## 126        0 Plasma concentration IQ0815 0.00755     <NA> ug/mL 0.001  <NA>  0
## 127        0 Plasma concentration IQ0815 0.00219     <NA> ug/mL 0.001  <NA>  0
## 128        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 129        0 Plasma concentration IQ0815 0.00101     <NA> ug/mL 0.001  <NA>  0
## 130        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 131        0 Plasma concentration IQ0815 0.00241     <NA> ug/mL 0.001  <NA>  0
## 132        0 Plasma concentration IQ0815 0.01060     <NA> ug/mL 0.001  <NA>  0
## 133        0 Plasma concentration IQ0815 0.01630     <NA> ug/mL 0.001  <NA>  0
## 134        0 Plasma concentration IQ0815 0.02530     <NA> ug/mL 0.001  <NA>  0
## 135        0 Plasma concentration IQ0815 0.20500     <NA> ug/mL 0.001  <NA>  0
## 136        0 Plasma concentration IQ0815 0.01860     <NA> ug/mL 0.001  <NA>  0
## 137        0 Plasma concentration IQ0815 0.00534     <NA> ug/mL 0.001  <NA>  0
## 138        0 Plasma concentration IQ0815 0.00213     <NA> ug/mL 0.001  <NA>  0
## 139        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 140        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 141        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 142        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 143        0 Plasma concentration IQ0815 0.00905     <NA> ug/mL 0.001  <NA>  0
## 144        0 Plasma concentration IQ0815 0.02640     <NA> ug/mL 0.001  <NA>  0
## 145        0 Plasma concentration IQ0815 0.03400     <NA> ug/mL 0.001  <NA>  0
## 146        0 Plasma concentration IQ0815 0.04700     <NA> ug/mL 0.001  <NA>  0
## 147        0 Plasma concentration IQ0815 0.03710     <NA> ug/mL 0.001  <NA>  0
## 148        0 Plasma concentration IQ0815 0.02450     <NA> ug/mL 0.001  <NA>  0
## 149        0 Plasma concentration IQ0815 0.00779     <NA> ug/mL 0.001  <NA>  0
## 150        0 Plasma concentration IQ0815 0.00116     <NA> ug/mL 0.001  <NA>  0
## 151        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 152        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 153        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 154        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 155        0 Plasma concentration IQ0815 0.00433     <NA> ug/mL 0.001  <NA>  0
## 156        0 Plasma concentration IQ0815 0.01200     <NA> ug/mL 0.001  <NA>  0
## 157        0 Plasma concentration IQ0815 0.01940     <NA> ug/mL 0.001  <NA>  0
## 158        0 Plasma concentration IQ0815 0.03030     <NA> ug/mL 0.001  <NA>  0
## 159        0 Plasma concentration IQ0815 0.03300     <NA> ug/mL 0.001  <NA>  0
## 160        0 Plasma concentration IQ0815 0.02270     <NA> ug/mL 0.001  <NA>  0
## 161        0 Plasma concentration IQ0815 0.00835     <NA> ug/mL 0.001  <NA>  0
## 162        0 Plasma concentration IQ0815 0.00266     <NA> ug/mL 0.001  <NA>  0
## 163        0 Plasma concentration IQ0815 0.00241     <NA> ug/mL 0.001  <NA>  0
## 164        0 Plasma concentration IQ0815 0.00127     <NA> ug/mL 0.001  <NA>  0
## 165        0 Plasma concentration IQ0815 0.00124     <NA> ug/mL 0.001  <NA>  0
## 166        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 167        0 Plasma concentration IQ0815 0.00936     <NA> ug/mL 0.001  <NA>  0
## 168        0 Plasma concentration IQ0815 0.02200     <NA> ug/mL 0.001  <NA>  0
## 169        0 Plasma concentration IQ0815 0.03310     <NA> ug/mL 0.001  <NA>  0
## 170        0 Plasma concentration IQ0815 0.05420     <NA> ug/mL 0.001  <NA>  0
## 171        0 Plasma concentration IQ0815 0.05030     <NA> ug/mL 0.001  <NA>  0
## 172        0 Plasma concentration IQ0815 0.04100     <NA> ug/mL 0.001  <NA>  0
## 173        0 Plasma concentration IQ0815 0.01170     <NA> ug/mL 0.001  <NA>  0
## 174        0 Plasma concentration IQ0815 0.00311     <NA> ug/mL 0.001  <NA>  0
## 175        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 176        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 177        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 178        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 179        0 Plasma concentration IQ0815 0.01390     <NA> ug/mL 0.001  <NA>  0
## 180        0 Plasma concentration IQ0815 0.03260     <NA> ug/mL 0.001  <NA>  0
## 181        0 Plasma concentration IQ0815 0.05050     <NA> ug/mL 0.001  <NA>  0
## 182        0 Plasma concentration IQ0815 0.06240     <NA> ug/mL 0.001  <NA>  0
## 183        0 Plasma concentration IQ0815 0.05440     <NA> ug/mL 0.001  <NA>  0
## 184        0 Plasma concentration IQ0815 0.03180     <NA> ug/mL 0.001  <NA>  0
## 185        0 Plasma concentration IQ0815 0.00749     <NA> ug/mL 0.001  <NA>  0
## 186        0 Plasma concentration IQ0815 0.00232     <NA> ug/mL 0.001  <NA>  0
## 187        0 Plasma concentration IQ0815 0.00309     <NA> ug/mL 0.001  <NA>  0
## 188        0 Plasma concentration IQ0815 0.00261     <NA> ug/mL 0.001  <NA>  0
## 189        0 Plasma concentration IQ0815 0.00165     <NA> ug/mL 0.001  <NA>  0
## 190        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 191        0 Plasma concentration IQ0815 0.01290     <NA> ug/mL 0.001  <NA>  0
## 192        0 Plasma concentration IQ0815 0.03290     <NA> ug/mL 0.001  <NA>  0
## 193        0 Plasma concentration IQ0815 0.04310     <NA> ug/mL 0.001  <NA>  0
## 194        0 Plasma concentration IQ0815 0.05360     <NA> ug/mL 0.001  <NA>  0
## 195        0 Plasma concentration IQ0815 0.05700     <NA> ug/mL 0.001  <NA>  0
## 196        0 Plasma concentration IQ0815 0.04370     <NA> ug/mL 0.001  <NA>  0
## 197        0 Plasma concentration IQ0815 0.01170     <NA> ug/mL 0.001  <NA>  0
## 198        0 Plasma concentration IQ0815 0.00297     <NA> ug/mL 0.001  <NA>  0
## 199        0 Plasma concentration IQ0815 0.00114     <NA> ug/mL 0.001  <NA>  0
## 200        0 Plasma concentration IQ0815 0.00131     <NA> ug/mL 0.001  <NA>  0
## 201        0 Plasma concentration IQ0815 0.00121     <NA> ug/mL 0.001  <NA>  0
## 202        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 203        0 Plasma concentration IQ0815 0.01480     <NA> ug/mL 0.001  <NA>  0
## 204        0 Plasma concentration IQ0815 0.03720     <NA> ug/mL 0.001  <NA>  0
## 205        0 Plasma concentration IQ0815 0.06000     <NA> ug/mL 0.001  <NA>  0
## 206        0 Plasma concentration IQ0815 0.08750     <NA> ug/mL 0.001  <NA>  0
## 207        0 Plasma concentration IQ0815 0.07030     <NA> ug/mL 0.001  <NA>  0
## 208        0 Plasma concentration IQ0815 0.07920     <NA> ug/mL 0.001  <NA>  0
## 209        0 Plasma concentration IQ0815 0.02850     <NA> ug/mL 0.001  <NA>  0
## 210        0 Plasma concentration IQ0815 0.00963     <NA> ug/mL 0.001  <NA>  0
## 211        0 Plasma concentration IQ0815 0.00283     <NA> ug/mL 0.001  <NA>  0
## 212        0 Plasma concentration IQ0815 0.00248     <NA> ug/mL 0.001  <NA>  0
## 213        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 214        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 215        0 Plasma concentration IQ0815 0.04720     <NA> ug/mL 0.001  <NA>  0
## 216        0 Plasma concentration IQ0815 0.11400     <NA> ug/mL 0.001  <NA>  0
## 217        0 Plasma concentration IQ0815 0.15200     <NA> ug/mL 0.001  <NA>  0
## 218        0 Plasma concentration IQ0815 0.17300     <NA> ug/mL 0.001  <NA>  0
## 219        0 Plasma concentration IQ0815 0.14500     <NA> ug/mL 0.001  <NA>  0
## 220        0 Plasma concentration IQ0815 0.10100     <NA> ug/mL 0.001  <NA>  0
## 221        0 Plasma concentration IQ0815 0.01950     <NA> ug/mL 0.001  <NA>  0
## 222        0 Plasma concentration IQ0815 0.00940     <NA> ug/mL 0.001  <NA>  0
## 223        0 Plasma concentration IQ0815 0.00528     <NA> ug/mL 0.001  <NA>  0
## 224        0 Plasma concentration IQ0815 0.00482     <NA> ug/mL 0.001  <NA>  0
## 225        0 Plasma concentration IQ0815 0.00229     <NA> ug/mL 0.001  <NA>  0
## 226        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 227        0 Plasma concentration IQ0815 0.01730     <NA> ug/mL 0.001  <NA>  0
## 228        0 Plasma concentration IQ0815 0.04370     <NA> ug/mL 0.001  <NA>  0
## 229        0 Plasma concentration IQ0815 0.07930     <NA> ug/mL 0.001  <NA>  0
## 230        0 Plasma concentration IQ0815 0.08940     <NA> ug/mL 0.001  <NA>  0
## 231        0 Plasma concentration IQ0815 0.09610     <NA> ug/mL 0.001  <NA>  0
## 232        0 Plasma concentration IQ0815 0.07590     <NA> ug/mL 0.001  <NA>  0
## 233        0 Plasma concentration IQ0815 0.01350     <NA> ug/mL 0.001  <NA>  0
## 234        0 Plasma concentration IQ0815 0.00340     <NA> ug/mL 0.001  <NA>  0
## 235        0 Plasma concentration IQ0815 0.00208     <NA> ug/mL 0.001  <NA>  0
## 236        0 Plasma concentration IQ0815 0.00112     <NA> ug/mL 0.001  <NA>  0
## 237        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 238        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 239        0 Plasma concentration IQ0815 0.03800     <NA> ug/mL 0.001  <NA>  0
## 240        0 Plasma concentration IQ0815 0.11800     <NA> ug/mL 0.001  <NA>  0
## 241        0 Plasma concentration IQ0815 0.15600     <NA> ug/mL 0.001  <NA>  0
## 242        0 Plasma concentration IQ0815 0.26800     <NA> ug/mL 0.001  <NA>  0
## 243        0 Plasma concentration IQ0815 0.22600     <NA> ug/mL 0.001  <NA>  0
## 244        0 Plasma concentration IQ0815 0.18700     <NA> ug/mL 0.001  <NA>  0
## 245        0 Plasma concentration IQ0815 0.07220     <NA> ug/mL 0.001  <NA>  0
## 246        0 Plasma concentration IQ0815 0.01980     <NA> ug/mL 0.001  <NA>  0
## 247        0 Plasma concentration IQ0815 0.00557     <NA> ug/mL 0.001  <NA>  0
## 248        0 Plasma concentration IQ0815 0.00625     <NA> ug/mL 0.001  <NA>  0
## 249        0 Plasma concentration IQ0815 0.00489     <NA> ug/mL 0.001  <NA>  0
## 250        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 251        0 Plasma concentration IQ0815 0.05450     <NA> ug/mL 0.001  <NA>  0
## 252        0 Plasma concentration IQ0815 0.17100     <NA> ug/mL 0.001  <NA>  0
## 253        0 Plasma concentration IQ0815 0.25400     <NA> ug/mL 0.001  <NA>  0
## 254        0 Plasma concentration IQ0815 0.25600     <NA> ug/mL 0.001  <NA>  0
## 255        0 Plasma concentration IQ0815 0.25300     <NA> ug/mL 0.001  <NA>  0
## 256        0 Plasma concentration IQ0815 0.20200     <NA> ug/mL 0.001  <NA>  0
## 257        0 Plasma concentration IQ0815 0.09480     <NA> ug/mL 0.001  <NA>  0
## 258        0 Plasma concentration IQ0815 0.02510     <NA> ug/mL 0.001  <NA>  0
## 259        0 Plasma concentration IQ0815 0.00726     <NA> ug/mL 0.001  <NA>  0
## 260        0 Plasma concentration IQ0815 0.00550     <NA> ug/mL 0.001  <NA>  0
## 261        0 Plasma concentration IQ0815 0.00584     <NA> ug/mL 0.001  <NA>  0
## 262        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 263        0 Plasma concentration IQ0815 0.08550     <NA> ug/mL 0.001  <NA>  0
## 264        0 Plasma concentration IQ0815 0.18200     <NA> ug/mL 0.001  <NA>  0
## 265        0 Plasma concentration IQ0815 0.32300     <NA> ug/mL 0.001  <NA>  0
## 266        0 Plasma concentration IQ0815 0.43400     <NA> ug/mL 0.001  <NA>  0
## 267        0 Plasma concentration IQ0815 0.41700     <NA> ug/mL 0.001  <NA>  0
## 268        0 Plasma concentration IQ0815 0.23200     <NA> ug/mL 0.001  <NA>  0
## 269        0 Plasma concentration IQ0815 0.03960     <NA> ug/mL 0.001  <NA>  0
## 270        0 Plasma concentration IQ0815 0.00877     <NA> ug/mL 0.001  <NA>  0
## 271        0 Plasma concentration IQ0815 0.00778     <NA> ug/mL 0.001  <NA>  0
## 272        0 Plasma concentration IQ0815 0.00419     <NA> ug/mL 0.001  <NA>  0
## 273        0 Plasma concentration IQ0815 0.00410     <NA> ug/mL 0.001  <NA>  0
## 274        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 275        0 Plasma concentration IQ0815 0.18300     <NA> ug/mL 0.001  <NA>  0
## 276        0 Plasma concentration IQ0815 0.50000     <NA> ug/mL 0.001  <NA>  0
## 277        0 Plasma concentration IQ0815 0.70600     <NA> ug/mL 0.001  <NA>  0
## 278        0 Plasma concentration IQ0815 0.98400     <NA> ug/mL 0.001  <NA>  0
## 279        0 Plasma concentration IQ0815 0.83000     <NA> ug/mL 0.001  <NA>  0
## 280        0 Plasma concentration IQ0815 0.59300     <NA> ug/mL 0.001  <NA>  0
## 281        0 Plasma concentration IQ0815 0.19600     <NA> ug/mL 0.001  <NA>  0
## 282        0 Plasma concentration IQ0815 0.05670     <NA> ug/mL 0.001  <NA>  0
## 283        0 Plasma concentration IQ0815 0.01880     <NA> ug/mL 0.001  <NA>  0
## 284        0 Plasma concentration IQ0815 0.01930     <NA> ug/mL 0.001  <NA>  0
## 285        0 Plasma concentration IQ0815 0.01510     <NA> ug/mL 0.001  <NA>  0
##     ADDL ID  TIMEPOS EVID MDV CENS AMT      DV TINF RATE ADM YTYPE      TAD
## 1      0  3 167.5833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 2      0  3 167.7493    0   0    1   0 0.00100    0    0   0     1   0.0830
## 3      0  3 167.9163    0   0    0   0 0.00153    0    0   0     1   0.2500
## 4      0  3 168.1663    0   0    0   0 0.00350    0    0   0     1   0.5000
## 5      0  3 168.6663    0   0    0   0 0.00380    0    0   0     1   1.0000
## 6      0  3 169.6663    0   0    0   0 0.00333    0    0   0     1   2.0000
## 7      0  3 171.6663    0   0    0   0 0.00291    0    0   0     1   4.0000
## 8      0  3 179.6663    0   0    1   0 0.00100    0    0   0     1  12.0000
## 9      0  3 191.6663    0   0    1   0 0.00100    0    0   0     1  24.0000
## 10     0  3 215.6663    0   0    1   0 0.00100    0    0   0     1  48.0000
## 11     0  3 263.6663    0   0    1   0 0.00100    0    0   0     1  96.0000
## 12     0  3 335.6663    0   0    1   0 0.00100    0    0   0     1 168.0000
## 13     0  4 168.0000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 14     0  4 168.1660    0   0    0   0 0.00138    0    0   0     1   0.0830
## 15     0  4 168.3330    0   0    0   0 0.00212    0    0   0     1   0.2500
## 16     0  4 168.5830    0   0    0   0 0.00359    0    0   0     1   0.5000
## 17     0  4 169.0830    0   0    0   0 0.00542    0    0   0     1   1.0000
## 18     0  4 170.0830    0   0    0   0 0.00526    0    0   0     1   2.0000
## 19     0  4 172.0830    0   0    0   0 0.00391    0    0   0     1   4.0000
## 20     0  4 180.0830    0   0    1   0 0.00100    0    0   0     1  12.0000
## 21     0  4 192.0830    0   0    1   0 0.00100    0    0   0     1  24.0000
## 22     0  4 216.0830    0   0    1   0 0.00100    0    0   0     1  48.0000
## 23     0  4 264.0830    0   0    1   0 0.00100    0    0   0     1  96.0000
## 24     0  4 336.0830    0   0    1   0 0.00100    0    0   0     1 168.0000
## 25     0  5 168.0500    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 26     0  5 168.2160    0   0    1   0 0.00100    0    0   0     1   0.0830
## 27     0  5 168.3830    0   0    0   0 0.00168    0    0   0     1   0.2500
## 28     0  5 168.3831    0   0    0   0 0.00168    0    0   0     1   0.2501
## 29     0  5 169.1330    0   0    0   0 0.00221    0    0   0     1   1.0000
## 30     0  5 170.1330    0   0    0   0 0.00307    0    0   0     1   2.0000
## 31     0  5 172.1330    0   0    0   0 0.00133    0    0   0     1   4.0000
## 32     0  5 192.1330    0   0    1   0 0.00100    0    0   0     1  24.0000
## 33     0  5 216.1330    0   0    1   0 0.00100    0    0   0     1  48.0000
## 34     0  5 264.1330    0   0    1   0 0.00100    0    0   0     1  96.0000
## 35     0  5 336.1330    0   0    1   0 0.00100    0    0   0     1 168.0000
## 36     0  7 167.9333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 37     0  7 168.0993    0   0    0   0 0.00174    0    0   0     1   0.0830
## 38     0  7 168.2663    0   0    0   0 0.00299    0    0   0     1   0.2500
## 39     0  7 168.5163    0   0    0   0 0.00555    0    0   0     1   0.5000
## 40     0  7 169.0163    0   0    0   0 0.00780    0    0   0     1   1.0000
## 41     0  7 170.0163    0   0    0   0 0.00706    0    0   0     1   2.0000
## 42     0  7 172.0163    0   0    0   0 0.00526    0    0   0     1   4.0000
## 43     0  7 180.0163    0   0    1   0 0.00100    0    0   0     1  12.0000
## 44     0  7 192.0163    0   0    1   0 0.00100    0    0   0     1  24.0000
## 45     0  7 264.0163    0   0    1   0 0.00100    0    0   0     1  96.0000
## 46     0  7 336.0163    0   0    1   0 0.00100    0    0   0     1 168.0000
## 47     0  9 167.9833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 48     0  9 168.1493    0   0    0   0 0.00123    0    0   0     1   0.0830
## 49     0  9 168.3163    0   0    0   0 0.00238    0    0   0     1   0.2500
## 50     0  9 168.5663    0   0    0   0 0.00480    0    0   0     1   0.5000
## 51     0  9 169.0663    0   0    0   0 0.00672    0    0   0     1   1.0000
## 52     0  9 170.0663    0   0    0   0 0.00509    0    0   0     1   2.0000
## 53     0  9 172.0663    0   0    0   0 0.00396    0    0   0     1   4.0000
## 54     0  9 180.0663    0   0    0   0 0.00160    0    0   0     1  12.0000
## 55     0  9 192.0663    0   0    1   0 0.00100    0    0   0     1  24.0000
## 56     0  9 216.0663    0   0    1   0 0.00100    0    0   0     1  48.0000
## 57     0  9 264.0663    0   0    1   0 0.00100    0    0   0     1  96.0000
## 58     0  9 336.0663    0   0    1   0 0.00100    0    0   0     1 168.0000
## 59     0 12 168.7000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 60     0 12 168.8660    0   0    1   0 0.00100    0    0   0     1   0.0830
## 61     0 12 169.0330    0   0    0   0 0.00380    0    0   0     1   0.2500
## 62     0 12 169.2830    0   0    0   0 0.00510    0    0   0     1   0.5000
## 63     0 12 169.7830    0   0    0   0 0.00396    0    0   0     1   1.0000
## 64     0 12 170.7830    0   0    0   0 0.00596    0    0   0     1   2.0000
## 65     0 12 172.7830    0   0    0   0 0.00445    0    0   0     1   4.0000
## 66     0 12 180.7830    0   0    1   0 0.00100    0    0   0     1  12.0000
## 67     0 12 192.7830    0   0    1   0 0.00100    0    0   0     1  24.0000
## 68     0 12 216.7830    0   0    1   0 0.00100    0    0   0     1  48.0000
## 69     0 12 264.7830    0   0    1   0 0.00100    0    0   0     1  96.0000
## 70     0 12 336.7830    0   0    1   0 0.00100    0    0   0     1 168.0000
## 71     0 15 168.3167    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 72     0 15 168.4827    0   0    0   0 0.00174    0    0   0     1   0.0830
## 73     0 15 168.6497    0   0    0   0 0.00432    0    0   0     1   0.2500
## 74     0 15 168.8997    0   0    0   0 0.00766    0    0   0     1   0.5000
## 75     0 15 169.3997    0   0    0   0 0.01030    0    0   0     1   1.0000
## 76     0 15 170.3997    0   0    0   0 0.00802    0    0   0     1   2.0000
## 77     