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1. Raue, Bioinformatics 31(21), 2015↩︎

2. Kaschek, dMod, 2016 (https://cran.r-project.org/package=dMod)↩︎

Simulate Virtual Subjects, Cohorts, Populations

sim_IQRvirtualSubjects.Rd

Virtual subjects, cohorts, and populations that have been exported using the function exportVirtualSubjects_IQRnlmeProject() can be simulated with this function. A list is returned, containing the plot and the simulation results as data.frame. Only a single output can be considered at a time - which is OK as the function is mainly for demo at the moment ... for real simulations one would probably do something fit for purpose or call this function several times ... it is fast anyway.

sim_IQRvirtualSubjects(
  VPpath,
  output,
  simtime,
  dosingTable = NULL,
  problow = 0.1,
  probhigh = 0.9,
  FLAGindiv = TRUE
)

Arguments

VPpath

Path to which the export was done with exportVirtualSubjects_IQRnlmeProject()

output

Name of the state, variable, or reaction in the model to return. Only a single readout can be considered at this point by this function. No limitation - as by some lines of script everything is possible!

simtime

Vector defining the simulation time. If exported VSs were in steady-state any perturbation of the system can start at time 0. Otherwise - think about "run-in" time.

dosingTable

IQRdosing object to apply to all virtual subjects.

problow

Lower quantile to compute (0-1) and plot. Median always determined.

probhigh

Upper quantile to compute (0-1) and plot. Median always determined.

FLAGindiv

If TRUE also the individual simulations are plotted. If FALSE not.

See also

Other QSP: IQRsysEst(), IQRsysModel(), IQRsysProject(), addOutputs_IQRmodel(), addRelations_IQRmodel(), as_IQRsysEst(), as_IQRsysProjectMulti(), as_IQRsysProject(), comparePars_IQRsysModel(), duplicate_IQRsysProject(), exportVariant_IQRmodel(), exportVirtualSubjects_IQRnlmeProject(), export_IQRsysData(), getDosing_IQRsysModel(), getEmpiricalETACovarianceMatrix_IQRsysProject(), getOptTrace_IQRsysProject(), getPars_IQRoptTrace(), getPars_IQRsysModel(), getPrediction_IQRsysModel(), hasrun_IQRsysProject(), importVariant_IQRmodel(), import_IQRsysData(), is_IQRsysEst(), is_IQRsysModel(), is_IQRsysProjectMulti(), is_IQRsysProject(), load_IQRsysProject(), modelSpec_IQRsysEst(), model_IQRsysModel(), offsetTIME_IQRsysData(), plotDVPRED_IQRsysModel(), plotFit_IQRsysModel(), plotPars_IQRsysModel(), plotPred_IQRsysModel(), plotProfile_IQRsysModel(), plotWRES_IQRsysModel(), plotWaterfall_IQRsysModel(), plot_IQRoptTrace(), plot_IQRsysModel(), print.IQRsensitivity(), print.IQRsysProject(), profile_IQRsysModel(), replaceTerms_IQRmodel(), run_IQRsysProjectMulti(), run_IQRsysProject(), sample_IQRsysModel(), sensitivity_IQRmodel(), setPars_IQRsysModel(), sim_IQRsysModel(), simbio_CSV2namedVector(), simbio_updateParamIC_IQRmodel(), spmIIV_IQRsysProject(), spm_IQRsysProject(), switchOpt_IQRsysModel(), tablePars_IQRsysModel()