0 15 172.3997    0   0    0   0 0.00742    0    0   0     1   4.0000
## 78     0 15 180.3997    0   0    0   0 0.00300    0    0   0     1  12.0000
## 79     0 15 192.3997    0   0    1   0 0.00100    0    0   0     1  24.0000
## 80     0 15 216.3997    0   0    1   0 0.00100    0    0   0     1  48.0000
## 81     0 15 264.3997    0   0    1   0 0.00100    0    0   0     1  96.0000
## 82     0 15 336.3997    0   0    1   0 0.00100    0    0   0     1 168.0000
## 83     0 16 167.2833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 84     0 16 167.4493    0   0    0   0 0.00370    0    0   0     1   0.0830
## 85     0 16 167.6163    0   0    0   0 0.00826    0    0   0     1   0.2500
## 86     0 16 167.8663    0   0    0   0 0.01440    0    0   0     1   0.5000
## 87     0 16 168.3663    0   0    0   0 0.01460    0    0   0     1   1.0000
## 88     0 16 169.3663    0   0    0   0 0.01770    0    0   0     1   2.0000
## 89     0 16 171.3663    0   0    0   0 0.00857    0    0   0     1   4.0000
## 90     0 16 179.3663    0   0    0   0 0.00199    0    0   0     1  12.0000
## 91     0 16 191.3663    0   0    1   0 0.00100    0    0   0     1  24.0000
## 92     0 16 215.3663    0   0    1   0 0.00100    0    0   0     1  48.0000
## 93     0 16 263.3663    0   0    1   0 0.00100    0    0   0     1  96.0000
## 94     0 16 335.3663    0   0    0   0 0.00101    0    0   0     1 168.0000
## 95     0 17 168.6667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 96     0 17 168.8327    0   0    0   0 0.00386    0    0   0     1   0.0830
## 97     0 17 168.9997    0   0    0   0 0.00888    0    0   0     1   0.2500
## 98     0 17 169.2497    0   0    0   0 0.01700    0    0   0     1   0.5000
## 99     0 17 169.7497    0   0    0   0 0.01830    0    0   0     1   1.0000
## 100    0 17 170.7497    0   0    0   0 0.01980    0    0   0     1   2.0000
## 101    0 17 172.7497    0   0    0   0 0.00950    0    0   0     1   4.0000
## 102    0 17 180.7497    0   0    0   0 0.00334    0    0   0     1  12.0000
## 103    0 17 192.7497    0   0    1   0 0.00100    0    0   0     1  24.0000
## 104    0 17 216.7497    0   0    1   0 0.00100    0    0   0     1  48.0000
## 105    0 17 264.7497    0   0    1   0 0.00100    0    0   0     1  96.0000
## 106    0 17 336.7497    0   0    1   0 0.00100    0    0   0     1 168.0000
## 107    0 19 169.0833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 108    0 19 169.2493    0   0    0   0 0.00689    0    0   0     1   0.0830
## 109    0 19 169.4163    0   0    0   0 0.01530    0    0   0     1   0.2500
## 110    0 19 169.6663    0   0    0   0 0.02390    0    0   0     1   0.5000
## 111    0 19 170.1663    0   0    0   0 0.04110    0    0   0     1   1.0000
## 112    0 19 171.1663    0   0    0   0 0.03820    0    0   0     1   2.0000
## 113    0 19 173.1663    0   0    0   0 0.02730    0    0   0     1   4.0000
## 114    0 19 181.1663    0   0    0   0 0.00528    0    0   0     1  12.0000
## 115    0 19 193.1663    0   0    0   0 0.00198    0    0   0     1  24.0000
## 116    0 19 217.1663    0   0    1   0 0.00100    0    0   0     1  48.0000
## 117    0 19 265.1663    0   0    1   0 0.00100    0    0   0     1  96.0000
## 118    0 19 337.1663    0   0    1   0 0.00100    0    0   0     1 168.0000
## 119    0 20 168.3667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 120    0 20 168.5327    0   0    0   0 0.00515    0    0   0     1   0.0830
## 121    0 20 168.6997    0   0    0   0 0.01130    0    0   0     1   0.2500
## 122    0 20 168.9497    0   0    0   0 0.01910    0    0   0     1   0.5000
## 123    0 20 169.4497    0   0    0   0 0.03580    0    0   0     1   1.0000
## 124    0 20 170.4497    0   0    0   0 0.02670    0    0   0     1   2.0000
## 125    0 20 172.4497    0   0    0   0 0.01850    0    0   0     1   4.0000
## 126    0 20 180.4497    0   0    0   0 0.00755    0    0   0     1  12.0000
## 127    0 20 192.4497    0   0    0   0 0.00219    0    0   0     1  24.0000
## 128    0 20 264.4497    0   0    1   0 0.00100    0    0   0     1  96.0000
## 129    0 20 336.4497    0   0    0   0 0.00101    0    0   0     1 168.0000
## 130    0 22 167.4500    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 131    0 22 167.6160    0   0    0   0 0.00241    0    0   0     1   0.0830
## 132    0 22 167.7830    0   0    0   0 0.01060    0    0   0     1   0.2500
## 133    0 22 168.0330    0   0    0   0 0.01630    0    0   0     1   0.5000
## 134    0 22 168.5330    0   0    0   0 0.02530    0    0   0     1   1.0000
## 135    0 22 169.5330    0   0    0   0 0.20500    0    0   0     1   2.0000
## 136    0 22 171.5330    0   0    0   0 0.01860    0    0   0     1   4.0000
## 137    0 22 179.5330    0   0    0   0 0.00534    0    0   0     1  12.0000
## 138    0 22 191.5330    0   0    0   0 0.00213    0    0   0     1  24.0000
## 139    0 22 215.5330    0   0    1   0 0.00100    0    0   0     1  48.0000
## 140    0 22 263.5330    0   0    1   0 0.00100    0    0   0     1  96.0000
## 141    0 22 335.5330    0   0    1   0 0.00100    0    0   0     1 168.0000
## 142    0 23 167.7667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 143    0 23 167.9327    0   0    0   0 0.00905    0    0   0     1   0.0830
## 144    0 23 168.0997    0   0    0   0 0.02640    0    0   0     1   0.2500
## 145    0 23 168.3497    0   0    0   0 0.03400    0    0   0     1   0.5000
## 146    0 23 168.8497    0   0    0   0 0.04700    0    0   0     1   1.0000
## 147    0 23 169.8497    0   0    0   0 0.03710    0    0   0     1   2.0000
## 148    0 23 171.8497    0   0    0   0 0.02450    0    0   0     1   4.0000
## 149    0 23 179.8497    0   0    0   0 0.00779    0    0   0     1  12.0000
## 150    0 23 191.8497    0   0    0   0 0.00116    0    0   0     1  24.0000
## 151    0 23 215.8497    0   0    1   0 0.00100    0    0   0     1  48.0000
## 152    0 23 263.8497    0   0    1   0 0.00100    0    0   0     1  96.0000
## 153    0 23 335.8497    0   0    1   0 0.00100    0    0   0     1 168.0000
## 154    0 24 168.1333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 155    0 24 168.2993    0   0    0   0 0.00433    0    0   0     1   0.0830
## 156    0 24 168.4663    0   0    0   0 0.01200    0    0   0     1   0.2500
## 157    0 24 168.7163    0   0    0   0 0.01940    0    0   0     1   0.5000
## 158    0 24 169.2163    0   0    0   0 0.03030    0    0   0     1   1.0000
## 159    0 24 170.2163    0   0    0   0 0.03300    0    0   0     1   2.0000
## 160    0 24 172.2163    0   0    0   0 0.02270    0    0   0     1   4.0000
## 161    0 24 180.2163    0   0    0   0 0.00835    0    0   0     1  12.0000
## 162    0 24 192.2163    0   0    0   0 0.00266    0    0   0     1  24.0000
## 163    0 24 216.2163    0   0    0   0 0.00241    0    0   0     1  48.0000
## 164    0 24 264.2163    0   0    0   0 0.00127    0    0   0     1  96.0000
## 165    0 24 336.2163    0   0    0   0 0.00124    0    0   0     1 168.0000
## 166    0 26 167.4833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 167    0 26 167.6493    0   0    0   0 0.00936    0    0   0     1   0.0830
## 168    0 26 167.8163    0   0    0   0 0.02200    0    0   0     1   0.2500
## 169    0 26 168.0663    0   0    0   0 0.03310    0    0   0     1   0.5000
## 170    0 26 168.5663    0   0    0   0 0.05420    0    0   0     1   1.0000
## 171    0 26 169.5663    0   0    0   0 0.05030    0    0   0     1   2.0000
## 172    0 26 171.5663    0   0    0   0 0.04100    0    0   0     1   4.0000
## 173    0 26 179.5663    0   0    0   0 0.01170    0    0   0     1  12.0000
## 174    0 26 191.5663    0   0    0   0 0.00311    0    0   0     1  24.0000
## 175    0 26 215.5663    0   0    1   0 0.00100    0    0   0     1  48.0000
## 176    0 26 263.5663    0   0    1   0 0.00100    0    0   0     1  96.0000
## 177    0 26 335.5663    0   0    1   0 0.00100    0    0   0     1 168.0000
## 178    0 27 168.8000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 179    0 27 168.9660    0   0    0   0 0.01390    0    0   0     1   0.0830
## 180    0 27 169.1330    0   0    0   0 0.03260    0    0   0     1   0.2500
## 181    0 27 169.3830    0   0    0   0 0.05050    0    0   0     1   0.5000
## 182    0 27 169.8830    0   0    0   0 0.06240    0    0   0     1   1.0000
## 183    0 27 170.8830    0   0    0   0 0.05440    0    0   0     1   2.0000
## 184    0 27 172.8830    0   0    0   0 0.03180    0    0   0     1   4.0000
## 185    0 27 180.8830    0   0    0   0 0.00749    0    0   0     1  12.0000
## 186    0 27 192.8830    0   0    0   0 0.00232    0    0   0     1  24.0000
## 187    0 27 216.8830    0   0    0   0 0.00309    0    0   0     1  48.0000
## 188    0 27 264.8830    0   0    0   0 0.00261    0    0   0     1  96.0000
## 189    0 27 336.8830    0   0    0   0 0.00165    0    0   0     1 168.0000
## 190    0 30 167.6333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 191    0 30 167.7993    0   0    0   0 0.01290    0    0   0     1   0.0830
## 192    0 30 167.9663    0   0    0   0 0.03290    0    0   0     1   0.2500
## 193    0 30 168.2163    0   0    0   0 0.04310    0    0   0     1   0.5000
## 194    0 30 168.7163    0   0    0   0 0.05360    0    0   0     1   1.0000
## 195    0 30 169.7163    0   0    0   0 0.05700    0    0   0     1   2.0000
## 196    0 30 171.7163    0   0    0   0 0.04370    0    0   0     1   4.0000
## 197    0 30 179.7163    0   0    0   0 0.01170    0    0   0     1  12.0000
## 198    0 30 191.7163    0   0    0   0 0.00297    0    0   0     1  24.0000
## 199    0 30 215.7163    0   0    0   0 0.00114    0    0   0     1  48.0000
## 200    0 30 263.7163    0   0    0   0 0.00131    0    0   0     1  96.0000
## 201    0 30 335.7163    0   0    0   0 0.00121    0    0   0     1 168.0000
## 202    0 31 168.0833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 203    0 31 168.2493    0   0    0   0 0.01480    0    0   0     1   0.0830
## 204    0 31 168.4163    0   0    0   0 0.03720    0    0   0     1   0.2500
## 205    0 31 168.6663    0   0    0   0 0.06000    0    0   0     1   0.5000
## 206    0 31 169.1663    0   0    0   0 0.08750    0    0   0     1   1.0000
## 207    0 31 170.1663    0   0    0   0 0.07030    0    0   0     1   2.0000
## 208    0 31 172.1663    0   0    0   0 0.07920    0    0   0     1   4.0000
## 209    0 31 180.1663    0   0    0   0 0.02850    0    0   0     1  12.0000
## 210    0 31 192.1663    0   0    0   0 0.00963    0    0   0     1  24.0000
## 211    0 31 216.1663    0   0    0   0 0.00283    0    0   0     1  48.0000
## 212    0 31 264.1663    0   0    0   0 0.00248    0    0   0     1  96.0000
## 213    0 31 336.1663    0   0    1   0 0.00100    0    0   0     1 168.0000
## 214    0 32 168.1333    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 215    0 32 168.2993    0   0    0   0 0.04720    0    0   0     1   0.0830
## 216    0 32 168.4663    0   0    0   0 0.11400    0    0   0     1   0.2500
## 217    0 32 168.7163    0   0    0   0 0.15200    0    0   0     1   0.5000
## 218    0 32 169.2163    0   0    0   0 0.17300    0    0   0     1   1.0000
## 219    0 32 170.2163    0   0    0   0 0.14500    0    0   0     1   2.0000
## 220    0 32 172.2163    0   0    0   0 0.10100    0    0   0     1   4.0000
## 221    0 32 180.2163    0   0    0   0 0.01950    0    0   0     1  12.0000
## 222    0 32 192.2163    0   0    0   0 0.00940    0    0   0     1  24.0000
## 223    0 32 216.2163    0   0    0   0 0.00528    0    0   0     1  48.0000
## 224    0 32 264.2163    0   0    0   0 0.00482    0    0   0     1  96.0000
## 225    0 32 336.2163    0   0    0   0 0.00229    0    0   0     1 168.0000
## 226    0 34 167.8667    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 227    0 34 168.0327    0   0    0   0 0.01730    0    0   0     1   0.0830
## 228    0 34 168.1997    0   0    0   0 0.04370    0    0   0     1   0.2500
## 229    0 34 168.4497    0   0    0   0 0.07930    0    0   0     1   0.5000
## 230    0 34 168.9497    0   0    0   0 0.08940    0    0   0     1   1.0000
## 231    0 34 169.9497    0   0    0   0 0.09610    0    0   0     1   2.0000
## 232    0 34 171.9497    0   0    0   0 0.07590    0    0   0     1   4.0000
## 233    0 34 179.9497    0   0    0   0 0.01350    0    0   0     1  12.0000
## 234    0 34 191.9497    0   0    0   0 0.00340    0    0   0     1  24.0000
## 235    0 34 215.9497    0   0    0   0 0.00208    0    0   0     1  48.0000
## 236    0 34 263.9497    0   0    0   0 0.00112    0    0   0     1  96.0000
## 237    0 34 335.9497    0   0    1   0 0.00100    0    0   0     1 168.0000
## 238    0 37 167.9000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 239    0 37 168.0660    0   0    0   0 0.03800    0    0   0     1   0.0830
## 240    0 37 168.2330    0   0    0   0 0.11800    0    0   0     1   0.2500
## 241    0 37 168.4830    0   0    0   0 0.15600    0    0   0     1   0.5000
## 242    0 37 168.9830    0   0    0   0 0.26800    0    0   0     1   1.0000
## 243    0 37 169.9830    0   0    0   0 0.22600    0    0   0     1   2.0000
## 244    0 37 171.9830    0   0    0   0 0.18700    0    0   0     1   4.0000
## 245    0 37 179.9830    0   0    0   0 0.07220    0    0   0     1  12.0000
## 246    0 37 191.9830    0   0    0   0 0.01980    0    0   0     1  24.0000
## 247    0 37 215.9830    0   0    0   0 0.00557    0    0   0     1  48.0000
## 248    0 37 263.9830    0   0    0   0 0.00625    0    0   0     1  96.0000
## 249    0 37 335.9830    0   0    0   0 0.00489    0    0   0     1 168.0000
## 250    0 38 167.1833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 251    0 38 167.3493    0   0    0   0 0.05450    0    0   0     1   0.0830
## 252    0 38 167.5163    0   0    0   0 0.17100    0    0   0     1   0.2500
## 253    0 38 167.7663    0   0    0   0 0.25400    0    0   0     1   0.5000
## 254    0 38 168.2663    0   0    0   0 0.25600    0    0   0     1   1.0000
## 255    0 38 169.2663    0   0    0   0 0.25300    0    0   0     1   2.0000
## 256    0 38 171.2663    0   0    0   0 0.20200    0    0   0     1   4.0000
## 257    0 38 179.2663    0   0    0   0 0.09480    0    0   0     1  12.0000
## 258    0 38 191.2663    0   0    0   0 0.02510    0    0   0     1  24.0000
## 259    0 38 215.2663    0   0    0   0 0.00726    0    0   0     1  48.0000
## 260    0 38 263.2663    0   0    0   0 0.00550    0    0   0     1  96.0000
## 261    0 38 335.2663    0   0    0   0 0.00584    0    0   0     1 168.0000
## 262    0 44 168.2833    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 263    0 44 168.4493    0   0    0   0 0.08550    0    0   0     1   0.0830
## 264    0 44 168.6163    0   0    0   0 0.18200    0    0   0     1   0.2500
## 265    0 44 168.8663    0   0    0   0 0.32300    0    0   0     1   0.5000
## 266    0 44 169.3663    0   0    0   0 0.43400    0    0   0     1   1.0000
## 267    0 44 170.3663    0   0    0   0 0.41700    0    0   0     1   2.0000
## 268    0 44 172.3663    0   0    0   0 0.23200    0    0   0     1   4.0000
## 269    0 44 180.3663    0   0    0   0 0.03960    0    0   0     1  12.0000
## 270    0 44 192.3663    0   0    0   0 0.00877    0    0   0     1  24.0000
## 271    0 44 216.3663    0   0    0   0 0.00778    0    0   0     1  48.0000
## 272    0 44 264.3663    0   0    0   0 0.00419    0    0   0     1  96.0000
## 273    0 44 336.3663    0   0    0   0 0.00410    0    0   0     1 168.0000
## 274    0 48 167.6000    0   0    1   0 0.00100    0    0   0     1  -0.0830
## 275    0 48 167.7660    0   0    0   0 0.18300    0    0   0     1   0.0830
## 276    0 48 167.9330    0   0    0   0 0.50000    0    0   0     1   0.2500
## 277    0 48 168.1830    0   0    0   0 0.70600    0    0   0     1   0.5000
## 278    0 48 168.6830    0   0    0   0 0.98400    0    0   0     1   1.0000
## 279    0 48 169.6830    0   0    0   0 0.83000    0    0   0     1   2.0000
## 280    0 48 171.6830    0   0    0   0 0.59300    0    0   0     1   4.0000
## 281    0 48 179.6830    0   0    0   0 0.19600    0    0   0     1  12.0000
## 282    0 48 191.6830    0   0    0   0 0.05670    0    0   0     1  24.0000
## 283    0 48 215.6830    0   0    0   0 0.01880    0    0   0     1  48.0000
## 284    0 48 263.6830    0   0    0   0 0.01930    0    0   0     1  96.0000
## 285    0 48 335.6830    0   0    0   0 0.01510    0    0   0     1 168.0000
##     DOSE WT0 AGE0 HT0 SEX BLOQ           TRTNAMElabel AGE0CAT
## 1      0  80   28 180   1  yes   1mg oral single dose       1
## 2      1  80   28 180   1  yes   1mg oral single dose       1
## 3      1  80   28 180   1   no   1mg oral single dose       1
## 4      1  80   28 180   1   no   1mg oral single dose       1
## 5      1  80   28 180   1   no   1mg oral single dose       1
## 6      1  80   28 180   1   no   1mg oral single dose       1
## 7      1  80   28 180   1   no   1mg oral single dose       1
## 8      1  80   28 180   1  yes   1mg oral single dose       1
## 9      1  80   28 180   1  yes   1mg oral single dose       1
## 10     1  80   28 180   1  yes   1mg oral single dose       1
## 11     1  80   28 180   1  yes   1mg oral single dose       1
## 12     1  80   28 180   1  yes   1mg oral single dose       1
## 13     0  68   25 166   1  yes   1mg oral single dose       1
## 14     1  68   25 166   1   no   1mg oral single dose       1
## 15     1  68   25 166   1   no   1mg oral single dose       1
## 16     1  68   25 166   1   no   1mg oral single dose       1
## 17     1  68   25 166   1   no   1mg oral single dose       1
## 18     1  68   25 166   1   no   1mg oral single dose       1
## 19     1  68   25 166   1   no   1mg oral single dose       1
## 20     1  68   25 166   1  yes   1mg oral single dose       1
## 21     1  68   25 166   1  yes   1mg oral single dose       1
## 22     1  68   25 166   1  yes   1mg oral single dose       1
## 23     1  68   25 166   1  yes   1mg oral single dose       1
## 24     1  68   25 166   1  yes   1mg oral single dose       1
## 25     0  86   29 183   1  yes   1mg oral single dose       1
## 26     1  86   29 183   1  yes   1mg oral single dose       1
## 27     1  86   29 183   1   no   1mg oral single dose       1
## 28     1  86   29 183   1   no   1mg oral single dose       1
## 29     1  86   29 183   1   no   1mg oral single dose       1
## 30     1  86   29 183   1   no   1mg oral single dose       1
## 31     1  86   29 183   1   no   1mg oral single dose       1
## 32     1  86   29 183   1  yes   1mg oral single dose       1
## 33     1  86   29 183   1  yes   1mg oral single dose       1
## 34     1  86   29 183   1  yes   1mg oral single dose       1
## 35     1  86   29 183   1  yes   1mg oral single dose       1
## 36     0  88   28 181   1  yes   2mg oral single dose       1
## 37     2  88   28 181   1   no   2mg oral single dose       1
## 38     2  88   28 181   1   no   2mg oral single dose       1
## 39     2  88   28 181   1   no   2mg oral single dose       1
## 40     2  88   28 181   1   no   2mg oral single dose       1
## 41     2  88   28 181   1   no   2mg oral single dose       1
## 42     2  88   28 181   1   no   2mg oral single dose       1
## 43     2  88   28 181   1  yes   2mg oral single dose       1
## 44     2  88   28 181   1  yes   2mg oral single dose       1
## 45     2  88   28 181   1  yes   2mg oral single dose       1
## 46     2  88   28 181   1  yes   2mg oral single dose       1
## 47     0  79   29 175   1  yes   2mg oral single dose       1
## 48     2  79   29 175   1   no   2mg oral single dose       1
## 49     2  79   29 175   1   no   2mg oral single dose       1
## 50     2  79   29 175   1   no   2mg oral single dose       1
## 51     2  79   29 175   1   no   2mg oral single dose       1
## 52     2  79   29 175   1   no   2mg oral single dose       1
## 53     2  79   29 175   1   no   2mg oral single dose       1
## 54     2  79   29 175   1   no   2mg oral single dose       1
## 55     2  79   29 175   1  yes   2mg oral single dose       1
## 56     2  79   29 175   1  yes   2mg oral single dose       1
## 57     2  79   29 175   1  yes   2mg oral single dose       1
## 58     2  79   29 175   1  yes   2mg oral single dose       1
## 59     0  68   28 178   1  yes   2mg oral single dose       1
## 60     2  68   28 178   1  yes   2mg oral single dose       1
## 61     2  68   28 178   1   no   2mg oral single dose       1
## 62     2  68   28 178   1   no   2mg oral single dose       1
## 63     2  68   28 178   1   no   2mg oral single dose       1
## 64     2  68   28 178   1   no   2mg oral single dose       1
## 65     2  68   28 178   1   no   2mg oral single dose       1
## 66     2  68   28 178   1  yes   2mg oral single dose       1
## 67     2  68   28 178   1  yes   2mg oral single dose       1
## 68     2  68   28 178   1  yes   2mg oral single dose       1
## 69     2  68   28 178   1  yes   2mg oral single dose       1
## 70     2  68   28 178   1  yes   2mg oral single dose       1
## 71     0  65   29 171   1  yes   5mg oral single dose       1
## 72     5  65   29 171   1   no   5mg oral single dose       1
## 73     5  65   29 171   1   no   5mg oral single dose       1
## 74     5  65   29 171   1   no   5mg oral single dose       1
## 75     5  65   29 171   1   no   5mg oral single dose       1
## 76     5  65   29 171   1   no   5mg oral single dose       1
## 77     5  65   29 171   1   no   5mg oral single dose       1
## 78     5  65   29 171   1   no   5mg oral single dose       1
## 79     5  65   29 171   1  yes   5mg oral single dose       1
## 80     5  65   29 171   1  yes   5mg oral single dose       1
## 81     5  65   29 171   1  yes   5mg oral single dose       1
## 82     5  65   29 171   1  yes   5mg oral single dose       1
## 83     0  74   24 174   1  yes   5mg oral single dose       1
## 84     5  74   24 174   1   no   5mg oral single dose       1
## 85     5  74   24 174   1   no   5mg oral single dose       1
## 86     5  74   24 174   1   no   5mg oral single dose       1
## 87     5  74   24 174   1   no   5mg oral single dose       1
## 88     5  74   24 174   1   no   5mg oral single dose       1
## 89     5  74   24 174   1   no   5mg oral single dose       1
## 90     5  74   24 174   1   no   5mg oral single dose       1
## 91     5  74   24 174   1  yes   5mg oral single dose       1
## 92     5  74   24 174   1  yes   5mg oral single dose       1
## 93     5  74   24 174   1  yes   5mg oral single dose       1
## 94     5  74   24 174   1   no   5mg oral single dose       1
## 95     0  90   25 176   1  yes   5mg oral single dose       1
## 96     5  90   25 176   1   no   5mg oral single dose       1
## 97     5  90   25 176   1   no   5mg oral single dose       1
## 98     5  90   25 176   1   no   5mg oral single dose       1
## 99     5  90   25 176   1   no   5mg oral single dose       1
## 100    5  90   25 176   1   no   5mg oral single dose       1
## 101    5  90   25 176   1   no   5mg oral single dose       1
## 102    5  90   25 176   1   no   5mg oral single dose       1
## 103    5  90   25 176   1  yes   5mg oral single dose       1
## 104    5  90   25 176   1  yes   5mg oral single dose       1
## 105    5  90   25 176   1  yes   5mg oral single dose       1
## 106    5  90   25 176   1  yes   5mg oral single dose       1
## 107    0  83   27 178   1  yes  10mg oral single dose       1
## 108   10  83   27 178   1   no  10mg oral single dose       1
## 109   10  83   27 178   1   no  10mg oral single dose       1
## 110   10  83   27 178   1   no  10mg oral single dose       1
## 111   10  83   27 178   1   no  10mg oral single dose       1
## 112   10  83   27 178   1   no  10mg oral single dose       1
## 113   10  83   27 178   1   no  10mg oral single dose       1
## 114   10  83   27 178   1   no  10mg oral single dose       1
## 115   10  83   27 178   1   no  10mg oral single dose       1
## 116   10  83   27 178   1  yes  10mg oral single dose       1
## 117   10  83   27 178   1  yes  10mg oral single dose       1
## 118   10  83   27 178   1  yes  10mg oral single dose       1
## 119    0  77   29 175   1  yes  10mg oral single dose       1
## 120   10  77   29 175   1   no  10mg oral single dose       1
## 121   10  77   29 175   1   no  10mg oral single dose       1
## 122   10  77   29 175   1   no  10mg oral single dose       1
## 123   10  77   29 175   1   no  10mg oral single dose       1
## 124   10  77   29 175   1   no  10mg oral single dose       1
## 125   10  77   29 175   1   no  10mg oral single dose       1
## 126   10  77   29 175   1   no  10mg oral single dose       1
## 127   10  77   29 175   1   no  10mg oral single dose       1
## 128   10  77   29 175   1  yes  10mg oral single dose       1
## 129   10  77   29 175   1   no  10mg oral single dose       1
## 130    0  88   26 183   1  yes  10mg oral single dose       1
## 131   10  88   26 183   1   no  10mg oral single dose       1
## 132   10  88   26 183   1   no  10mg oral single dose       1
## 133   10  88   26 183   1   no  10mg oral single dose       1
## 134   10  88   26 183   1   no  10mg oral single dose       1
## 135   10  88   26 183   1   no  10mg oral single dose       1
## 136   10  88   26 183   1   no  10mg oral single dose       1
## 137   10  88   26 183   1   no  10mg oral single dose       1
## 138   10  88   26 183   1   no  10mg oral single dose       1
## 139   10  88   26 183   1  yes  10mg oral single dose       1
## 140   10  88   26 183   1  yes  10mg oral single dose       1
## 141   10  88   26 183   1  yes  10mg oral single dose       1
## 142    0  85   24 176   1  yes  10mg oral single dose       1
## 143   10  85   24 176   1   no  10mg oral single dose       1
## 144   10  85   24 176   1   no  10mg oral single dose       1
## 145   10  85   24 176   1   no  10mg oral single dose       1
## 146   10  85   24 176   1   no  10mg oral single dose       1
## 147   10  85   24 176   1   no  10mg oral single dose       1
## 148   10  85   24 176   1   no  10mg oral single dose       1
## 149   10  85   24 176   1   no  10mg oral single dose       1
## 150   10  85   24 176   1   no  10mg oral single dose       1
## 151   10  85   24 176   1  yes  10mg oral single dose       1
## 152   10  85   24 176   1  yes  10mg oral single dose       1
## 153   10  85   24 176   1  yes  10mg oral single dose       1
## 154    0  75   18 183   1  yes  10mg oral single dose       1
## 155   10  75   18 183   1   no  10mg oral single dose       1
## 156   10  75   18 183   1   no  10mg oral single dose       1
## 157   10  75   18 183   1   no  10mg oral single dose       1
## 158   10  75   18 183   1   no  10mg oral single dose       1
## 159   10  75   18 183   1   no  10mg oral single dose       1
## 160   10  75   18 183   1   no  10mg oral single dose       1
## 161   10  75   18 183   1   no  10mg oral single dose       1
## 162   10  75   18 183   1   no  10mg oral single dose       1
## 163   10  75   18 183   1   no  10mg oral single dose       1
## 164   10  75   18 183   1   no  10mg oral single dose       1
## 165   10  75   18 183   1   no  10mg oral single dose       1
## 166    0  87   23 179   1  yes  20mg oral single dose       1
## 167   20  87   23 179   1   no  20mg oral single dose       1
## 168   20  87   23 179   1   no  20mg oral single dose       1
## 169   20  87   23 179   1   no  20mg oral single dose       1
## 170   20  87   23 179   1   no  20mg oral single dose       1
## 171   20  87   23 179   1   no  20mg oral single dose       1
## 172   20  87   23 179   1   no  20mg oral single dose       1
## 173   20  87   23 179   1   no  20mg oral single dose       1
## 174   20  87   23 179   1   no  20mg oral single dose       1
## 175   20  87   23 179   1  yes  20mg oral single dose       1
## 176   20  87   23 179   1  yes  20mg oral single dose       1
## 177   20  87   23 179   1  yes  20mg oral single dose       1
## 178    0  68   28 184   1  yes  20mg oral single dose       1
## 179   20  68   28 184   1   no  20mg oral single dose       1
## 180   20  68   28 184   1   no  20mg oral single dose       1
## 181   20  68   28 184   1   no  20mg oral single dose       1
## 182   20  68   28 184   1   no  20mg oral single dose       1
## 183   20  68   28 184   1   no  20mg oral single dose       1
## 184   20  68   28 184   1   no  20mg oral single dose       1
## 185   20  68   28 184   1   no  20mg oral single dose       1
## 186   20  68   28 184   1   no  20mg oral single dose       1
## 187   20  68   28 184   1   no  20mg oral single dose       1
## 188   20  68   28 184   1   no  20mg oral single dose       1
## 189   20  68   28 184   1   no  20mg oral single dose       1
## 190    0  78   27 181   1  yes  20mg oral single dose       1
## 191   20  78   27 181   1   no  20mg oral single dose       1
## 192   20  78   27 181   1   no  20mg oral single dose       1
## 193   20  78   27 181   1   no  20mg oral single dose       1
## 194   20  78   27 181   1   no  20mg oral single dose       1
## 195   20  78   27 181   1   no  20mg oral single dose       1
## 196   20  78   27 181   1   no  20mg oral single dose       1
## 197   20  78   27 181   1   no  20mg oral single dose       1
## 198   20  78   27 181   1   no  20mg oral single dose       1
## 199   20  78   27 181   1   no  20mg oral single dose       1
## 200   20  78   27 181   1   no  20mg oral single dose       1
## 201   20  78   27 181   1   no  20mg oral single dose       1
## 202    0  74   23 176   1  yes  50mg oral single dose       1
## 203   50  74   23 176   1   no  50mg oral single dose       1
## 204   50  74   23 176   1   no  50mg oral single dose       1
## 205   50  74   23 176   1   no  50mg oral single dose       1
## 206   50  74   23 176   1   no  50mg oral single dose       1
## 207   50  74   23 176   1   no  50mg oral single dose       1
## 208   50  74   23 176   1   no  50mg oral single dose       1
## 209   50  74   23 176   1   no  50mg oral single dose       1
## 210   50  74   23 176   1   no  50mg oral single dose       1
## 211   50  74   23 176   1   no  50mg oral single dose       1
## 212   50  74   23 176   1   no  50mg oral single dose       1
## 213   50  74   23 176   1  yes  50mg oral single dose       1
## 214    0  85   29 180   1  yes  50mg oral single dose       1
## 215   50  85   29 180   1   no  50mg oral single dose       1
## 216   50  85   29 180   1   no  50mg oral single dose       1
## 217   50  85   29 180   1   no  50mg oral single dose       1
## 218   50  85   29 180   1   no  50mg oral single dose       1
## 219   50  85   29 180   1   no  50mg oral single dose       1
## 220   50  85   29 180   1   no  50mg oral single dose       1
## 221   50  85   29 180   1   no  50mg oral single dose       1
## 222   50  85   29 180   1   no  50mg oral single dose       1
## 223   50  85   29 180   1   no  50mg oral single dose       1
## 224   50  85   29 180   1   no  50mg oral single dose       1
## 225   50  85   29 180   1   no  50mg oral single dose       1
## 226    0  84   27 181   1  yes  50mg oral single dose       1
## 227   50  84   27 181   1   no  50mg oral single dose       1
## 228   50  84   27 181   1   no  50mg oral single dose       1
## 229   50  84   27 181   1   no  50mg oral single dose       1
## 230   50  84   27 181   1   no  50mg oral single dose       1
## 231   50  84   27 181   1   no  50mg oral single dose       1
## 232   50  84   27 181   1   no  50mg oral single dose       1
## 233   50  84   27 181   1   no  50mg oral single dose       1
## 234   50  84   27 181   1   no  50mg oral single dose       1
## 235   50  84   27 181   1   no  50mg oral single dose       1
## 236   50  84   27 181   1   no  50mg oral single dose       1
## 237   50  84   27 181   1  yes  50mg oral single dose       1
## 238    0  78   22 178   1  yes 100mg oral single dose       1
## 239  100  78   22 178   1   no 100mg oral single dose       1
## 240  100  78   22 178   1   no 100mg oral single dose       1
## 241  100  78   22 178   1   no 100mg oral single dose       1
## 242  100  78   22 178   1   no 100mg oral single dose       1
## 243  100  78   22 178   1   no 100mg oral single dose       1
## 244  100  78   22 178   1   no 100mg oral single dose       1
## 245  100  78   22 178   1   no 100mg oral single dose       1
## 246  100  78   22 178   1   no 100mg oral single dose       1
## 247  100  78   22 178   1   no 100mg oral single dose       1
## 248  100  78   22 178   1   no 100mg oral single dose       1
## 249  100  78   22 178   1   no 100mg oral single dose       1
## 250    0  80   21 184   1  yes 100mg oral single dose       1
## 251  100  80   21 184   1   no 100mg oral single dose       1
## 252  100  80   21 184   1   no 100mg oral single dose       1
## 253  100  80   21 184   1   no 100mg oral single dose       1
## 254  100  80   21 184   1   no 100mg oral single dose       1
## 255  100  80   21 184   1   no 100mg oral single dose       1
## 256  100  80   21 184   1   no 100mg oral single dose       1
## 257  100  80   21 184   1   no 100mg oral single dose       1
## 258  100  80   21 184   1   no 100mg oral single dose       1
## 259  100  80   21 184   1   no 100mg oral single dose       1
## 260  100  80   21 184   1   no 100mg oral single dose       1
## 261  100  80   21 184   1   no 100mg oral single dose       1
## 262    0  78   28 183   1  yes 200mg oral single dose       1
## 263  200  78   28 183   1   no 200mg oral single dose       1
## 264  200  78   28 183   1   no 200mg oral single dose       1
## 265  200  78   28 183   1   no 200mg oral single dose       1
## 266  200  78   28 183   1   no 200mg oral single dose       1
## 267  200  78   28 183   1   no 200mg oral single dose       1
## 268  200  78   28 183   1   no 200mg oral single dose       1
## 269  200  78   28 183   1   no 200mg oral single dose       1
## 270  200  78   28 183   1   no 200mg oral single dose       1
## 271  200  78   28 183   1   no 200mg oral single dose       1
## 272  200  78   28 183   1   no 200mg oral single dose       1
## 273  200  78   28 183   1   no 200mg oral single dose       1
## 274    0  77   22 176   1  yes 200mg oral single dose       1
## 275  200  77   22 176   1   no 200mg oral single dose       1
## 276  200  77   22 176   1   no 200mg oral single dose       1
## 277  200  77   22 176   1   no 200mg oral single dose       1
## 278  200  77   22 176   1   no 200mg oral single dose       1
## 279  200  77   22 176   1   no 200mg oral single dose       1
## 280  200  77   22 176   1   no 200mg oral single dose       1
## 281  200  77   22 176   1   no 200mg oral single dose       1
## 282  200  77   22 176   1   no 200mg oral single dose       1
## 283  200  77   22 176   1   no 200mg oral single dose       1
## 284  200  77   22 176   1   no 200mg oral single dose       1
## 285  200  77   22 176   1   no 200mg oral single dose       1
## 
## attr(,"data")$stratified$`Plasma concentration IQ0815_2`
##     IXGDF IGNORE           USUBJID CENTER         STUDY STUDYN
## 1      71   <NA> IQ00701-0100-0006    100           FIH      1
## 2      73   <NA> IQ00701-0100-0006    100           FIH      1
## 3      74   <NA> IQ00701-0100-0006    100           FIH      1
## 4      75   <NA> IQ00701-0100-0006    100           FIH      1
## 5      76   <NA> IQ00701-0100-0006    100           FIH      1
## 6      77   <NA> IQ00701-0100-0006    100           FIH      1
## 7      78   <NA> IQ00701-0100-0006    100           FIH      1
## 8      79   <NA> IQ00701-0100-0006    100           FIH      1
## 9      80   <NA> IQ00701-0100-0006    100           FIH      1
## 10     81   <NA> IQ00701-0100-0006    100           FIH      1
## 11     82   <NA> IQ00701-0100-0006    100           FIH      1
## 12     83   <NA> IQ00701-0100-0006    100           FIH      1
## 13    123   <NA> IQ00701-0100-0010    100           FIH      1
## 14    125   <NA> IQ00701-0100-0010    100           FIH      1
## 15    126   <NA> IQ00701-0100-0010    100           FIH      1
## 16    127   <NA> IQ00701-0100-0010    100           FIH      1
## 17    128   <NA> IQ00701-0100-0010    100           FIH      1
## 18    129   <NA> IQ00701-0100-0010    100           FIH      1
## 19    130   <NA> IQ00701-0100-0010    100           FIH      1
## 20    131   <NA> IQ00701-0100-0010    100           FIH      1
## 21    132   <NA> IQ00701-0100-0010    100           FIH      1
## 22    133   <NA> IQ00701-0100-0010    100           FIH      1
## 23    134   <NA> IQ00701-0100-0010    100           FIH      1
## 24    135   <NA> IQ00701-0100-0010    100           FIH      1
## 25    139   <NA> IQ00701-0100-0011    100           FIH      1
## 26    141   <NA> IQ00701-0100-0011    100           FIH      1
## 27    142   <NA> IQ00701-0100-0011    100           FIH      1
## 28    143   <NA> IQ00701-0100-0011    100           FIH      1
## 29    144   <NA> IQ00701-0100-0011    100           FIH      1
## 30    145   <NA> IQ00701-0100-0011    100           FIH      1
## 31    146   <NA> IQ00701-0100-0011    100           FIH      1
## 32    147   <NA> IQ00701-0100-0011    100           FIH      1
## 33    148   <NA> IQ00701-0100-0011    100           FIH      1
## 34    149   <NA> IQ00701-0100-0011    100           FIH      1
## 35    150   <NA> IQ00701-0100-0011    100           FIH      1
## 36    151   <NA> IQ00701-0100-0011    100           FIH      1
## 37    172   <NA> IQ00701-0100-0013    100           FIH      1
## 38    174   <NA> IQ00701-0100-0013    100           FIH      1
## 39    175   <NA> IQ00701-0100-0013    100           FIH      1
## 40    176   <NA> IQ00701-0100-0013    100           FIH      1
## 41    177   <NA> IQ00701-0100-0013    100           FIH      1
## 42    178   <NA> IQ00701-0100-0013    100           FIH      1
## 43    179   <NA> IQ00701-0100-0013    100           FIH      1
## 44    180   <NA> IQ00701-0100-0013    100           FIH      1
## 45    181   <NA> IQ00701-0100-0013    100           FIH      1
## 46    182   <NA> IQ00701-0100-0013    100           FIH      1
## 47    183   <NA> IQ00701-0100-0013    100           FIH      1
## 48    184   <NA> IQ00701-0100-0013    100           FIH      1
## 49    189   <NA> IQ00701-0100-0014    100           FIH      1
## 50    191   <NA> IQ00701-0100-0014    100           FIH      1
## 51    192   <NA> IQ00701-0100-0014    100           FIH      1
## 52    193   <NA> IQ00701-0100-0014    100           FIH      1
## 53    194   <NA> IQ00701-0100-0014    100           FIH      1
## 54    195   <NA> IQ00701-0100-0014    100           FIH      1
## 55    196   <NA> IQ00701-0100-0014    100           FIH      1
## 56    197   <NA> IQ00701-0100-0014    100           FIH      1
## 57    198   <NA> IQ00701-0100-0014    100           FIH      1
## 58    199   <NA> IQ00701-0100-0014    100           FIH      1
## 59    200   <NA> IQ00701-0100-0014    100           FIH      1
## 60    201   <NA> IQ00701-0100-0014    100           FIH      1
## 61    308   <NA> IQ00701-0100-0021    100           FIH      1
## 62    310   <NA> IQ00701-0100-0021    100           FIH      1
## 63    311   <NA> IQ00701-0100-0021    100           FIH      1
## 64    312   <NA> IQ00701-0100-0021    100           FIH      1
## 65    313   <NA> IQ00701-0100-0021    100           FIH      1
## 66    314   <NA> IQ00701-0100-0021    100           FIH      1
## 67    315   <NA> IQ00701-0100-0021    100           FIH      1
## 68    316   <NA> IQ00701-0100-0021    100           FIH      1
## 69    317   <NA> IQ00701-0100-0021    100           FIH      1
## 70    318   <NA> IQ00701-0100-0021    100           FIH      1
## 71    319   <NA> IQ00701-0100-0021    100           FIH      1
## 72    320   <NA> IQ00701-0100-0021    100           FIH      1
## 73    376   <NA> IQ00701-0100-0025    100           FIH      1
## 74    378   <NA> IQ00701-0100-0025    100           FIH      1
## 75    379   <NA> IQ00701-0100-0025    100           FIH      1
## 76    380   <NA> IQ00701-0100-0025    100           FIH      1
## 77    381   <NA> IQ00701-0100-0025    100           FIH      1
## 78    382   <NA> IQ00701-0100-0025    100           FIH      1
## 79    383   <NA> IQ00701-0100-0025    100           FIH      1
## 80    384   <NA> IQ00701-0100-0025    100           FIH      1
## 81    385   <NA> IQ00701-0100-0025    100           FIH      1
## 82    386   <NA> IQ00701-0100-0025    100           FIH      1
## 83    387   <NA> IQ00701-0100-0025    100           FIH      1
## 84    388   <NA> IQ00701-0100-0025    100           FIH      1
## 85    427   <NA> IQ00701-0100-0028    100           FIH      1
## 86    429   <NA> IQ00701-0100-0028    100           FIH      1
## 87    430   <NA> IQ00701-0100-0028    100           FIH      1
## 88    431   <NA> IQ00701-0100-0028    100           FIH      1
## 89    432   <NA> IQ00701-0100-0028    100           FIH      1
## 90    433   <NA> IQ00701-0100-0028    100           FIH      1
## 91    434   <NA> IQ00701-0100-0028    100           FIH      1
## 92    435   <NA> IQ00701-0100-0028    100           FIH      1
## 93    436   <NA> IQ00701-0100-0028    100           FIH      1
## 94    437   <NA> IQ00701-0100-0028    100           FIH      1
## 95    438   <NA> IQ00701-0100-0028    100           FIH      1
## 96    439   <NA> IQ00701-0100-0028    100           FIH      1
## 97    444   <NA> IQ00701-0100-0029    100           FIH      1
## 98    446   <NA> IQ00701-0100-0029    100           FIH      1
## 99    447   <NA> IQ00701-0100-0029    100           FIH      1
## 100   448   <NA> IQ00701-0100-0029    100           FIH      1
## 101   449   <NA> IQ00701-0100-0029    100           FIH      1
## 102   450   <NA> IQ00701-0100-0029    100           FIH      1
## 103   451   <NA> IQ00701-0100-0029    100           FIH      1
## 104   452   <NA> IQ00701-0100-0029    100           FIH      1
## 105   453   <NA> IQ00701-0100-0029    100           FIH      1
## 106   454   <NA> IQ00701-0100-0029    100           FIH      1
## 107   455   <NA> IQ00701-0100-0029    100           FIH      1
## 108   456   <NA> IQ00701-0100-0029    100           FIH      1
## 109   512   <NA> IQ00701-0100-0033    100           FIH      1
## 110   514   <NA> IQ00701-0100-0033    100           FIH      1
## 111   515   <NA> IQ00701-0100-0033    100           FIH      1
## 112   516   <NA> IQ00701-0100-0033    100           FIH      1
## 113   517   <NA> IQ00701-0100-0033    100           FIH      1
## 114   518   <NA> IQ00701-0100-0033    100           FIH      1
## 115   519   <NA> IQ00701-0100-0033    100           FIH      1
## 116   520   <NA> IQ00701-0100-0033    100           FIH      1
## 117   521   <NA> IQ00701-0100-0033    100           FIH      1
## 118   522   <NA> IQ00701-0100-0033    100           FIH      1
## 119   523   <NA> IQ00701-0100-0033    100           FIH      1
## 120   524   <NA> IQ00701-0100-0033    100           FIH      1
## 121   546   <NA> IQ00701-0100-0035    100           FIH      1
## 122   548   <NA> IQ00701-0100-0035    100           FIH      1
## 123   549   <NA> IQ00701-0100-0035    100           FIH      1
## 124   550   <NA> IQ00701-0100-0035    100           FIH      1
## 125   551   <NA> IQ00701-0100-0035    100           FIH      1
## 126   552   <NA> IQ00701-0100-0035    100           FIH      1
## 127   553   <NA> IQ00701-0100-0035    100           FIH      1
## 128   554   <NA> IQ00701-0100-0035    100           FIH      1
## 129   555   <NA> IQ00701-0100-0035    100           FIH      1
## 130   556   <NA> IQ00701-0100-0035    100           FIH      1
## 131   557   <NA> IQ00701-0100-0035    100           FIH      1
## 132   558   <NA> IQ00701-0100-0035    100           FIH      1
## 133   563   <NA> IQ00701-0100-0036    100           FIH      1
## 134   565   <NA> IQ00701-0100-0036    100           FIH      1
## 135   566   <NA> IQ00701-0100-0036    100           FIH      1
## 136   567   <NA> IQ00701-0100-0036    100           FIH      1
## 137   568   <NA> IQ00701-0100-0036    100           FIH      1
## 138   569   <NA> IQ00701-0100-0036    100           FIH      1
## 139   570   <NA> IQ00701-0100-0036    100           FIH      1
## 140   571   <NA> IQ00701-0100-0036    100           FIH      1
## 141   572   <NA> IQ00701-0100-0036    100           FIH      1
## 142   573   <NA> IQ00701-0100-0036    100           FIH      1
## 143   574   <NA> IQ00701-0100-0036    100           FIH      1
## 144   575   <NA> IQ00701-0100-0036    100           FIH      1
## 145   614   <NA> IQ00701-0100-0039    100 FIH extension      2
## 146   616   <NA> IQ00701-0100-0039    100 FIH extension      2
## 147   617   <NA> IQ00701-0100-0039    100 FIH extension      2
## 148   618   <NA> IQ00701-0100-0039    100 FIH extension      2
## 149   619   <NA> IQ00701-0100-0039    100 FIH extension      2
## 150   620   <NA> IQ00701-0100-0039    100 FIH extension      2
## 151   621   <NA> IQ00701-0100-0039    100 FIH extension      2
## 152   622   <NA> IQ00701-0100-0039    100 FIH extension      2
## 153   623   <NA> IQ00701-0100-0039    100 FIH extension      2
## 154   624   <NA> IQ00701-0100-0039    100 FIH extension      2
## 155   625   <NA> IQ00701-0100-0039    100 FIH extension      2
## 156   626   <NA> IQ00701-0100-0039    100 FIH extension      2
## 157   631   <NA> IQ00701-0100-0040    100 FIH extension      2
## 158   633   <NA> IQ00701-0100-0040    100 FIH extension      2
## 159   634   <NA> IQ00701-0100-0040    100 FIH extension      2
## 160   635   <NA> IQ00701-0100-0040    100 FIH extension      2
## 161   636   <NA> IQ00701-0100-0040    100 FIH extension      2
## 162   637   <NA> IQ00701-0100-0040    100 FIH extension      2
## 163   638   <NA> IQ00701-0100-0040    100 FIH extension      2
## 164   639   <NA> IQ00701-0100-0040    100 FIH extension      2
## 165   640   <NA> IQ00701-0100-0040    100 FIH extension      2
## 166   641   <NA> IQ00701-0100-0040    100 FIH extension      2
## 167   642   <NA> IQ00701-0100-0040    100 FIH extension      2
## 168   643   <NA> IQ00701-0100-0040    100 FIH extension      2
## 169   648   <NA> IQ00701-0100-0041    100 FIH extension      2
## 170   650   <NA> IQ00701-0100-0041    100 FIH extension      2
## 171   651   <NA> IQ00701-0100-0041    100 FIH extension      2
## 172   652   <NA> IQ00701-0100-0041    100 FIH extension      2
## 173   653   <NA> IQ00701-0100-0041    100 FIH extension      2
## 174   654   <NA> IQ00701-0100-0041    100 FIH extension      2
## 175   655   <NA> IQ00701-0100-0041    100 FIH extension      2
## 176   656   <NA> IQ00701-0100-0041    100 FIH extension      2
## 177   657   <NA> IQ00701-0100-0041    100 FIH extension      2
## 178   658   <NA> IQ00701-0100-0041    100 FIH extension      2
## 179   659   <NA> IQ00701-0100-0041    100 FIH extension      2
## 180   660   <NA> IQ00701-0100-0041    100 FIH extension      2
## 181   665   <NA> IQ00701-0100-0042    100 FIH extension      2
## 182   667   <NA> IQ00701-0100-0042    100 FIH extension      2
## 183   668   <NA> IQ00701-0100-0042    100 FIH extension      2
## 184   669   <NA> IQ00701-0100-0042    100 FIH extension      2
## 185   670   <NA> IQ00701-0100-0042    100 FIH extension      2
## 186   671   <NA> IQ00701-0100-0042    100 FIH extension      2
## 187   672   <NA> IQ00701-0100-0042    100 FIH extension      2
## 188   673   <NA> IQ00701-0100-0042    100 FIH extension      2
## 189   674   <NA> IQ00701-0100-0042    100 FIH extension      2
## 190   675   <NA> IQ00701-0100-0042    100 FIH extension      2
## 191   676   <NA> IQ00701-0100-0042    100 FIH extension      2
## 192   677   <NA> IQ00701-0100-0042    100 FIH extension      2
## 193   682   <NA> IQ00701-0100-0043    100 FIH extension      2
## 194   684   <NA> IQ00701-0100-0043    100 FIH extension      2
## 195   685   <NA> IQ00701-0100-0043    100 FIH extension      2
## 196   686   <NA> IQ00701-0100-0043    100 FIH extension      2
## 197   687   <NA> IQ00701-0100-0043    100 FIH extension      2
## 198   688   <NA> IQ00701-0100-0043    100 FIH extension      2
## 199   689   <NA> IQ00701-0100-0043    100 FIH extension      2
## 200   690   <NA> IQ00701-0100-0043    100 FIH extension      2
## 201   691   <NA> IQ00701-0100-0043    100 FIH extension      2
## 202   692   <NA> IQ00701-0100-0043    100 FIH extension      2
## 203   693   <NA> IQ00701-0100-0043    100 FIH extension      2
## 204   694   <NA> IQ00701-0100-0043    100 FIH extension      2
## 205   716   <NA> IQ00701-0100-0045    100 FIH extension      2
## 206   718   <NA> IQ00701-0100-0045    100 FIH extension      2
## 207   719   <NA> IQ00701-0100-0045    100 FIH extension      2
## 208   720   <NA> IQ00701-0100-0045    100 FIH extension      2
## 209   721   <NA> IQ00701-0100-0045    100 FIH extension      2
## 210   722   <NA> IQ00701-0100-0045    100 FIH extension      2
## 211   723   <NA> IQ00701-0100-0045    100 FIH extension      2
## 212   724   <NA> IQ00701-0100-0045    100 FIH extension      2
## 213   725   <NA> IQ00701-0100-0045    100 FIH extension      2
## 214   726   <NA> IQ00701-0100-0045    100 FIH extension      2
## 215   727   <NA> IQ00701-0100-0045    100 FIH extension      2
## 216   728   <NA> IQ00701-0100-0045    100 FIH extension      2
## 217   733   <NA> IQ00701-0100-0046    100 FIH extension      2
## 218   735   <NA> IQ00701-0100-0046    100 FIH extension      2
## 219   736   <NA> IQ00701-0100-0046    100 FIH extension      2
## 220   737   <NA> IQ00701-0100-0046    100 FIH extension      2
## 221   738   <NA> IQ00701-0100-0046    100 FIH extension      2
## 222   739   <NA> IQ00701-0100-0046    100 FIH extension      2
## 223   740   <NA> IQ00701-0100-0046    100 FIH extension      2
## 224   741   <NA> IQ00701-0100-0046    100 FIH extension      2
## 225   742   <NA> IQ00701-0100-0046    100 FIH extension      2
## 226   743   <NA> IQ00701-0100-0046    100 FIH extension      2
## 227   744   <NA> IQ00701-0100-0046    100 FIH extension      2
## 228   745   <NA> IQ00701-0100-0046    100 FIH extension      2
## 229   750   <NA> IQ00701-0100-0047    100 FIH extension      2
## 230   752   <NA> IQ00701-0100-0047    100 FIH extension      2
## 231   753   <NA> IQ00701-0100-0047    100 FIH extension      2
## 232   754   <NA> IQ00701-0100-0047    100 FIH extension      2
## 233   755   <NA> IQ00701-0100-0047    100 FIH extension      2
## 234   756   <NA> IQ00701-0100-0047    100 FIH extension      2
## 235   757   <NA> IQ00701-0100-0047    100 FIH extension      2
## 236   758   <NA> IQ00701-0100-0047    100 FIH extension      2
## 237   759   <NA> IQ00701-0100-0047    100 FIH extension      2
## 238   760   <NA> IQ00701-0100-0047    100 FIH extension      2
## 239   761   <NA> IQ00701-0100-0047    100 FIH extension      2
## 240   762   <NA> IQ00701-0100-0047    100 FIH extension      2
##                    TRTNAME TRT VISIT BASE SCREEN TIMEUNIT           NT    TIME
## 1     1mg oral single dose   3     2    0      0    HOURS  -0.08333333  -0.083
## 2     1mg oral single dose   3     2    0      0    HOURS   0.08333333   0.083
## 3     1mg oral single dose   3     2    0      0    HOURS   0.25000000   0.250
## 4     1mg oral single dose   3     2    0      0    HOURS   0.50000000   0.500
## 5     1mg oral single dose   3     2    0      0    HOURS   1.00000000   1.000
## 6     1mg oral single dose   3     2    0      0    HOURS   2.00000000   2.000
## 7     1mg oral single dose   3     2    0      0    HOURS   4.00000000   4.000
## 8     1mg oral single dose   3     2    0      0    HOURS  12.00000000  12.000
## 9     1mg oral single dose   3     3    0      0    HOURS  24.00000000  24.000
## 10    1mg oral single dose   3     4    0      0    HOURS  48.00000000  48.000
## 11    1mg oral single dose   3     5    0      0    HOURS  96.00000000  96.000
## 12    1mg oral single dose   3     6    0      0    HOURS 168.00000000 168.000
## 13    2mg oral single dose   6     2    0      0    HOURS  -0.08333333  -0.083
## 14    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.083
## 15    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.250
## 16    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.500
## 17    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.000
## 18    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.000
## 19    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.000
## 20    2mg oral single dose   6     2    0      0    HOURS  12.00000000  12.000
## 21    2mg oral single dose   6     3    0      0    HOURS  24.00000000  24.000
## 22    2mg oral single dose   6     4    0      0    HOURS  48.00000000  48.000
## 23    2mg oral single dose   6     5    0      0    HOURS  96.00000000  96.000
## 24    2mg oral single dose   6     6    0      0    HOURS 168.00000000 168.000
## 25    2mg oral single dose   6     2    0      0    HOURS  -0.08333333  -0.083
## 26    2mg oral single dose   6     2    0      0    HOURS   0.08333333   0.083
## 27    2mg oral single dose   6     2    0      0    HOURS   0.25000000   0.250
## 28    2mg oral single dose   6     2    0      0    HOURS   0.50000000   0.500
## 29    2mg oral single dose   6     2    0      0    HOURS   1.00000000   1.000
## 30    2mg oral single dose   6     2    0      0    HOURS   2.00000000   2.000
## 31    2mg oral single dose   6     2    0      0    HOURS   4.00000000   4.000
## 32    2mg oral single dose   6     2    0      0    HOURS  12.00000000  12.000
## 33    2mg oral single dose   6     3    0      0    HOURS  24.00000000  24.000
## 34    2mg oral single dose   6     4    0      0    HOURS  48.00000000  48.000
## 35    2mg oral single dose   6     5    0      0    HOURS  96.00000000  96.000
## 36    2mg oral single dose   6     6    0      0    HOURS 168.00000000 168.000
## 37    5mg oral single dose   8     2    0      0    HOURS  -0.08333333  -0.083
## 38    5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.083
## 39    5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.250
## 40    5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.500
## 41    5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.000
## 42    5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.000
## 43    5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.000
## 44    5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.000
## 45    5mg oral single dose   8     3    0      0    HOURS  24.00000000  24.000
## 46    5mg oral single dose   8     4    0      0    HOURS  48.00000000  48.000
## 47    5mg oral single dose   8     5    0      0    HOURS  96.00000000  96.000
## 48    5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.000
## 49    5mg oral single dose   8     2    0      0    HOURS  -0.08333333  -0.083
## 50    5mg oral single dose   8     2    0      0    HOURS   0.08333333   0.083
## 51    5mg oral single dose   8     2    0      0    HOURS   0.25000000   0.250
## 52    5mg oral single dose   8     2    0      0    HOURS   0.50000000   0.500
## 53    5mg oral single dose   8     2    0      0    HOURS   1.00000000   1.000
## 54    5mg oral single dose   8     2    0      0    HOURS   2.00000000   2.000
## 55    5mg oral single dose   8     2    0      0    HOURS   4.00000000   4.000
## 56    5mg oral single dose   8     2    0      0    HOURS  12.00000000  12.000
## 57    5mg oral single dose   8     3    0      0    HOURS  24.00000000  24.000
## 58    5mg oral single dose   8     4    0      0    HOURS  48.00000000  48.000
## 59    5mg oral single dose   8     5    0      0    HOURS  96.00000000  96.000
## 60    5mg oral single dose   8     6    0      0    HOURS 168.00000000 168.000
## 61   10mg oral single dose   2     2    0      0    HOURS  -0.08333333  -0.083
## 62   10mg oral single dose   2     2    0      0    HOURS   0.08333333   0.083
## 63   10mg oral single dose   2     2    0      0    HOURS   0.25000000   0.250
## 64   10mg oral single dose   2     2    0      0    HOURS   0.50000000   0.500
## 65   10mg oral single dose   2     2    0      0    HOURS   1.00000000   1.000
## 66   10mg oral single dose   2     2    0      0    HOURS   2.00000000   2.000
## 67   10mg oral single dose   2     2    0      0    HOURS   4.00000000   4.000
## 68   10mg oral single dose   2     2    0      0    HOURS  12.00000000  12.000
## 69   10mg oral single dose   2     3    0      0    HOURS  24.00000000  24.000
## 70   10mg oral single dose   2     4    0      0    HOURS  48.00000000  48.000
## 71   10mg oral single dose   2     5    0      0    HOURS  96.00000000  96.000
## 72   10mg oral single dose   2     6    0      0    HOURS 168.00000000 168.000
## 73   20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.083
## 74   20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.083
## 75   20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.250
## 76   20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.500
## 77   20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.000
## 78   20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.000
## 79   20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.000
## 80   20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.000
## 81   20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.000
## 82   20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.000
## 83   20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.000
## 84   20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.000
## 85   20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.083
## 86   20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.083
## 87   20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.250
## 88   20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.500
## 89   20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.000
## 90   20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.000
## 91   20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.000
## 92   20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.000
## 93   20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.000
## 94   20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.000
## 95   20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.000
## 96   20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.000
## 97   20mg oral single dose   5     2    0      0    HOURS  -0.08333333  -0.083
## 98   20mg oral single dose   5     2    0      0    HOURS   0.08333333   0.083
## 99   20mg oral single dose   5     2    0      0    HOURS   0.25000000   0.250
## 100  20mg oral single dose   5     2    0      0    HOURS   0.50000000   0.500
## 101  20mg oral single dose   5     2    0      0    HOURS   1.00000000   1.000
## 102  20mg oral single dose   5     2    0      0    HOURS   2.00000000   2.000
## 103  20mg oral single dose   5     2    0      0    HOURS   4.00000000   4.000
## 104  20mg oral single dose   5     2    0      0    HOURS  12.00000000  12.000
## 105  20mg oral single dose   5     3    0      0    HOURS  24.00000000  24.000
## 106  20mg oral single dose   5     4    0      0    HOURS  48.00000000  48.000
## 107  20mg oral single dose   5     5    0      0    HOURS  96.00000000  96.000
## 108  20mg oral single dose   5     6    0      0    HOURS 168.00000000 168.000
## 109  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.083
## 110  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.083
## 111  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.250
## 112  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.500
## 113  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.000
## 114  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.000
## 115  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.000
## 116  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.000
## 117  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.000
## 118  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.000
## 119  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.000
## 120  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.000
## 121  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.083
## 122  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.083
## 123  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.250
## 124  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.500
## 125  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.000
## 126  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.000
## 127  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.000
## 128  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.000
## 129  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.000
## 130  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.000
## 131  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.000
## 132  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.000
## 133  50mg oral single dose   7     2    0      0    HOURS  -0.08333333  -0.083
## 134  50mg oral single dose   7     2    0      0    HOURS   0.08333333   0.083
## 135  50mg oral single dose   7     2    0      0    HOURS   0.25000000   0.250
## 136  50mg oral single dose   7     2    0      0    HOURS   0.50000000   0.500
## 137  50mg oral single dose   7     2    0      0    HOURS   1.00000000   1.000
## 138  50mg oral single dose   7     2    0      0    HOURS   2.00000000   2.000
## 139  50mg oral single dose   7     2    0      0    HOURS   4.00000000   4.000
## 140  50mg oral single dose   7     2    0      0    HOURS  12.00000000  12.000
## 141  50mg oral single dose   7     3    0      0    HOURS  24.00000000  24.000
## 142  50mg oral single dose   7     4    0      0    HOURS  48.00000000  48.000
## 143  50mg oral single dose   7     5    0      0    HOURS  96.00000000  96.000
## 144  50mg oral single dose   7     6    0      0    HOURS 168.00000000 168.000
## 145 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.083
## 146 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.083
## 147 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.250
## 148 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.500
## 149 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.000
## 150 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.000
## 151 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.000
## 152 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.000
## 153 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.000
## 154 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.000
## 155 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.000
## 156 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.000
## 157 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.083
## 158 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.083
## 159 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.250
## 160 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.500
## 161 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.000
## 162 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.000
## 163 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.000
## 164 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.000
## 165 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.000
## 166 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.000
## 167 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.000
## 168 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.000
## 169 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.083
## 170 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.083
## 171 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.250
## 172 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.500
## 173 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.000
## 174 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.000
## 175 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.000
## 176 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.000
## 177 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.000
## 178 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.000
## 179 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.000
## 180 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.000
## 181 100mg oral single dose   1     2    0      0    HOURS  -0.08333333  -0.083
## 182 100mg oral single dose   1     2    0      0    HOURS   0.08333333   0.083
## 183 100mg oral single dose   1     2    0      0    HOURS   0.25000000   0.250
## 184 100mg oral single dose   1     2    0      0    HOURS   0.50000000   0.500
## 185 100mg oral single dose   1     2    0      0    HOURS   1.00000000   1.000
## 186 100mg oral single dose   1     2    0      0    HOURS   2.00000000   2.000
## 187 100mg oral single dose   1     2    0      0    HOURS   4.00000000   4.000
## 188 100mg oral single dose   1     2    0      0    HOURS  12.00000000  12.000
## 189 100mg oral single dose   1     3    0      0    HOURS  24.00000000  24.000
## 190 100mg oral single dose   1     4    0      0    HOURS  48.00000000  48.000
## 191 100mg oral single dose   1     5    0      0    HOURS  96.00000000  96.000
## 192 100mg oral single dose   1     6    0      0    HOURS 168.00000000 168.000
## 193 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.083
## 194 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.083
## 195 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.250
## 196 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.500
## 197 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.000
## 198 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.000
## 199 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.000
## 200 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.000
## 201 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.000
## 202 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.000
## 203 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.000
## 204 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.000
## 205 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.083
## 206 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.083
## 207 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.250
## 208 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.500
## 209 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.000
## 210 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.000
## 211 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.000
## 212 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.000
## 213 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.000
## 214 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.000
## 215 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.000
## 216 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.000
## 217 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.083
## 218 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.083
## 219 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.250
## 220 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.500
## 221 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.000
## 222 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.000
## 223 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.000
## 224 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.000
## 225 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.000
## 226 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.000
## 227 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.000
## 228 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.000
## 229 200mg oral single dose   4     2    0      0    HOURS  -0.08333333  -0.083
## 230 200mg oral single dose   4     2    0      0    HOURS   0.08333333   0.083
## 231 200mg oral single dose   4     2    0      0    HOURS   0.25000000   0.250
## 232 200mg oral single dose   4     2    0      0    HOURS   0.50000000   0.500
## 233 200mg oral single dose   4     2    0      0    HOURS   1.00000000   1.000
## 234 200mg oral single dose   4     2    0      0    HOURS   2.00000000   2.000
## 235 200mg oral single dose   4     2    0      0    HOURS   4.00000000   4.000
## 236 200mg oral single dose   4     2    0      0    HOURS  12.00000000  12.000
## 237 200mg oral single dose   4     3    0      0    HOURS  24.00000000  24.000
## 238 200mg oral single dose   4     4    0      0    HOURS  48.00000000  48.000
## 239 200mg oral single dose   4     5    0      0    HOURS  96.00000000  96.000
## 240 200mg oral single dose   4     6    0      0    HOURS 168.00000000 168.000
##     DURATION                        NAME   VALUE VALUETXT  UNIT  LLOQ ROUTE II
## 1          0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 2          0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 3          0 Plasma concentration IQ0815 0.00128     <NA> ug/mL 0.001  <NA>  0
## 4          0 Plasma concentration IQ0815 0.00220     <NA> ug/mL 0.001  <NA>  0
## 5          0 Plasma concentration IQ0815 0.00278     <NA> ug/mL 0.001  <NA>  0
## 6          0 Plasma concentration IQ0815 0.00221     <NA> ug/mL 0.001  <NA>  0
## 7          0 Plasma concentration IQ0815 0.00153     <NA> ug/mL 0.001  <NA>  0
## 8          0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 9          0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 10         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 11         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 12         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 13         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 14         0 Plasma concentration IQ0815 0.00157     <NA> ug/mL 0.001  <NA>  0
## 15         0 Plasma concentration IQ0815 0.00205     <NA> ug/mL 0.001  <NA>  0
## 16         0 Plasma concentration IQ0815 0.00446     <NA> ug/mL 0.001  <NA>  0
## 17         0 Plasma concentration IQ0815 0.00462     <NA> ug/mL 0.001  <NA>  0
## 18         0 Plasma concentration IQ0815 0.00555     <NA> ug/mL 0.001  <NA>  0
## 19         0 Plasma concentration IQ0815 0.00329     <NA> ug/mL 0.001  <NA>  0
## 20         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 21         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 22         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 23         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 24         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 25         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 26         0 Plasma concentration IQ0815 0.00127     <NA> ug/mL 0.001  <NA>  0
## 27         0 Plasma concentration IQ0815 0.00345     <NA> ug/mL 0.001  <NA>  0
## 28         0 Plasma concentration IQ0815 0.00491     <NA> ug/mL 0.001  <NA>  0
## 29         0 Plasma concentration IQ0815 0.00692     <NA> ug/mL 0.001  <NA>  0
## 30         0 Plasma concentration IQ0815 0.00736     <NA> ug/mL 0.001  <NA>  0
## 31         0 Plasma concentration IQ0815 0.00420     <NA> ug/mL 0.001  <NA>  0
## 32         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 33         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 34         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 35         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 36         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 37         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 38         0 Plasma concentration IQ0815 0.00593     <NA> ug/mL 0.001  <NA>  0
## 39         0 Plasma concentration IQ0815 0.01100     <NA> ug/mL 0.001  <NA>  0
## 40         0 Plasma concentration IQ0815 0.02130     <NA> ug/mL 0.001  <NA>  0
## 41         0 Plasma concentration IQ0815 0.02640     <NA> ug/mL 0.001  <NA>  0
## 42         0 Plasma concentration IQ0815 0.02360     <NA> ug/mL 0.001  <NA>  0
## 43         0 Plasma concentration IQ0815 0.00808     <NA> ug/mL 0.001  <NA>  0
## 44         0 Plasma concentration IQ0815 0.00128     <NA> ug/mL 0.001  <NA>  0
## 45         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 46         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 47         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 48         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 49         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 50         0 Plasma concentration IQ0815 0.00428     <NA> ug/mL 0.001  <NA>  0
## 51         0 Plasma concentration IQ0815 0.01080     <NA> ug/mL 0.001  <NA>  0
## 52         0 Plasma concentration IQ0815 0.01920     <NA> ug/mL 0.001  <NA>  0
## 53         0 Plasma concentration IQ0815 0.01960     <NA> ug/mL 0.001  <NA>  0
## 54         0 Plasma concentration IQ0815 0.01400     <NA> ug/mL 0.001  <NA>  0
## 55         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 56         0 Plasma concentration IQ0815 0.00112     <NA> ug/mL 0.001  <NA>  0
## 57         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 58         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 59         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 60         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 61         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 62         0 Plasma concentration IQ0815 0.00374     <NA> ug/mL 0.001  <NA>  0
## 63         0 Plasma concentration IQ0815 0.00866     <NA> ug/mL 0.001  <NA>  0
## 64         0 Plasma concentration IQ0815 0.01570     <NA> ug/mL 0.001  <NA>  0
## 65         0 Plasma concentration IQ0815 0.01960     <NA> ug/mL 0.001  <NA>  0
## 66         0 Plasma concentration IQ0815 0.02190     <NA> ug/mL 0.001  <NA>  0
## 67         0 Plasma concentration IQ0815 0.02200     <NA> ug/mL 0.001  <NA>  0
## 68         0 Plasma concentration IQ0815 0.00786     <NA> ug/mL 0.001  <NA>  0
## 69         0 Plasma concentration IQ0815 0.00382     <NA> ug/mL 0.001  <NA>  0
## 70         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 71         0 Plasma concentration IQ0815 0.00108     <NA> ug/mL 0.001  <NA>  0
## 72         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 73         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 74         0 Plasma concentration IQ0815 0.01190     <NA> ug/mL 0.001  <NA>  0
## 75         0 Plasma concentration IQ0815 0.03410     <NA> ug/mL 0.001  <NA>  0
## 76         0 Plasma concentration IQ0815 0.05540     <NA> ug/mL 0.001  <NA>  0
## 77         0 Plasma concentration IQ0815 0.05080     <NA> ug/mL 0.001  <NA>  0
## 78         0 Plasma concentration IQ0815 0.05230     <NA> ug/mL 0.001  <NA>  0
## 79         0 Plasma concentration IQ0815 0.03200     <NA> ug/mL 0.001  <NA>  0
## 80         0 Plasma concentration IQ0815 0.01060     <NA> ug/mL 0.001  <NA>  0
## 81         0 Plasma concentration IQ0815 0.00196     <NA> ug/mL 0.001  <NA>  0
## 82         0 Plasma concentration IQ0815 0.00168     <NA> ug/mL 0.001  <NA>  0
## 83         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 84         0 Plasma concentration IQ0815 0.00117     <NA> ug/mL 0.001  <NA>  0
## 85         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 86         0 Plasma concentration IQ0815 0.00609     <NA> ug/mL 0.001  <NA>  0
## 87         0 Plasma concentration IQ0815 0.01570     <NA> ug/mL 0.001  <NA>  0
## 88         0 Plasma concentration IQ0815 0.02970     <NA> ug/mL 0.001  <NA>  0
## 89         0 Plasma concentration IQ0815 0.05030     <NA> ug/mL 0.001  <NA>  0
## 90         0 Plasma concentration IQ0815 0.04650     <NA> ug/mL 0.001  <NA>  0
## 91         0 Plasma concentration IQ0815 0.04090     <NA> ug/mL 0.001  <NA>  0
## 92         0 Plasma concentration IQ0815 0.00898     <NA> ug/mL 0.001  <NA>  0
## 93         0 Plasma concentration IQ0815 0.00265     <NA> ug/mL 0.001  <NA>  0
## 94         0 Plasma concentration IQ0815 0.00169     <NA> ug/mL 0.001  <NA>  0
## 95         0 Plasma concentration IQ0815 0.00170     <NA> ug/mL 0.001  <NA>  0
## 96         0 Plasma concentration IQ0815 0.00145     <NA> ug/mL 0.001  <NA>  0
## 97         0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 98         0 Plasma concentration IQ0815 0.00971     <NA> ug/mL 0.001  <NA>  0
## 99         0 Plasma concentration IQ0815 0.02690     <NA> ug/mL 0.001  <NA>  0
## 100        0 Plasma concentration IQ0815 0.04840     <NA> ug/mL 0.001  <NA>  0
## 101        0 Plasma concentration IQ0815 0.06530     <NA> ug/mL 0.001  <NA>  0
## 102        0 Plasma concentration IQ0815 0.05790     <NA> ug/mL 0.001  <NA>  0
## 103        0 Plasma concentration IQ0815 0.03360     <NA> ug/mL 0.001  <NA>  0
## 104        0 Plasma concentration IQ0815 0.00991     <NA> ug/mL 0.001  <NA>  0
## 105        0 Plasma concentration IQ0815 0.00188     <NA> ug/mL 0.001  <NA>  0
## 106        0 Plasma concentration IQ0815 0.00296     <NA> ug/mL 0.001  <NA>  0
## 107        0 Plasma concentration IQ0815 0.00149     <NA> ug/mL 0.001  <NA>  0
## 108        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 109        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 110        0 Plasma concentration IQ0815 0.02670     <NA> ug/mL 0.001  <NA>  0
## 111        0 Plasma concentration IQ0815 0.06480     <NA> ug/mL 0.001  <NA>  0
## 112        0 Plasma concentration IQ0815 0.11000     <NA> ug/mL 0.001  <NA>  0
## 113        0 Plasma concentration IQ0815 0.12500     <NA> ug/mL 0.001  <NA>  0
## 114        0 Plasma concentration IQ0815 0.14300     <NA> ug/mL 0.001  <NA>  0
## 115        0 Plasma concentration IQ0815 0.06950     <NA> ug/mL 0.001  <NA>  0
## 116        0 Plasma concentration IQ0815 0.01640     <NA> ug/mL 0.001  <NA>  0
## 117        0 Plasma concentration IQ0815 0.00447     <NA> ug/mL 0.001  <NA>  0
## 118        0 Plasma concentration IQ0815 0.00313     <NA> ug/mL 0.001  <NA>  0
## 119        0 Plasma concentration IQ0815 0.00299     <NA> ug/mL 0.001  <NA>  0
## 120        0 Plasma concentration IQ0815 0.00201     <NA> ug/mL 0.001  <NA>  0
## 121        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 122        0 Plasma concentration IQ0815 0.04720     <NA> ug/mL 0.001  <NA>  0
## 123        0 Plasma concentration IQ0815 0.10600     <NA> ug/mL 0.001  <NA>  0
## 124        0 Plasma concentration IQ0815 0.13700     <NA> ug/mL 0.001  <NA>  0
## 125        0 Plasma concentration IQ0815 0.18200     <NA> ug/mL 0.001  <NA>  0
## 126        0 Plasma concentration IQ0815 0.16700     <NA> ug/mL 0.001  <NA>  0
## 127        0 Plasma concentration IQ0815 0.09100     <NA> ug/mL 0.001  <NA>  0
## 128        0 Plasma concentration IQ0815 0.01220     <NA> ug/mL 0.001  <NA>  0
## 129        0 Plasma concentration IQ0815 0.00554     <NA> ug/mL 0.001  <NA>  0
## 130        0 Plasma concentration IQ0815 0.00404     <NA> ug/mL 0.001  <NA>  0
## 131        0 Plasma concentration IQ0815 0.00415     <NA> ug/mL 0.001  <NA>  0
## 132        0 Plasma concentration IQ0815 0.00204     <NA> ug/mL 0.001  <NA>  0
## 133        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 134        0 Plasma concentration IQ0815 0.03750     <NA> ug/mL 0.001  <NA>  0
## 135        0 Plasma concentration IQ0815 0.08430     <NA> ug/mL 0.001  <NA>  0
## 136        0 Plasma concentration IQ0815 0.13000     <NA> ug/mL 0.001  <NA>  0
## 137        0 Plasma concentration IQ0815 0.22300     <NA> ug/mL 0.001  <NA>  0
## 138        0 Plasma concentration IQ0815 0.19500     <NA> ug/mL 0.001  <NA>  0
## 139        0 Plasma concentration IQ0815 0.14900     <NA> ug/mL 0.001  <NA>  0
## 140        0 Plasma concentration IQ0815 0.02950     <NA> ug/mL 0.001  <NA>  0
## 141        0 Plasma concentration IQ0815 0.00783     <NA> ug/mL 0.001  <NA>  0
## 142        0 Plasma concentration IQ0815 0.00447     <NA> ug/mL 0.001  <NA>  0
## 143        0 Plasma concentration IQ0815 0.00439     <NA> ug/mL 0.001  <NA>  0
## 144        0 Plasma concentration IQ0815 0.00191     <NA> ug/mL 0.001  <NA>  0
## 145        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 146        0 Plasma concentration IQ0815 0.07300     <NA> ug/mL 0.001  <NA>  0
## 147        0 Plasma concentration IQ0815 0.19400     <NA> ug/mL 0.001  <NA>  0
## 148        0 Plasma concentration IQ0815 0.25700     <NA> ug/mL 0.001  <NA>  0
## 149        0 Plasma concentration IQ0815 0.41900     <NA> ug/mL 0.001  <NA>  0
## 150        0 Plasma concentration IQ0815 0.43900     <NA> ug/mL 0.001  <NA>  0
## 151        0 Plasma concentration IQ0815 0.32000     <NA> ug/mL 0.001  <NA>  0
## 152        0 Plasma concentration IQ0815 0.05640     <NA> ug/mL 0.001  <NA>  0
## 153        0 Plasma concentration IQ0815 0.01690     <NA> ug/mL 0.001  <NA>  0
## 154        0 Plasma concentration IQ0815 0.01180     <NA> ug/mL 0.001  <NA>  0
## 155        0 Plasma concentration IQ0815 0.00834     <NA> ug/mL 0.001  <NA>  0
## 156        0 Plasma concentration IQ0815 0.00685     <NA> ug/mL 0.001  <NA>  0
## 157        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 158        0 Plasma concentration IQ0815 0.08670     <NA> ug/mL 0.001  <NA>  0
## 159        0 Plasma concentration IQ0815 0.20300     <NA> ug/mL 0.001  <NA>  0
## 160        0 Plasma concentration IQ0815 0.29300     <NA> ug/mL 0.001  <NA>  0
## 161        0 Plasma concentration IQ0815 0.33400     <NA> ug/mL 0.001  <NA>  0
## 162        0 Plasma concentration IQ0815 0.29100     <NA> ug/mL 0.001  <NA>  0
## 163        0 Plasma concentration IQ0815 0.24300     <NA> ug/mL 0.001  <NA>  0
## 164        0 Plasma concentration IQ0815 0.05680     <NA> ug/mL 0.001  <NA>  0
## 165        0 Plasma concentration IQ0815 0.01150     <NA> ug/mL 0.001  <NA>  0
## 166        0 Plasma concentration IQ0815 0.00503     <NA> ug/mL 0.001  <NA>  0
## 167        0 Plasma concentration IQ0815 0.00278     <NA> ug/mL 0.001  <NA>  0
## 168        0 Plasma concentration IQ0815 0.00216     <NA> ug/mL 0.001  <NA>  0
## 169        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 170        0 Plasma concentration IQ0815 0.06290     <NA> ug/mL 0.001  <NA>  0
## 171        0 Plasma concentration IQ0815 0.14200     <NA> ug/mL 0.001  <NA>  0
## 172        0 Plasma concentration IQ0815 0.21500     <NA> ug/mL 0.001  <NA>  0
## 173        0 Plasma concentration IQ0815 0.31800     <NA> ug/mL 0.001  <NA>  0
## 174        0 Plasma concentration IQ0815 0.25400     <NA> ug/mL 0.001  <NA>  0
## 175        0 Plasma concentration IQ0815 0.16900     <NA> ug/mL 0.001  <NA>  0
## 176        0 Plasma concentration IQ0815 0.02870     <NA> ug/mL 0.001  <NA>  0
## 177        0 Plasma concentration IQ0815 0.00977     <NA> ug/mL 0.001  <NA>  0
## 178        0 Plasma concentration IQ0815 0.00555     <NA> ug/mL 0.001  <NA>  0
## 179        0 Plasma concentration IQ0815 0.00413     <NA> ug/mL 0.001  <NA>  0
## 180        0 Plasma concentration IQ0815 0.00196     <NA> ug/mL 0.001  <NA>  0
## 181        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 182        0 Plasma concentration IQ0815 0.08270     <NA> ug/mL 0.001  <NA>  0
## 183        0 Plasma concentration IQ0815 0.20200     <NA> ug/mL 0.001  <NA>  0
## 184        0 Plasma concentration IQ0815 0.28400     <NA> ug/mL 0.001  <NA>  0
## 185        0 Plasma concentration IQ0815 0.31000     <NA> ug/mL 0.001  <NA>  0
## 186        0 Plasma concentration IQ0815 0.25600     <NA> ug/mL 0.001  <NA>  0
## 187        0 Plasma concentration IQ0815 0.18200     <NA> ug/mL 0.001  <NA>  0
## 188        0 Plasma concentration IQ0815 0.02720     <NA> ug/mL 0.001  <NA>  0
## 189        0 Plasma concentration IQ0815 0.01400     <NA> ug/mL 0.001  <NA>  0
## 190        0 Plasma concentration IQ0815 0.01130     <NA> ug/mL 0.001  <NA>  0
## 191        0 Plasma concentration IQ0815 0.00537     <NA> ug/mL 0.001  <NA>  0
## 192        0 Plasma concentration IQ0815 0.00258     <NA> ug/mL 0.001  <NA>  0
## 193        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 194        0 Plasma concentration IQ0815 0.16600     <NA> ug/mL 0.001  <NA>  0
## 195        0 Plasma concentration IQ0815 0.37400     <NA> ug/mL 0.001  <NA>  0
## 196        0 Plasma concentration IQ0815 0.50400     <NA> ug/mL 0.001  <NA>  0
## 197        0 Plasma concentration IQ0815 0.86200     <NA> ug/mL 0.001  <NA>  0
## 198        0 Plasma concentration IQ0815 0.78800     <NA> ug/mL 0.001  <NA>  0
## 199        0 Plasma concentration IQ0815 0.49000     <NA> ug/mL 0.001  <NA>  0
## 200        0 Plasma concentration IQ0815 0.14300     <NA> ug/mL 0.001  <NA>  0
## 201        0 Plasma concentration IQ0815 0.02110     <NA> ug/mL 0.001  <NA>  0
## 202        0 Plasma concentration IQ0815 0.00575     <NA> ug/mL 0.001  <NA>  0
## 203        0 Plasma concentration IQ0815 0.00667     <NA> ug/mL 0.001  <NA>  0
## 204        0 Plasma concentration IQ0815 0.00593     <NA> ug/mL 0.001  <NA>  0
## 205        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 206        0 Plasma concentration IQ0815 0.17500     <NA> ug/mL 0.001  <NA>  0
## 207        0 Plasma concentration IQ0815 0.37600     <NA> ug/mL 0.001  <NA>  0
## 208        0 Plasma concentration IQ0815 0.59300     <NA> ug/mL 0.001  <NA>  0
## 209        0 Plasma concentration IQ0815 0.63500     <NA> ug/mL 0.001  <NA>  0
## 210        0 Plasma concentration IQ0815 0.51700     <NA> ug/mL 0.001  <NA>  0
## 211        0 Plasma concentration IQ0815 0.42900     <NA> ug/mL 0.001  <NA>  0
## 212        0 Plasma concentration IQ0815 0.09240     <NA> ug/mL 0.001  <NA>  0
## 213        0 Plasma concentration IQ0815 0.01930     <NA> ug/mL 0.001  <NA>  0
## 214        0 Plasma concentration IQ0815 0.01220     <NA> ug/mL 0.001  <NA>  0
## 215        0 Plasma concentration IQ0815 0.00661     <NA> ug/mL 0.001  <NA>  0
## 216        0 Plasma concentration IQ0815 0.00625     <NA> ug/mL 0.001  <NA>  0
## 217        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 218        0 Plasma concentration IQ0815 0.08050     <NA> ug/mL 0.001  <NA>  0
## 219        0 Plasma concentration IQ0815 0.19300     <NA> ug/mL 0.001  <NA>  0
## 220        0 Plasma concentration IQ0815 0.32400     <NA> ug/mL 0.001  <NA>  0
## 221        0 Plasma concentration IQ0815 0.54500     <NA> ug/mL 0.001  <NA>  0
## 222        0 Plasma concentration IQ0815 0.48700     <NA> ug/mL 0.001  <NA>  0
## 223        0 Plasma concentration IQ0815 0.32100     <NA> ug/mL 0.001  <NA>  0
## 224        0 Plasma concentration IQ0815 0.05940     <NA> ug/mL 0.001  <NA>  0
## 225        0 Plasma concentration IQ0815 0.01070     <NA> ug/mL 0.001  <NA>  0
## 226        0 Plasma concentration IQ0815 0.00319     <NA> ug/mL 0.001  <NA>  0
## 227        0 Plasma concentration IQ0815 0.00324     <NA> ug/mL 0.001  <NA>  0
## 228        0 Plasma concentration IQ0815 0.00277     <NA> ug/mL 0.001  <NA>  0
## 229        0 Plasma concentration IQ0815 0.00050     <NA> ug/mL 0.001  <NA>  0
## 230        0 Plasma concentration IQ0815 0.11000     <NA> ug/mL 0.001  <NA>  0
## 231        0 Plasma concentration IQ0815 0.26500     <NA> ug/mL 0.001  <NA>  0
## 232        0 Plasma concentration IQ0815 0.42700     <NA> ug/mL 0.001  <NA>  0
## 233        0 Plasma concentration IQ0815 0.55200     <NA> ug/mL 0.001  <NA>  0
## 234        0 Plasma concentration IQ0815 0.43200     <NA> ug/mL 0.001  <NA>  0
## 235        0 Plasma concentration IQ0815 0.35400     <NA> ug/mL 0.001  <NA>  0
## 236        0 Plasma concentration IQ0815 0.09750     <NA> ug/mL 0.001  <NA>  0
## 237        0 Plasma concentration IQ0815 0.02520     <NA> ug/mL 0.001  <NA>  0
## 238        0 Plasma concentration IQ0815 0.01240     <NA> ug/mL 0.001  <NA>  0
## 239        0 Plasma concentration IQ0815 0.01140     <NA> ug/mL 0.001  <NA>  0
## 240        0 Plasma concentration IQ0815 0.00855     <NA> ug/mL 0.001  <NA>  0
##     ADDL ID  TIMEPOS EVID MDV CENS AMT      DV TINF RATE ADM YTYPE     TAD DOSE
## 1      0  6 167.9667    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 2      0  6 168.1327    0   0    1   0 0.00100    0    0   0     1   0.083    1
## 3      0  6 168.2997    0   0    0   0 0.00128    0    0   0     1   0.250    1
## 4      0  6 168.5497    0   0    0   0 0.00220    0    0   0     1   0.500    1
## 5      0  6 169.0497    0   0    0   0 0.00278    0    0   0     1   1.000    1
## 6      0  6 170.0497    0   0    0   0 0.00221    0    0   0     1   2.000    1
## 7      0  6 172.0497    0   0    0   0 0.00153    0    0   0     1   4.000    1
## 8      0  6 180.0497    0   0    1   0 0.00100    0    0   0     1  12.000    1
## 9      0  6 192.0497    0   0    1   0 0.00100    0    0   0     1  24.000    1
## 10     0  6 216.0497    0   0    1   0 0.00100    0    0   0     1  48.000    1
## 11     0  6 264.0497    0   0    1   0 0.00100    0    0   0     1  96.000    1
## 12     0  6 336.0497    0   0    1   0 0.00100    0    0   0     1 168.000    1
## 13     0 10 167.9333    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 14     0 10 168.0993    0   0    0   0 0.00157    0    0   0     1   0.083    2
## 15     0 10 168.2663    0   0    0   0 0.00205    0    0   0     1   0.250    2
## 16     0 10 168.5163    0   0    0   0 0.00446    0    0   0     1   0.500    2
## 17     0 10 169.0163    0   0    0   0 0.00462    0    0   0     1   1.000    2
## 18     0 10 170.0163    0   0    0   0 0.00555    0    0   0     1   2.000    2
## 19     0 10 172.0163    0   0    0   0 0.00329    0    0   0     1   4.000    2
## 20     0 10 180.0163    0   0    1   0 0.00100    0    0   0     1  12.000    2
## 21     0 10 192.0163    0   0    1   0 0.00100    0    0   0     1  24.000    2
## 22     0 10 216.0163    0   0    1   0 0.00100    0    0   0     1  48.000    2
## 23     0 10 264.0163    0   0    1   0 0.00100    0    0   0     1  96.000    2
## 24     0 10 336.0163    0   0    1   0 0.00100    0    0   0     1 168.000    2
## 25     0 11 167.6333    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 26     0 11 167.7993    0   0    0   0 0.00127    0    0   0     1   0.083    2
## 27     0 11 167.9663    0   0    0   0 0.00345    0    0   0     1   0.250    2
## 28     0 11 168.2163    0   0    0   0 0.00491    0    0   0     1   0.500    2
## 29     0 11 168.7163    0   0    0   0 0.00692    0    0   0     1   1.000    2
## 30     0 11 169.7163    0   0    0   0 0.00736    0    0   0     1   2.000    2
## 31     0 11 171.7163    0   0    0   0 0.00420    0    0   0     1   4.000    2
## 32     0 11 179.7163    0   0    1   0 0.00100    0    0   0     1  12.000    2
## 33     0 11 191.7163    0   0    1   0 0.00100    0    0   0     1  24.000    2
## 34     0 11 215.7163    0   0    1   0 0.00100    0    0   0     1  48.000    2
## 35     0 11 263.7163    0   0    1   0 0.00100    0    0   0     1  96.000    2
## 36     0 11 335.7163    0   0    1   0 0.00100    0    0   0     1 168.000    2
## 37     0 13 168.5000    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 38     0 13 168.6660    0   0    0   0 0.00593    0    0   0     1   0.083    5
## 39     0 13 168.8330    0   0    0   0 0.01100    0    0   0     1   0.250    5
## 40     0 13 169.0830    0   0    0   0 0.02130    0    0   0     1   0.500    5
## 41     0 13 169.5830    0   0    0   0 0.02640    0    0   0     1   1.000    5
## 42     0 13 170.5830    0   0    0   0 0.02360    0    0   0     1   2.000    5
## 43     0 13 172.5830    0   0    0   0 0.00808    0    0   0     1   4.000    5
## 44     0 13 180.5830    0   0    0   0 0.00128    0    0   0     1  12.000    5
## 45     0 13 192.5830    0   0    1   0 0.00100    0    0   0     1  24.000    5
## 46     0 13 216.5830    0   0    1   0 0.00100    0    0   0     1  48.000    5
## 47     0 13 264.5830    0   0    1   0 0.00100    0    0   0     1  96.000    5
## 48     0 13 336.5830    0   0    1   0 0.00100    0    0   0     1 168.000    5
## 49     0 14 168.5667    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 50     0 14 168.7327    0   0    0   0 0.00428    0    0   0     1   0.083    5
## 51     0 14 168.8997    0   0    0   0 0.01080    0    0   0     1   0.250    5
## 52     0 14 169.1497    0   0    0   0 0.01920    0    0   0     1   0.500    5
## 53     0 14 169.6497    0   0    0   0 0.01960    0    0   0     1   1.000    5
## 54     0 14 170.6497    0   0    0   0 0.01400    0    0   0     1   2.000    5
## 55     0 14 172.6497    0   0    1   0 0.00100    0    0   0     1   4.000    5
## 56     0 14 180.6497    0   0    0   0 0.00112    0    0   0     1  12.000    5
## 57     0 14 192.6497    0   0    1   0 0.00100    0    0   0     1  24.000    5
## 58     0 14 216.6497    0   0    1   0 0.00100    0    0   0     1  48.000    5
## 59     0 14 264.6497    0   0    1   0 0.00100    0    0   0     1  96.000    5
## 60     0 14 336.6497    0   0    1   0 0.00100    0    0   0     1 168.000    5
## 61     0 21 167.6000    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 62     0 21 167.7660    0   0    0   0 0.00374    0    0   0     1   0.083   10
## 63     0 21 167.9330    0   0    0   0 0.00866    0    0   0     1   0.250   10
## 64     0 21 168.1830    0   0    0   0 0.01570    0    0   0     1   0.500   10
## 65     0 21 168.6830    0   0    0   0 0.01960    0    0   0     1   1.000   10
## 66     0 21 169.6830    0   0    0   0 0.02190    0    0   0     1   2.000   10
## 67     0 21 171.6830    0   0    0   0 0.02200    0    0   0     1   4.000   10
## 68     0 21 179.6830    0   0    0   0 0.00786    0    0   0     1  12.000   10
## 69     0 21 191.6830    0   0    0   0 0.00382    0    0   0     1  24.000   10
## 70     0 21 215.6830    0   0    1   0 0.00100    0    0   0     1  48.000   10
## 71     0 21 263.6830    0   0    0   0 0.00108    0    0   0     1  96.000   10
## 72     0 21 335.6830    0   0    1   0 0.00100    0    0   0     1 168.000   10
## 73     0 25 167.5000    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 74     0 25 167.6660    0   0    0   0 0.01190    0    0   0     1   0.083   20
## 75     0 25 167.8330    0   0    0   0 0.03410    0    0   0     1   0.250   20
## 76     0 25 168.0830    0   0    0   0 0.05540    0    0   0     1   0.500   20
## 77     0 25 168.5830    0   0    0   0 0.05080    0    0   0     1   1.000   20
## 78     0 25 169.5830    0   0    0   0 0.05230    0    0   0     1   2.000   20
## 79     0 25 171.5830    0   0    0   0 0.03200    0    0   0     1   4.000   20
## 80     0 25 179.5830    0   0    0   0 0.01060    0    0   0     1  12.000   20
## 81     0 25 191.5830    0   0    0   0 0.00196    0    0   0     1  24.000   20
## 82     0 25 215.5830    0   0    0   0 0.00168    0    0   0     1  48.000   20
## 83     0 25 263.5830    0   0    1   0 0.00100    0    0   0     1  96.000   20
## 84     0 25 335.5830    0   0    0   0 0.00117    0    0   0     1 168.000   20
## 85     0 28 167.8667    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 86     0 28 168.0327    0   0    0   0 0.00609    0    0   0     1   0.083   20
## 87     0 28 168.1997    0   0    0   0 0.01570    0    0   0     1   0.250   20
## 88     0 28 168.4497    0   0    0   0 0.02970    0    0   0     1   0.500   20
## 89     0 28 168.9497    0   0    0   0 0.05030    0    0   0     1   1.000   20
## 90     0 28 169.9497    0   0    0   0 0.04650    0    0   0     1   2.000   20
## 91     0 28 171.9497    0   0    0   0 0.04090    0    0   0     1   4.000   20
## 92     0 28 179.9497    0   0    0   0 0.00898    0    0   0     1  12.000   20
## 93     0 28 191.9497    0   0    0   0 0.00265    0    0   0     1  24.000   20
## 94     0 28 215.9497    0   0    0   0 0.00169    0    0   0     1  48.000   20
## 95     0 28 263.9497    0   0    0   0 0.00170    0    0   0     1  96.000   20
## 96     0 28 335.9497    0   0    0   0 0.00145    0    0   0     1 168.000   20
## 97     0 29 167.8000    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 98     0 29 167.9660    0   0    0   0 0.00971    0    0   0     1   0.083   20
## 99     0 29 168.1330    0   0    0   0 0.02690    0    0   0     1   0.250   20
## 100    0 29 168.3830    0   0    0   0 0.04840    0    0   0     1   0.500   20
## 101    0 29 168.8830    0   0    0   0 0.06530    0    0   0     1   1.000   20
## 102    0 29 169.8830    0   0    0   0 0.05790    0    0   0     1   2.000   20
## 103    0 29 171.8830    0   0    0   0 0.03360    0    0   0     1   4.000   20
## 104    0 29 179.8830    0   0    0   0 0.00991    0    0   0     1  12.000   20
## 105    0 29 191.8830    0   0    0   0 0.00188    0    0   0     1  24.000   20
## 106    0 29 215.8830    0   0    0   0 0.00296    0    0   0     1  48.000   20
## 107    0 29 263.8830    0   0    0   0 0.00149    0    0   0     1  96.000   20
## 108    0 29 335.8830    0   0    1   0 0.00100    0    0   0     1 168.000   20
## 109    0 33 168.5167    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 110    0 33 168.6827    0   0    0   0 0.02670    0    0   0     1   0.083   50
## 111    0 33 168.8497    0   0    0   0 0.06480    0    0   0     1   0.250   50
## 112    0 33 169.0997    0   0    0   0 0.11000    0    0   0     1   0.500   50
## 113    0 33 169.5997    0   0    0   0 0.12500    0    0   0     1   1.000   50
## 114    0 33 170.5997    0   0    0   0 0.14300    0    0   0     1   2.000   50
## 115    0 33 172.5997    0   0    0   0 0.06950    0    0   0     1   4.000   50
## 116    0 33 180.5997    0   0    0   0 0.01640    0    0   0     1  12.000   50
## 117    0 33 192.5997    0   0    0   0 0.00447    0    0   0     1  24.000   50
## 118    0 33 216.5997    0   0    0   0 0.00313    0    0   0     1  48.000   50
## 119    0 33 264.5997    0   0    0   0 0.00299    0    0   0     1  96.000   50
## 120    0 33 336.5997    0   0    0   0 0.00201    0    0   0     1 168.000   50
## 121    0 35 168.2833    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 122    0 35 168.4493    0   0    0   0 0.04720    0    0   0     1   0.083   50
## 123    0 35 168.6163    0   0    0   0 0.10600    0    0   0     1   0.250   50
## 124    0 35 168.8663    0   0    0   0 0.13700    0    0   0     1   0.500   50
## 125    0 35 169.3663    0   0    0   0 0.18200    0    0   0     1   1.000   50
## 126    0 35 170.3663    0   0    0   0 0.16700    0    0   0     1   2.000   50
## 127    0 35 172.3663    0   0    0   0 0.09100    0    0   0     1   4.000   50
## 128    0 35 180.3663    0   0    0   0 0.01220    0    0   0     1  12.000   50
## 129    0 35 192.3663    0   0    0   0 0.00554    0    0   0     1  24.000   50
## 130    0 35 216.3663    0   0    0   0 0.00404    0    0   0     1  48.000   50
## 131    0 35 264.3663    0   0    0   0 0.00415    0    0   0     1  96.000   50
## 132    0 35 336.3663    0   0    0   0 0.00204    0    0   0     1 168.000   50
## 133    0 36 168.5833    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 134    0 36 168.7493    0   0    0   0 0.03750    0    0   0     1   0.083   50
## 135    0 36 168.9163    0   0    0   0 0.08430    0    0   0     1   0.250   50
## 136    0 36 169.1663    0   0    0   0 0.13000    0    0   0     1   0.500   50
## 137    0 36 169.6663    0   0    0   0 0.22300    0    0   0     1   1.000   50
## 138    0 36 170.6663    0   0    0   0 0.19500    0    0   0     1   2.000   50
## 139    0 36 172.6663    0   0    0   0 0.14900    0    0   0     1   4.000   50
## 140    0 36 180.6663    0   0    0   0 0.02950    0    0   0     1  12.000   50
## 141    0 36 192.6663    0   0    0   0 0.00783    0    0   0     1  24.000   50
## 142    0 36 216.6663    0   0    0   0 0.00447    0    0   0     1  48.000   50
## 143    0 36 264.6663    0   0    0   0 0.00439    0    0   0     1  96.000   50
## 144    0 36 336.6663    0   0    0   0 0.00191    0    0   0     1 168.000   50
## 145    0 39 167.9000    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 146    0 39 168.0660    0   0    0   0 0.07300    0    0   0     1   0.083  100
## 147    0 39 168.2330    0   0    0   0 0.19400    0    0   0     1   0.250  100
## 148    0 39 168.4830    0   0    0   0 0.25700    0    0   0     1   0.500  100
## 149    0 39 168.9830    0   0    0   0 0.41900    0    0   0     1   1.000  100
## 150    0 39 169.9830    0   0    0   0 0.43900    0    0   0     1   2.000  100
## 151    0 39 171.9830    0   0    0   0 0.32000    0    0   0     1   4.000  100
## 152    0 39 179.9830    0   0    0   0 0.05640    0    0   0     1  12.000  100
## 153    0 39 191.9830    0   0    0   0 0.01690    0    0   0     1  24.000  100
## 154    0 39 215.9830    0   0    0   0 0.01180    0    0   0     1  48.000  100
## 155    0 39 263.9830    0   0    0   0 0.00834    0    0   0     1  96.000  100
## 156    0 39 335.9830    0   0    0   0 0.00685    0    0   0     1 168.000  100
## 157    0 40 168.2000    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 158    0 40 168.3660    0   0    0   0 0.08670    0    0   0     1   0.083  100
## 159    0 40 168.5330    0   0    0   0 0.20300    0    0   0     1   0.250  100
## 160    0 40 168.7830    0   0    0   0 0.29300    0    0   0     1   0.500  100
## 161    0 40 169.2830    0   0    0   0 0.33400    0    0   0     1   1.000  100
## 162    0 40 170.2830    0   0    0   0 0.29100    0    0   0     1   2.000  100
## 163    0 40 172.2830    0   0    0   0 0.24300    0    0   0     1   4.000  100
## 164    0 40 180.2830    0   0    0   0 0.05680    0    0   0     1  12.000  100
## 165    0 40 192.2830    0   0    0   0 0.01150    0    0   0     1  24.000  100
## 166    0 40 216.2830    0   0    0   0 0.00503    0    0   0     1  48.000  100
## 167    0 40 264.2830    0   0    0   0 0.00278    0    0   0     1  96.000  100
## 168    0 40 336.2830    0   0    0   0 0.00216    0    0   0     1 168.000  100
## 169    0 41 168.2333    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 170    0 41 168.3993    0   0    0   0 0.06290    0    0   0     1   0.083  100
## 171    0 41 168.5663    0   0    0   0 0.14200    0    0   0     1   0.250  100
## 172    0 41 168.8163    0   0    0   0 0.21500    0    0   0     1   0.500  100
## 173    0 41 169.3163    0   0    0   0 0.31800    0    0   0     1   1.000  100
## 174    0 41 170.3163    0   0    0   0 0.25400    0    0   0     1   2.000  100
## 175    0 41 172.3163    0   0    0   0 0.16900    0    0   0     1   4.000  100
## 176    0 41 180.3163    0   0    0   0 0.02870    0    0   0     1  12.000  100
## 177    0 41 192.3163    0   0    0   0 0.00977    0    0   0     1  24.000  100
## 178    0 41 216.3163    0   0    0   0 0.00555    0    0   0     1  48.000  100
## 179    0 41 264.3163    0   0    0   0 0.00413    0    0   0     1  96.000  100
## 180    0 41 336.3163    0   0    0   0 0.00196    0    0   0     1 168.000  100
## 181    0 42 168.9000    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 182    0 42 169.0660    0   0    0   0 0.08270    0    0   0     1   0.083  100
## 183    0 42 169.2330    0   0    0   0 0.20200    0    0   0     1   0.250  100
## 184    0 42 169.4830    0   0    0   0 0.28400    0    0   0     1   0.500  100
## 185    0 42 169.9830    0   0    0   0 0.31000    0    0   0     1   1.000  100
## 186    0 42 170.9830    0   0    0   0 0.25600    0    0   0     1   2.000  100
## 187    0 42 172.9830    0   0    0   0 0.18200    0    0   0     1   4.000  100
## 188    0 42 180.9830    0   0    0   0 0.02720    0    0   0     1  12.000  100
## 189    0 42 192.9830    0   0    0   0 0.01400    0    0   0     1  24.000  100
## 190    0 42 216.9830    0   0    0   0 0.01130    0    0   0     1  48.000  100
## 191    0 42 264.9830    0   0    0   0 0.00537    0    0   0     1  96.000  100
## 192    0 42 336.9830    0   0    0   0 0.00258    0    0   0     1 168.000  100
## 193    0 43 168.6833    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 194    0 43 168.8493    0   0    0   0 0.16600    0    0   0     1   0.083  200
## 195    0 43 169.0163    0   0    0   0 0.37400    0    0   0     1   0.250  200
## 196    0 43 169.2663    0   0    0   0 0.50400    0    0   0     1   0.500  200
## 197    0 43 169.7663    0   0    0   0 0.86200    0    0   0     1   1.000  200
## 198    0 43 170.7663    0   0    0   0 0.78800    0    0   0     1   2.000  200
## 199    0 43 172.7663    0   0    0   0 0.49000    0    0   0     1   4.000  200
## 200    0 43 180.7663    0   0    0   0 0.14300    0    0   0     1  12.000  200
## 201    0 43 192.7663    0   0    0   0 0.02110    0    0   0     1  24.000  200
## 202    0 43 216.7663    0   0    0   0 0.00575    0    0   0     1  48.000  200
## 203    0 43 264.7663    0   0    0   0 0.00667    0    0   0     1  96.000  200
## 204    0 43 336.7663    0   0    0   0 0.00593    0    0   0     1 168.000  200
## 205    0 45 168.4667    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 206    0 45 168.6327    0   0    0   0 0.17500    0    0   0     1   0.083  200
## 207    0 45 168.7997    0   0    0   0 0.37600    0    0   0     1   0.250  200
## 208    0 45 169.0497    0   0    0   0 0.59300    0    0   0     1   0.500  200
## 209    0 45 169.5497    0   0    0   0 0.63500    0    0   0     1   1.000  200
## 210    0 45 170.5497    0   0    0   0 0.51700    0    0   0     1   2.000  200
## 211    0 45 172.5497    0   0    0   0 0.42900    0    0   0     1   4.000  200
## 212    0 45 180.5497    0   0    0   0 0.09240    0    0   0     1  12.000  200
## 213    0 45 192.5497    0   0    0   0 0.01930    0    0   0     1  24.000  200
## 214    0 45 216.5497    0   0    0   0 0.01220    0    0   0     1  48.000  200
## 215    0 45 264.5497    0   0    0   0 0.00661    0    0   0     1  96.000  200
## 216    0 45 336.5497    0   0    0   0 0.00625    0    0   0     1 168.000  200
## 217    0 46 167.9000    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 218    0 46 168.0660    0   0    0   0 0.08050    0    0   0     1   0.083  200
## 219    0 46 168.2330    0   0    0   0 0.19300    0    0   0     1   0.250  200
## 220    0 46 168.4830    0   0    0   0 0.32400    0    0   0     1   0.500  200
## 221    0 46 168.9830    0   0    0   0 0.54500    0    0   0     1   1.000  200
## 222    0 46 169.9830    0   0    0   0 0.48700    0    0   0     1   2.000  200
## 223    0 46 171.9830    0   0    0   0 0.32100    0    0   0     1   4.000  200
## 224    0 46 179.9830    0   0    0   0 0.05940    0    0   0     1  12.000  200
## 225    0 46 191.9830    0   0    0   0 0.01070    0    0   0     1  24.000  200
## 226    0 46 215.9830    0   0    0   0 0.00319    0    0   0     1  48.000  200
## 227    0 46 263.9830    0   0    0   0 0.00324    0    0   0     1  96.000  200
## 228    0 46 335.9830    0   0    0   0 0.00277    0    0   0     1 168.000  200
## 229    0 47 168.1333    0   0    1   0 0.00100    0    0   0     1  -0.083    0
## 230    0 47 168.2993    0   0    0   0 0.11000    0    0   0     1   0.083  200
## 231    0 47 168.4663    0   0    0   0 0.26500    0    0   0     1   0.250  200
## 232    0 47 168.7163    0   0    0   0 0.42700    0    0   0     1   0.500  200
## 233    0 47 169.2163    0   0    0   0 0.55200    0    0   0     1   1.000  200
## 234    0 47 170.2163    0   0    0   0 0.43200    0    0   0     1   2.000  200
## 235    0 47 172.2163    0   0    0   0 0.35400    0    0   0     1   4.000  200
## 236    0 47 180.2163    0   0    0   0 0.09750    0    0   0     1  12.000  200
## 237    0 47 192.2163    0   0    0   0 0.02520    0    0   0     1  24.000  200
## 238    0 47 216.2163    0   0    0   0 0.01240    0    0   0     1  48.000  200
## 239    0 47 264.2163    0   0    0   0 0.01140    0    0   0     1  96.000  200
## 240    0 47 336.2163    0   0    0   0 0.00855    0    0   0     1 168.000  200
##     WT0 AGE0 HT0 SEX BLOQ           TRTNAMElabel AGE0CAT
## 1    70   35 181   1  yes   1mg oral single dose       2
## 2    70   35 181   1  yes   1mg oral single dose       2
## 3    70   35 181   1   no   1mg oral single dose       2
## 4    70   35 181   1   no   1mg oral single dose       2
## 5    70   35 181   1   no   1mg oral single dose       2
## 6    70   35 181   1   no   1mg oral single dose       2
## 7    70   35 181   1   no   1mg oral single dose       2
## 8    70   35 181   1  yes   1mg oral single dose       2
## 9    70   35 181   1  yes   1mg oral single dose       2
## 10   70   35 181   1  yes   1mg oral single dose       2
## 11   70   35 181   1  yes   1mg oral single dose       2
## 12   70   35 181   1  yes   1mg oral single dose       2
## 13   87   32 174   1  yes   2mg oral single dose       2
## 14   87   32 174   1   no   2mg oral single dose       2
## 15   87   32 174   1   no   2mg oral single dose       2
## 16   87   32 174   1   no   2mg oral single dose       2
## 17   87   32 174   1   no   2mg oral single dose       2
## 18   87   32 174   1   no   2mg oral single dose       2
## 19   87   32 174   1   no   2mg oral single dose       2
## 20   87   32 174   1  yes   2mg oral single dose       2
## 21   87   32 174   1  yes   2mg oral single dose       2
## 22   87   32 174   1  yes   2mg oral single dose       2
## 23   87   32 174   1  yes   2mg oral single dose       2
## 24   87   32 174   1  yes   2mg oral single dose       2
## 25   79   30 177   1  yes   2mg oral single dose       2
## 26   79   30 177   1   no   2mg oral single dose       2
## 27   79   30 177   1   no   2mg oral single dose       2
## 28   79   30 177   1   no   2mg oral single dose       2
## 29   79   30 177   1   no   2mg oral single dose       2
## 30   79   30 177   1   no   2mg oral single dose       2
## 31   79   30 177   1   no   2mg oral single dose       2
## 32   79   30 177   1  yes   2mg oral single dose       2
## 33   79   30 177   1  yes   2mg oral single dose       2
## 34   79   30 177   1  yes   2mg oral single dose       2
## 35   79   30 177   1  yes   2mg oral single dose       2
## 36   79   30 177   1  yes   2mg oral single dose       2
## 37   66   36 178   1  yes   5mg oral single dose       2
## 38   66   36 178   1   no   5mg oral single dose       2
## 39   66   36 178   1   no   5mg oral single dose       2
## 40   66   36 178   1   no   5mg oral single dose       2
## 41   66   36 178   1   no   5mg oral single dose       2
## 42   66   36 178   1   no   5mg oral single dose       2
## 43   66   36 178   1   no   5mg oral single dose       2
## 44   66   36 178   1   no   5mg oral single dose       2
## 45   66   36 178   1  yes   5mg oral single dose       2
## 46   66   36 178   1  yes   5mg oral single dose       2
## 47   66   36 178   1  yes   5mg oral single dose       2
## 48   66   36 178   1  yes   5mg oral single dose       2
## 49   71   34 176   1  yes   5mg oral single dose       2
## 50   71   34 176   1   no   5mg oral single dose       2
## 51   71   34 176   1   no   5mg oral single dose       2
## 52   71   34 176   1   no   5mg oral single dose       2
## 53   71   34 176   1   no   5mg oral single dose       2
## 54   71   34 176   1   no   5mg oral single dose       2
## 55   71   34 176   1  yes   5mg oral single dose       2
## 56   71   34 176   1   no   5mg oral single dose       2
## 57   71   34 176   1  yes   5mg oral single dose       2
## 58   71   34 176   1  yes   5mg oral single dose       2
## 59   71   34 176   1  yes   5mg oral single dose       2
## 60   71   34 176   1  yes   5mg oral single dose       2
## 61   78   34 181   1  yes  10mg oral single dose       2
## 62   78   34 181   1   no  10mg oral single dose       2
## 63   78   34 181   1   no  10mg oral single dose       2
## 64   78   34 181   1   no  10mg oral single dose       2
## 65   78   34 181   1   no  10mg oral single dose       2
## 66   78   34 181   1   no  10mg oral single dose       2
## 67   78   34 181   1   no  10mg oral single dose       2
## 68   78   34 181   1   no  10mg oral single dose       2
## 69   78   34 181   1   no  10mg oral single dose       2
## 70   78   34 181   1  yes  10mg oral single dose       2
## 71   78   34 181   1   no  10mg oral single dose       2
## 72   78   34 181   1  yes  10mg oral single dose       2
## 73   78   32 186   1  yes  20mg oral single dose       2
## 74   78   32 186   1   no  20mg oral single dose       2
## 75   78   32 186   1   no  20mg oral single dose       2
## 76   78   32 186   1   no  20mg oral single dose       2
## 77   78   32 186   1   no  20mg oral single dose       2
## 78   78   32 186   1   no  20mg oral single dose       2
## 79   78   32 186   1   no  20mg oral single dose       2
## 80   78   32 186   1   no  20mg oral single dose       2
## 81   78   32 186   1   no  20mg oral single dose       2
## 82   78   32 186   1   no  20mg oral single dose       2
## 83   78   32 186   1  yes  20mg oral single dose       2
## 84   78   32 186   1   no  20mg oral single dose       2
## 85   77   32 168   1  yes  20mg oral single dose       2
## 86   77   32 168   1   no  20mg oral single dose       2
## 87   77   32 168   1   no  20mg oral single dose       2
## 88   77   32 168   1   no  20mg oral single dose       2
## 89   77   32 168   1   no  20mg oral single dose       2
## 90   77   32 168   1   no  20mg oral single dose       2
## 91   77   32 168   1   no  20mg oral single dose       2
## 92   77   32 168   1   no  20mg oral single dose       2
## 93   77   32 168   1   no  20mg oral single dose       2
## 94   77   32 168   1   no  20mg oral single dose       2
## 95   77   32 168   1   no  20mg oral single dose       2
## 96   77   32 168   1   no  20mg oral single dose       2
## 97   74   31 181   1  yes  20mg oral single dose       2
## 98   74   31 181   1   no  20mg oral single dose       2
## 99   74   31 181   1   no  20mg oral single dose       2
## 100  74   31 181   1   no  20mg oral single dose       2
## 101  74   31 181   1   no  20mg oral single dose       2
## 102  74   31 181   1   no  20mg oral single dose       2
## 103  74   31 181   1   no  20mg oral single dose       2
## 104  74   31 181   1   no  20mg oral single dose       2
## 105  74   31 181   1   no  20mg oral single dose       2
## 106  74   31 181   1   no  20mg oral single dose       2
## 107  74   31 181   1   no  20mg oral single dose       2
## 108  74   31 181   1  yes  20mg oral single dose       2
## 109  76   35 174   1  yes  50mg oral single dose       2
## 110  76   35 174   1   no  50mg oral single dose       2
## 111  76   35 174   1   no  50mg oral single dose       2
## 112  76   35 174   1   no  50mg oral single dose       2
## 113  76   35 174   1   no  50mg oral single dose       2
## 114  76   35 174   1   no  50mg oral single dose       2
## 115  76   35 174   1   no  50mg oral single dose       2
## 116  76   35 174   1   no  50mg oral single dose       2
## 117  76   35 174   1   no  50mg oral single dose       2
## 118  76   35 174   1   no  50mg oral single dose       2
## 119  76   35 174   1   no  50mg oral single dose       2
## 120  76   35 174   1   no  50mg oral single dose       2
## 121  94   34 181   1  yes  50mg oral single dose       2
## 122  94   34 181   1   no  50mg oral single dose       2
## 123  94   34 181   1   no  50mg oral single dose       2
## 124  94   34 181   1   no  50mg oral single dose       2
## 125  94   34 181   1   no  50mg oral single dose       2
## 126  94   34 181   1   no  50mg oral single dose       2
## 127  94   34 181   1   no  50mg oral single dose       2
## 128  94   34 181   1   no  50mg oral single dose       2
## 129  94   34 181   1   no  50mg oral single dose       2
## 130  94   34 181   1   no  50mg oral single dose       2
## 131  94   34 181   1   no  50mg oral single dose       2
## 132  94   34 181   1   no  50mg oral single dose       2
## 133  75   34 182   1  yes  50mg oral single dose       2
## 134  75   34 182   1   no  50mg oral single dose       2
## 135  75   34 182   1   no  50mg oral single dose       2
## 136  75   34 182   1   no  50mg oral single dose       2
## 137  75   34 182   1   no  50mg oral single dose       2
## 138  75   34 182   1   no  50mg oral single dose       2
## 139  75   34 182   1   no  50mg oral single dose       2
## 140  75   34 182   1   no  50mg oral single dose       2
## 141  75   34 182   1   no  50mg oral single dose       2
## 142  75   34 182   1   no  50mg oral single dose       2
## 143  75   34 182   1   no  50mg oral single dose       2
## 144  75   34 182   1   no  50mg oral single dose       2
## 145  85   32 179   1  yes 100mg oral single dose       2
## 146  85   32 179   1   no 100mg oral single dose       2
## 147  85   32 179   1   no 100mg oral single dose       2
## 148  85   32 179   1   no 100mg oral single dose       2
## 149  85   32 179   1   no 100mg oral single dose       2
## 150  85   32 179   1   no 100mg oral single dose       2
## 151  85   32 179   1   no 100mg oral single dose       2
## 152  85   32 179   1   no 100mg oral single dose       2
## 153  85   32 179   1   no 100mg oral single dose       2
## 154  85   32 179   1   no 100mg oral single dose       2
## 155  85   32 179   1   no 100mg oral single dose       2
## 156  85   32 179   1   no 100mg oral single dose       2
## 157  92   33 179   1  yes 100mg oral single dose       2
## 158  92   33 179   1   no 100mg oral single dose       2
## 159  92   33 179   1   no 100mg oral single dose       2
## 160  92   33 179   1   no 100mg oral single dose       2
## 161  92   33 179   1   no 100mg oral single dose       2
## 162  92   33 179   1   no 100mg oral single dose       2
## 163  92   33 179   1   no 100mg oral single dose       2
## 164  92   33 179   1   no 100mg oral single dose       2
## 165  92   33 179   1   no 100mg oral single dose       2
## 166  92   33 179   1   no 100mg oral single dose       2
## 167  92   33 179   1   no 100mg oral single dose       2
## 168  92   33 179   1   no 100mg oral single dose       2
## 169  88   34 178   1  yes 100mg oral single dose       2
## 170  88   34 178   1   no 100mg oral single dose       2
## 171  88   34 178   1   no 100mg oral single dose       2
## 172  88   34 178   1   no 100mg oral single dose       2
## 173  88   34 178   1   no 100mg oral single dose       2
## 174  88   34 178   1   no 100mg oral single dose       2
## 175  88   34 178   1   no 100mg oral single dose       2
## 176  88   34 178   1   no 100mg oral single dose       2
## 177  88   34 178   1   no 100mg oral single dose       2
## 178  88   34 178   1   no 100mg oral single dose       2
## 179  88   34 178   1   no 100mg oral single dose       2
## 180  88   34 178   1   no 100mg oral single dose       2
## 181  90   31 188   1  yes 100mg oral single dose       2
## 182  90   31 188   1   no 100mg oral single dose       2
## 183  90   31 188   1   no 100mg oral single dose       2
## 184  90   31 188   1   no 100mg oral single dose       2
## 185  90   31 188   1   no 100mg oral single dose       2
## 186  90   31 188   1   no 100mg oral single dose       2
## 187  90   31 188   1   no 100mg oral single dose       2
## 188  90   31 188   1   no 100mg oral single dose       2
## 189  90   31 188   1   no 100mg oral single dose       2
## 190  90   31 188   1   no 100mg oral single dose       2
## 191  90   31 188   1   no 100mg oral single dose       2
## 192  90   31 188   1   no 100mg oral single dose       2
## 193  73   31 176   1  yes 200mg oral single dose       2
## 194  73   31 176   1   no 200mg oral single dose       2
## 195  73   31 176   1   no 200mg oral single dose       2
## 196  73   31 176   1   no 200mg oral single dose       2
## 197  73   31 176   1   no 200mg oral single dose       2
## 198  73   31 176   1   no 200mg oral single dose       2
## 199  73   31 176   1   no 200mg oral single dose       2
## 200  73   31 176   1   no 200mg oral single dose       2
## 201  73   31 176   1   no 200mg oral single dose       2
## 202  73   31 176   1   no 200mg oral single dose       2
## 203  73   31 176   1   no 200mg oral single dose       2
## 204  73   31 176   1   no 200mg oral single dose       2
## 205  67   31 172   1  yes 200mg oral single dose       2
## 206  67   31 172   1   no 200mg oral single dose       2
## 207  67   31 172   1   no 200mg oral single dose       2
## 208  67   31 172   1   no 200mg oral single dose       2
## 209  67   31 172   1   no 200mg oral single dose       2
## 210  67   31 172   1   no 200mg oral single dose       2
## 211  67   31 172   1   no 200mg oral single dose       2
## 212  67   31 172   1   no 200mg oral single dose       2
## 213  67   31 172   1   no 200mg oral single dose       2
## 214  67   31 172   1   no 200mg oral single dose       2
## 215  67   31 172   1   no 200mg oral single dose       2
## 216  67   31 172   1   no 200mg oral single dose       2
## 217  77   32 178   1  yes 200mg oral single dose       2
## 218  77   32 178   1   no 200mg oral single dose       2
## 219  77   32 178   1   no 200mg oral single dose       2
## 220  77   32 178   1   no 200mg oral single dose       2
## 221  77   32 178   1   no 200mg oral single dose       2
## 222  77   32 178   1   no 200mg oral single dose       2
## 223  77   32 178   1   no 200mg oral single dose       2
## 224  77   32 178   1   no 200mg oral single dose       2
## 225  77   32 178   1   no 200mg oral single dose       2
## 226  77   32 178   1   no 200mg oral single dose       2
## 227  77   32 178   1   no 200mg oral single dose       2
## 228  77   32 178   1   no 200mg oral single dose       2
## 229  91   38 174   1  yes 200mg oral single dose       2
## 230  91   38 174   1   no 200mg oral single dose       2
## 231  91   38 174   1   no 200mg oral single dose       2
## 232  91   38 174   1   no 200mg oral single dose       2
## 233  91   38 174   1   no 200mg oral single dose       2
## 234  91   38 174   1   no 200mg oral single dose       2
## 235  91   38 174   1   no 200mg oral single dose       2
## 236  91   38 174   1   no 200mg oral single dose       2
## 237  91   38 174   1   no 200mg oral single dose       2
## 238  91   38 174   1   no 200mg oral single dose       2
## 239  91   38 174   1   no 200mg oral single dose       2
## 240  91   38 174   1   no 200mg oral single dose       2
Covariates

The function plotCovDistribution_IQRdataGENERAL() visualizes the distribution of continuous and covariates, thus being a graphical counterpart to the summaryCov_IQRdataGENERAL() and summaryCat_IQRdataGENERAL() functions. Graphically we can explore also the correlations among continuous covariates (plotCorCov_IQRdataGENERAL()), among categorical covariates (plotCorCat_IQRdataGENERAL()), and between continuous and categorical covariates (plotCorCovCat_IQRdataGENERAL()). In our example, we make use of the input arguments covNames/catNames to neglect the SEX covariate in the plots as it contains only one category (see summary table above).

# Distribution of continuous and categorical covariates
plotCovDistribution_IQRdataGENERAL(data1CleanM3, covNames = c("STUDYN", "TRT"))
## $continuous
## NULL
## 
## $categorical

## 
## attr(,"data")
## attr(,"data")$cat
##    COLNAME           USUBJID                  VALUE    NAME UNIT
## 1   STUDYN IQ00701-0100-0003                    FIH   Study    -
## 2   STUDYN IQ00701-0100-0004                    FIH   Study    -
## 3   STUDYN IQ00701-0100-0005                    FIH   Study    -
## 4   STUDYN IQ00701-0100-0006                    FIH   Study    -
## 5   STUDYN IQ00701-0100-0007                    FIH   Study    -
## 6   STUDYN IQ00701-0100-0009                    FIH   Study    -
## 7   STUDYN IQ00701-0100-0010                    FIH   Study    -
## 8   STUDYN IQ00701-0100-0011                    FIH   Study    -
## 9   STUDYN IQ00701-0100-0012                    FIH   Study    -
## 10  STUDYN IQ00701-0100-0013                    FIH   Study    -
## 11  STUDYN IQ00701-0100-0014                    FIH   Study    -
## 12  STUDYN IQ00701-0100-0015                    FIH   Study    -
## 13  STUDYN IQ00701-0100-0016                    FIH   Study    -
## 14  STUDYN IQ00701-0100-0017                    FIH   Study    -
## 15  STUDYN IQ00701-0100-0019                    FIH   Study    -
## 16  STUDYN IQ00701-0100-0020                    FIH   Study    -
## 17  STUDYN IQ00701-0100-0021                    FIH   Study    -
## 18  STUDYN IQ00701-0100-0022                    FIH   Study    -
## 19  STUDYN IQ00701-0100-0023                    FIH   Study    -
## 20  STUDYN IQ00701-0100-0024                    FIH   Study    -
## 21  STUDYN IQ00701-0100-0025                    FIH   Study    -
## 22  STUDYN IQ00701-0100-0026                    FIH   Study    -
## 23  STUDYN IQ00701-0100-0027                    FIH   Study    -
## 24  STUDYN IQ00701-0100-0028                    FIH   Study    -
## 25  STUDYN IQ00701-0100-0029                    FIH   Study    -
## 26  STUDYN IQ00701-0100-0030                    FIH   Study    -
## 27  STUDYN IQ00701-0100-0031                    FIH   Study    -
## 28  STUDYN IQ00701-0100-0032                    FIH   Study    -
## 29  STUDYN IQ00701-0100-0033                    FIH   Study    -
## 30  STUDYN IQ00701-0100-0034                    FIH   Study    -
## 31  STUDYN IQ00701-0100-0035                    FIH   Study    -
## 32  STUDYN IQ00701-0100-0036                    FIH   Study    -
## 33  STUDYN IQ00701-0100-0037          FIH extension   Study    -
## 34  STUDYN IQ00701-0100-0038          FIH extension   Study    -
## 35  STUDYN IQ00701-0100-0039          FIH extension   Study    -
## 36  STUDYN IQ00701-0100-0040          FIH extension   Study    -
## 37  STUDYN IQ00701-0100-0041          FIH extension   Study    -
## 38  STUDYN IQ00701-0100-0042          FIH extension   Study    -
## 39  STUDYN IQ00701-0100-0043          FIH extension   Study    -
## 40  STUDYN IQ00701-0100-0044          FIH extension   Study    -
## 41  STUDYN IQ00701-0100-0045          FIH extension   Study    -
## 42  STUDYN IQ00701-0100-0046          FIH extension   Study    -
## 43  STUDYN IQ00701-0100-0047          FIH extension   Study    -
## 44  STUDYN IQ00701-0100-0048          FIH extension   Study    -
## 45     TRT IQ00701-0100-0003   1mg oral single dose TRTNAME    -
## 46     TRT IQ00701-0100-0004   1mg oral single dose TRTNAME    -
## 47     TRT IQ00701-0100-0005   1mg oral single dose TRTNAME    -
## 48     TRT IQ00701-0100-0006   1mg oral single dose TRTNAME    -
## 49     TRT IQ00701-0100-0007   2mg oral single dose TRTNAME    -
## 50     TRT IQ00701-0100-0009   2mg oral single dose TRTNAME    -
## 51     TRT IQ00701-0100-0010   2mg oral single dose TRTNAME    -
## 52     TRT IQ00701-0100-0011   2mg oral single dose TRTNAME    -
## 53     TRT IQ00701-0100-0012   2mg oral single dose TRTNAME    -
## 54     TRT IQ00701-0100-0013   5mg oral single dose TRTNAME    -
## 55     TRT IQ00701-0100-0014   5mg oral single dose TRTNAME    -
## 56     TRT IQ00701-0100-0015   5mg oral single dose TRTNAME    -
## 57     TRT IQ00701-0100-0016   5mg oral single dose TRTNAME    -
## 58     TRT IQ00701-0100-0017   5mg oral single dose TRTNAME    -
## 59     TRT IQ00701-0100-0019  10mg oral single dose TRTNAME    -
## 60     TRT IQ00701-0100-0020  10mg oral single dose TRTNAME    -
## 61     TRT IQ00701-0100-0021  10mg oral single dose TRTNAME    -
## 62     TRT IQ00701-0100-0022  10mg oral single dose TRTNAME    -
## 63     TRT IQ00701-0100-0023  10mg oral single dose TRTNAME    -
## 64     TRT IQ00701-0100-0024  10mg oral single dose TRTNAME    -
## 65     TRT IQ00701-0100-0025  20mg oral single dose TRTNAME    -
## 66     TRT IQ00701-0100-0026  20mg oral single dose TRTNAME    -
## 67     TRT IQ00701-0100-0027  20mg oral single dose TRTNAME    -
## 68     TRT IQ00701-0100-0028  20mg oral single dose TRTNAME    -
## 69     TRT IQ00701-0100-0029  20mg oral single dose TRTNAME    -
## 70     TRT IQ00701-0100-0030  20mg oral single dose TRTNAME    -
## 71     TRT IQ00701-0100-0031  50mg oral single dose TRTNAME    -
## 72     TRT IQ00701-0100-0032  50mg oral single dose TRTNAME    -
## 73     TRT IQ00701-0100-0033  50mg oral single dose TRTNAME    -
## 74     TRT IQ00701-0100-0034  50mg oral single dose TRTNAME    -
## 75     TRT IQ00701-0100-0035  50mg oral single dose TRTNAME    -
## 76     TRT IQ00701-0100-0036  50mg oral single dose TRTNAME    -
## 77     TRT IQ00701-0100-0037 100mg oral single dose TRTNAME    -
## 78     TRT IQ00701-0100-0038 100mg oral single dose TRTNAME    -
## 79     TRT IQ00701-0100-0039 100mg oral single dose TRTNAME    -
## 80     TRT IQ00701-0100-0040 100mg oral single dose TRTNAME    -
## 81     TRT IQ00701-0100-0041 100mg oral single dose TRTNAME    -
## 82     TRT IQ00701-0100-0042 100mg oral single dose TRTNAME    -
## 83     TRT IQ00701-0100-0043 200mg oral single dose TRTNAME    -
## 84     TRT IQ00701-0100-0044 200mg oral single dose TRTNAME    -
## 85     TRT IQ00701-0100-0045 200mg oral single dose TRTNAME    -
## 86     TRT IQ00701-0100-0046 200mg oral single dose TRTNAME    -
## 87     TRT IQ00701-0100-0047 200mg oral single dose TRTNAME    -
## 88     TRT IQ00701-0100-0048 200mg oral single dose TRTNAME    -
##             COVlabel
## 1  STUDYN\nStudy (-)
## 2  STUDYN\nStudy (-)
## 3  STUDYN\nStudy (-)
## 4  STUDYN\nStudy (-)
## 5  STUDYN\nStudy (-)
## 6  STUDYN\nStudy (-)
## 7  STUDYN\nStudy (-)
## 8  STUDYN\nStudy (-)
## 9  STUDYN\nStudy (-)
## 10 STUDYN\nStudy (-)
## 11 STUDYN\nStudy (-)
## 12 STUDYN\nStudy (-)
## 13 STUDYN\nStudy (-)
## 14 STUDYN\nStudy (-)
## 15 STUDYN\nStudy (-)
## 16 STUDYN\nStudy (-)
## 17 STUDYN\nStudy (-)
## 18 STUDYN\nStudy (-)
## 19 STUDYN\nStudy (-)
## 20 STUDYN\nStudy (-)
## 21 STUDYN\nStudy (-)
## 22 STUDYN\nStudy (-)
## 23 STUDYN\nStudy (-)
## 24 STUDYN\nStudy (-)
## 25 STUDYN\nStudy (-)
## 26 STUDYN\nStudy (-)
## 27 STUDYN\nStudy (-)
## 28 STUDYN\nStudy (-)
## 29 STUDYN\nStudy (-)
## 30 STUDYN\nStudy (-)
## 31 STUDYN\nStudy (-)
## 32 STUDYN\nStudy (-)
## 33 STUDYN\nStudy (-)
## 34 STUDYN\nStudy (-)
## 35 STUDYN\nStudy (-)
## 36 STUDYN\nStudy (-)
## 37 STUDYN\nStudy (-)
## 38 STUDYN\nStudy (-)
## 39 STUDYN\nStudy (-)
## 40 STUDYN\nStudy (-)
## 41 STUDYN\nStudy (-)
## 42 STUDYN\nStudy (-)
## 43 STUDYN\nStudy (-)
## 44 STUDYN\nStudy (-)
## 45  TRT\nTRTNAME (-)
## 46  TRT\nTRTNAME (-)
## 47  TRT\nTRTNAME (-)
## 48  TRT\nTRTNAME (-)
## 49  TRT\nTRTNAME (-)
## 50  TRT\nTRTNAME (-)
## 51  TRT\nTRTNAME (-)
## 52  TRT\nTRTNAME (-)
## 53  TRT\nTRTNAME (-)
## 54  TRT\nTRTNAME (-)
## 55  TRT\nTRTNAME (-)
## 56  TRT\nTRTNAME (-)
## 57  TRT\nTRTNAME (-)
## 58  TRT\nTRTNAME (-)
## 59  TRT\nTRTNAME (-)
## 60  TRT\nTRTNAME (-)
## 61  TRT\nTRTNAME (-)
## 62  TRT\nTRTNAME (-)
## 63  TRT\nTRTNAME (-)
## 64  TRT\nTRTNAME (-)
## 65  TRT\nTRTNAME (-)
## 66  TRT\nTRTNAME (-)
## 67  TRT\nTRTNAME (-)
## 68  TRT\nTRTNAME (-)
## 69  TRT\nTRTNAME (-)
## 70  TRT\nTRTNAME (-)
## 71  TRT\nTRTNAME (-)
## 72  TRT\nTRTNAME (-)
## 73  TRT\nTRTNAME (-)
## 74  TRT\nTRTNAME (-)
## 75  TRT\nTRTNAME (-)
## 76  TRT\nTRTNAME (-)
## 77  TRT\nTRTNAME (-)
## 78  TRT\nTRTNAME (-)
## 79  TRT\nTRTNAME (-)
## 80  TRT\nTRTNAME (-)
## 81  TRT\nTRTNAME (-)
## 82  TRT\nTRTNAME (-)
## 83  TRT\nTRTNAME (-)
## 84  TRT\nTRTNAME (-)
## 85  TRT\nTRTNAME (-)
## 86  TRT\nTRTNAME (-)
## 87  TRT\nTRTNAME (-)
## 88  TRT\nTRTNAME (-)
# Correlation of continuous covariates
plotCorCov_IQRdataGENERAL(data1CleanM3)
# Correlation of categorical covariates
plotCorCat_IQRdataGENERAL(data1CleanM3, catNames = c("STUDYN", "TRT"))

# Correlation of continuous and categorical covariates
plotCorCovCat_IQRdataGENERAL(data1CleanM3, catNames = c("STUDYN", "TRT"))